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By: MJ Alonso Lab
Our latest paper, published in Journal of Drug Targeting: “Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system”
February 11, 2019The objective of this work was to evaluate the influence of particle size (≈100 versus 200 nm) and surface composition of polymeric nanocapsules (chitosan, polyarginine and carboxymethyl-β-glucan) on their ability to target specific immune cells in the lymphatics.
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Get free access to our latest paper: “Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells”
January 25, 2019Free access until February 21 to this article, dedicated to Prof. N. Peppas and Prof. R. Langer, published in Journal of Controlled Release
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Alonso’s Lab: champion and member of the month of the Oral Drug Delivery Focus Group of the Controlled Release Society
January 17, 2019The Oral Delivery Focus Group of the CRS announced Maria Jose Alonso as the Controlled Release Society Oral Delivery Focus Group February Member of the Month and published a ‘Member Spotlight’ profile highlighting her achievements in science.
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“A multifunctional drug nanocarrier for efficient anticancer therapy”, article dedicated to Prof. N. Peppas and Prof. R. Langer, published in Journal of Controlled Release
December 26, 2018The nanocarrier consisting of functionalized Lyp1-hyaluronic acid nanocapsules accumulated drastically in the tumor tissue (a-37 times higher tumor accumulation than Taxotere®), a fact that was translated into a drastic decrease in tumor growth and metastatic spreading, in an orthotopic lung cancer model.
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Alonso’s Lab Mini-Congress 2018
December 26, 2018The Alonso’s Lab mini-congress is an annual event aimed to motivate and encourage PhD students and Post-Doctoral fellows to present their work in an attractive way, yet not losing the essence of the work.
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Our latest publication: “Engineering, on‐demand manufacturing, and scaling‐up of polymeric nanocapsules”
October 30, 2018In our recent publication “Engineering, on‐demand manufacturing, and scaling‐up of polymeric nanocapsules” we have designed formulation and technological approaches to produce tailor‐made polymeric NCs, according to different scale‐down (microliters) and scale‐up (liter) techniques.
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María José Alonso receives the prestigious “Founders Award” of Controlled Release Society (CRS) and joins the CRS College of Fellows
July 24, 2018María José Alonso, Professor of Biopharmaceutics and Pharmaceutical Technology at the University of Santiago de Compostela (USC), received the prestigious “CRS Founders Award”, the highest distinction granted by the Controlled Release Society, Inc. (CRS, Inc), the worldwide leading organization in delivery sciences and technologies.
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Our latest contribution to Science “Bilayer polymeric nanocapsules: A formulation approach for a thermostable and adjuvanted E. coli antigen vaccine” is now published by the Journal of Controlled Release
July 20, 2018This paper describes a new bilayer nanosystem that entraps IutA antigen from E. Coli in a sandwich-like structure. The research not only opens a new path to develop a vaccine against UPEC infections but also represents a general way of stabilizing and controlling the release of purified protein antigens.
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María José Alonso receives the Castelao Medal from the Government of Galicia
June 28, 2018Castelao Medal is one of the most prestigious awards in this Spanish region and distinguishes Galicians whose social contribution deserves the recognition of their fellow citizens
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The EuroNanoMedIII project 2-INTRATARGET Develops Nano-Immunotherapeutics for the Intracellular targeting of Cancer Cells and Tumor Associated Macrophages
June 15, 2018This public-private European Consortium will develop new nanostructures to deliver selected cancer immunotherapies, such as polynucleotides, to their intracellular targets inside cancer cells and into tumor associated macrophages (TAMs), both at the primary tumor site and in their metastatic niches
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