- Publication: Niu Z, Samaridou E, Jaumain E, et al. PEG-PGA Enveloped Octaarginine-Peptide Nanocomplexes: An Oral Peptide Delivery Strategy. J Control Release. 2018;276:125-139.
Our latest contribution entitled “PEG-PGA Enveloped Octaarginine-Peptide Nanocomplexes: An Oral Peptide Delivery Strategy”, by Zhigao Niu, Eleni Samaridou et al. and Maria José Alonso is now published in the Journal of Controlled Release [https://doi.org/10.1016/j.jconrel.2018.03.004].
This paper describes a new peptide delivery nanosystem, which was rationally designed to overcome the extracellular and cellular barriers associated to the oral modality of administration. Insulin was used as a model drug. The results showed that the developed system was able to overcome the intestinal barriers (proteolysis, permeability through biological membranes) and remain accumulated at the intestinal level – a result that suggests the potential of this nanosystem for local peptide-based therapies. Overall, this paper represents a large amount of work performed within the frame of the European research project “TRANS-INT – New oral nanomedicines: transporting therapeutic macromolecules across the intestinal barrier” [No. 281035], coordinated by Prof. Alonso.
