ECTS credits ECTS credits: 3
ECTS Hours Rules/Memories Expository Class: 18 Interactive Classroom: 6 Total: 24
Use languages Spanish, Galician
Type: Ordinary subject Master’s Degree RD 1393/2007 - 822/2021
Departments: Morphological Science, External department linked to the degrees
Areas: Human Anatomy and Embryology, Área externa M.U en Biofabricación
Center Faculty of Pharmacy
Call: First Semester
Teaching: With teaching
Enrolment: Enrollable | 1st year (Yes)
Identify and characterize the cell types commonly employed in biomanufacturing, with emphasis on their structural, functional, and phenotypic properties.
Integrate advanced knowledge of cellular architecture, signaling, functionality, and viability to optimize and apply cell-based strategies in biomanufacturing workflows.
UNIT 1. Introduction to Cell Structure and Function
Overview of the cell as the basic unit of life. Principles of cell compartmentalization and organelle function.
UNIT 2. Characteristics of Human Cell Types and Tissue Biology
Functional and structural features of different human cell types. Introduction to the biology of tissues and organs, including the cardiovascular, respiratory, genitourinary, digestive, and nervous systems.
UNIT 3. Fundamentals of Cell Interaction and Communication
Basic mechanisms of cellular interaction. Membrane receptors, signaling pathways, cell division, and programmed cell death.
UNIT 4. Principles of Cell Renewal, Specification, and Differentiation
Molecular and cellular foundations of tissue renewal processes. Mechanisms underlying cell fate determination and differentiation.
UNIT 5. Types of Cell Cultures and Laboratory Practices
Overview of primary, explant, organ, histotypic, and organotypic cultures. Applications, advantages, and limitations. Introduction to cell culture laboratories and biosafety levels.
UNIT 6. Biomaterials, Biocompatibility, and Biointegration
Key concepts in biomaterials used in biomanufacturing. Biocompatibility assessment: definitions, regulatory frameworks, and biological testing methods.
BASIC BIBLIOGRAPHY
ALBERTS B, BRAY D, LEWIS J, RAFF M, ROBERTS K, WATSON J, MOLECULAR BIOLOGY OF THE CELL, 978-84-282-1638-8,
6, OMEGA, 2016.
CALVO GONZÁLEZ, ALFONSO, BIOMEDICAL CELL BIOLOGY, 978-84-9113-959-1, 2, ELSEVIER, 2023
CARLSON, BM, HUMAN EMBRYOLOGY AND DEVELOPMENTAL BIOLOGY, 84-8174-471-9, 6, ELSEVIER, 2019
KIERSZENBAUM AL, TRES LL., HISTOLOGY AND CELL BIOLOGY. INTRODUCTION TO PATHOLOGICAL ANATOMY,
978-84-9113-773-3, 5, ELSEVIER, 2020
Kasper C. Charwat V., Lavrentieva A., Cell culture Technology, 978-3-319-74853-5/https://doi.org/10.1007/978-3-319-74854-2, 1, Springer, 2018
ADDITIONAL BIBLIOGRAPHY
Ralf Pörtner et al, Cell Culture Engineering and Technology, 978-3-030-79873-4 /
https://doi.org/10.1007/978-3-030-79871-0, 1, Springer, 2022
Duval K, Grover H, Han LH, Mou Y, Pegoraro AF, Fredberg J, Chen Z., Modeling Physiological Events in 2D vs. 3D Cell Culture, doi: 10.1152/physiol.00036.2016., Physiosiology, 2017
Jensen C, Teng Y., Is It Time to Start Transitioning From 2D to 3D Cell Culture?, doi: 10.3389/fmolb.2020.00033, Front Mol Biosci., 2020.
A5. Identify and characterize the main cell types used in biomanufacturing, with emphasis on their structural, functional, and phenotypic features.
A6. Apply advanced knowledge of cell structure, function, communication, and viability to the development and optimization of biomanufacturing processes.
B2. Understand the fundamental principles and laboratory techniques of cell biology relevant to biomanufacturing applications.
B8. Design and implement preclinical assays using cells and tissues relevant to biomanufacturing, assessing their applicability and translational potential.
C1. Acquire in-depth and up-to-date knowledge in the field of biomanufacturing, demonstrating a solid understanding of both theoretical foundations and methodological approaches.
C2. Apply and integrate specialized knowledge to solve complex problems in new or multidisciplinary contexts, whether in research or in highly specialized professional environments.
D1 (CG1). Master techniques for information retrieval and critical analysis; identify appropriate scientific theories and methodological strategies for the design and evaluation of biomanufacturing processes.
D2 (CG2). Apply knowledge to solve problems and manage multidisciplinary research and innovation projects in the field of biomanufacturing.
D8 (CT1). Present and defend research projects independently in multidisciplinary contexts; manage activities related to research, development, and technological innovation in biomanufacturing.
D9 (CT2). Use Information and Communication Technologies (ICTs) effectively for the transmission of knowledge, results, and conclusions in specialized contexts with clarity and scientific rigor.
D10 (CT3). Demonstrate initiative for continuous learning and the ability to address emerging scientific and technological challenges.
D11 (CT4). Understand and apply the gender perspective across academic and professional domains to promote equity and social justice.
D12 (CT5). Commit to sustainability and responsible resource management, ensuring equitable and efficient use of environmental assets.
D18 (CE6). Identify the cell types used in biomanufacturing processes, understand their biological properties, and analyze the interactions between cells and biomaterials.
D19 (CE7). Develop and apply basic cell culture techniques and protocols in accordance with biomanufacturing standards.
MASTER CLASS
The instructor will present key concepts related to the diversity of cell types involved in Biomanufacturing processes. Sessions will include interaction and discussion with students, focusing on critical considerations when working with cells in this context. Supporting materials will be made available through the Virtual Campus platform.
PROBLEM SOLVING
Students will work on solving problems and practical case studies related to cell culture laboratories within the field of Biomanufacturing.
LABORATORY PRACTICES
Laboratory sessions are designed to develop practical skills in performing cell culture assays. These activities aim to familiarize students with standard procedures in cell culture laboratories and serve as preparatory training for subjects in the specialized module. Students will be required to submit a laboratory report and/or answer specific questions and exercises. All necessary supporting materials will be provided via the Virtual Campus platform.
PROBLEM SOLVING
Students will solve questions and problems covered in class, mainly related to topics 5 and 6.
Weight in final grade: 15%.
LABORATORY PRACTICES
Students must submit a lab report and/or solve specific questions or tasks related to the practical sessions. This component will account for 70% of the laboratory grade. In addition, active participation and engagement during the laboratory sessions will represent the remaining 30%.
Weight in final grade: 15%.
OBJECTIVE EXAM
A written exam assessing fundamental concepts of the course. The exam will be held on the date specified in the official course schedule and will include multiple-choice and/or short-answer questions (including problem-solving).
To pass the course, students must obtain at least 40% of the total score in this section.
Weight in final grade: 70%.
ADDITIONAL EVALUATION NOTES
In case of a justified absence from laboratory sessions, students must take a final integrative test that covers the content addressed in both lectures and practical sessions. This test will include multiple-choice questions, short-answer questions, and/or problem-solving exercises.
A minimum score of 40% is required in this test to pass the course. In such cases, the final grade will be calculated as follows:
85% final integrative test + 15% problem-solving activities completed during class.
Master Class
14 hours of classroom instruction
35 hours of independent work
otal: 49 hours
Problem solving
4 hours of classroom instruction
6 hours of independent work
Total: 10 hours
Laboratory Practices
6 hours of classroom instruction
9 hours of independent work
Total: 15 hours
Objective Question Exam
1 hour of classroom assessment
Total: 1 hour
Regular attendance and active participation in both theoretical and practical sessions are strongly recommended. Daily review of the material covered should be complemented by self-assessment to monitor understanding. It is also advisable to revisit the course content periodically through the recommended texts and to make use of tutorials to clarify any doubts. Students are encouraged to focus on understanding the concepts and exploring their potential applications in the field of biomanufacturing, rather than merely memorizing information. To facilitate this, creating well-organized diagrams or concept maps that highlight the interconnections between different topics is highly recommended.
To make the most of the course, it is recommended that students have prior knowledge of cell biology and embryology. A good command of English is also advisable, as it will facilitate the use of bibliographic and teaching resources. In addition, students should have basic skills in information and communication technologies. A virtual classroom will be available on the institution's online campus platform, providing access to learning materials and communication tools. Microsoft Teams and email may also be used to facilitate communication between students and instructors.
Ana Isabel Rodriguez Perez
- Department
- Morphological Science
- Area
- Human Anatomy and Embryology
- Phone
- 881812464
- anai.rodriguez [at] usc.es
- Category
- Professor: University Lecturer
Rita Valenzuela Limiñana
- Department
- Morphological Science
- Area
- Human Anatomy and Embryology
- rita.valenzuela [at] usc.es
- Category
- Professor: University Lecturer
| Monday | |||
|---|---|---|---|
| 15:00-19:30 | Grupo /CLE_01 | Spanish | 5035 Inorganic Chemistry Seminar Room |
| Tuesday | |||
| 15:00-19:30 | Grupo /CLE_01 | Spanish | 5035 Inorganic Chemistry Seminar Room |
| Wednesday | |||
| 15:00-19:30 | Grupo /CLE_01 | Spanish | 5035 Inorganic Chemistry Seminar Room |
| Thursday | |||
| 15:00-19:30 | Grupo /CLE_01 | Spanish | 5035 Inorganic Chemistry Seminar Room |
| Friday | |||
| 10:00-16:00 | Grupo /CLIL_01 | - | 5035 Inorganic Chemistry Seminar Room |