Polyon Complex (PIC) micelles prepared by electrostatic interaction between a dendritic block copolymer and an oppositely charged bioactive protein. Applications in nanomedicine, drug delivery process and diagnosis.
A pH-sensitive PIC (polyion complex) type polymeric micelle formed by electrostatic interaction between a dendritic block copolymer and another polymer of opposite charge. The presence of a dendritic block copolymer confers high stability to the micelles in physiological conditions, while in the acid medium of tumor tissues (pH 6.5) or cell compartments, such as the endosome/lysosome (pH 5.0-5.5), the micelles tend to become destabilized, being able to selectively release drugs or macromolecules encapsulated therein. The micelles are characterized by high stability against ionic strength, dilution and temperature. They can further be lyophilized and conserved in solid state.
Micelas PIC dendríticas con proteínas bioactivas. Se refiere a una micela polimérica de complejo poliiónico (Polyion Complex, PIC) formada por interacción entre una proteína bioactiva y un copolímero de bloque dendrítico de carga opuesta.
La tradicional baja estabilidad de micelas PIC con proteínas bioactivas frente a la fuerza iónica es compensada en la presente invención por la estabilidad que aporta el bloque dendrítico. El proceso global de preparación de estas micelas se ve facilitado por la sencillez de la síntesis de copolímeros de bloque dendríticos.
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