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In: NANOMEDICINE
Our latest paper, published in Journal of Drug Targeting: “Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system”
February 11, 2019The objective of this work was to evaluate the influence of particle size (≈100 versus 200 nm) and surface composition of polymeric nanocapsules (chitosan, polyarginine and carboxymethyl-β-glucan) on their ability to target specific immune cells in the lymphatics.
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Get free access to our latest paper: “Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells”
January 25, 2019Free access until February 21 to this article, dedicated to Prof. N. Peppas and Prof. R. Langer, published in Journal of Controlled Release
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“A multifunctional drug nanocarrier for efficient anticancer therapy”, article dedicated to Prof. N. Peppas and Prof. R. Langer, published in Journal of Controlled Release
December 26, 2018The nanocarrier consisting of functionalized Lyp1-hyaluronic acid nanocapsules accumulated drastically in the tumor tissue (a-37 times higher tumor accumulation than Taxotere®), a fact that was translated into a drastic decrease in tumor growth and metastatic spreading, in an orthotopic lung cancer model.
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Our latest publication: “Engineering, on‐demand manufacturing, and scaling‐up of polymeric nanocapsules”
October 30, 2018In our recent publication “Engineering, on‐demand manufacturing, and scaling‐up of polymeric nanocapsules” we have designed formulation and technological approaches to produce tailor‐made polymeric NCs, according to different scale‐down (microliters) and scale‐up (liter) techniques.
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Our latest contribution to Science “Bilayer polymeric nanocapsules: A formulation approach for a thermostable and adjuvanted E. coli antigen vaccine” is now published by the Journal of Controlled Release
July 20, 2018This paper describes a new bilayer nanosystem that entraps IutA antigen from E. Coli in a sandwich-like structure. The research not only opens a new path to develop a vaccine against UPEC infections but also represents a general way of stabilizing and controlling the release of purified protein antigens.
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Nanomedicine against Alzheimer’s: EU Project B-SMART Releases Animated Clip
April 2, 2018The European research project B-SMART has released a short animated clip illustrating the project’s innovative approach and raising awareness for the importance of nanomedicine in treating neurodegenerative diseases such as Alzheimer’s.
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Well done Irene and Sara!
May 2, 2017Our colleagues in the Lab Irene Santalices and Ana Sara Cordeiro have just received two well-deserved awards
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The TRANS-INT project brings important advances in the use of nanotechnology for the development of new oral therapies, with relevance for the treatment of diabetes, obesity and other pathologies
April 24, 2017The European consortium “TRANS-INT” finishes the project “New oral nanomedicines: transporting therapeutic macromolecules across the intestinal barrier”
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