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Publications

2023

In vitro development of imipenem/relebactam resistance in KPC-producing Klebsiella pneumoniae involves multiple mutations including OmpK36 disruption and KPC modification 
E. Gato, P. Guijarro-Sánchez, I. Alonso-García, R. Pedraza-Merino, A. Conde, E. Lence, S. Rumbo-Feal, A. Peña-Escolano, C. Lasarte-Monterrubio, T. Blanco-Martín, A. Fernández-González, M.C. Fernández-López, R. Maceiras, M. Martínez-Guitián, J.C. Vázquez-Ucha, L. Martínez-Martínez, C. González-Bello, J. Arca-Suárez, A. Beceiro, G. Bou

Interplay Between OXA-10 β-lactamase Production and Low Outer Membrane Permeability in Carbapenem Resistance in Enterobacterales
I. Alonso-García, J.C. Vázquez-Ucha, M. Martínez-Guitián, C. Lasarte-Monterrubio, S. Rodríguez-Pallares, P. Camacho-Zamora, S. Rumbo-Feal, P. Aja-Macaya, L. González-Pinto, M. Outeda, R. Maceiras, P. Guijarro-Sánchez, M.J. Muíño-Andrade, A. Fernández-González, M. Oviaño, C- González-Bello, J. Arca-Suárez, A. Beceiro, G. Bou

Antimicrobial Activity of Cefiderocol against the carbapenemase-producing Enterobacter cloacae complex and characterization of reduced susceptibility associated with metallo-β-lactamase VIM-1
C. Lasarte-Monterrubio, P. Guijarro-Sánchez, J. Vázquez-Ucha, I. Alonso-García, L. Alvarez-Fraga, M. Outeda, M. Martínez-Guitián, A. Peña-Escolano, R. Maceiras, E. Lence, C. González-Bello, J. Arca-Suárez, G. Bou, A. Beceiro

Siderophores: Chemical tools for precise antibiotic delivery
D. Rodríguez, C. González-Bello

Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme—A molecular insight
Á. Rodríguez, M. Maneiro, E. Lence, J.M. Otero, M.J. van Raaij, P. Thompson, A.R. Hawkins, C. González-Bello

Singlet Oxygen and Radical-Mediated Mechanisms in the Oxidative Cellular Damage Photosensitized by the Protease Inhibitor Simeprevir
G. García-Lainez, M. El Ouardi, A. Moreno, E. Lence, C. González-Bello, M.A. Miranda, I. Andreu

2022

Switching from ultrafast electron transfer to proton transfer in excited drug–protein complexes upon biotransformation
L. Tamarit, M. El Ouardi, E. Lence, I. Andreu, C. González-Bello, I. Vayá, M.A. Miranda

Regioselective Synthesis of 2-Aryl-5-cyano-1-(2-hydroxyaryl)-1H-imidazole-4-carboxamides Self-Assisted by a 2-Hydroxyaryl Group
F. Pedroso de Lima, E. Lence, P. Suárez de Cepeda, C. Correia, M.A. Carvalho, C. González-Bello, M.F. Proença

Discovery of 3H-pyrrolo[2,3-c]quinolines with activity against Mycobacterium tuberculosis by allosteric inhibition of the glutamate-5-kinase enzyme
M. Panciera, E. Lence. A. Rodríguez, B. Gracia, J.A. Aínsa, C. Marco-Marín, V. Rubio, C. Roque Duarte Correira, C. González-Bello

Selection of AmpC β-Lactamase Variants and Metallo-β-Lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/XDR Pseudomonas aeruginosa Infections
A. Ruedas-López, I. Alonso-García, C. Lasarte-Monterrubio, P. Guijarro-Sánchez, E. Gato, J.C. Vázquez-Ucha, J.A. Vallejo, P.A. Fraile-Ribot, B. Fernández-Pérez, D. Velasco, J.M. Gutiérrez-Urbón, M. Oviaño, A. Beceiro, C. González-Bello, A. Oliver, J. Arca-Suárez, G. Bou