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Publicacións

2021

Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition
X. Wang, W. Jespers, R. Prieto-Díaz, M. Majellaro, A.P. Ijzerman, G.J.P. van Westen, E. Sotelo, L.H. Heitman, H. Gutiérrez-de-Terán

Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach
A. Mallo-Abreu, I. Reyes-Resina, J. Azuaje, R. Franco, A. García-Rey, M. Majellaro, D. Miranda-Pastoriza, X. García-Mera, W. Jespers, H. Gutiérrez-de-Terán, G. Navarro, E. Sotelo

3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A(2B)Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition
M. Majellaro, W. Jespers, A. Crespo, M.J. Núñez, S. Novio, J. Azuaje, R. Prieto-Díaz, C. Gioé, B. Alispahic, J. Brea, M.I. Loza, M. Freire-Garabal, C. Garcia-Santiago, C. Rodríguez-García, X. García-Mera, O. Caamaño, C. Fernandez-Masaguer, J.F. Sardina, A. Stefanachi, A. El Maatougui, A. Mallo-Abreu, J. Åqvist, H. Gutiérrez-de-Terán, E. Sotelo

Catalytic performance of a metal-free graphene oxide-Al2O3 composite assembled by 3D printing
J. Azuaje, A. Rama, A. Mallo-Abreu, M.G. Boado, M. Majellaro, C.R. Tubío, R. Prieto, X. García-Mera, F. Guitián, E. Sotelo, A. Gil

2020

X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A(2A) Adenosine Receptor Antagonists
W. Jespers, G. Verdon, J. Azuaje, M. Majellar, H. Keränen, X. García‐Mera, M. Congreve, F. Deflorian, C. de Graaf, A. Zhukov, A.S. Doré, J.S. Mason, J. Åqvist, R.M. Cooke, E. Sotelo, H. Gutiérrez‐de‐Terán

Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2BAdenosine Receptor Antagonists
A. Mallo-Abreu, R. Prieto-Díaz, W. Jespers, J. Azuaje, M. Majellaro, C. Velando, X. García-Mera, O. Caamaño, J. Brea, M.I. Loza, H. Gutiérrez-de-Terán, E. Sotelo

The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling
M.E. Sommer, J. Selent, J. Carlsson, C. De Graaf, D.E. Gloriam, G.M. Keseru, M. Kosloff, S. Mordalski, A. Rizk, M.M. Rosenkilde, E. Sotelo, J.K.S. Tiemann, A. Tobin, N. Vardjan, M. Waldhoer, P. Kolb

2019

Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition
A. Mallo-Abreu, M. Majellaro, W. Jespers, J. Azuaje, O. Caamaño, X. García-Mera, J.M. Brea, M.I. Loza, H. Gutiérrez-de-Terán, E. Sotelo

Free-Energy Calculations for Bioisosteric Modifications of A3 Adenosine Receptor Antagonists
Z. Jandova, W. Jespers, E. Sotelo, H. Guitérrez-de-Terán, C. Oostenbrink

2018

Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke
A. da Silva-Candal, A. Pérez-Díaz, M. Santamaría, C. Correa-Paz, M. Rodríguez-Yáñez, A. Ardá, M. Pérez-Mato, R. Iglesias-Rey, J. Brea, J. Azuaje, E. Sotelo, T. Sobrino, M.I. Loza, J. Castillo F. Campos