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Publications

2015

Irreversible Covalent Modification of Type I Dehydroquinase by a Stable Schiff Base
L. Tizón, M. Maneiro, A. Peón, J.M. Otero, E. Lence, S. Poza, M.J. van Raaij, P. Thompson, A. R. Hawkins, C. González Bello

2014

Insights into substrate binding and catalysis in bacterial type I dehydroquinase
M. Maneiro, A. Peón, E. Lence, J.M. Otero, M. J. Van Raaij, P. Thompson, A. R. Hawjins, C. González Bello

Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors
B. Blanco, S. Sedes, A. Peón, J.M. Otero, M.J. van Raaij, P. Thompson, A. R. Hawkins, C. González Bello

Mechanistic Insight Into the Reaction Catalysed by Bacterial Type II Dehydroquinases
C. Coderch, E. Lence, A. Peón, H. Lamb, A.R. Hawkins,F. Gago, C. González Bello

Dual role of 2-tosylaminomethylaniline as a ligand and a nucleophile in the copper-mediated oxidation of methanol
J. Sanmartín Matalobos, A.M. García Deibe, L. Briones Miguéns, C González Bello, C Portela García, M Fondo

2013

Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids
E. Lence, L. Tizón, J.M. Otero,A. Peón, V.F.V. Prazeres, A. I. Llamas-Sais, G.C. Fox, M.L. van Raaij, H. Lamb, A.R. Hawkins, C. González-Bello

Comparative Binding Energy (COMBINE) Analysis for Understanding the Binding Determinants of Type II Dehydroquinase Inhibitor
A. Peón; C. Coderch; F. Gago; C. González-Bello

Serendipitous formation of 3-tosyl-1,2,3,4-tetrahydroquinazoline
J. Sanmartín-Matalobos, A. M. García-Deibe, L. Briones-Miguéns, E. Lence, C. González-Bello, C. Portela-García, M. Fondo

Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover
B. Blanco, V. Prado, E. Lence, J. M. Otero, C. Garcia-Doval, M. J. van Raaij, A. L. Llamas-Saiz, H. Lamb, A. R. Hawkins, C. González-Bello

2012

Synthesis of 3-Alkyl Enol Mimics Inhibitors of Type II Dehydroquinase: Factors Influencing Their Inhibition Potency
B. Blanco, A. Sedes, A. Peón, H. Lamb, A. R. Hawkins, L. Castedo, C. González-Bello