Ángel García Alonso - Platelet Proteomics
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Current Research Projects

We participate in the european project TAPAS (ITN-European Joint Doctorate) in the search for novel antitrombotics with antiplatelet activity.

Our current projects focus on the study of the general proteome and signalling cascades in platelets by proteomics. Platelet secretome and microvesicles are also investigated. This is being done by a combination of proteomics and classical biochemistry and molecular biology approaches. Such studies focus on healthy individuals and patients with obesity and coronary artery disease. The aim is to investigate platelets at molecular level to identify novel biomarkers and drug targets that may help to treat / diagnose ACS and other cardiovascular diseases where unwanted platelet activation plays a role. Potential drug targets identified by proteomics are being investigated in collaboration with the Biofarma group to find small molecules that can inhibit/modulate them.

Main funding is from the Spanish Ministry of Economy and Competitiveness, the Agencia Estatal de Investigación, the Consellería de Cultura, Educación e Ordenación Universitaria and the European Regional Development Fund (ERDF).



Platelet Proteomics Group Members:

 Past Members:

  • Ángel García:Principal Investigador and team leader.
  • Sara Troitiño Cora:: PhD student.
  • Eva M. Fernández Sáez: PhD student.
  • Aurelio M. Sueiro: Clinical researcher (endocrinologist).
  • José M. García Acuña: Clinical researcher (cardiologist).
  • Andrea Castello Núñez: Master student.
  • Sofía Pérez Espinazo: PhD student.
  • Yingnan Huang: PhD.
  • Xueqing Wang: PhD.
  • Luis A. Morán Lara: PhD.
  • Lidia Hermida-Nogueira: PhD.
  • Marcin Sowa: PhD.
  • María Nuñez Barrachina: PhD.
  • Irene Izquierdo Berjano: PhD.
  • Andrés F. Parguiña: PhD.
  • Paula Vélez : PhD.
  • Isaac Rosa : Research Assistant.
  • Lilian Grigorian: Clinical researcher (cardiologist).
  • Beatriz Calderón Cruz: Posdoctoral researcher.
  • Raymundo Ocaranza-Sánchez: Clinical researcher (cardiologist).
  • Delia I. Fernández de la Fuente: PhD.

 

Key Collaborators

• Prof. María Isabel Loza – Coordinator of the BioFarma Group at the Dpt of Pharmacology and the Pharmacology Applied to Drug Discovery group at CIMUS (Universidade de Santiago de Compostela) (http://www.usc.es/biofarma/).

• Dr. José Ramón González-Juanatey, Head of the Cardiology Department (Santiago University Hospital).

• Dr. Steve Watson: Platelet Group, University of Birmingham (UK).

• Dra. Montserrat Carrascal: CSIC/UAB Proteomics Laboratory, IIBB-CSIC-IDIBAPS, Barcelona.

• Drs. Pedro Diz Dios and Juan Blanco Carrión: Grupo de Investigación en Odontología Médico-Quirúrgica. Departamento de Cirugía y Especialidades Médico-Quirúrgicas – Universidade de Santiago de Compostela.

• Dra. María Pardo: Head of the Obesidomica Group at the Instituto de Investigación Sanitaria de Santiago (IDIS) – Endocrinology Area.

• Dr. Jesús Requena: Head of the Brain Protein Malfunction Group at CIMUS.

• Dr. José Rivera: Centro Regional de Hemodonación de Murcia.