ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Student's work ECTS: 102 Hours of tutorials: 6 Expository Class: 18 Interactive Classroom: 24 Total: 150
Use languages Spanish, Galician
Type: Ordinary subject Master’s Degree RD 1393/2007 - 822/2021
Departments: Pharmacology, Pharmacy and Pharmaceutical Technology, External department linked to the degrees
Areas: Pharmacology, Área externa M.U en Investigación y Desarrollo de Medicamentos
Center Faculty of Pharmacy
Call: First Semester
Teaching: With teaching
Enrolment: Enrollable | 1st year (Yes)
To introduce students to current approaches in early-stage drug discovery programs. To provide students with theoretical and practical training for the design and execution of drug screening cascades.
The course is divided into two content modules:
Introductory Module (M1): (3 ECTS credits) is a general view of Pharmacology oriented to researchers with little or no previous training in Pharmacology. This module will comprehensively review the principles of Pharmacology, including the molecular basis of drug action mechanisms, and modern approaches to the design of drug discovery programs.
The program of this module includes the following main thematic blocks:
1. Preclinical R&D in the process of drug discovery.
2. Basic concepts of Pharmacodynamics. General mechanisms of action of drugs.
Specialized Module (M2): (3 ECTS credits) is focused on the application of drug screening processes targeting therapeutic and anti-target sites.
The program of this module includes the following fundamental thematic blocks:
1. Identification and validation of targets in preliminary drug discovery. Applied proteomics.
2. Design and execution of low (LTS) and high (HTS) throughput screening drug discovery campaigns.
3. Low and high performance screening methodologies: binding, biochemical, cell-based, siRNA, etc.
4. Proposal for early drug discovery programs.
The two modules of the course will be offered, also, independently as own research courses of the USC open to researchers who do not perform the Master course. The students of the course will be automatically enrolled in both of them.
Brea J, Loza MI. New approaches applied to drug screening. En: Botana LM, Loza M, editores. Therapeutic targets: modulation, inhibition and activation. John Wiley & Sons, Inc. New Jersey 2012, p. 455-476. ISBN: 978-0-470-58719-5.
Dugger SA, Platt A, Goldstein DB. Drug development in the era of precision medicine. Nat Rev Drug Discov 2018; 17:183-196.
Park H, Ha J, Park SB. Label-free target identification in drug discovery via phenotypic screening. Curr Opinion Chem Biol 2019; 50:66-72.
Learning outcomes:
• Learn the basic vocabulary in Pharmacology applied to drug discovery
Competencies: CB6, CG3, CG11
• Know and apply the general principles of early drug discovery to real situations
Competencies: CB6, CB9, CG1, CG4, CG10, CE2, CE3, CE7, CE8, CE9, CE13, CE14
• Design practical work on drug screening
Competencies: CB10, CG4, CG5, CG7, CG8, CG9, CG10, CE3, CE4, CE5, CE6, CE10, CE11, CE12, CE15
• Develop a multidisciplinary vision of Pharmacology
Competencies: CB7, CB8, CB10, CG2, CG6, CG7, CG11, CE1, CE14, CE15
The methodology used in the Introductory Module (M1) consists of theoretical classes and seminars.
The methodology used in the Specialized Module (M2) involving seminars and discussion sessions in which students will prepare and present work on selected topics, with new methodologies used in professional environments with the standard formats provided by the teachers in which they will incorporate their own vision after the bibliographic searches.
Students participate in webinars and, as far as possible, visit and learn about the activities in early drug discovery of the ERIC EU-OPENSCREEN Innopharma Platform of the USC
•Attendance: requirement
Evaluated competencies: CE1, CB6
•Continuous assessment according to the criteria discussed with students (Canvas: contributions, tutoring, group spokesperson) *: 40% of the final grade
Evaluated competencies: CB6, CB7, CB8, CG1, CG2, CG3, CG7, CG10, CG11, CE2, CE5, CE9, CE12, CE15
•Development of an initial drug discovery program *: 60% of the final grade
Assessed competencies: CB9, CB10, CG2, CG4, CG5, CG6, CG7, CG8, CG9, CG10, CE3, CE4, CE5, CE6, CE7, CE8, CE9, CE10, CE11, CE13, CE14
The course consists of 6 ECTS credits, distributed in 3 ECTS credits per module.
It includes 88 hours of classroom activities and 62 hours of student study and personal work.
It is recommended that students actively participate in the proposed activities and attend conferences by external experts.
Students are expected to make use of the recommended bibliography, develop their English reading skills, and carry out bibliographic research.
In cases of fraudulent completion of exercises or tests, the provisions of the USC regulation entitled “Normativa de avaliación do rendemento académico dos estudantes e de revisión de cualificacións” will apply.
Maria Isabel Loza Garcia
Coordinador/a- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- Phone
- 881815005
- mabel.loza [at] usc.es
- Category
- Professor: University Professor
Maria De Los Angeles Castro Perez
- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- Phone
- 881815457
- marian.castro [at] usc.es
- Category
- Professor: University Lecturer
Jose Manuel Brea Floriani
- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- pepo.brea [at] usc.es
- Category
- Professor: University Lecturer
Anton Leandro Martinez Rodriguez
- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- Phone
- 881815484
- antonleandro.martinez [at] usc.es
- Category
- Professor: LOU (Organic Law for Universities) PhD Assistant Professor
| Monday | |||
|---|---|---|---|
| 16:30-17:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 17:30-18:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 18:30-19:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 19:30-20:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| Tuesday | |||
| 16:30-17:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 17:30-18:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 18:30-19:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 19:30-20:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| Wednesday | |||
| 16:30-17:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 17:30-18:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 18:30-19:30 | Grupo /CLIL_01 | Spanish | 5035 Pharmaceutical Technology Laboratory 8 |
| 19:30-20:30 | Grupo /CLIL_01 | Spanish | 5035 Pharmaceutical Technology Laboratory 8 |
| Thursday | |||
| 16:30-17:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 17:30-18:30 | Grupo /CLE_01 | Spanish | 5035 Bromatology Seminar Room |
| 18:30-19:30 | Grupo /CLIL_01 | Spanish | 5035 Pharmaceutical Technology Laboratory 8 |
| 19:30-20:30 | Grupo /CLIL_01 | Spanish | 5035 Pharmaceutical Technology Laboratory 8 |