• Publication: Adriana M. Ledo, Maria S.Sasso, VincenzoBronte, Ilaria Marigo, Ben J. Boyd, Marcos Garcia-Fuentes, María J. Alonso, Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells, J. Control Rel, 295, 60-73 (2019). https://doi.org/10.1016/j.jconrel.2018.12.041

The objective of this work was to develop a delivery carrier, multilayer polymer nanocapsules, with the capacity to co-encapsulate two types of immunomodulatory drugs, a chemokine and an RNAi sequence, aimed at reverting MDSC-mediated immunosuppression. The multilayer polymer nanocapsules described are efficient vehicles for the co-delivery of proteins and RNA, and are potential candidates as nanomedicines for the modulation of MDSCs.

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