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Publications

2018

Three-Dimensional Printing in Catalysis: Combining 3D Heterogeneous Copper and Palladium Catalysts for Multicatalytic Multicomponent Reactions
A.S. Díaz-Marta,  C.R. Tubío, C. Carbajales, C. Fernández, L. Escalante, E. Sotelo, F. Guitián, V. L. Barrio, A. Gil, A. Coelho

Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms
W. Jespers, A.C. Schiedel, L.H. Heitman, R.M. Cooke, L. Kleene, G.J.P. van Westen, D.E. Gloriam, C.E. Müller, E. Sotelo, H. Gutiérrez-de-Terán

2017

Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases
L. Kalash, C. Val, J. Azuaje, M.I. Loza, F. Svensson, A. Zoufir, L. Mervin, G. Ladds, J. Brea, R. Glen, E. Sotelo, A. Bender

Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors
W. Jespers, A. Oliveira, R. Prieto-Díaz, M. Majellaro, J. Åqvist, E. Sotelo, H. Gutiérrez-de-Terán

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid
V. Fernández-Dueñas, J. Azuaje, X. Morató, B. Cordobilla, J.C. Domingo, E. Sotelo, F. Ciruela

Exploring the influence of the substituent at position 4 in a series of 3,4-dihydropyrimidin-2(1H)-one A2Badenosine receptor antagonists
A. Crespo, A. El Maatougui, J. Azuaje, L. Escalante, M. Majellaro, M.I. Loza, J. Brea, M.I. Cadavid, H. Gutiérrez-de-Terán, E. Sotelo

Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors
J. Azuaje, P. López, A. Iglesias, R.A. de la Fuente, J.M. Pérez-Rubio, D. García, T.M. Stępniewski, X. García-Mera, J.M. Brea, J. Selent, D. Pérez, M. Castro, M.I. Loza, E. Sotelo

Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N‑(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists
J. Azuaje, W. Jespers, V. Yaziji, A. Mallo, M. Majellaro, O. Caamaño, M.I. Loza, M. I. Cadavid, J. Brea, J. Åqvist, E. Sotelo, H. Gutierrez-de-Terán

3-Oxopyridazin-5-yl−Chalcone Hybrids: Potent Antiplatelet Agents That Prevent Glycoprotein IIb/IIIa Activation
A. El Maatougui, M. Yáñez, A. Crespo, N. Fraiz, A. Coelho, E. Raviña, R. Laguna, E. Cano, M. I. Loza, J. Brea, H. Gutiérrez de Terán, E. Sotelo

Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates
C. Carbajales, J. Azuaje, A. Oliveir, M.I. Loza, J. Brea, M.I. Cadavid, C.F. Masaguer, X. García-Mera, H. Gutiérrez-de-Terán, E. Sotelo