Research Interests

The sequencing of the human genome at the beginning of this century has revealed that the complexity of an organism is primarily given by a complex proteome. The "Proteome" is the whole set of proteins present in a cell, tissue, body fluid or organism at one time, including all the post-translational modifications (PTMs, such as phosphorylation and glycosylation). Proteomics is based on 2-DE/DIGE and/or liquid chromatography for protein separation, and mass spectrometry for protein identification. The use of sub-cellular pre-fractionation techniques in combination with 1D-SDS-PAGE and liquid chromatography-tandem mass spectrometry (LC-MS/MS), the use of multidimensional nanoscale capillary LC-MS/MS (MudPIT), and label free approaches and quantitative mass spec-based methods are very relevant in modern proteomics.

Proteomics allows the identification of cell-surface receptors and the dissection of intracellular signalling cascades, which includes the analysis of the phosphoproteome, because protein phosphorylation plays a key role in intracellular signalling and, therefore, in the regulation of protein function. Proteomics is also a key tool for biomarker discovery, allowing a differential analysis by comparing healthy vs. diseased samples.

Prof. Ángel García´s background

Dr. Ángel García has been involved in platelet proteomics research since 2001. At that time he was working as a postdoctoral researcher at the Oxford Glycobiology Institute, University of Oxford, where he stayed for more than four years. In December 2005, Dr. García joined the University of Santiago de Compostela (USC), to develop research in the field of Proteomics applied to cardiovascular research. In 2007, he obtained a 5-year Ramón y Cajal position linked to the "BioFarma" research group coordinated by Dr. Mabel Loza at the Dpt. of Pharmacology - USC. Since the end of 2012 he is Professor at the Dpt of Pharmacology (USC). Prof. García is Head of the Platelet Proteomics Group at the Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), USC, and the Instituto de Investigación Sanitaria de Santiago (IDIS) [Santiago Health Research Institute].

Dr. García is Member of Executive Board of the Spanish Proteomics Society (SEProt), in which he was President for the period 2015-2019. He is also member of the International Society on Thrombosis and Haemostasis (ISTH) and the Spanish Societies of Thrombosis and Haemostasis (SETH), and Biochemistry and Molecular Biology (SEBBM). Prof. García has over 70 publications and 2000 citations with a H-index of 25 (Oct 2022).