Publications

Durán-Lobato M., Tovar S., Cuñarro J., Ramos-Membrive R., Peñuelas I., Marigo I., Benetti F., Chenlo M., V. Álvarez C., Ildikó V., Urbanics R., Szebeni J., Alonso M.J., Bioinspired orthogonal-shaped protein–biometal nanocrystals enable oral protein absorption, J. Control. Rel. 377, 17-36 (2025)

Stephen W. Linderman, Louis DeRidder, Lucía Sanjurjo, Michael B. Foote, María José
Alonso, Ameya R. Kirtane, Robert Langer, Giovanni Traverso, Enhancing immunotherapy with tumour-responsive nanomaterials, Nature reviews clinical oncology (Accepted)

López-Estévez A.m., Carrascal-Miniño A., Torres D., Alonso M.J., de Rosales R. T. M., Pellico J., Biodistribution of 89Zr-Radiolabeled Nanoassemblies for Monoclonal Antibody Delivery Revealed through In Vivo PET Imaging, ACS Omega (2025) https://doi.org/10.1021/acsomega.4c09823

Elena Ibeas Moreno, María José Alonso, Anna Abbadessa, Intraocular injectable hydrogels for the delivery of cells and nanoparticles, Materials Today Bio, Volume 32, 2025, 101767, ISSN 2590-0064, https://doi.org/10.1016/j.mtbio.2025.101767

López Estévez A.M., Lapuhs P., Piñeiro Alonso L., Alonso M.J., Personalized cancer nanomedicine: Overcoming biological barriers for intracellular delivery of biopharmaceuticals, Adv. Materials 36, 2309355 (2024)
https://doi.org/10.1002/adma.202309355

Berrecoso, G., Bravo, S.B., Arriaga, I, Abrescia N., Crecente-Campo J., Alonso M.J., Controlling the protein corona of polymeric nanocapsules: effect of polymer shell on protein adsorption, Drug Deliv. and Transl. Res., 14, 918-933 (2024)
https://doi.org/10.1007/s13346-023-01441-5

Esteban, I.; Pastor-Quiñones, C.; Usero, L.; Aurrecoechea, E.; Franceschini, L.; Esprit, A.; Gelpí, J.L.; Martínez-Jiménez, F.; López-Bigas, N.; Breckpot, K.; et al. Assessment of Human SARS CoV-2-Specific T-Cell Responses Elicited In Vitro by New Computationally Designed mRNA Immunogens (COVARNA). Vaccines, 12, 15. (2024)
https://doi.org/10.3390/vaccines12010015

Laura Marcos-Villar,Beatriz Perdiguero, Shubaash Anthiya, Mireya L. Borrajo, Gustavo Lou, Lorenzo Franceschini, Ignasi Esteban, Pedro J. Sánchez-Cordón, Carmen Zamora, Carlos Óscar S. Sorzano, Luis Jordá, Laia Codó, Josep L. Gelpí, Marta Sisteré-Oró, Andreas Meyerhans, Kris Thielemans, Francisco Martínez-Jiménez, Nuria López-Vigas, Felipe García, María J. Alonso, Montserrat Plana, Mariano Esteban,Carmen Elena Gómez, Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium, npj Vaccines 9, 53 (2024)
https://doi.org/10.1038/s41541-024-00838-8

Mireya L. Borrajo, Gustavo Lou, Shubaash Anthiya, Philipp Lapuhs, David Moreira Álvarez, Araceli Tobío, María Isabel Loza, Anxo Vidal, María José Alonso, Nanoemulsions and nanocapsules as carriers for the development of intranasal mRNA vaccines, Drug Deliv. and Transl. Res. (2024) (In Press)
https://doi.org/10.1007/s13346-024-01635-5

López-Estévez, A.M., Zhang, Y., Medel, M. et al. Engineering hyaluronic acid-based nanoassemblies for monoclonal antibody delivery – design, characterization, and biological insights. Nano Res. (2024). https://doi.org/10.1007/s12274-024-6826-8

Ana M. López-Estévez, Lucía Sanjurjo, Ángela Turrero, Iker Arriaga, Nicola G.A. Abrescia, Ana Poveda, Jesús Jiménez-Barbero, Anxo Vidal, Dolores Torres, María José Alonso, Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors, Journal of Controlled Release, Volume 373, 2024, Pages 277-292, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2024.07.032

Laura Marcos-Villar, Beatriz Perdiguero, María López-Bravo, Carmen Zamora, Laura Sin, Enrique Álvarez, Carlos Óscar S. Sorzano, Pedro J. Sánchez-Cordón, José M. Casasnovas , David Astorgano, Juan García-Arriaza, Shubaash Anthiya, Mireya L. Borrajo, Gustavo Lou, Belén Cuesta, Lorenzo Franceschini, Josep L. Gelpí, Kris Thielemans , Marta Sisteré-Orók, Andreas Meyerhans, Felipe García, Ignasi Estebann, Núria López-Bigas, Montserrat Plana, María J. Alonso, Mariano Estebana, Carmen Elena GómezHeterologous mRNA/MVA delivering trimeric-RBD as effective vaccination regimen against SARS-CoV-2: COVARNA Consortium, Emerging Microbes & Infections, 13, 2387906 (15 pages) (2024)

Mireya L. Borrajo, Aloia Quijano, Philipp Lapuhs, Ana I. Rodriguez-Perez, Shubaash Anthiya, José L. Labandeira-Garcia, Rita Valenzuela, María José Alonso, Ionizable nanoemulsions for RNA delivery into the central nervous system – importance of diffusivity, Journal of Controlled Release, Volume 372, 2024, Pages 295-303, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2024.06.051

Joyce, P., Allen, C.J., Alonso, M.J. et al. A translational framework to DELIVER nanomedicines to the clinic. Nat. Nanotechnol. (2024). https://doi.org/10.1038/s41565-024-01754-7

Durán-Lobato, M., Tovar, S., de Oliveira Diz, T. et al. Formulation of protein-loaded nanoparticles via freeze-drying. Drug Deliv. and Transl. Res. (2024). https://doi.org/10.1007/s13346-024-01712-9

Durán-Lobato M, Tovar S, Cuñarro J, Ramos-Membrive R, Peñuelas I, Marigo I, Benetti F, Chenlo M, Álvarez CV, Ildikó V, Urbanics R, Szebeni J, Alonso MJ. Bioinspired orthogonal-shaped protein–biometal nanocrystals enable oral protein absorption. J Control Release, 2024 Nov 16;377:17-36. ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2024.11.016

 

López-Estévez AM, Lapuhs P, Piñeiro-Alonso L et Alonso MJ, Personalized Cancer Nanomedicine: Overcoming Biological Barriers for intracellular Delivery of biopharmaceuticals, Adv. Mater., 2023, 2309355
https://doi.org/10.1002/adma.202309355
https://onlinelibrary.wiley.com/doi/10.1002/adma.202309355

Fernández-Mariño I, Anfray C, Crecente-Campo J, et al. Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor associated macrophages, Drug Deliv. and Transl. Res. 13, 1896-1911 (2023)
https://doi.org/10.1007/s13346-022-01265-9
https://link.springer.com/article/10.1007/s13346-022-01265-9

Anthiya S., Oztürk S.C., Yanik H., Tavukcuoglu E., Sahin A., Datta D., Charisse K., Moreira Alvarez D., Loza M.I., Calvo A., Sulheim E., Loevenich S., Klinkenberg G., Schmid R., Manoharan M., Esendagli G., Alonso M.J., Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors, J. Control. Rel. 357, 67–83 (2023)
https://doi.org/10.1016/j.jconrel.2023.03.016
https://www.sciencedirect.com/science/article/pii/S0168365923001839?via%3Dihub

Mali A., Franci G., Zannella C., Chianese A., Anthiya S., López-Estévez A.M., Monti A., De Filippis A., Doti N., Alonso M.J., Galdiero M., Antiviral Peptides Delivered by Chitosan-Based Nanoparticles to Neutralize SARS-CoV-2 and HCoV-OC43, Pharmaceutics, 15, 1621 (2023)
https://doi.org/10.3390/pharmaceutics15061621
https://www.mdpi.com/1999-4923/15/6/1621

Berrecoso G. Bravo S., Crecente-Campo J., Alonso M.J., Controlling the protein corona of polymeric nanocapsules: effect of polymer shell on protein adsorption, Drug Deliv. and Transl. Res. (In press)
https://doi.org/10.1007/s13346-023-01441-5
https://link.springer.com/article/10.1007/s13346-023-01441-5

Berrecoso G., Crecente‐Campo J., Alonso M.J., Quantification of the actual composition of polymeric nanocapsules: a quality control analysis, Drug Deliv. and Transl. Res. 12, 2865-2874 (2022).
https://doi.org/10.1007/s13346-022-01150-5
https://link.springer.com/article/10.1007/s13346-022-01150-5

Lundquist P., Khodus G., Zhigao N., Thwala L.N., McCartney F., Simoff I., Andersson E., Beloqui A., Mabondzo A., Robla S., Webb D.L., Hellström P.M., Keita A.V., Sima E., Csaba N., Sundbom M., Preat V., Brayden D.J., Alonso M.J., Artursson P., Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat, ACS Nano 2022 (In Press)
https://doi.org/10.1021/acsnano.2c04330
https://pubs.acs.org/doi/10.1021/acsnano.2c04330

Bhanu Teja Surikutchi, Rebeca Obenza-Otero, Emanuele Russo, Mischa Zelzer, Irene Golán Cancela, José A. Costoya, José Crecente Campo, Maria José Alonso, Maria Marlow, Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration, Int. J. Pharmaceut., 622, 121828 (2022)
https://doi.org/10.1016/j.ijpharm.2022.121828
https://www.sciencedirect.com/science/article/pii/S0378517322003830?via%3Dihub

Goldberg, M., Manzi, A., Conway, P. et al. A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat Commun 13, 4829 (2022).
https://doi.org/10.1038/s41467-022-31859-3
https://www.nature.com/articles/s41467-022-31859-3

Cordeiro, A. S., Farsakoglu, Y., Crecente-Campo, J., de la Fuente, M., González, S. F., & Alonso, M. J. (2021). Carboxymethyl-β-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen delivery. Drug Delivery and Translational Research, 11(4), 1689–1702. https://doi.org/10.1007/s13346-021-00968-9
https://link.springer.com/article/10.1007/s13346-021-00968-9#citeas

Santalices, I., Vázquez-Vázquez, C., Santander-Ortega, M. J., Lozano, V., Araújo, F., Sarmento, B., Shrestha, N., Préat, V., Chenlo, M., Alvarez, C. V., Benetti, F., Cuñarro, J., Tovar, S., Torres, D., & Alonso, M. J. (2021). A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin. Drug Delivery and Translational Research, 11(2), 524–545. https://doi.org/10.1007/s13346-021-00920-x
https://link.springer.com/article/10.1007/s13346-021-00920-x#citeas

Bouzo, B. L., Lores, S., Jatal, R., Alijas, S., Alonso, M. J., Conejos-Sánchez, I., & de la Fuente, M. (2021). Sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer. Scientific Reports, 11(1).
https://doi.org/10.1038/s41598-021-96578-z
https://www.nature.com/articles/s41598-021-96578-z#citeas

Borrajo, M. L., & Alonso, M. J. (2022). Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA. Drug Delivery and Translational Research, 12(4), 862–880.
https://doi.org/10.1007/s13346-021-01086-2
https://link.springer.com/article/10.1007/s13346-021-01086-2

Matilde Durán-Lobato, Ana María López-Estévez, Ana Sara Cordeiro, Tamara G. Dacoba, José Crecente-Campo, Dolores Torres, María José Alonso, Nanotechnologies for the delivery of biologicals: Historical perspective and current landscape, Advanced Drug Delivery Reviews, Volume 176, 2021, 113899, ISSN 0169-409X.
https://doi.org/10.1016/j.addr.2021.113899
https://www.sciencedirect.com/science/article/pii/S0169409X21002921?via%3Dihub

Dacoba T. G., Anthiya S., Berrecoso G., Fernández-Mariño I., Fernández-Varela C., Crecente-Campo J., Teijeiro-Osorio D., Torres-Andón F., Alonso M.J., Nano‐Oncologicals: A Tortoise Trail Reaching New Avenues, Adv. Funct. Mater., 2009860 (1-36) (2021)
https://doi.org/10.1002/adfm.202009860
https://onlinelibrary.wiley.com/doi/10.1002/adfm.202009860

Quattini F., Berrecoso G., Crecente-Campo J., Alonso M.J., Asymmetric flow field-flow fractionation as a multifunctional technique for the characterization of polymeric nanocarriers, Drug Deliv. and Transl. Res., 11, 373–395 (2021)
https://doi.org/10.1007/s13346-021-00918-5
https://link.springer.com/article/10.1007/s13346-021-00918-5

Crecente-Campo J., Virgilio T., Morone D., Cristina Calviño-Sampedro, Fernandez-Mariño D., Olivera A., Varela-Calviño R., Gonzalez S.F., Alonso M.J., Design of polymeric nanocapsules to improve their lympho-targeting capacity, Nanomedicine, 119657 (2020)
https://doi.org/10.2217/nnm-2019-0206
https://www.futuremedicine.com/doi/10.2217/nnm-2019-0206

Samaridou E., Kalamidas N., Santalices I., Crecente-Campo J., Alonso M.J., Tuning the PEG surface density of the PEG-PGA enveloped Octaarginine-peptide Nanocomplexes., Drug Deliv. Res., 10, 241-258, (2020)
https://doi.org/10.1007/s13346-019-00678-3
https://link.springer.com/article/10.1007/s13346-019-00678-3

Samaridou E., Walgrave H., Salta E., Moreira Álvarez D., Castro-López V., Loza M., Alonso M.J., Nose-to-brain delivery of enveloped RNA – cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases, Biomaterials, 230, 119657 (2020)
https://doi.org/10.1016/j.biomaterials.2019.119657
https://www.sciencedirect.com/science/article/pii/S0142961219307562?via%3Dihub

Klein, Menta M., Dacoba T. G., Crecente-Campo J., Alonso M.J., Dupin D., Loinaz I., Grassl B., Séby F., Advanced nanomedicine characterization by DLS and AF4-UV-MALS: Application to an HIV nanovaccine, Journal of Pharmaceutical and Biomedical Analysis, 179, 113017 (2020)
https://doi.org/10.1016/j.jpba.2019.113017
https://www.sciencedirect.com/science/article/pii/S0731708519321880

Dacoba T. G., Ruiz-Gatón L., Benito A., Klein M., Dupin S., Luo M., Menta M., Teijeiro-Osorio D., Loinaz I., Alonso M.J., Crecente-Campo J., Technological challenges in the preclinical development of a HIV nanovaccine candidate, Drug Deliv. and Transl.Res, 10, 621–634 (2020)
https://doi.org/10.1007/s13346-020-00721-8
https://link.springer.com/article/10.1007/s13346-020-00721-8

Ledo A., Senra A., Rilo-Alvarez H., Borrajo E., Vidal A., Alonso M.J., Garcia-Fuentes M., mRNA-activated matrices encoding transcription factors as primers of cell differentiation in tissue engineering, Biomaterials, 247 120016 (2020)
https://doi.org/10.1016/j.biomaterials.2020.120016
https://www.sciencedirect.com/science/article/pii/S0142961220302623

Storozhylova N., Crecente-Campo J., Cabaleiro D., Lugo L., Dussouy C., Simoes S., Monteiro M., Grandjean C., Alonso M.J., An in Situ Hyaluronic Acid-Fibrin Hydrogel Containing Drug-Loaded Nanocapsules for Intra-Articular Treatment of Inflammatory Joint Diseases, Regen. Transl. Med., 6, 201–216 (2020) DOI : 10.1007/s40883-020-00154-2
https://hal.science/hal-02990612/document

Ledo, A., H. Vining K., Alonso M.J., Garcia-Fuentes M., Mooney D. J., Extracellular matrix mechanics regulate transfection and SOX9-directed differentiation of mesenchymal stem cells, Acta Biomaterialia, 110, 153-163 (2020)
https://doi.org/10.1016/j.actbio.2020.04.027
https://www.sciencedirect.com/science/article/pii/S1742706120302245
https://doi.org/10.1007/s13346-020-00767-8
https://link.springer.com/article/10.1007/s13346-020-00767-8

Alonso, M.J. My one-year perspective as editor-in-chief of DDTR. Drug Deliv. and Transl. Res., 10, 565–566 (2020)
https://doi.org/10.1007/s13346-020-00767-8
https://link.springer.com/article/10.1007/s13346-020-00767-8

Dacoba T.G., Anfray C., Mainini F., Allavena P., Alonso M.J., Torres Andón F., Crecente-Campo J., Arginine-Based Poly(I:C)-Loaded Nanocomplexes for the Polarization of Macrophages Toward M1-Antitumoral Effectors, Frontiers in Immunology, 11, 1412 (2020)
https://doi.org/10.3389/fimmu.2020.01412
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01412/full

Del Río-Sancho S., Pan Delgado D., de la Fuente G., García-Caballero T., Taboada-Suárez A., Csaba N., Bao-Varela, Alonso M.J., Laser-induced transient skin disruption to enhance cutaneous drug delivery, Eur. J. Pharm. Biopharm, 156, 165-175 (2020)
https://doi.org/10.1016/j.ejpb.2020.08.027
https://www.sciencedirect.com/science/article/pii/S093964112030271X

Vázquez-Ucha J.C., Martínez-Guitián M., Lasarte-Monterrubio C., Conde-Pérez K., Arca-Suárez J., Álvarez-Fraga L., Pérez A., Crecente-Campo J., Alonso M.J., Bou G., Poza M., Beceiro A., Syzygium aromaticum (clove) and Thymus zygis (thyme) essential oils increase susceptibility to colistin in the nosocomial pathogens Acinetobacter baumannii and Klebsiella pneumoniae, Biomedicine & Pharmacotherapy 130, 110606 (2020)
https://doi.org/10.1016/j.biopha.2020.110606
https://www.sciencedirect.com/science/article/pii/S075333222030799X?via%3Dihub

Nikki P. L. Toledo, Hongzhao Li, Robert W. Omange, Tamara G. Dacoba, Jose Crecente-Campo, Dane Schalk, Mohammad A. Kashem, Eva Rakasz, Nancy Schultz-Darken, Qingsheng Li, James B. Whitney, Maria J. Alonso, Francis A. Plummer, Ma Luo, Cervico-Vaginal Inflammatory Cytokine and Chemokine Responses to Two Different SIV Immunogens, Front. Immunol. 11, 1935 (2020)
https://doi.org/10.3389/fimmu.2020.01935
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01935/full

Li H., Omange R.W. Liang B., Toledo N., Hai Y., Liu L.R., Schalk D., Crecente-Campo J., Dacoba T.G., Lambe A.B., Lim S.-Y., Li L., Kashem M.A., Wan Y., Correia-Pinto J.F., Seaman M.S., Liu X.-Q., Balshaw R.F., Li Q., Schultz-Darken N., Alonso M.J., Plummer F.A., Whitney J.B., Luo M., Vaccine targeting SIVmac251 protease cleavage sites protects macaques against vaginal infection, J. Clin. Invest. 130(12):6429-6442 (2020)
DOI: 10.1172/JCI138728
https://www.jci.org/articles/view/138728

Robla S., Alonso M.J., Csaba N., Polyaminoacid-based nanocarriers: a review of the latest candidates for oral drug delivery, Expert Opin. Drug Deliv., 17 (8), 1081-1092 (2020)
https://doi.org/10.1080/17425247.2020.1776698
https://www.tandfonline.com/doi/full/10.1080/17425247.2020.1776698

Berrecoso G., Crecente-Campo J., Alonso M.J., Unveiling the pitfalls of the protein corona of polymeric drug nanocarriers, Drug Deliv. and Transl. Res., 10, 730–750 (2020)
https://doi.org/10.1007/s13346-020-00745-0
https://link.springer.com/article/10.1007/s13346-020-00745-0

Abbadessa A, Crecente-Campo J, Alonso MJ. Engineering Anisotropic Meniscus: Zonal Functionality and Spatiotemporal Drug Delivery. Tissue Eng Part B Rev. 2021 Apr;27(2):133-154. doi: 10.1089/ten.TEB.2020.0096. Epub 2020 Aug 26. PMID: 32723019.
https://doi.org/10.1089/ten.teb.2020.0096
https://www.liebertpub.com/doi/10.1089/ten.teb.2020.0096

Crecente-Campo J., Alonso M.J., Engineering, on-demand manufacturing, and scaling-up of polymeric nanocapsules, Bioengineering & Translational Medicine, 4, 38–50 (2019)
https://doi.org/10.1002/btm2.10118
https://aiche.onlinelibrary.wiley.com/doi/10.1002/btm2.10118

M. Ledo A., Sasso M.E., Bronte V., Marigo I., Boyde B.J., Garcia-Fuentes M., Alonso M.J., Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells, J. Control. Rel., 295, 60–73 (2019)
https://doi.org/10.1016/j.jconrel.2018.12.041
https://www.sciencedirect.com/science/article/pii/S0168365918307466?via%3Dihub

Teijeiro-Valiño C, Novoa-Carballal R., Borrajo E., Vidal A., Alonso-Nocelo M., de la Fuente Freire M., Lopez-Casase P.P., Hidalgo M., Csaba N., Alonso M.J., A multifunctional drug nanocarrier for efficient anticancer therapy, J. Control. Rel., 294, 154–164 (2019)
https://doi.org/10.1016/j.jconrel.2018.12.002
https://www.sciencedirect.com/science/article/pii/S0168365918306977?via%3Dihub

Cordeiro A. S, Crecente-Campo J., L. Bouzo B., González, S.F. de la Fuente M., Alonso M.J., Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system, J. Drug Target., 27(5-6):646-658 (2019)
https://doi.org/10.1080/1061186X.2018.1561886
https://www.tandfonline.com/doi/abs/10.1080/1061186X.2018.1561886?journalCode=idrt20

Dacoba T.G., Omange R.W., Li H., Crecente-Campo J., Luo M., Alonso M.J., Polysaccharide nanoparticles can efficiently modulate the immune response against an HIV peptide antigen, ACS Nano, 13, 5, 4947–4959 (2019)
https://doi.org/10.1021/acsnano.8b07662
https://pubs.acs.org/doi/10.1021/acsnano.8b07662

Štakaka I., Cadete A., Surikutchi B.T., Abuzaid H., Bradshaw T.D., Alonso M.J., Marlow M., A novel low molecular weight nanocomposite hydrogel formulation for intra-tumoural delivery of anti-cancer drugs, Int. J. Pharmaceut., 565, 151–161 (2019)
https://doi.org/10.1016/j.ijpharm.2019.04.070
https://www.sciencedirect.com/science/article/pii/S0378517319303400?via%3Dihub

Molina-Crespo A., Ana Cadete, David Sarrio, Gamez Chiachio M., Martinez L., Chao K., Olivera A., Gonella A., Diaz A., Palacios J., Dhal P.K., Besev M., Rodriguez-Serrano M., García-Bermejo M.L., Triviño J.C., Cano A., Garcia-Fuentes M., Herzberg O., Torres D., Alonso M.J., Moreno-Bueno G., Intracellular delivery of an antibody targeting Gasdermin-B reduces HER2 breast cancer aggressiveness, Clin Cancer Res; 25(15), 4846-4858 (2019)
https://doi.org/10.1158/1078-0432.CCR-18-2381
https://aacrjournals.org/clincancerres/article/25/15/4846/264902/Intracellular-Delivery-of-an-Antibody-Targeting

Crecente-Campo J., Guerra-Varela J., Peleteiro M., Gutiérrez-Lovera C., Fernández-Mariño I., Diéguez-Docampo A., González-Fernández A., Sánchez L., Alonso M.J., The size and composition of polymeric nanocapsules dictate their interaction with macrophages and biodistribution in the zebrafish model, J. Control. Rel., 308, 98-108 (2019)
https://doi.org/10.1016/j.jconrel.2019.07.011
https://www.sciencedirect.com/science/article/pii/S0168365919303980?via%3Dihub

Reimondez-Troitiño S., González-Aramundiz J.V., Ruiz-Bañobrea J., López-López R., Alonso M.J., Csaba N., de la Fuente M., Versatile protamine nanocapsules to restore miR-145 levels and interferetumor growth in colorectal cancer cells, Eur. J. Pharm. Biopharm, 142, 449-459 (2019)
https://doi.org/10.1016/j.ejpb.2019.07.016
https://www.sciencedirect.com/science/article/pii/S0939641119304308

Cadete A., Olivera A., Besev M., Dhal P.K., Gonçalves L., Almeida A.J., Bastiat G., Benoit J.P., de la Fuente M., Garcia-Fuentes M., Alonso M.J., Torres D., Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs, Scientific Reports, 9, 11565 (2019)
https://doi.org/10.1038/s41598-019-47995-8
https://www.nature.com/articles/s41598-019-47995-8

Durán-Lobato M., Zhigao N., Alonso M.J., Oral delivery of biologics for precision medicine, Adv. Mater., 32(13), e1901935 (2019)
https://doi.org/10.1002/adma.201901935
https://onlinelibrary.wiley.com/doi/10.1002/adma.201901935

Del Rio-Sancho S., Castro-Lopez V., Alonso M.J., Enhancing cutaneous delivery with laser technology: almost there, but not yet, J. Control Rel., 315, 150-165 (2019)
https://doi.org/10.1016/j.jconrel.2019.09.014
https://www.sciencedirect.com/science/article/pii/S0168365919305541

Leong, H.S., Butler, K.S., Brinker, C.J. et al. On the issue of transparency and reproducibility in nanomedicine. Nat. Nanotechnol. ,14, 629–635 (2019)
https://doi.org/10.1038/s41565-019-0496-9
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Crecente-Campo J., Lorenzo-Abalde S., Mora A., Marzoa J., Csaba N., Blanco J., González-Fernández A., Alonso M.J., Bilayer polymeric nanocapsules: A formulation approach for a thermostable and adjuvanted E. coli antigen vaccine, J. Control. Rel., 286, 20-32 (2018),
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Hongzhao Li, Mikaela Nykoluk, Lin Li, Lewis R. Liu, Robert W. Omange, Geoff Soule, Lukas T. Schroeder, Nikki Toledo, Mohammad Abul Kashem, Jorge F. Correia-Pinto, Binhua Liang, Nancy Schultz-Darken, Maria J. Alonso, James B. Whitney, Francis A. Plummer, Ma Luo, Natural and cross-inducible anti-SIV antibodies in Mauritian cynomolgus macaques, PLOS ONE, 12(10): e0186079 (2017)
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Hidalgo T., Giménez-Marqués M., Bellido E., Avila J., Asensio M.C., Salles F., Lozano M. V., Guillevic M., Simón-Vázquez R., González-Fernández A., Serre C. Alonso M.J., Horcajada P., Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers, Scientific Reports, 7, 43099 (2017)
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Teijeiro-Valiño C., Yebra-Pimentel E., Guerra-Varela J., Csaba N., Alonso M.J., Sánchez L., Assessment of the permeability and toxicity of polymeric nanocapsules using the zebrafish model, Nanomedicine, 12, 2069–2082 (2017)
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Gonzalez-Paredes A., Torres D., Alonso M.J., Polyarginine nanocapsules: A versatile nanocarrier with potential in transmucosal drug delivery, Int. J. Pharmaceut., 529, 474–485 (2017)
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Hongzhao Li, Robert W. Omange, Chris Czarnecki, Jorge F. Correia-Pinto, Jose Crecente-Campo, Meika Richmond, Lin Li, Nancy Schultz-Darken, Maria J. Alonso, James B. Whitney, Francis A. Plummer, Ma Luo, Mauritian Cynomolgus Macaques with M3M4 MHC Genotype Control SIVmac251 Infection, Journal of Medical Primatology, 46, 137-143 (2017)
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Zhigao Niu, Tedesco E., Benetti F., Mabondzo A., MontagnerI.M., Marigo I., Gonzalez-Touceda D., Tovar S., Diéguez C., Santander-Ortega M.J., AlonsoM.J., Rational design of polyarginine nanocapsules intended to help peptides overcoming intestinal barriers, J. Control. Rel., 263, 4-17 (2017)
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Jakubiak P., Thwala L.N., Cadete A., Préat V., Alonso M.J., Beloqui A., Csaba N., Solvent-free protamine nanocapsules as carriers for mucosal delivery of therapeutics, Eur. Polym. J. 93, 695-705 (2017)
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González-Aramundiz J.V., Presas E., Dalmau-Mena I., Martínez-Pulgarín S., Alonso C., Escribano J.M., Alonso M.J., Csaba N., Rational design of protamine nanocapsules as antigen delivery carriers, J. Control. Rel., 245, 62–69 (2017)
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Abellan-Pose R., Rodríguez-Évora M., Vicente S., Csaba N., Évora C., Alonso M.J., Delgado A., Biodistribution of radiolabeled polyglutamic acid and PEG-polyglutamic acid nanocapsules, Eur. J. Pharm. Biopharm., 112, 155–163 (2017)
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Lollo G., Gonzalez-Paredes A., Garcia-Fuentes M., Calvo P., Torres D., Alonso M.J., Polyarginine nanocapsules as a potential oral peptide delivery carrier, J.Pharm. Sci., 106, 611-618 (2017)
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Torres Andón F., Digifico E., Maeda A., Erreni M., Mantovani A., Alonso M.J., Allavena P., Targeting tumor associated macrophages: The new challenge for nanomedicine, Seminars in Immunology , 34, 103-113 (2017)
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G. Dacoba T., Olivera A., Torres D., Crecente-Campo J., Alonso M.J., Modulating the immune system through nanotechnology, Seminars in Immunology, 34, 78-102 (2017)
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Santalices, Gonella A.,Torres D., Alonso, M.J. Advances on the formulation of proteins using nanotechnologies, J. Drug Del. Sci. Tech , 42, 155-180 (2017)
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Saraiva S.M., Castro-López V., Pañeda C., Alonso M.J., Synthetic nanocarriers for the delivery of polynucleotides to the eye, Eur. J. Pharm. Sci., 103, 5-18 (2017)
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Brayden D., Alonso M.J., Oral delivery of peptides – Opportunities and issues for translation, Adv. Drug Deliver. Rev., 106-Part B, 193-195 (2016)
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Thwala L.N., Beloqui A., Csaba N.S., González Touceda D., Tovar S., Dieguez C., Alonso M.J., Préat V., The interaction of protamine nanocapsules with the intestinal epithelium: a mechanistic approach, J. Control. Rel., 243, 109–120 (2016)
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Goycoolea F. M., Brunel F., Gueddari N. E. E., Coggiola A., Lollo G., Moerschbacher B.M., Remuñán-López C., Delair T., Domard A., Alonso M.J., Physical Properties and Stability of Soft Gelled Chitosan-Based Nanoparticles, Macromol. Biosci., 16, 1873-1882 (2016)
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Cadete A., Alonso M.J., Targeting cancer with hyaluronic acid-based nanocarriers: recent advances and translational perspectives, Nanomedicine, 11, 2341-2357 (2016)
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Borrajo E., Abellan-Pose,R., Soto A., Garcia-Fuentes M., Csaba N., Alonso M.J., Vidal A., Docetaxel-loaded polyglutamic acid-PEG nanocapsules for the treatment of metastatic cancer, J. Control. Rel., 238, 263-271 (2016)
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Zhigao N., Conejos-Sánchez I., Griffin B, O’Driscoll C., Alonso M.J., Lipid-based nanocarriers for oral peptide delivery, Adv. Drug Deliver. Rev., 106-Part B, 332-354 (2016)
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Aguirre T.A.S., Teijeiro-Osorio D., Rosa M., Coulter I.S., Alonso M.J., Brayden D.J., Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials, Adv. Drug Deliver. Rev., 106-Part B, 223-241 (2016)
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Reimondez-Troitiño S., Alcalde I., Csaba N., Íñigo Portugués A., De la Fuente M., Bech F., Riestra A. C., Merayo-Lloves J., Alonso M.J., Polymeric nanocapsules: a potential new therapy for corneal wound healing, Drug Delivery and Translational Research, 6(6), 708-721 (2016)
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Griffin B.T., Guo J., Presas E. , Donovan M.D., Alonso M.J., O’Driscoll C.M., Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs, Adv. Drug Deliver. Rev, 106-Part B, 367-380 (2016)
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Alonso-Nocelo M., Abellan-Pose R., Vidal A., Abal M., Csaba N., Alonso M.J., Lopez-Lopez R., De la Fuente M., Selective interaction of PEGylated Polyglutamic Acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node, Journal of Nanobiotechnology, 14:51, 1-9 (2016)
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Abellan-Pose R., Teijeiro-Valiño C., Santander-Ortega M.J., Borrajo E., Vidal A., Garcia-Fuentes M., PhD; Csaba N., Alonso M.J., Polyaminoacid nanocapsules for drug delivery to the lymphatic system: effect of the particle size, Int. J. Pharmaceut., 509, 107-117 (2016)
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Cordeiro A.S., Alonso M.J., Recent advances in vaccine delivery, Pharmaceutical Patent Analyst, 5, 49-73 (2016)
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Beloqui A., Memvanga P.B., Coco R., Reimondez-Troitiño S., Mireille Alhouayek M., Muccioli G.G., Alonso M.J., Csaba N., De la Fuente M., Préat V., A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease, Colloid Surf. B-Biointerfaces, 143, 327-335 (2016)
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Abellan-Pose R., Csaba N., Alonso M.J., Lymphatic Targeting of Nanosystems for Anticancer Drug Therapy, Current Pharmaceutical Design, 22, 1194-1209 (2016)
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Alonso-Sande M., Csaba N., Alonso M.J., New perspectives in oral peptide and protein delivery: from nanocarrier design to in vivo effectiveness, pp.46-64, In Advances and challenges in the oral delivery of macromolecules, Future Science Ltd, Unitec House, 2 Albert Place, London, N3 1QB, UK. eBook. (2016)
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Torres Andón F., Alonso M.J., Nanomedicine and cancer immunotherapy – targeting immunosuppressive cells, J. Drug Targeting, 23, 656-671 (2015)
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Reimondez-Troitiño, Csaba N., Alonso M.J., de la Fuente M., Nanotherapies for the treatment of ocular diseases, Eur. J. Pharm. Biopharm., 95, 279-293 (2015)
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Cordeiro A.S, Alonso M.J, de la Fuente M., Nanoengineering of vaccines using natural polysaccharides, Biotechnology Advances, 33, 1279-1293 (2015)
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Borrajo E., Vidal A., Alonso M.J., Garcia-Fuentes M., How regenerative medicine can benefit from nucleic acids delivery nanocarriers, in Polymers in Regenerative Medicine: Biomedical Applications from Nano- to Macro-Structures, Manuel Monleon Pradas and María J. Vincent (EDs), Willey, ISBN: 978-0-470-59638-8 (2015)
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Lollo G., Hervella P., Calvo P., Avilés P., Guillén M.J., García-Fuentes M., Alonso M.J., Torres D., Enhanced in vivo therapeutic efficacy of plitidepsin-loaded nanocapsules decorated with a new poly-aminoacid-PEG derivative, Int. J. Pharmaceut., 483, 212-219 (2015)
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Bellido E., Hidalgo T., Lozano M.V., Guillevic M., Simon-Vazquez R., Santander-Ortega M.J., Gonzalez-Fernandez A., Serre C., Alonso M.J., Horcajada P., Heparin-engineered mesoporous iron Metal-Organic Framework Nanoparticles: towards stealth drug nanocarriers, Adv. Healthc. Mater., 4, 1246-1257 (2015)
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Correia Pinto J.F., Peleteiro M., Csaba N., González-Fernández A., Alonso M.J., Multi-enveloping of particulated antigens with biopolymers and immunostimulant polynucleotides, J. Drug Del. Sci. Tech., 30, 424-434 (2015)
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Correia-Pinto J.F., Csaba N., Schiller J.T., Alonso M.J., Chitosan-Poly (I:C)-PADRE based nanoparticles as delivery vehicles for synthetic peptide vaccines, Vaccines, 3, 730-750 (2015)
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González Aramundiz J.V., Peleteiro M., González-Fernandez A., Alonso M.J., Csaba N., Protamine-Based Nanoparticles As New Antigen Delivery Systems, Eur. J. Pharm. Biopharm., 97, 51-59 (2015)
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Vicente S., Peleteiro M., Gonzalez-Aramundiz J.V., Díaz-Freitas B., Martínez-Pulgarín S., Neissa J.I., Escribano J.M., Sanchez A., González-Fernández A., Alonso M.J., Highly versatile immunostimulating nanocapsules for specific immune potentiation, Nanomedicine, 9, 2273-2289 (2014)
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Lollo G., Rivera-Rodriguez G.R., Bejaud J., Tristan M., Passirani C., Benoit J.P., García-Fuentes M., Alonso M.J., Torres D., Polyglutamic acid-PEG nanocapsules as long circulating carriers for the delivery of docetaxel, Eur. J. Pharm. Biopharm., 87, 47-54 (2014)
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Nano-Oncologicals: new targeting and delivery approaches, Advances in Delivery Science and Technology Series, Alonso M.J. and Garcia-Fuentes M. (EDs), Springer, ISBN: 978-3-319-08083-3 (2014) (BOOK)
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Teijeiro,C., McGlone A., Csaba N., Garcia-Fuentes M., Alonso, M.J., Polysaccharide-based nanocarriers for drug delivery, In: Handbook of Nanobiomedical Research (M.L. Yarmush and D. Shi, series Ed.) (2014), Vol. 3 (V. Torchilin Ed.), Chapter 7, pp. 235-277, World Scientific Ed., ISBN 978-981-4520-64-5 (also as e-book: ISBN – 978-981-4520-66-9)
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De la Fuente M., Langer R., Alonso M.J., Nanotechnology Approaches for Cancer Immunotherapy and Immunomodulation, pp. 215-242, in Nano-Oncologicals: new targeting and delivery approaches, Advances in Delivery Science and Technology Series, Chapter 8, Alonso M.J. and Garcia-Fuentes M. (EDs), Springer, ISBN: 978-3-319-08083-3 (2014)
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Hervella P., Alonso-Sande M., Ledo F., Lucero M.L., Alonso M.J., Garcia-Fuentes M., PEGylated lipid nanocapsules with improved encapsulation and controlled release properties, Curr. Top. Med. Chem., 14, 1115-11123 (2014)
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Pereira Gomes C, Ferreira Lopes C.D, Duarte Moreno P.D., Varela-Moreira A., Alonso M.J., Pêgo A.P., Translating chitosan to clinical delivery of nucleic acid-based drugs, MRS Bulletin, 39, 60-70 (2014)
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Alonso M, Lozano M.V, Lopez R, Alonso M.J, Nanomedicamentos contra el cancer,Investigación y Ciencia, 450 (2014)
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Vicente S., Goins B, Sanchez A., Alonso M.J., Phillips W.T., Biodistribution and lymph node retention of polysaccharide-based immunostimulating nanocapsules, Vaccine, 32(15), 1685-92 (2014)
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Vila-Sanjurjo C., Fuenzalida J.P., Menchicchi B., Coelho D., Engwer C., Hoffman S., Pereira S., Remuñán-López C., Alonso M.J., Vidal A., Moeschbacher B., Kollenbrock S., Fetzner S., Philipp B., Goycoolea F.M., Chitosan-based nanomaterials for drug delivery and antibiotic-free bacterial control, pg. 217-220, In: Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3), Chapter 2: Bio Nano Materials, NSTI (ED), CRC Press, ISBN: 978-1-4822-0586-2 (2013)
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Rivera-Rodriguez G., Lollo G., Montier T., Benoit J.P., Passirani C., Alonso M.J., Torres D., In vivo evaluation of poly-l-asparagine nanocapsules as carriers for anti-cancer drug delivery, Int. J. Pharmaceut., 458, 83– 89 (2013)
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Lozano M.V., Lollo G., Alonso-Nocelo M., Brea J., Vidal A., Torres D., Polyarginine nanocapsules: a new platform for intracellular drug delivery, J. Nanopart. Res., 15, 1515 (1-14) (2013)
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Alonso-Sande M., des Rieux A., Fievez V. Sarmento B., Delgado A., Evora C., Remuñán-López C., Preat V., Alonso M.J., Development of PLGA-mannosamine nanoparticles as oral protein carriers, Biomacromolecules, 14, 4046−4052 (2013)
https://doi.org/10.1021/bm401141u
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Correia-Pinto J., Csaba N., Alonso M.J., Vaccine delivery carriers: Insights and future perspectives, Int. J. Pharmacol., 440, 27-38 (2013)
https://doi.org/10.1016/j.ijpharm.2012.04.047
https://www.sciencedirect.com/science/article/pii/S0378517312003936?via%3Dihub

Vicente S., Díaz-Freitas B., Peleteiro M., Sánchez A., Pascual D.W., González-Fernández A., Alonso M.J., A polymer/oil based nanovaccine as a single-dose immunization approach,PLOS ONE, 8, Issue 4, e62500 (1-8) (2013)
https://doi.org/10.1371/journal.pone.0062500
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062500

Oyarzun-Ampuero F.A., Rivera G., Alonso M.J., Torres D., Hyaluronan nanocapsules as a new vehicle for intracellular drug delivery, Eur. J. Pharm. Sci. , 49, 483-490 (2013)
https://doi.org/10.1016/j.ejps.2013.05.008
https://www.sciencedirect.com/science/article/pii/S0928098713001875?via%3Dihub

Gonzalo T., Lollo G., Garcia-Fuentes M., TorresD., Correa J., Riguera R., Fernandez-Megia E., Calvo P., Avilés P., Guillén M.J., Alonso M.J., A new potential nano-oncological therapy based on polyaminoacid nanocapsules, J. Control. Rel., 169, 10-16 (2013)
https://doi.org/10.1016/j.jconrel.2013.03.037
https://www.sciencedirect.com/science/article/pii/S0168365913002101

Trapani A., Di Gioia S., Ditaranto N., Cioffi N., Goycoolea F., Carbone A., Garcia-Fuentes M., Conese M., Alonso M.J., Systemic heparin delivery by the pulmonary route using chitosan and glycol chitosan nanoparticles, Int. J. Pharmaceut., 447, 115– 123 (2013)
https://doi.org/10.1016/j.ijpharm.2013.02.035
https://www.sciencedirect.com/science/article/pii/S0378517313001701?via%3Dihub

Lozano M.V., Esteban H., Brea J., Torres D., Alonso M.J., Intracellular delivery of docetaxel using freeze-dried polysaccharide nanocapsules,30,181-8 (2013)
https://doi.org/10.3109/02652048.2012.714411
https://www.tandfonline.com/doi/full/10.3109/02652048.2012.714411

Torrecilla D., Lozano M.V., Lallana E., Neissa J.I., Novoa-Carballal R., Vidal A., Fernández- Megia E., Torres D., Riguera R, Alonso M.J. and Dominguez F., Anti-Tumor Efficacy of Chitosan-g-Poly(ethyleneglycol) Nanocapsules containing docetaxel: anti- TMEFF-2 functionalized nanocapsules vs non-functionalized nanocapsules, Eur. J. Pharm. Biopharm., 83, 330–337 (2013)
https://doi.org/10.1016/j.ejpb.2012.10.017
https://www.sciencedirect.com/science/article/pii/S0939641112003438?via%3Dihub

Lozano M.V., Lollo G., Alonso-Nocelo M., Brea J., Vidal A., Torres D., Polyarginine nanocapsules: a new platform for intracellular drug delivery, J. Nanopart. Res., 15, 1515 (1-14) (2013)
https://doi.org/10.1007/s11051-013-1515-7
https://link.springer.com/article/10.1007/s11051-013-1515-7

Rivera G., Alonso M.J., Torres D., Poly-L-asparagine nanocapsules as anticancer drug delivery vehicles, Eur. J. Pharm. Biopharm., 85, 481-487 (2013)
https://doi.org/10.1016/j.ejpb.2013.08.001
https://www.sciencedirect.com/science/article/pii/S0939641113002804

Vicente S., Peleteiro M., Diaz-Freitas B., Sanchez A., Gonzalez-Fernandez A., Alonso M.J., Co-delivery of viral proteins and a TLR7 agonist from polysaccharide nanocapsules: A needle-free vaccination strategy, J. Control. Rel., 172, 773-781 (2013)
https://doi.org/10.1016/j.jconrel.2013.09.012
https://www.sciencedirect.com/science/article/pii/S0168365913008006?via%3Dihub

De la Fuente M., Raviña M., Sousa-Hervés A., Correa J., Riguera R., Fernandez-Megia E., Sánchez A., Alonso M.J., Exploring the efficiency of gallic acid-based dendrimers as carriers in gene delivery, Nanomedicine, 7, 1667-1681 (2012)
https://doi.org/10.2217/nnm.12.51
https://www.futuremedicine.com/doi/10.2217/nnm.12.51

Alonso M.J. and Couvreur P., Historical view of the design and development of nanostructured materials for overcoming mucosal barriers, pg. 3-38, In: Nanostructured Biomaterials for Overcoming Biological Barriers, Alonso M.J. and Csaba N. (Eds), RSC Drug Discovery Series, RSC Publising, Cambridge, UK, (2012)
https://doi.org/10.1039/9781849735292
https://books.rsc.org/books/edited-volume/1818/Nanostructured-Biomaterials-for-Overcoming#%21divbookcontent

Nanostructured Biomaterials for Overcoming Biological Barriers, Alonso M.J. and Csaba N (Eds), RSC Drug Discovery Series, RSC Publising, Cambridge, UK, (2012) (BOOK)
https://books.rsc.org/books/edited-volume/1818/Nanostructured-Biomaterials-for-Overcoming#%21divbookcontent

Herrero E.P., Alonso M.J., Csaba N., Polymer-based oral peptide nanomedicines,Therapeutic Delivery, 3, 657-668 (2012)
https://doi.org/10.4155/tde.12.40
https://www.future-science.com/doi/10.4155/tde.12.40

Garcia-Fuentes M., Alonso M.J., Chitosan-based nanocarriers: Where do we stand?, J. Control. Rel. 161, 496-504 (2012)
https://doi.org/10.1016/j.jconrel.2012.03.017
https://www.sciencedirect.com/science/article/pii/S0168365912002052?via%3Dihub

Oyarzun-Ampuero F.A., Brea J., Loza M.I., Alonso M.J. y Torres D., A potential nanomedicine consisting in heparin-loaded polysaccharide nanocarriers for the treatment of asthma, Macromol. Biosci., 12, 176–183 (2012)
https://doi.org/10.1002/mabi.201100102
https://onlinelibrary.wiley.com/doi/10.1002/mabi.201100102

 

Lollo G., Rivera Rodríguez G., Torres D., Alonso M.J., Nanoterapias oncológicas: aplicaciones actuales y perspectivas futuras, Anales de la Real Academia Nacional de Farmacia, 77, No 4 (2011)
https://analesranf.com/wp-content/uploads/2011/77_04/7704_07.pdf

Oyarzun-Ampuero F.A., Goycoolea F., Torres D., Alonso M.J., A new drug nanocarrier consisting of polyarginine and hyaluronic acid, Eur. J. Pharm. Biopharm., 79, 54-57 (2011)
https://doi.org/10.1016/j.ejpb.2011.04.008
https://www.sciencedirect.com/science/article/pii/S0939641111001500

Hervella P., Lollo G., Oyarzun-Ampuero F., Rivera G., Torres D., Alonso M.J, Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules, Nanocomposite particles for bio-aplications: Materials and bio-interfaces, Tito Trindade & Ana Luisa Daniel Eds., Pan Stanford Publishing, p.p.45-67 (2011)
https://www.routledge.com/Nanocomposite-Particles-for-Bio-Applications-Materials-and-Bio-Interfaces/Trindade-daSilva/p/book/9780429066283

Oyarzun-Ampuero F.A., Garcia-Fuentes M., Torres D., Alonso M.J., Chitosan-coated lipid nanocarriers for therapeutic applications, J. Drug Del. Sci. Tech., 20 (4) 259-265 (2010)
https://doi.org/10.1016/S1773-2247(10)50043-1
https://www.sciencedirect.com/science/article/pii/S1773224710500431

Paolicelli P., Prego C., Sanchez A., Alonso M.J., Surface-modified PLGA-based Nanoparticles that can Efficiently Associate and Deliver Virus-like Particles, Nanomedicine, 5(6), 843-853 (2010)
https://doi.org/10.2217/nnm.10.69
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Raviña M., Cubillo E., Olmeda D., Novoa-Carballal R., Fernandez-Megia E., Riguera R., Cano A., Alonso M.J., Hyaluronic Acid / Chitosan-g-Poly(ethylene glycol) nanoparticles for gene therapy: an application for pDNA and siRNA delivery, Pharm. Res., 27, 2544-2555 (2010)
https://doi.org/10.1007/s11095-010-0263-y
https://link.springer.com/article/10.1007/s11095-010-0263-y

Angelo I., Garcia-Fuentes M., Parajó Y., Welle A., Vántus T., Horváth A., Bökönyi G., Kéri G., Alonso M.J., Nanoparticles based on PLGA:Poloxamer blends for the delivery of proangiogenic growth factors, Mol. Pharmaceutics, 7, 1724-1733 (2010)
https://doi.org/10.1021/mp1001262
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Parajó Y., d’Angelo I., Horváth A., Vantusb T., Györgyb T., Wellec A., Garcia-Fuentes M., Alonso M.J., PLGA:poloxamer blend micro- and nanoparticles as controlled release systems for synthetic proangiogenic factors, Eur. J. Pharm. Sci.,41, 644-9 (2010)
https://doi.org/10.1016/j.ejps.2010.09.008
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Raviña M., de la Fuente M., Correa J., Sousa-Herves A., Pinto J., Fernandez-Megia E., Riguera R., Sanchez A., Alonso M.J., Core-Shell Dendriplexes with Sterically Induced Stoichiometry for Gene Delivery, Macromolecules 43 (17), 6953–6961 (2010)
https://doi.org/10.1021/ma100785m
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Parajó Y., Angelo I., Welle A., Garcia-Fuentes M., Alonso M.J., Hyaluronic acid/Chitosan nanoparticles as delivery vehicles for VEGF and PDGF-BB, Drug Delivery, 17, 596–604 (2010)
https://doi.org/10.3109/10717544.2010.509357
https://www.tandfonline.com/doi/full/10.3109/10717544.2010.509357

Paolicelli P., Prego C., Sanchez A., Alonso M.J., Surface-modified PLGA-based nanoparticles that can efficiently associate and deliver virus-like particles, Nanomedicine, 5, 843-853. (2010)
https://doi.org/10.2217/nnm.10.69
https://www.futuremedicine.com/doi/10.2217/nnm.10.69

Trapani A., Lopedota A., Franco M., Cioffi N., Ieva E., Garcia-Fuentes M., Alonso M.J., A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides, Eur. J. Pharm. Biopharm., 75, 26–32 (2010)
https://doi.org/10.1016/j.ejpb.2010.01.010
https://www.sciencedirect.com/science/article/pii/S0939641110000299?via%3Dihub

De la Fuente M., Raviña M., Paolicelli P., Sanchez A., Seijo B., Alonso M.J., Chitosan-based nanostructures: a delivery platform for ocular therapeutics, Advanced Drug Delivery Reviews, 62, 100–117 (2010)
https://doi.org/10.1016/j.addr.2009.11.026
https://www.sciencedirect.com/science/article/pii/S0169409X09003810

Prego C., Paolicelli P., Díaz B., Vicente S., Sánchez A., González-Fernández A., Alonso M.J., Chitosan-based Nanoparticles for Improving Immunization against Hepatitis B Infection, Vaccine, 28, 2607–2614 (2010)
https://doi.org/10.1016/j.vaccine.2010.01.011
https://www.sciencedirect.com/science/article/pii/S0264410X10000423?via%3Dihub

Santander-Ortega M.J., Csaba N., Gonzalez L., Bastos-González D., Ortega-Vinuesa J.L., Alonso M.J., Protein-loaded PLGA: PEO blend nanoparticles: encapsulation, release and degradation characteristics, Colloid Polym Sci, 288, 141–150 (2010)
https://doi.org/10.1007/s00396-009-2131-z
https://link.springer.com/article/10.1007/s00396-009-2131-z

Gref R., Quellec P., Sanchez A., Calvo P., Dellacherie E., Alonso M.J., Development and characterization of CyA-loaded PLA-PEG micro and nanoparticles. Comparison with conventional PLA particulate carriers, Eur. J. Pharm. Biopharm., 51, 2, 111-118 (2010)
https://doi.org/10.1016/S0939-6411(00)00143-0
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Csaba N., Köping-Höggård M., Fernandez-Megia E., Novoa-Carballal R., Riguera R., Alonso M.J., Ionically Crosslinked Chitosan Nanoparticles as Gene Delivery Systems:Effect of PEGylation Degree on In Vitro and In Vivo GeneTransfer, J. Biomed. Nanotechnol. 5, 162-171 (2009)
https://doi.org/10.1166/jbn.2009.1017
https://www.ingentaconnect.com/content/asp/jbn/2009/00000005/00000002/art00003;jsessionid=smbqnqubod3e.x-ic-live-02

Goycoolea F., Lollo G., Remuñán-Lopez C., Quaglia F., Alonso M.J., Chitosan-Alginate Blended Nanoparticles as Carriers for the Transmucosal Delivery of Macromolecules,Biomacromolecules , 10, 1736–1743 (2009)
https://doi.org/10.1021/bm9001377
https://pubs.acs.org/doi/10.1021/bm9001377

Csaba N., Köping-Höggård M., Alonso M.J., Ionically crosslinked chitosan nanoparticles for oligonucleotide and plasmid DNA delivery, Int. J. Pharm, 382, 205–214 (2009)
ESTE TITULO ESTA MAL. ES: Ionically crosslinked chitosan/tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery
https://doi.org/10.1016/j.ijpharm.2009.07.028
https://www.sciencedirect.com/science/article/pii/S0378517309005006?via%3Dihub

Oyarzun-Ampuero F.A., Brea J., Loza M.I., Torres D., Alonso M.J., Chitosan-hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma, Int. J. Pharm. 381,122–129 (2009)
https://doi.org/10.1016/j.ijpharm.2009.04.009
https://www.sciencedirect.com/science/article/pii/S0378517309002129?via%3Dihub

Teijeiro-Osorio D., Remuñán-López C., Alonso M.J., New generation of hybrid Poly/Oligosaccharide nanoparticles as carriers for the nasal delivery of macromolecules,Biomacromolecules, 10, 243-249 (2009)
https://doi.org/10.1021/bm800975j
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Teijeiro-Osorio D., Remuñán-López C., Alonso M.J., Chitosan/cyclodextrin nanoparticles can efficiently transfect the airway epithelium in vitro, J. Pharm. Biopharm., 71, 257-263 (2009)
https://doi.org/10.1016/j.ejpb.2008.09.020
https://www.sciencedirect.com/science/article/pii/S0939641108003731?via%3Dihub

Santander-Ortega M., Alonso M.J., Insulin-Loaded PLGA nanoparticles for oral administration: An in vitro physico-chemical characterization, J. Biomed. Nanotechnol., 5, 45-53 (2009)
https://doi.org/10.1166/jbn.2009.022
https://www.ingentaconnect.com/content/asp/jbn/2009/00000005/00000001/art00004

Alonso-Sande M., Teijeiro-Osorio D., Remuñán-López C., Alonso M.J., Glucomannan, a promising polysaccharide for biopharmaceutical purposes, Eur. J. Pharm. Biopharm. 72, 453–462 (2009)
https://doi.org/10.1016/j.ejpb.2008.02.005
https://www.sciencedirect.com/science/article/pii/S0939641108000490

Paolicelli P., De la Fuente M., Sánchez A., Seijo B., Alonso M.J., Chitosan nanoparticles for drug delivery to the eye, Expert Opin. Drug Deliv., 6, 239-253 (2009)
https://doi.org/10.1517/17425240902762818
https://informahealthcare.com/doi/abs/10.1517/17425240902762818

Csaba N., García Fuentes M., Alonso M.J., Nanoparticles for nasal vaccination, Adv Drug Deliv Rev, 27;61(2):140-57 (2009)
https://doi.org/10.1016/j.addr.2008.09.005
https://www.sciencedirect.com/science/article/pii/S0169409X08002640?via%3Dihub

 

De la Fuente M., Csaba N., García-Fuentes M., Alonso M. J., Nanoparticles as protein and gene carriers to mucosal surfaces, Nanomedicine, 3, 845-857 (2008)
https://doi.org/10.2217/17435889.3.6.845
https://www.futuremedicine.com/doi/abs/10.2217/17435889.3.6.845?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Hervella P., Lozano V., Garcia-Fuentes M., Alonso M. J., Nanomedicine: New challenges and opportunities in cancer therapy, J. Biomed. Nanotechnol. 4, 276-292 (2008)
https://doi.org/10.1166/jbn.2008.339
https://www.ingentaconnect.com/content/asp/jbn/2008/00000004/00000003/art00006?crawler=true&mimetype=application/pdf

Lozano M.V., Torrecilla D., Torres D., Vidal A., Domínguez F., Alonso M.J., Highly efficient system to deliver taxanes into tumor cells: docetaxel-loaded chitosan oligomer colloidal carriers, Biomacromolecules, 9, 2186-2193 (2008)
https://doi.org/10.1021/bm800298u
https://pubs.acs.org/doi/full/10.1021/bm800298u

Trapani A., García-Fuentes M., Alonso M. J., Novel drug nanocarriers combining hydrophilic cyclodextrins and chitosan, Nanotechnology, 19, 185101 (2008)
DOI 10.1088/0957-4484/19/18/185101
https://iopscience.iop.org/article/10.1088/0957-4484/19/18/185101/pdf

De la Fuente M., Seijo B., and Alonso M.J., Design of novel polysaccharidic nanostructures for gene delivery, Nanotechnology, 19, 075105 (2008)
DOI 10.1088/0957-4484/19/7/075105
https://iopscience.iop.org/article/10.1088/0957-4484/19/7/075105

De la Fuente M., Seijo B, Alonso M.J., Bioadhesive hyaluronan-chitosan nanoparticles can transport genes across the ocular mucosa and transfect ocular tissue, Gene Ther., 15, 668-676 (2008)
https://doi.org/10.1038/gt.2008.16
https://www.nature.com/articles/gt200816

De la Fuente M., Seijo B., Alonso M.J., Novel hyaluronic acid-chitosan nanoparticles for ocular gene therapy, Invest. Ophthalmol. Vis. Sci., 49, 2016-2024 (2008)
https://doi.org/10.1167/iovs.07-1077
https://iovs.arvojournals.org/article.aspx?articleid=2125569

De la Fuente M., Seijo B., Alonso M.J., Novel hyaluronan based nanocarriers for transmucosal delivery of macromolecules, Macromol Biosci., 8, 441–450 (2008)
https://doi.org/10.1002/mabi.200700190
https://onlinelibrary.wiley.com/doi/10.1002/mabi.200700190

 

Krauland A.H., Alonso M.J., Chitosan/Cyclodextrin nanoparticles as macromolecular drug delivery systems, Int. J. Pharm, 340, 134-142 (2007)
https://doi.org/10.1016/j.ijpharm.2007.03.005
https://www.sciencedirect.com/science/article/pii/S0378517307002360?via%3Dihub

Diebold Y., Jarrín M., Sáez V., Carvalho E.L.S., Orea M., Calonge M., Seijo B., Alonso M.J., Ocular drug delivery by liposome-chitosan nanoparticle complexes (LCS-NP), Biomaterials, 28, 1553-1564 (2007)
https://doi.org/10.1016/j.biomaterials.2006.11.028
https://www.sciencedirect.com/science/article/pii/S0142961206009926?via%3Dihub

 

 

Alonso-Sande M., Cuña M., Remuñán-López C., Teijeiro-Osorio D., Alonso M.J., Formation of new glucomannan – chitosan nanoparticles and study of their ability to associate and deliver proteins, Macromolecules, 39, 4152-4158 (2006)
https://doi.org/10.1021/ma060230j
https://pubs.acs.org/doi/full/10.1021/ma060230j

García Fuentes M., Trapani A., Alonso M.J., Protection of the peptide glutathione by complex formation with cyclodextrin: NMR spectroscopic análisis and stability study, Eur. J. Pharm. Biopharm., 64, 146-153 (2006)
https://doi.org/10.1016/j.ejpb.2006.05.010
https://www.sciencedirect.com/science/article/pii/S0939641106001421?via%3Dihub

Prego C., Fabre M., Torres D., Alonso M. J., Efficacy and Mechanism of Action of Chitosan Nanocapsules for Oral Peptide Delivery, Pharm. Res., 23, 549-556 (2006)
https://doi.org/10.1007/s11095-006-9570-8
https://link.springer.com/article/10.1007/s11095-006-9570-8

Csaba N., Sanchez A., Alonso M.J., PLGA: Poloxamer and PLGA: Poloxamine blend nanostructures as carriers for nasal gene delivery, J. Control Rel., 113, 164-172 (2006)
https://doi.org/10.1016/j.jconrel.2006.03.017
https://www.sciencedirect.com/science/article/pii/S0168365906001465?via%3Dihub

Prego C., Torres D., Fernandez-Megia E., Novoa-Carballal R., Quiñoá E., Alonso M.J., Chitosan-PEG nanocapsules as new carriers for oral peptide delivery. Effect of chitosan pegylation degree, J. Control Rel., 111, 299-308 (2006)
https://doi.org/10.1016/j.jconrel.2005.12.015
https://www.sciencedirect.com/science/article/pii/S0168365906000022?via%3Dihub

Maestrelli F., Garcia-Fuentes M., Mura P. and Alonso M. J., A new drug nanocarrier consisting of chitosan and hydoxypropylcyclodextrin, Eur. J. Pharm. Biopharm., 63, 79-86 (2006)
https://doi.org/10.1016/j.ejpb.2005.12.006
https://www.sciencedirect.com/science/article/pii/S0939641105003371?via%3Dihub

Csaba N., García Fuentes M., Alonso M.J.The performance of nanocarriers for transmucosal drug delivery, Expert Opin. Drug Deliv., 3, 463-478 (2006)
https://doi.org/10.1517/17425247.3.4.463
https://www.tandfonline.com/doi/full/10.1517/17425247.3.4.463

Prego C., Torres D., Alonso M.J., Chitosan nanocapsules as carriers for oral peptide delivery: Effect of chitosan molecular weight and type of salt on the in vitro behaviour and in vivo effectiveness, J. Nanosci. Nanotechnol., 6, 2921-2928 (2006)
https://doi.org/10.1166/jnn.2006.429
https://www.ingentaconnect.com/content/asp/jnn/2006/00000006/f0020009/art00032

Prego C., Torres D., Alonso M.J., Chitosan nanocapsules: a new carrier for nasal peptide delivery, J. Drug Del. Sci. Tech., 16, 331-337 (2006)
https://doi.org/10.1016/S1773-2247(06)50061-9
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Prego C., Torres D., Alonso M.J., The potential of chitosan for the oral administration of peptides, Expert Opin. Drug Deliv., 2, 843-854 (2005)
https://doi.org/10.1517/17425247.2.5.843
https://www.tandfonline.com/doi/abs/10.1517/17425247.2.5.843

Köping-Höggard M., Sánchez A., Alonso M.J., Nanoparticles as carriers for nasal vaccine delivery, Expert Rev. Vaccines 4, 185-196 (2005)
https://doi.org/10.1586/14760584.4.2.185
https://www.tandfonline.com/doi/full/10.1586/14760584.4.2.185

Garcia-Fuentes M., Prego C., Torres D., Alonso M. J., A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly (ethylene glycol) as carriers for oral calcitonin delivery, Eur. J. Pharm. Sci., 25, 133-143 (2005)
https://doi.org/10.1016/j.ejps.2005.02.008
https://www.sciencedirect.com/science/article/pii/S0928098705000680?via%3Dihub

Vila A., Sánchez A., Évora C., Soriano I., Alonso M.J., PLA-PEG particles as nasal protein carriers: influence of the particle size, Int. J. Pharm., 292, 43-52 (2005)
https://doi.org/10.1016/j.ijpharm.2004.09.002
https://www.sciencedirect.com/science/article/pii/S0378517304005319?via%3Dihub

Prego C., García M., Torres D., Alonso M.J., Transmucosal macromolecular drug delivery, J. Control. Rel., 101 (1-3 SPEC. ISS.), 151-162 (2005)
https://doi.org/10.1016/j.jconrel.2004.07.030
https://www.sciencedirect.com/science/article/pii/S0168365904003499?via%3Dihub

Csaba N., Caamaño P., Sánchez A., Domínguez F., Alonso M.J., PLGA: poloxamer and PLGA: poloxamine blend nanoparticles: new carriers for gene delivery, Biomacromolecules, 6, 271-8 (2005)
https://doi.org/10.1021/bm049577p
https://pubs.acs.org/doi/10.1021/bm049577p

 

Csaba, N., González, L., Sánchez, A., & Alonso, M. J. (2004). Design and characterisation of new nanoparticulate polymer blends for drug delivery. Journal of Biomaterials Science. Polymer Edition, 15(9), 1137–1151.
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Vila, A., Sánchez, A., Janes, K., Behrens, I., Kissel, T., Jato, J. L. V., & Alonso, M. J. (2004). Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik e.V, 57(1), 123–131.
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Vila A., Gill H., McCallion O., Alonso, M.J., Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density,J. Control. Rel. 98, 231-244 (2004)
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De Campos A.M., Diebold Y., Carvahlo E.S., Sánchez A., Alonso M.J., Chitosan nanoparticles as new ocular drug delivery systems: in vitro stability, in vivo fate and cellular toxicity, Pharm. Res., 21, 803-810 (2004)
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Vila A., Sánchez A., Évora C., Soriano I., Vila Jato J.L., Alonso M. J., PEG-PLA nanoparticles as carriers for nasal protein/vaccine delivery,J. Aerosol. Med., 17, 174-185 (2004)
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Alonso M.J., Sánchez A., The potential of chitosan in ocular drug delivery, J. Pharm. Pharmacol., 55, 1451-1663 (2003)
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De Campos A., Sánchez A., Gref R., Calvo P., Alonso M.J., The effect of a PEG coating vs. a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa, Eur. J. Pharm. Sci., 20, 73-81 (2003)
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Janes, K. A., & Alonso, M. J. (2003). Depolymerized chitosan nanoparticles for protein delivery: Preparation and characterization. Journal of Applied Polymer Science, 88(12), 2769–2776.
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Sánchez, A., Tobı́o, M., González, L., Fabra, A., & Alonso, M. J. (2003). Biodegradable micro- and nanoparticles as long-term delivery vehicles for interferon-alpha. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences, 18(3–4), 221–229.
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Diebold, Y., de Salamanca, A. E., Jarrín, M., Callejo, S., Vila, A., & Alonso, M. J. (2003). Uptake of bioadhesive nanoparticles in a normal human conjunctiva (NHC) epithelial cell line. Investigative ophthalmology & visual science, 44(13), 3785–3785.
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Behrens I., Vila Pena A., Alonso M.J., Kissel T., Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human epithelial cell lines and rats: the effect of mucus on particle adsorption and transport, Pharm. Res., 19, 1185-1193 (2002)
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Vila A., Sánchez A., Tobío M., Calvo P., Alonso M.J., Design of biodegradable particles for protein delivery, J. Control. Rel., 78, 15-24 (2002)
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Pérez C., Sánchez A., Putnam D., Ting D., Langer R., Alonso M.J., Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA, J. Control. Rel., 75, 211-224 (2001)
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Janes K., Calvo P., Alonso M.J., Polysaccharide colloidal particles as delivery systems for macromolecules, Adv. Drug Deliv. Rev., 47, 83-97 (2001)
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Janes K., Fresneau M.P., Marazuela A., Fabra A., Alonso M.J., Chitosan nanoparticles as delivery sytems for doxorubicin, J. Control. Rel., 73, 255-267 (2001)
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Gref R., Quellec P., Sanchez A., Calvo P., Dellacherie E., Alonso M.J., Development and characterization of CyA-loaded PLA-PEG micro and nanoparticles. Comparison with conventional PLA particulate carriers, Eur. J. Pharm. Biopharm., 51, 2, 111-118 (2001)
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Tobío M., Sánchez A., Vila A., Soriano I., Evora C., Vila Jato J.L., Alonso M.J., The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration, Colloid Surf. B-Biointerfaces, 18, 315-323 (2000)
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Portero A., Remuñán-López C., Lemos M., Vila Jato J.L., Núñez M.J., Alonso M.J., Chitosan microspheres for specific delivery of amoxicillin to the gastric cavity, S.T.P. Pharma Sci., 10, 69-76 (2000)
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Tobío M., Schewndeman P.S., Guo Y. , J. McIver J., Langer R., Alonso M.J., Improved immunogenicity of a core-coated tetanus toxoid delivery vehicle, Vaccine, 18, 618-622 (2000)
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Fernández Urrusuno R., Romaní D., Calvo P., Vila Jato J.L., Alonso M.J., Development of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration, S.T.P. Pharma Sci., 9, 429-436 (1999)
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Fernández Urrusuno R., Calvo P., Remuñán-López C., Vila Jato J.L., Alonso M.J., Enhancement of nasal absorption of insulin using chitosan nanoparticles, Pharm. Res., 16, 1576-1581 (1999)
https://doi.org/10.1023/A:1018908705446
https://link.springer.com/article/10.1023/A:1018908705446

Sánchez A., Villamayor B., Guo Y., McIver J., Alonso M.J., Formulation strategies for the solubilization of tetanus toxoid in poly(lactide-co-glycolide) microspheres,Int. J. Pharm., 185, 255-266 (1999)
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Tobío M., Nolley J., Y. Guo, J. McIver, Alonso M.J., A novel system based on a PLGA/Poloxamer blend as a tetanus toxoid delivery vehicle, Pharm. Res., 16, 682-688, (1999)
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Quellec P., Gref R., Perrin L., Dellacherie E., Sommer F., Verbavatz J.M., Alonso M. J., Protein encapsulation within PEG-coated nanospheres II: In vitro release,J. Biomed. Mater. Res., 47, 388-395 (1999)
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Portero, A., Remuñán-López, C., Vila-Jato, J. L., Effect of chitosan and chitosan glutamate enhancing the dissolution properties of the poorly water soluble drug nifedipine, Int. J. Pharm., 175, 75-84 (1998)
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Williams R.O., Barron M.K., Alonso M.J., Remuñán-López C., Investigation of a pMDI system containing chitosan microspheres and P134a, Int. J. Pharm., 174, 209-222 (1998)
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Tobío M., Alonso M.J., Study of the inactivation process of the tetanus toxoid in contact with poly(lactic/glycolic acid) degrading microspheres, S.T.P. Pharma Sci., 8, 303-310 (1998)
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Lorenzo-Lamosa M. L., Remuñán-Lopez C., Vila-Jato J. L., Alonso M. J., Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery, J. Control. Rel., 55, 143-152 (1998)
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Quellec P., Gref R., Perrin L., Dellacherie E., Sommer F., Verbavatz J.M., Alonso M. J., Protein encapsulation within PEG-coated nanospheres I: Physicochemical characterization,J. Biomed. Mater. Res., 42, 45-54 (1998)
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Blanco D., Alonso M. J., Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants, Eur. J. Pharm. Biopharm., 45, 285-294 (1998)
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Lorenzo-Lamosa M.L., Remuñán-Lopez C., Vila-Jato J.L., Alonso M. J., Design of microencapsulated chitosan microspheres for colonic drug delivery, J. Control. Rel., 52, 109-118 (1998)
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Swendeman S., Tobío M., Joworowicz M., Alonso M.J., Langer R., New strategies for the microencapsulation of tetanus vaccine, J. Microencapsulation, 15, 299-318 (1998)
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Gaspar M., Blanco D., Cruz M.E.M., Alonso M. J., Formulation of L-asparaginase loaded poly(lactide-co-glycolide) nanoparticles: influence of polymer properties on enzyme loading, activity and in vitro release, J. Control. Rel., 52, 53-62 (1998)
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Remuñán-López C., Lorenzo-Lamosa M.L., Vila-Jato J.L., Alonso M. J., Development of new chitosan-cellulose multicore microparticles for controlled drug delivery, Eur. J. Pharm. Biopharm., 45, 49-56 (1998)
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Zambaux M.F., Bonneaux F., Gref R., Maincent P., Dellacherie E., Alonso M.J., Labrude, Vigneron C., Influence of experimental parmeters on the characteristics of PLA nanoparticles prepared by a double emulsion method, J. Control. Rel., 50, 31-40 (1998)
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Tobío M., Gref R., Sánchez A., Langer R., Alonso M.J., Stealth PLA-PEG nanoparticles as nasal protein delivery systems , Pharm. Res., 15, 270-275 (1998)
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Juberías J.R., Calonge M., Gómez S., López M.I., Calvo P., Herreras J.M., Alonso M. J. Efficacy of topical cyclosporine-loaded nanocapsules on keratoplasty rejection in the rat,Curr. Eye Res., 17(1), 39-46 (1998)
https://doi.org/10.1076/ceyr.17.1.39.5251
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Calvo P., Remuñán-López C., Vila-Jato J.L., Alonso M. J., Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines, Pharm. Res., 14, 1431-1436 (1997)
https://doi.org/10.1023/A:1012128907225
https://link.springer.com/article/10.1023/A:1012128907225

Lorenzo-Lamosa M. L., Cuña M., Torres D., Vila-Jato J.L., Alonso M. J., Development of a microencapsulated form of cefuroxime axetil using pH-sensitive acrylic polymers, J. Microencapsulation, 14, 607-616 (1997)
https://doi.org/10.3109/02652049709006813
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Gupta R. K., Alroy J., Alonso M. J., Langer R., Siber G. R., Chronic local tissue reactions, long term immunogenicity and immunologic priming of mice and guinea pigs to tetanus toxoid encapsulated in biodegradable polymer microspheres composed of poly lactide-co-glycolide polymers, Vaccine, 15, 1716-1723 (1997)
https://doi.org/10.1016/S0264-410X(97)00116-3
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Calvo P., Vila-Jato J.L., Alonso M. J., Effect of lysozyme on the stability of polyester nanocapsules: stabilization approaches, Biomaterials, 18, 1305-1310 (1997)
https://doi.org/10.1016/S0142-9612(97)00061-6
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Calvo P., Vila-Jato J.L., Alonso M. J., Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers, Int. J. Pharm., 153, 41-50 (1997)
https://doi.org/10.1016/S0378-5173(97)00083-5
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Blanco D., Alonso M. J., Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres, Eur. J. Pharm. Biopharm., 43, 287-294 (1997)
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Cuña M., Lorenzo-Lamosa M.L., Torres D., Vila-Jato J.L., Alonso M. J., PH-dependent cellulosic microspheres containing cefuroxime axetil: stability and in vitro release behavior,Drug Dev. Ind. Pharm., 23, 259-265 (1997)
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Calvo P., Remuñán-López C., Vila-Jato J.L., Alonso M. J., Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers, J. Appl. Polymer Sci., 63, 125-132 (1997)
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Calvo P., Remuñán-López C., Vila-Jato J.L., Alonso M. J., Development of positively charged colloidal drug carries: chitosan-coated polyester nanocapsules and submicron-emulsions,Colloid. Polymer Sci., 275, 46-53 (1997)
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Sánchez A., Gupta R., Alonso M.J., Siber G., Langer R., Pulsed controlled release system for potential use in vaccine delivery, J. Pharm. Sci., 85, 547-552 (1996)
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Calvo P., Vila-Jato J.L., Alonso M. J., Improved ocular bioavailability of indomethacin by novel ocular drug carriers, J. Pharm. Pharmacol., 22, 1147-1152 (1996)
https://doi.org/10.1111/j.2042-7158.1996.tb03911.x
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Calvo P., Vila Jato J.L., Alonso M. J., Comparative evaluation of several colloidal systems, as ocular drug carriers, J. Pharm. Sci., 85, 530-536 (1996)
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Calvo P., Sánchez A., Martinez J., López M.I., Calonge M. Pastor J.C., Alonso M.J., Polyester nanocapsules as new topical ocular delivery systems for Cyclosporin A, Pharm. Res., 13, 126-130 (1996)
https://doi.org/10.1023/A:1016015803611
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Sánchez A., Seoane R., Quireza O., Alonso M.J., Poly(DL-lactide-co-glycolide) micro and nanospheres as a way to prolong blood/plasma levels of subcutaneously injected Cyclosporin A., Eur. J. Pharm. Biopharm., 41, 31-37 (1995)
ISSN 0939-6411
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Lorenzo-Lamosa M.L., Remuñán-López C., Alonso M. J., Interés y aplicaciones del biopolímero chitosan en tecnología farmacéutica (II), Industria Farmacéutica, 1-2, 49-52 (1995)
ISSN 0213-5574
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Sánchez A., Tobío M., Alonso M. J., Los copolímeros del ácido láctico y glicólico: características y aplicaciones en la liberación de macromoléculas, Industria Farmacéutica, 1-2, 69-76 (1995)
ISSN 0213-5574
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Sánchez A., Seoane R., Quireza O., Alonso M.J., In vivo study of the tissue distribution and immunosuppressive response of cyclosporin a-loaded polyester micro- and nanospheres, Drug Delivery, 2, 21-28 (1995).
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Cohen S., Alonso M. J., Langer R., Novel approaches to controlled release antigen delivery,Int. J. Tech. Health Care, 10, 121-130 (1994)
https://doi.org/10.1017/S0266462300014045
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Lorenzo-Lamosa M. L., Remuñán-López, Alonso M. J., Interés y aplicaciones del biopolímero chitosan en tecnología farmacéutica, Industria Farmacéutica, 11-12, 71-75 (1994)
ISSN: 0213-5574
https://investigacion.usc.gal/documentos/5d1df6ca29995204f767888e?lang=en

Sánchez A., Tobío M., Alonso M. J., Los polianhídridos: características y aplicaciones en la liberación controlada de moléculas activas, Industria Farmacéutica, 11-12, 83-90 (1994)
ISSN 0213-5574
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Sánchez A., Calvo P., Vila Jato J.L., Alonso M. J., Ciclosporina A: limitaciones en su utilización clínica y nuevas formas de administración, Farmacia Clínica, 43, 675-695 (1994)

Park T. G., Alonso M.J., Langer R., Controlled release of proteins from poly(L-lactic acid) coated polyisobutylcyanoacrylate microcapsules, J. Appl. Polymer. Sci., 52, 1797-1807 (1994)
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Gopferich A., Alonso M.J., Langer R., Development and characterization of microencapsulated microspheres, Pharm. Res., 11, 1568-1574 (1994)
https://doi.org/10.1023/A:1018901619230
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Calvo P., Thomas, Alonso M.J., Vila Jato J.L., Robinson J., Study of the mechanisms of interaction of poly-E-caprolactone nanocapsules with the cornea by confocal laser scanning microscopy, Int. J. Pharm., 103, 283-291 (1994)
https://doi.org/10.1016/0378-5173(94)90179-1
https://www.sciencedirect.com/science/article/abs/pii/0378517394901791

Alonso M. J., Gupta R. K., Min C., Siber G., Langer R., Biodegradable microspheres as controlled release tetanus toxoid delivery systems, Vaccine, 12, 299-306 (1994)
https://doi.org/10.1016/0264-410X(94)90092-2
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Alonso M. J., Cohen S., Park T.G., Gupta R. K., Siber G., Langer R., Determinants of the release rate of tetanus toxoid from polyester microspheres, Pharm. Res., 10, 945-953 (1993)
https://doi.org/10.1023/A:1018942118148
https://link.springer.com/article/10.1023/A:1018942118148

Sánchez A., Vila Jato J.L., Alonso M.J., Development of biodegradable microspheres and nanospheres for the controlled release of cyclosporin A, Int. J. Pharm., 99, 263-273 (1993)
https://doi.org/10.1016/0378-5173(93)90369-Q
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Losa C. M., Marchal-Heussler L., Orallo F., Vila Jato J.L., Alonso M.J., Design of new formulations for topical ocular administration: polymeric nanocapsules containing metipranolol, Pharm. Res., 10, 80-87 (1993)
https://doi.org/10.1023/A:1018977130559
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Losa C., Alonso M.J., Vila J.L., Orallo F., Martinez J. Saavedra J.A., Pastor J.C., Reduction of cardiovascular side effects associated with ocular administration of metipranolol by inclusion in polymeric nanocapsules,J. Ocular Pharmacol., 8, 191-198 (1992)
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Julienne M.C., Alonso M.J., Gómez Amoza J. L., Benoit J. P., Preparation of poly(D,L-lactide/glycolide) nanoparticles of controlled particle size distribution: application of experimental designs,Drug Dev. Ind. Pharm., 18, 1063-1077 (1992)
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Egea M. A., Valls O., Alsina M. A., García M. L., Losa C., Vila J. L., Alonso M. J.,Interaction of amikacin loaded nanoparticles with phosphatidylcholine monolayers as membrane models, Int. J. Pharm., 67, 103-112 (1991)
https://doi.org/10.1016/0378-5173(91)90422-K
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Losa C., Calvo P., Castro E., Vila Jato J. L., Alonso M. J., Improvement of ocular penetration of amikacin sulphate by association to poly(butylcyanoacrylate) nanoparticles, J. Pharm. Pharmacol., 43, 548-552 (1991)
https://doi.org/10.1111/j.2042-7158.1991.tb03534.x
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Alonso M. J., Losa C., Calvo P., Vila Jato J.L., Approaches to improve the association of amikacin sulphate to poly(alkylcyanoacrylate) nanoparticles, Int. J. Pharm., 68, 69-76 (1991)
https://doi.org/10.1016/0378-5173(91)90128-B
https://www.sciencedirect.com/science/article/abs/pii/037851739190128B

Vila Jato J. L., Alonso M. J., Seijo B., Torres D., Sistemas biodegradables para la administración de medicamentos por vía parenteral (II), Industria Farmacéutica, 5, 57-65 (1991)

Vila Jato J. L., Alonso M. J., Seijo B., Torres D., Sistemas biodegradables para la administración de medicamentos por vía parenteral (I), Industria Farmacéutica, 3, 67-75 (1991)

Sánchez A., Vila Jato J. L., Alonso M.J., Sistemas de liberación controlada de fármacos a base de polímeros y copolímeros de los ácidos láctico y glicólico, Farmacia Clínica, 8, 824-830 (1991)

Alonso M.J., Sánchez A., Seijo B., Torres D., Vila Jato J.L., Joint effects of monomer and stabilizer concentrations on physico-chemical characteristics of Poly(butyl 2-cyanoacrylate) nanoparticles, J. Microencapsulation, 7, 517-526 (1990)
https://doi.org/10.3109/02652049009040475
https://www.tandfonline.com/doi/abs/10.3109/02652049009040475

Torres D, Seijo, B, García-Encina G., Alonso M.J., Vila Jato J.L., Microencapsulation of ion-exchange resins by interfacial nylon polymerization, Int. J. Pharm., 59, 9-17 (1990)
https://doi.org/10.1016/0378-5173(90)90059-D
https://www.sciencedirect.com/science/article/abs/pii/037851739090059D

 

Youssef M., Fattal E., Alonso M.J., Roblot-Treupel L., Sauzires J., Tancrede C., Omns A., Couvreur P., Andremont A., Effectiveness of Nanoparticle-Bound Ampicillin in Treatment of Listeria monocitogenes Infection in Athymic Nude Mice, Antimicrob. Agents Chemother., 32, 8, 1204-1207 (1988)
https://doi.org/10.1128/aac.32.8.1204
https://journals.asm.org/doi/10.1128/aac.32.8.1204

Alonso M.J., Maincent P., García Arias T., Vila Jato J.L., A Comparative Biopharmaceutical Study of Fresh and Ageing Tolbutamide-Polyethyleneglycols Solid Dispersions, Int. J. Pharm., 42, 27-33 (1988)
https://doi.org/10.1016/0378-5173(88)90156-1
https://www.sciencedirect.com/science/article/abs/pii/0378517388901561

Vila Jato J. L., Seijo B., Alonso M. J., Torres J., Interés de los Sistemas Bioadhesivos, Revista A.E.F.H. XII, 3, 217-227 (1988)

Henry-Micheland M.J., Alonso M.J., Andremont A., Sauzieres J., Couvreur P., Attachment of Antibiotics to Nanoparticles: Preparation, Drug-Release and Antimicrobial Activity In VitroInt. J. Pharm., 35, 121-127 (1987)
https://doi.org/10.1016/0378-5173(87)90080-9
https://www.sciencedirect.com/science/article/abs/pii/0378517387900809

Alonso M.J., Maincent P., Blanco J., Vila Jato, J.L., Etude de Stabilité de la Dispersion Solide Glybornuride-P.E.G. 20000: Caracterisation Physico-chimique et Evaluation Biopharmacetique, S.T.P. Pharma, 3 , 569-574 (1987)

Alonso M. J., Vila Jato J. L., Avances en el Diseño de Formas de Dosificación de Medicamentos de Uso Oftálmico, Revista A.E.F.H. XI, 3 (1987)

Vila Jato J. L., Concheiro A., Torres D., Alonso M. J., Disgregantes de Comprimidos: Aspectos Tecnológicos y Biofarmacéuticos, Revista A.E.F.H., XI, 2, 133-148 (1987)

Alonso M. J., Blanco J., Vila Jato, J. L., Las Nanopartículas como Sistemas de Liberación de Medicamentos, Revista A.E.F.H., IX, 4, 205-218 (1986)

Vila Jato J.L., Alonso M.J., Blanco, J., The Aging of Solid Dispersions of Glybornuride in Polyethylene Glycol 6000, Drug Dev. Ind. Pharm., 12, 1545-1552 (1986)
https://doi.org/10.3109/03639048609065876
https://www.tandfonline.com/doi/abs/10.3109/03639048609065876

Vila Jato J.L., Alonso M.J., Biopharmaceutical Study of Glybornuride in Polyethylene Glycol Systems, Drug Dev. Ind. Pharm., 12, 701-711 (1986)
DOI: 10.3109/03639048609043486
https://www.tandfonline.com/doi/abs/10.3109/03639048609043486

Vila Jato J.L., Blanco J., Alonso M.J., The Effect of the Molecular Weight of Polyethylene Glycol on the Bioavailability of Paracetamol-Polyethylene Glycol Solid Dispersions, J. Pharm. Pharmacol., 38, 126-128 (1986)
https://doi.org/10.1111/j.2042-7158.1986.tb04525.x
https://academic.oup.com/jpp/article-abstract/38/2/126/6177128?redirectedFrom=fulltext&login=true

 

Vila Jato J.L., Alonso M.J., Blanco J., Dispersiones Sólidas de Tolbutamida en Polietilénglicoles: Influencia del Método de Preparación y del Peso Molecular de los Polímeros, C.I.F., 3, 204-209 (1984)

Vila Jato J. L., Blanco J., Alonso M. J., Las Dispersiones Sólidas: Interés Biofarmacéutico (Parte I), Farmacia Clínica, 4, 264-278 (1983)

Vila Jato J. L., Blanco J., Alonso M. J., Las Dispersiones Sólidas: Interés Biofarmacéutico (Parte II), Farmacia Clínica, 5, 29-43 (1983)

Vila Jato J.L., Concheiro A., Llabrés M., Alonso M.J., Biodisponibilidad Oral del Cefadroxilo: Influencia de la Alimentación, Arch. Farmaco. Toxico. VIII, 171-177 (1982)
https://www.scopus.com/record/display.uri?eid=2-s2.0-0020261477&origin=resultslist

CONTACT

Phone: (34) 881815454
E-Mail: mariaj.alonso@usc.es
Mailing Address:
CIMUS Research Institute
Avda. de Barcelona s/n
Campus Vida s/n
15782, Santiago de Compostela