Papers published by the group in the last years
(A full list can be consulted in Pubmed)
Pedrosa MA, Valenzuela R, Garrido-Gil P, Labandeira CM, Navarro G, Franco R, Labandeira-Garcia JL, Rodriguez-Perez AI (2021) Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clin Sci (Lond) 135:465-481.
Rivas-Santisteban R, Lillo J, Muñoz A, Rodríguez-Pérez AI, Labandeira-García JL, Navarro G, Franco R (2021) Novel Interactions Involving the Mas Receptor Show Potential of the Renin-Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia. Neurotherapeutics 1-19
Diaz-Ruiz C, Villar-Cheda B, Dominguez-Meijide A, Garrido-Gil P, Guerra MJ, Labandeira-Garcia JL (2020) Aging-Related Overactivity of the Angiotensin/AT1 Axis Decreases Sirtuin 3 Levels in the Substantia Nigra, Which Induces Vulnerability to Oxidative Stress and Neurodegeneration. J Gerontol A Biol Sci Med Sci 75:416-424.
Rodriguez-Perez AI, Garrido-Gil P, Pedrosa MA, Garcia-Garrote M, Valenzuela R, Navarro G, Franco R, Labandeira-Garcia JL (2020) Angiotensin type 2 receptors: Role in aging and neuroinflammation in the substantia nigra. Brain Behav Immun 87:256-271
Rivas-Santisteban R, Rodriguez-Perez AI, Muñoz A, Reyes-Resina I, Labandeira-García JL, Navarro G, Franco R (2020) Angiotensin AT(1) and AT(2) receptor heteromer expression in the hemilesioned rat model of Parkinson's disease that increases with levodopa-induced dyskinesia. J Neuroinflammation 17:243
Muñoz A, Lopez-Lopez A, Labandeira CM, Labandeira-Garcia JL (2020) Interactions Between the Serotonergic and Other Neurotransmitter Systems in the Basal Ganglia: Role in Parkinson's Disease and Adverse Effects of L-DOPA. Front Neuroanat 14:26.
Lopez-Lopez A, Labandeira CM, Labandeira-Garcia JL, Muñoz A (2020) Rho kinase inhibitor fasudil reduces l-DOPA-induced dyskinesia in a rat model of Parkinson's disease. Br J Pharmacol 177:5622-5641.
Labandeira-Garcia JL, Valenzuela R, Costa-Besada MA, Villar-Cheda B, Rodriguez-Perez AI (2020) The intracellular renin-angiotensin system: Friend or foe. Some light from the dopaminergic neurons. Prog Neurobiol 101919.
Garrido-Gil P, Rodriguez-Perez AI, Lage L, Labandeira-Garcia JL (2020) Estrogen deficiency and colonic function: surgical menopause and sex differences in angiotensin and dopamine receptor interaction. J Gerontol A Biol Sci Med Sci.
Franco R, Lillo A, Rivas-Santisteban R, Rodríguez-Pérez AI, Reyes-Resina I, Labandeira-García JL, Navarro G (2020) Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue. Int J Mol Sci 21.
Franco R, Rivas-Santisteban R, Serrano-Marín J, Rodríguez-Pérez AI, Labandeira-García JL, Navarro G (2020) SARS-CoV-2 as a Factor to Disbalance the Renin-Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production. J Immunol 205:1198-1206.
Seoane-Collazo P, Liñares-Pose L, Rial-Pensado E, Romero-Picó A, Moreno-Navarrete JM, Martínez-Sánchez N, Garrido-Gil P, Iglesias-Rey R, Morgan DA, Tomasini N, Malone SA, Senra A, Folgueira C, Medina-Gomez G, Sobrino T, Labandeira-García JL, Nogueiras R, Domingos AI, Fernández-Real JM, Rahmouni K, Diéguez C, López M (2019) Central nicotine induces browning through hypothalamic κ opioid receptor. Nat Commun 10:4037.
Garcia-Garrote M, Perez-Villalba A, Garrido-Gil P, Belenguer G, Parga JA, Perez-Sanchez F, Labandeira-Garcia JL, Fariñas I, Rodriguez-Pallares J (2019) Interaction between Angiotensin Type 1, Type 2, and Mas Receptors to Regulate Adult Neurogenesis in the Brain Ventricular-Subventricular Zone. Cells 8
Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal E, Fondevila MF, Barja-Fernández S, Gallego R, Hernández-Bautista R, Castelao C, Senra A, Seoane P, Gómez N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-García JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Frühbeck G, Seoane LM, Nogueiras R (2019) Hypothalamic dopamine signaling regulates brown fat thermogenesis. Nature metabolism 1:811-829.
Pignataro D, Sucunza D, Rico AJ, Dopeso-Reyes IG, Roda E, Rodríguez-Perez AI, Labandeira-Garcia JL, Broccoli V, Kato S, Kobayashi K, Lanciego JL (2018) Gene therapy approaches in the non-human primate model of Parkinson's disease. J Neural Transm (Vienna) 125:575-589.
Reyes-Resina I, Aguinaga D, Labandeira-García JL, Lanciego JL, Navarro G, Franco R (2018) Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas. Histol Histopathol 33:909-917.
Diaz-Ruiz C, Villar-Cheda B, Dominguez-Meijide A, Garrido-Gil P, Guerra MJ, Labandeira-Garcia JL (2018) Aging-Related Overactivity of the Angiotensin/AT1 Axis Decreases Sirtuin 3 Levels in the Substantia Nigra, which Induces Vulnerability to Oxidative Stress and Neurodegeneration. J Gerontol A Biol Sci Med Sci.
Rodriguez-Perez AI, Sucunza D, Pedrosa MA, Garrido-Gil P, Kulisevsky J, Lanciego JL, Labandeira-Garcia JL (2018) Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death. Neurotherapeutics.
Cruces-Sande A, Rodriguez-Perez AI, Herbello-Hermelo P, Bermejo-Barrera P, Mendez-Alvarez E, Labandeira-Garcia JL, Soto-Otero R (2018) Copper Increases Brain Oxidative Stress and Enhances the Ability of 6-Hydroxydopamine to Cause Dopaminergic Degeneration in a Rat Model of Parkinson's Disease. Mol Neurobiol.
Hernandez HG, Sandoval-Hernandez AG, Garrido-Gil P, Labandeira-Garcia JL, Zelaya MV, Bayon GF, Fernandez AF, Fraga MF, Arboleda G, Arboleda H (2018) Alzheimer's disease DNA methylome of pyramidal layers in frontal cortex: laser-assisted microdissection study. Epigenomics 10:1365-1382.
Parga JA, Rodriguez-Perez AI, Garcia-Garrote M, Rodriguez-Pallares J, Labandeira-Garcia JL (2018) Angiotensin II induces oxidative stress and upregulates neuroprotective signaling from the NRF2 and KLF9 pathway in dopaminergic cells. Free Radic Biol Med 129:394-406.
Parga JA, Rodriguez-Perez AI, Garcia-Garrote M, Rodriguez-Pallares J, Labandeira-Garcia JL (2018) Data on the effect of Angiotensin II and 6-hydroxydopamine on reactive oxygen species production, antioxidant gene expression and viability of different neuronal cell lines. Data Brief 21:934-942.
Garrido-Gil P, Rodriguez-Perez AI, Dominguez-Meijide A, Guerra MJ, Labandeira-Garcia JL (2018) Bidirectional Neural Interaction Between Central Dopaminergic and Gut Lesions in Parkinson's Disease Models. Mol Neurobiol.55:7297-7316.
Muñoz A, Correa CL, Lopez-Lopez A, Costa-Besada MA, Diaz-Ruiz C, Labandeira-Garcia JL (2018) Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT 1, SIRT3 and VEGF in the Substantia Nigra. J Gerontol A Biol Sci Med Sci. 73:1594-1601.
Garrido-Gil P, Dominguez-Meijide A, Moratalla R, Guerra MJ, Labandeira-Garcia JL (2018) Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly. Oncotarget 9:10834-10846.
Costa-Besada MA, Valenzuela R, Garrido-Gil P, Villar-Cheda B, Parga JA, Lanciego JL, Labandeira-Garcia JL (2017) Paracrine and Intracrine Angiotensin 1-7/Mas Receptor Axis in the Substantia Nigra of Rodents, Monkeys, and Humans. Mol Neurobiol 55:5847-5867
Parga JA, Garcia-Garrote M, Martinez S, Raya A, Labandeira-Garcia JL, Rodriguez-Pallares J (2018) Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons. Mol Neurobiol 55:4763-4776.
Labandeira-Garcia JL, Costa-Besada MA, Labandeira CM, Villar-Cheda B, Rodriguez-Perez AI (2017) Insulin-Like Growth Factor-1 and Neuroinflammation. Front Aging Neurosci 9:365.
Labandeira-Garcia JL, Rodriguez-Perez AI, Garrido-Gil P, Rodriguez-Pallares J, Lanciego JL, Guerra MJ (2017) Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration. Front Aging Neurosci 9:129.
Villar-Cheda B, Costa-Besada MA, Valenzuela R, Perez-Costas E, Melendez-Ferro M, Labandeira-Garcia JL (2017) The intracellular angiotensin system buffers deleterious effects of the extracellular paracrine system. Cell Death Dis 8:e3044.
Garrido-Gil P, Fernandez-Rodriguez P, Rodriguez-Pallares J, Labandeira-Garcia JL (2017) Laser capture microdissection protocol for gene expression analysis in the brain. Histochem Cell Biol 148:299-311.
Dominguez-Meijide A, Rodriguez-Perez AI, Diaz-Ruiz C, Guerra MJ, Labandeira-Garcia JL (2017) Dopamine modulates astroglial and microglial activity via glial renin-angiotensin system in cultures. Brain Behav Immun 62:277-290
Garrido-Gil P, Rodriguez-Perez AI, Fernandez-Rodriguez P, Lanciego JL, Labandeira-Garcia JL (2017) Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells. Brain Struct Funct 222(6):2559-2571
Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, Perez-Costas E, Villar-Cheda B, Garrido-Gil P, Melendez-Ferro M, Soto-Otero R, Lanciego JL, Henrion D, Franco R, Labandeira-Garcia JL (2016) Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death Dis 7:e2427.
Labandeira-Garcia JL, Rodriguez-Perez AI, Valenzuela R, Costa-Besada MA, Guerra MJ (2016) Menopause and Parkinson's disease. Interaction between estrogens and brain renin-angiotensin system in dopaminergic degeneration. Frontiers in neuroendocrinology 43:44-59.
Rodriguez-Perez AI, Borrajo A, Diaz-Ruiz C, Garrido-Gil P, Labandeira-Garcia JL (2016) Crosstalk between insulin-like growth factor-1 and angiotensin-II in dopaminergic neurons and glial cells: role in neuroinflammation and aging. Oncotarget 7:30049-30067
Rodriguez-Pallares J, Rodriguez-Perez AI, Munoz A, Parga JA, Toledo-Aral JJ, Labandeira-Garcia JL (2016) Effects of Rho Kinase Inhibitors on Grafts of Dopaminergic Cell Precursors in a Rat Model of Parkinson's Disease. Stem Cells Transl Med 5:804-815
Munoz A, Correa CL, Villar-Cheda B, Costa-Besada MA, Labandeira-Garcia JL (2015) Aging-related Increase in Rho Kinase Activity in the Nigral Region Is Counteracted by Physical Exercise. J Gerontol A Biol Sci Med Sci 71:1254-1257
Diaz-Ruiz C, Rodriguez-Perez AI, Beiroa D, Rodriguez-Pallares J, Labandeira-Garcia JL (2015) Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration. Oncotarget 6:26675-26689
Rodriguez-Perez AI, Borrajo A, Valenzuela R, Lanciego JL, Labandeira-Garcia JL (2015) Critical period for dopaminergic neuroprotection by hormonal replacement in menopausal rats. Neurobiology of aging 36:1194-1208.
Rodriguez-Perez AI, Borrajo A, Rodriguez-Pallares J, Guerra MJ, Labandeira-Garcia JL (2015) Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation. Glia 63:466-482.
