ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Hours of tutorials: 1 Expository Class: 36 Interactive Classroom: 17 Total: 54
Use languages Spanish, Galician
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Biochemistry and Molecular Biology
Areas: Biochemistry and Molecular Biology
Center Faculty of Biology
Call: First Semester
Teaching: Sin docencia (Extinguida)
Enrolment: No Matriculable
- Know the molecular basis of genetic information, delving into the study of aspects related to the structure of the genome in cells and its importance in the control of gene expression.
- Identify the relationship between genes and genomes and their importance in organisms.
- Know the mechanisms by which cells transmit information from the environment that allows cells to generate an appropriate response to a changing environment, delving into the study of transduction pathways activated by different types of signals.
- Know the specific mechanisms by which gene expression is controlled at different levels, especially in higher organisms and in complex processes such as cell division and death.
- Acquire the ability to assess the current state of scientific knowledge of the different topics of Molecular Biology.
- Know the Molecular Biology techniques that allow the study of the structure, function and regulation of nucleic acids and proteins in cells.
• EXPOSITIVE CLASSES (Theory Program, 36 Face -to Face hours)
I. THE STRUCTURE OF THE GENOME (10h).
Lesson 1. Molecular Biology and its origins. Nucleic acids DNA and RNAs (1.5h).
Lesson 2. Eukaryotic DNA Condensation: DNA Supercoils and Nucleosomes (3.5h).
Lesson 3. Organization of eukaryotic DNA: Chromatin and chromosome structures (2.5h).
Lesson 4. Genes and genomes (2.5h).
II. THE EXPRESSION OF THE GENOME AND ITS REGULATION (26h).
(A) CELL SIGNALING AND GENE EXPRESSION (14h).
Lesson 5. General principles and elements of cell signaling. General mechanisms of transduction by external and internal signals (2h).
Lesson 6. Proteins in cell signaling: transducing proteins, protein interactions and gene regulatory proteins (3h).
Lesson 7. Intracellular signaling pathways activated through G protein-coupled receptors (GPCRs) (2h).
Lesson 8. Intracellular signaling pathways activated by mitogenic factors, cytokines and receptors with kinase activity (3.5h).
Lesson 9: Bidirectional signaling, proteolytic pathways and lipid signaling (1.5h)
Lesson 10. Intracellular signaling pathways activated by hydrophobic signals (2h).
(B) THE REGULATION OF THE EXPRESSION OF THE EUKARYOTE GENOME (12h).
Lesson 11 Regulatory RNAs and regulation of gene expression (2.5h).
Lesson 12: Gene control. Epigenome: Chromatin structure and control of gene expression (2.5h).
Lesson 13. Regulation of gene expression I: Transcriptional control (3.5h).
Lesson 14. Regulation of gene expression II: Transport, localization and stability of mRNA and translational control (3.5h).
• INTERACTIVE CLASSES (17h; Face -to Face)
Interactive seminars (12h face-to-face).
Their objective is to promote learning through the student's participation in the class and to reinforce/ deepen on specific aspects of the subject (see teaching and evaluation methodology) that also allow its continuous evaluation.
Practices (5 hours face-to-face): Two sessions of compulsory and evaluable attendance:
- Session I (laboratory; 2.5h). Experimental analysis of DNA supercoils by electrophoresis in gel.
- Session II (computer classroom; 2.5h). Analysis and visualization of cis and trans elements involved in gene expression
through databases and bioinformatics applications.
• TUTORIAL CLASSES (1 Face -to Face hour)
Tutoring: at the beginning of the course, it will be used for the detailed presentation of the subject and the teaching guide.
Exam. Face-to-face exam (3h) that will include questions from the syllabus in different formats (multiple choice, relation of concepts, theoretical questions and reasoning questions...).
BIBLIOGRAFÍA BÁSICA
- Alberts, B. et al., 2022. Molecular Biology of the Cell. 6th ed. W.W. Norton & Company, New York.
- Hérraez, A., 2012. Texto ilustrado e interactivo de Biología Molecular e Ingeniería Genética. Conceptos, técnicas y
aplicaciones en ciencias de la salud. 2ª ed. Barcelona: Elsevier.
- Lodish, H., Berk, A., Kaiser, C.A., Krieger, M., Brestscher, A., Ploegh, H., Martin, K.C., Yaffe, M.B., Amon, A. 2021.
Molecular Cell Biology. 9th ed. Macmillan International, New York.
- Kraus. G., 2014. Biochemistry of Signal Transduction and Regulation. 5th ed. Weinheim: Wiley-VCH.
- Nelson, D.L. & Cox, M.M., 2021. Lehninger. Principles of Biochemistry. 8ª ed. New York: Macmillan International.
- Watson, J.D. et al., 2016. Biología molecular del gen. 7ª ed. Buenos Aires: Ed. Médica Panamericana
BIBLIOGRAFÍA COMPLEMENTARIA
- Brown, T.A., 2018. Genomes 4. 4th ed. New York: Garland Science.
- Clark, D.P. and Pazdernik, N.J., 2019. Molecular Biology. 3nd ed. Boston: Academic Press.
- Craig, N.L. et al., 2014. Molecular Biology. Principles of Genome Function. 2nd ed. Oxford: Oxford University Press.
- Latchman, D. S., 2015. Gene Control. 2nd ed. New York: Garland Science.
- Marks, F., Klingmüller, U., Müller-Decker, K., 2017. Cellular Signal Processing. 2nd ed. New York: Garland Sciences.
COMPETENCIES
General and basic skills
The competences that appear in the Biology Degree Memory
Transversal skills
• CT1. Ability to search, process, analyze and synthesize information from various sources.
• CT2. Capacity for reasoning, argumentation and critical thinking.
• CT3. Ability to work in a group and deal with problematic situations collectively.
• CT4. Ability to prepare and present an organized and understandable text.
• CT8. Ability to solve problems through the integrated application of their knowledge, promoting initiative and creativity
• CT9. Ability to organize and plan work.
• CT10. Ability to interpret experimental results
Specific skills
• CE3. Know and know how to apply instrumental techniques, and design work protocols in the laboratory and in the field, applying the regulations and appropriate techniques related to safety, hygiene, waste management and quality.
• CE4. Know the origin of life, the mechanisms of heredity and its evolution.
• CE7. Know the structure of biomolecules, their physicochemical properties and relate it to their functions, integrating the different levels of organization of living beings
• CE8. Understand the principles of bioenergetics and biosignaling, and know the main metabolic pathways and their regulation, as well as the flow of genetic and biochemical information in living beings.
• CE11. Understand and integrate the functioning and regulation of the main physiological processes of living beings as well as their interaction with the biotic and abiotic environment.
• Lectures: non-compulsory classroom activity in the format of master classes for the presentation of the lessons of the theoretical program of the subject with the use of blackboard and supported by computerized presentations.
• Interactive classes. They are face-to-face, evaluable, and not mandatory.
• Their objective is to enhance learning by promoting student participation by responding (orally or in writing) to different types of questions (see evaluation system) and they also aim to complete and strengthen specific aspects developed in the lectures that are of special interest, as well as reinforce and review key concepts of the subject.
• Practical classes: Compulsory and evaluable.
• Two types of representative practical activities will be carried out to complement the theoretical knowledge acquired in the lectures:
- Practical session for the extraction of a bacterial plasmid and its experimental analysis, in which the students will have, previously, a practice script.
- Bioinformatics session, in which some databases for information search and DNA analysis will be handled, of the modeling program for spatial analysis in 3D (visualization of DNA fragments linked to specific proteins). finally they will answer another very short questionnaire in writing.
• Tutorial classes: at the beginning of the course, it will be used for the detailed presentation of the subject and the
teaching guide.
• Exam. Face-to-face and compulsory on the theoretical content of the agenda explained in the expository classes that will include questions from the agenda in different formats (multiple test, list of concepts, theoretical questions and reasoning questions...).
The evaluation of learning will be done in person and will consist of:
(a) Evaluation of expository classes (Final exam). Compulsory evaluable activity complementary to the continuous evaluation.
The contents of the theoretical program will be evaluated by means of a written exam that will contain objective questions (multiple test...) or relating, reasoning, and arguing. The maximum grade obtained in the exam (10 points) is equivalent to 75% of the final grade, if the conditions indicated below are met (see final evaluation).
(b) Evaluation of interactive classes (Continuous evaluation).
- The seminars will be evaluated through the participation of the student, assessing their oral responses to identify, interpret, describe, and explain images/figures/diagrams related to the contents of the expository classes or by responding (orally or in writing) to issues/questions/ exercises posed (by the teacher) in the class itself and/or through questionnaires, previously accessible to students through the virtual classroom. The evaluation could also imply the presentation (delivery) and/or exhibition of works to deepen or reinforce specific concepts and topics of the subject.
It will be graded from 0 to 10 points and the grade obtained will account for 15% of the final grade for the subject (maximum 1.5 points of the grade for the subject, if it meets the requirements indicated below (see final assessment).
- (c) Laboratory practical classes and computer room.
- The execution of the practice or the proposed activities will be evaluated, with a maximum of 0.5 points. The resolution of the questionnaires and/or delivery of tasks will be valued with another 0.5 maximum points.
- The final mark of the practical activities will be the sum obtained in the execution and resolution and delivery of questionnaires or tasks, with a maximum value of 1 point, which represents 10% of the final mark of the subject.
(C) Final evaluation.
- The final grade will be obtained as the weighted average of the partial grades obtained in (a), (b) and (c), which represent, respectively, 75%, 15% and 10% of the final grade and if has reached in the qualification of (a) a minimum of 4.5 points and the minimum answer requirement (85% of the exam questions answered). The exam must also be compensated, in terms of the grade obtained in answers to objective questions (multiple choice...), with respect to that achieved in questions whose answer involves relating and/or arguing/reasoning concepts.
- The lack of qualification in (b) will imply that the student renounces that part of the note, so that he could obtain, at most, 8.5 points in the final qualification, if both in the content exam of the expositive classes as well as in the practices would have reached 10 points out of 10.
- In the second call, the evaluation dependent on the exam will be repeated exclusively and, if it has not been previously carried out, also the exam corresponding to the seminars, which will be voluntary. In any case, the students will only be evaluated in the seminars once per course. The percentages of each part of the evaluation will be the same as those indicated above.
- Repeaters. Repeating students will be exempted from carrying out the practices, but the qualification of the seminars of the previous course will not be kept.
- For cases of fraudulent completion of exercises or tests, the provisions of the "Regulations for evaluating student academic performance and reviewing grades will apply.
(C) Final evaluation.
- The final grade will be obtained as the weighted average of the partial grades obtained in (a), (b1) and (b2), which represent, respectively, 75%, 15% and 10% of the final grade and as long as has reached in the qualification of (a) a minimum of 4.5 points and the requirement of minimum answers (85% of the exam questions).
- The lack of qualification in (b1) will imply that the student renounces that part of the grade, so that he could obtain, at most, 8.5 points in the final qualification, in the event that both in the content exam of the expositive classes as in the practices would have reached 10 points out of 10.
- In the second call, only the evaluation dependent on the exam will be repeated and, if it has not been done previously, also the exam corresponding to the seminars, which will be voluntary. In any case, the students will only be evaluated from the seminars once per course. The percentages of each part of the evaluation will be the same as those indicated above.
- Repeaters. This subject does not have repeaters because it is the first course taught.
- For cases of fraudulent completion of exercises or tests, the provisions of the "Regulations for evaluating student academic performance and reviewing grades will apply.
ASSESSMENT OF COMPETENCES
Expository classes: The exam will assess the following skills:
Transversal skills.
• CT1, CT2, CT3, CT4, CT8, CT9 and CT10.
Specific skills.
• CE3, CE4, CE7, CE8 and CE11.
Interactive classes:
- In the seminars the following competences will be evaluated:
Transversal skills
• CT1, CT2, CT3, CT4, CT8, CT9 and CT10.
Specific skills
• CE3, CE4, CE7, CE8 and CE11.
- The practices will evaluate the following competences:
Transversal skills
• CT1, CT2, CT3, CT4, CT8, CT9 and CT10.
Specific skills
• CE3, CE7, CE8 and CE11.
PRESENTIAL WORK IN THE CLASSROOM
Master classes (expository): 36h
Interactive (seminars and practices): 5:00 p.m.
Tutorials: 1h
Exam: 3h
Total classroom work: 57h
PERSONAL OR GROUP WORK
Single Study: 93h
• Attendance at all teaching activities.
• Participation in the corresponding classes, responding orally to the issues/questions raised by the teacher, both in the class itself and in the specific ones of the seminars, even if they do not count for evaluation.
• Make summaries/outlines or scripts that synthesize the important content of each of the program's lessons, trying to combine and relate different aspects that are explained in each of them.
• Self-assessment of content understanding. The student should try to generate, by himself and using books, especially those recommended in the bibliography, a catalog of questions and answers so that he can face the exam with more chances of success.
• Make use of tutorials for any type of issue related to the subject.
• The contents, the order and the time devoted to each of the topics may be modified, with respect to the program presented in the teaching guide, due to the incorporation of new concepts and more recent updates to it.
• It is recommended that for a better understanding of biochemistry II, you have prior knowledge of subjects such as biochemistry I, genetics I/II, cell biology, animal and plant physiology, microbiology, in addition to basic notions of chemistry (organic and inorganic ).
• The information available to the student will be left through the virtual classroom and the contact/communication with the student will be established through email and/or the MS-Teams platform.
• For cases of fraudulent completion of exercises or tests, the provisions of the "Regulations for evaluating student academic performance and reviewing grades" will apply.
• It is expressly forbidden for students to distribute, among people outside the course, the teaching material (both written and audiovisual) available on the Virtual Campus or provided by the teaching staff through other channels.
Primitivo Barja Francisco
Coordinador/a- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881816931
- primi.barja [at] usc.es
- Category
- Professor: University Lecturer
Maria Lourdes Dominguez Gerpe
- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- ml.dominguez.gerpe [at] usc.es
- Category
- Professor: Temporary supply professor to reduce teaching hours
Álvaro Durán Bravo
- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- alvaroduran.bravo [at] usc.es
- Category
- Ministry Pre-doctoral Contract
| Wednesday | |||
|---|---|---|---|
| 12:00-13:00 | Grupo /CLE_01 | Spanish | Classroom 01. Charles Darwin |
| 13:00-14:00 | Grupo /CLE_02 | Spanish | Classroom 02. Gregor Mendel |
| Thursday | |||
| 12:00-13:00 | Grupo /CLE_01 | Spanish | Classroom 01. Charles Darwin |
| 13:00-14:00 | Grupo /CLE_02 | Spanish | Classroom 02. Gregor Mendel |
| Friday | |||
| 12:00-13:00 | Grupo /CLE_01 | Spanish | Classroom 01. Charles Darwin |
| 13:00-14:00 | Grupo /CLE_02 | Spanish | Classroom 02. Gregor Mendel |
| 01.08.2024 10:00-14:00 | Grupo /CLE_01 | Classroom 01. Charles Darwin |
| 01.08.2024 10:00-14:00 | Grupo /CLE_02 | Classroom 01. Charles Darwin |
| 01.08.2024 10:00-14:00 | Grupo /CLE_02 | Classroom 02. Gregor Mendel |
| 01.08.2024 10:00-14:00 | Grupo /CLE_01 | Classroom 02. Gregor Mendel |
| 01.08.2024 10:00-14:00 | Grupo /CLE_02 | Classroom 03. Carl Linnaeus |
| 01.08.2024 10:00-14:00 | Grupo /CLE_01 | Classroom 03. Carl Linnaeus |
| 06.28.2024 10:00-14:00 | Grupo /CLE_02 | Classroom 01. Charles Darwin |
| 06.28.2024 10:00-14:00 | Grupo /CLE_01 | Classroom 01. Charles Darwin |
| 06.28.2024 10:00-14:00 | Grupo /CLE_02 | Classroom 02. Gregor Mendel |
| 06.28.2024 10:00-14:00 | Grupo /CLE_01 | Classroom 02. Gregor Mendel |