Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach

Background: The prevalence of binge drinking (BD) has been on the rise in recent years. It is associated with a range of neurocognitive deficits among adolescents and young emerging
adults who are especially vulnerable to alcohol use. Attention is an essential dimension of executive functioning and attentional disturbances may be associated with hazardous drinking. The aim of the study was to examine the oscillatory neural dynamics of attentional control during visual target detection in emerging young adults as a function of BD.
Method: Fifty-one first-year university students (18±0.6 years) were assigned to light drinking (LD, N=26), and BD (N=25) groups based on their alcohol consumption patterns. High-density magnetoencephalography (MEG) signal was combined with structural magnetic resonance imaging (MRI) in an anatomically-constrained MEG model to estimate event-related source power in theta (4-7 Hz) frequency band. Phase-locked co-oscillations were further estimated between the principally activated regions during task performance.
Results: Overall, the greatest event-related theta power was elicited by targets in the right inferior frontal cortex (rIFC) and it correlated with performance accuracy and selective attention scores. BDs exhibited lower theta power and dysregulated oscillatory synchrony to targets in the rIFC which correlated with higher levels of alcohol consumption.
Conclusions: These results confirm that a highly interactive network in the rIFC subserves attentional control, revealing the importance of theta oscillations and neural synchrony for attentional capture and contextual maintenance. Attenuation of theta power and synchronous interactions in BDs may indicate early stages of suboptimal integrative processing in young,
highly functioning BDs.