ECTS credits ECTS credits: 4.5
ECTS Hours Rules/Memories Student's work ECTS: 74.2 Hours of tutorials: 2.25 Expository Class: 18 Interactive Classroom: 18 Total: 112.45
Use languages Spanish, Galician
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Biochemistry and Molecular Biology
Areas: Biochemistry and Molecular Biology
Center Faculty of Biology
Call: First Semester
Teaching: Sin docencia (Extinguida)
Enrolment: No Matriculable
The course attempts to integrate the student other materials to thereby be able to analyze the information flow, and molecular genetics and regulatory systems that operate in cells.
PROGRAM THEORY (Lectures, 26 hours)
I. GENOME STRUCTURE (7h)
Lesson 1. Molecular biology and its origins. The nucleic acids DNA and RNAs (1.5h)
Lesson 2. Condensation of DNA, chromatin and chromosomes (3.5 h)
Lesson 3. Genes and genomes (2h)
II. EXPRESSION OF GENOME AND REGULATION (19h)
(A) CELL SIGNALING AND GENE EXPRESSION (11h
Lesson 4. General mechanisms of signal transduction by external and internal signals (1.5h)
Lesson 5. Proteins in cell signaling: Transducing proteins, protein interactions and gene regulatory proteins (2.5h)
Lesson 6. Intracellular signaling pathways activated by hydrophilic signals (5h)
Lesson 7. Intracellular signaling pathways activated by hydrophobic signals (2h)
(B) ) THE REGULATION OF GENE EXPRESSION OF EUKARYOTE GENOME (8h)
Lesson 8. Regulatory RNAs and gene expression regulation (2h)
Lesson 9. The epigenome: Role of chromatin structure in gene control (2h)
Lesson 10. Regulation of gene expression I: Transcriptional regulation (2.5h)
Lesson 11. Regulation of gene expression II: Transport, localization and stability of mRNA and translational control
(3.5h)
INTERACTIVE LESSONS (SEMINARS; 1OH)
The seminars will have a double utility: (a) reinforcement of concepts explained in theory classes, problem solving and issues related to the subject and solving any doubts that students may pose, and also (b) continuous evaluation of the student (see teaching methodology).
TUTORIALS (5H)
Consultation / resolution of doubts and review of basic and general concepts of the subject explained in the expository and interactive classes.
BASIC BIBLIOGRAFY
- Alberts, B. et al., 2015. Molecular Biology of the Cell. 6th ed. New York: Garland Science.
- Hérraez, A., 2012. Texto ilustrado e interactivo de Biología Molecular e Ingeniería Genética. Conceptos, técnicas y
aplicaciones en ciencias de la salud. 2ª ed. Barcelona: Elsevier.
- Watson, J.D. et al., 2016. Biología molecular del gen. 7ª ed. Buenos Aires: Ed. Médica Panamericana
COMPLEMENTARY BIBLIOGRAFY
- Brown, T.A., 2018. Genomes 4. 4th ed. New York: Garland Science.
- Cantley, L.C., Hunter, T., Sever, R. and Torner, J., 2014. Signal Transduction. Principles, Pathways and Processes.
4th ed. New York: Cold Spring Harbor Laboratory Press.
- Clark, D.P. and Pazdernik, N.J., 2019. Molecular Biology. 2nd ed. Boston: Academic Press.
- Craig, N.L. et al., 2014. Molecular Biology. Principles of Genome Function. 2nd ed. Oxford: Oxford University Press.
- *Karp, G. 2014. Biología celular y molecular. Conceptos y experimentos. 7 ª ed. México: McGraw-Hill Interamericana.
Disponible “online”: https://accessmedicina-mhmedical-com.ezbusc.usc.gal/Book.aspx?bookid=28…
- Kraus. G., 2014. Biochemistry of Signal Transduction and Regulation. 5th ed. Weinheim: Wiley-VCH.
- *Paniagua, R., Nistal, M., Sesma, P., Álvarez-Uría, M., Fraile, B., Anadón, R., Saéz. F. J. 2017. Biología Celular y Molecular. 4ª Edición. McGraw-Hill de España, S.L. ISBN: 978-84-486-1297-9.
https://accessmedicina-mhmedical-com.ezbusc.usc.gal/book.aspx?bookID=22…
* These books are freely accessible through Refbusc from the USC library, on the McGraw-Hill Access Medicine platform: https://accessmedicine-mhmedical-com.ezbusc.usc.gal/: https://accessmedicina-mhmedical-com.ezbusc.usc.gal/
SKILLS
General and basic Competences
The competences that appear in Memory of Biology Degree:
Transversal Competences
• CT1 - Ability to analyze and synthesize.
• CT2 - Ability to reason and argument.
• CT6. Ability to make an exhibition in public in a clear, concise and coherent way
• CT5 - Ability to develop and present an organized and understandable text.
• CT9 - Use of bibliographic and Internet.
• CT10 - Use information in foreign language.
• CT11 - Ability to solve problems through the integrated application of knowledge.
Specific Competences
• CE2.a. Sphere of competence of origin and molecular basis of life:
Concepts, mechanisms and hypotheses.
• CE2.c. Sphere of competence of origin and molecular basis of life:
Molecular Biology of the Cell.
• CE2.e. Origin and molecular basis of life:
Analysis of biomolecules and metabolic processes.
• CE2.f - Sphere of competence of origin and molecular basis of life:
Molecular, cellular and tissue analysis,
• CE6.c. Sphere of competence of human biology, heredity and evolution:
The hereditary material.
• CE6.f. Sphere of competence of human biology, heredity and evolution:
The flow of genetic information.
• CE7a. Sphere of competence of biotechnology and biomedicine:
Biological basis of diseases.
• CE7.g. Sphere of competence of biotechnology and biomedicine:
Methods of clinical and molecular analysis.
Scenario 1. Normality
• Expository classes: Master classes for the presentation of the lessons of the theoretical program of the subject with the use of waxing and, where appropriate, supported by computer presentations.
• The contents, order and time dedicated to each of the topics may be modified, with respect to the program presented in the teaching guide, by the incorporation of new concepts and more recent updates.
• The interactive classes (seminars), in addition to reinforcing and reviewing concepts explained in theory or doubts of the students, will be used for the continuous evaluation of the student, assessing their compulsory active oral and / or written participation. It will be carried out by quantifying the student's responses to questionnaires that will include questions, issues and problems related to the subject's syllabus, and which will be formulated orally and / or in writing, at the teacher's request. The questionnaires could also be available to the student in advance of the seminars themselves, through the virtual classroom, and their delivery could be required for their evaluation.
• The virtual campus will be used to leave information related to the subject and that may be useful to students.
• Tutorial classes will be face-to-face.
Scenario 2. Distance
• Expository classes: Teaching will be face-to-face / virtual (asynchronous), according to the regulations determined by the center and the university itself, using, if necessary, electronic resources (virtual classroom, e-mail) for partial or complete explanations of lessons and / or answers to questions from students. The students would have, through the virtual classroom, the files corresponding to the lessons on the syllabus that could not have been explained in person.
• The programming of the classes and the thematic sequence will not vary with respect to the face-to-face teaching of scenario 1.
• Interactive classes (seminars). They will be face-to-face, if the circumstances allow it and, in case of distancing (scenario 2), contact through the virtual campus will prevail. In both cases they will serve for the continuous evaluation of the student, which will be carried out through the face-to-face proposal by the teacher, or through the virtual classroom, of tasks / questionnaires corresponding to the thematic blocks of the content classes and that the Students have to respond orally and / or in writing (in the case of classroom attendance) and / or by answering telematically or through the compulsory delivery of tasks / responses through the virtual classroom.
• The tutorial classes would be carried out (in case of distancing) telematically.
Scenario 3. Closure of facilities
• Expository classes: The classes will be virtual and asynchronous, promoting the individual work of the student,
who will be advised, when needed, using the available electronic resources (email, virtual campus).
• In these circumstances, students will have access to all the files corresponding to the program's lessons
(presentations) and, at least, to the part of the recommended bibliography, through the resources of the
university library.
• Interactive classes (seminars) and continuous assessment will be carried out by grading the tasks/
questionnaires proposed by the teacher through the virtual classroom and related to the thematic blocks
explained in the expository classes and classified as indicated in scenario 1. At the teacher's request, students
must respond electronically and / or by delivery, if this is proposed and mandatory for all students.
• The tutorial classes will be telematic.
FINAL EVALUATION SYISTEM
Scenario 1. Normality
The learning assessment will be done in person and will consist of:
(a) Evaluation of content (lectures) (Final Exam). Compulsory evaluable activity complementary to continuous evaluation.
The contents of the theoretical program will be evaluated by written exam (final exam). The maximum grade obtained in the exam (10 points) is equivalent to 85% of the final grade and as long as a minimum of 80% has been answered of exam questions.
(b) Evaluation of interactive classes (Continuous assessment). Non-mandatory evaluable activity.
They will be evaluated by qualifying the answers (oral and / or written) that the student can give to the questions raised in the seminar classes themselves or previously, through questionnaires, which could be posed through the virtual classroom for self-evaluation of the student and / or required delivery for evaluation. The assessment of this section may reach a maximum of 1.5 points, which will represent 15% of the final grade for the course. The grade in this section will be 0 if the student does not participate or submit the answers.
(c) Final evaluation. The final grade will be obtained as the weighted average of the partial grades obtained in (a) and (b), which represents, respectively, 85% and 15% of the final grade and as long as it has been achieved in the grade of (a) a minimum of 5 points. The lack of qualification in (b) will imply that the student could obtain a maximum of 8.5 points, in the event that in the examination of the contents of the expository classes he had reached 10 points.
- Given the nature of continuous evaluation, the evaluation depending on the exam will be repeated exclusively in the July exam.
- In the case of having to repeat the subject in the next course, NO notes will be saved and the repeaters will have to do the same as the new students.
- The summary evaluation criteria can be obtained at the following address:
http://www.usc.es/gl/centros/bioloxia/criteriosavaliacion.html
Scenario 2. Distance
The system and evaluation criteria would be similar to those indicated for scenario 1, with the following differences:
(a) Final exam. Compulsory evaluable activity complementary to continuous evaluation.
Telematic exam, through the virtual classroom, in the event that it cannot be done in person.
(b) Continuous evaluation (seminars). Non-mandatory evaluable activity. It will be based on the assessment of tasks / questionnaires proposed in person and / or through the virtual campus and those that students must answer orally / telematically and / or deliver, at the request of the teacher.
(c) Final evaluation. The final grade will be as indicated in the corresponding section of scenario 1 and, in the same way, the lack of assessment in (b) for not having oral answers (face-to-face situation) and / or written delivery of questionnaires raised orally or through the virtual classroom (in person or distance), will imply a grade of 0 points in the continuous evaluation and, as a consequence, the possibility of reaching 8.5 points as the maximum grade for the course.
If the distancing situation occurs due to interruption in an intermediate (or already advanced) phase of the course, the previous controls carried out until the moment in which the new scenario is applied will be taken into account.
Scenario 3. Closure of facilities
As long as there is no need / obligation to reduce the contents of the subject, the system and the evaluation criteria would be similar with respect to what is indicated for scenario 2, with the differences shown below:
(a) Final exam. Compulsory evaluable activity complementary to continuous evaluation.
Telematic exam, through the virtual classroom and will represent 80% of the final grade.
(b) Continuous evaluation (seminars).Non-mandatory evaluable activity. Their grade will be based on the assessment of tasks (questionnaires) proposed through the virtual campus that students must answer electronically and / or deliver in the classroom, within the indicated period, and will represent 20% of the final grade.
(c) Final evaluation. The computation of the student's final grade will be obtained by making the weighted sum of those obtained in each of them (80 and 20%, respectively), provided that at least 4.5 points have been obtained in the content exam and that the answered 80% of the exam. As in the previous cases, the absence of a grade in the continuous evaluation would imply a maximum possible grade of 8.0 points.
• For any of the possible scenarios, the repeating students must carry out the same type of activities as the first enrollment students, in all the scenarios.
• The realization or presentation of tasks / questionnaires carried out by the students upon request, the provisions of the Regulations for the evaluation of the academic performance of the students and the review of grades will be applied.
• Students may not use the material provided by the teacher, of whatever type, for distribution or outside the scope of personal study.
EVALUATION OF COMPETENCE
Evaluation of transversal competences
• CT1, CT2, CT5, CT9, CT10 and CT11, will be assessed through written tests (tests lectures and interactive classes).
CT6 will be assessed through oral questions / answers in the interactive classes.
Evaluation of specific skills
• CE1.c, CE2.a, CE2.c, CE2.e, CE2. f, CE6. c, CE6.f, CE7.a, CE7.g
Evaluation by examination corresponding to lectures and interactive classes matter.
WORK PRESENCIAL IN CLASSROM
Master classes (expositive) 26h
Seminars (interactive) 10h
Tutorials 5h
Examination 2.5h
Classroom work 43.5h
INDIVIDUAL WORK OR IN GROUP
Individual study 69h
• Attendance at all teaching activities.
• Participation in the corresponding classes, answering orally and / or in writing to the questions / questions posed by the teacher, both in the class itself and in those presented in the different lessons of the theoretical program and those specific to the seminars.
• Make summaries / diagrams or scripts that synthesize the important contents of each of the lessons of the program, trying to combine and relate different aspects that are explained in each one of them.
• Self-evaluation of the content understanding. The student should try to generate, by himself and using books, especially those recommended in the bibliography, a catalog of questions and answers so that he can face the exam with more possibilities of success.
• In scenarios 2/3, especially, management of the indicated bibliography with free access, through the library.
• Make use of tutorials for any type of matter related to the subject.
CONTINGENCY PLAN
TEACHING METHODOLOGY
Scenario 1. Normality
• Expository classes: Master classes for the presentation of the lessons of the theoretical program of the subject with the use of waxing and, where appropriate, supported by computer presentations.
• The contents, order and time dedicated to each of the topics may be modified, with respect to the program presented in the teaching guide, by the incorporation of new concepts and more recent updates.
• The interactive classes (seminars), in addition to reinforcing and reviewing concepts explained in theory or doubts of the students, will be used for the continuous evaluation of the student, assessing their compulsory active oral and / or written participation. It will be carried out by quantifying the student's responses to questionnaires that will include questions, issues and problems related to the subject's syllabus, and which will be formulated orally and / or in writing, at the teacher's request. The questionnaires could also be available to the student in advance of the seminars themselves, through the virtual classroom, and their delivery could be required for their evaluation.
• The virtual campus will be used to leave information related to the subject and that may be useful to students.
• Tutorial classes will be face-to-face.
Scenario 2. Distance
• Expository classes: Teaching will be face-to-face / virtual (asynchronous), according to the regulations determined by the center and the university itself, using, if necessary, electronic resources (virtual classroom, e-mail) for partial or complete explanations of lessons and / or answers to questions from students. The students would have, through the virtual classroom, the files corresponding to the lessons on the syllabus that could not have been explained in person.
• The programming of the classes and the thematic sequence will not vary with respect to the face-to-face teaching of scenario 1.
• Interactive classes (seminars). They will be face-to-face, if the circumstances allow it and, in case of distancing (scenario 2), contact through the virtual campus will prevail. In both cases they will serve for the continuous evaluation of the student, which will be carried out through the face-to-face proposal by the teacher, or through the virtual classroom, of tasks / questionnaires corresponding to the thematic blocks of the content classes and that the Students have to respond orally and / or in writing (in the case of classroom attendance) and / or by answering telematically or through the compulsory delivery of tasks / responses through the virtual classroom.
• The tutorial classes would be carried out (in case of distancing) telematically.
Scenario 3. Closure of facilities
• Expository classes: The classes will be virtual and asynchronous, promoting the individual work of the student,
who will be advised, when needed, using the available electronic resources (email, virtual campus).
• In these circumstances, students will have access to all the files corresponding to the program's lessons
(presentations) and, at least, to the part of the recommended bibliography, through the resources of the
university library.
• Interactive classes (seminars) and continuous assessment will be carried out by grading the tasks/
questionnaires proposed by the teacher through the virtual classroom and related to the thematic blocks
explained in the expository classes and classified as indicated in scenario 1. At the teacher's request, students
must respond electronically and / or by delivery, if this is proposed and mandatory for all students.
• The tutorial classes will be telematic.
FINAL EVALUATION SYISTEM
Scenario 1. Normality
The learning assessment will be done in person and will consist of:
(a) Evaluation of content (lectures) (Final Exam). Compulsory evaluable activity complementary to continuous evaluation.
The contents of the theoretical program will be evaluated by written exam (final exam) The maximum grade obtained in the exam (10 points) is equivalent to 85% of the final grade and as long as a minimum of 80 has been answered % of exam questions.
(b) Evaluation of interactive classes (Continuous assessment). Non-mandatory evaluable activity.
They will be evaluated by qualifying the answers (oral and / or written) that the student can give to the questions / questions raised in the seminar classes themselves or previously, through questionnaires, which could be posed through the virtual classroom for self-evaluation of the student and / or required delivery for evaluation. The assessment of this section may reach a maximum of 1.5 points, which will represent 15% of the final grade for the course. The grade in this section will be 0 if the student does not participate or submit the answers.
(c) Final evaluation. The final grade will be obtained as the weighted average of the partial grades obtained in (a) and (b), which represents, respectively, 85% and 15% of the final grade and as long as it has been achieved in the grade. of (a) a minimum of 5 points. The lack of qualification in (b) will imply that the student could obtain a maximum of 8.5 points, in the event that in the examination of the contents of the expository classes he had reached 10 points.
- Given the nature of continuous evaluation, the evaluation depending on the exam will be repeated exclusively in the July exam.
- In the case of having to repeat the subject in the next course, NO notes will be saved and the repeaters will have to do the same as the new students.
- The summary evaluation criteria can be obtained at the following address:
http://www.usc.es/gl/centros/bioloxia/criteriosavaliacion.html
Scenario 2. Distance
The system and evaluation criteria would be similar to those indicated for scenario 1, with the following differences:
(a) Final exam. Compulsory evaluable activity complementary to continuous evaluation.
Telematic exam, through the virtual classroom, in the event that it cannot be done in person.
(b) Continuous evaluation (seminars). Non-mandatory evaluable activity. It will be based on the assessment of tasks / questionnaires proposed in person and / or through the virtual campus and those that students must answer orally / telematically and / or deliver, at the request of the teacher.
(c) Final evaluation. The final grade will be as indicated in the corresponding section of scenario 1 and, in the same way, the lack of assessment in (b) for not having oral answers (face-to-face situation) and / or written delivery of questionnaires raised orally or through the virtual classroom (in person or distance), will imply a grade of 0 points in the continuous evaluation and, as a consequence, the possibility of reaching 8.5 points as the maximum grade for the course.
If the distancing situation occurs due to interruption in an intermediate (or already advanced) phase of the course, the previous controls carried out until the moment in which the new scenario is applied will be taken into account.
Scenario 3. Closure of facilities
As long as there is no need / obligation to reduce the contents of the subject, the system and the evaluation criteria would be similar with respect to what is indicated for scenario 2, with the differences shown below:
(a) Final exam. Compulsory evaluable activity complementary to continuous evaluation.
Telematic exam, through the virtual classroom and will represent 80% of the final grade.
(b) Continuous evaluation (seminars).Non-mandatory evaluable activity. Their grade will be based on the assessment of tasks (questionnaires) proposed through the virtual campus that students must answer elec tronically and / or deliver in the classroom, within the indicated period, and will represent 20% of the final grade.
(c) Final evaluation. The computation of the student's final grade will be obtained by making the weighted sum of those obtained in each of them (80 and 20%, respectively), provided that at least 4.5 points have been obtained in the content exam and that the answered 80% of the exam. As in the previous cases, the absence of a grade in the continuous evaluation would imply a maximum possible grade of 8.0 points.
• For any of the possible scenarios, the repeating students must carry out the same type of activities as the first enrollment students, in all the scenarios.
• The realization or presentation of tasks / questionnaires carried out by the students upon request, the provisions of the Regulations for the evaluation of the academic performance of the students and the review of grades will be applied.
• Students may not use the material provided by the teacher, of whatever type, for distribution or outside the scope of personal study.
Primitivo Barja Francisco
Coordinador/a- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881816931
- primi.barja [at] usc.es
- Category
- Professor: University Lecturer
| Monday | |||
|---|---|---|---|
| 15:00-16:00 | Grupo /CLE_02 | Spanish | Virtual classroom |
| 16:00-17:00 | Grupo /CLE_01 | Spanish | Virtual classroom |
| Wednesday | |||
| 15:00-16:00 | Grupo /CLE_02 | Spanish | Virtual classroom |
| 16:00-17:00 | Grupo /CLE_01 | Spanish | Virtual classroom |
| Thursday | |||
| 15:00-16:00 | Grupo /CLE_02 | Spanish | Virtual classroom |
| 16:00-17:00 | Grupo /CLE_01 | Spanish | Virtual classroom |
| 01.18.2021 10:00-14:00 | Grupo /CLE_01 | Classroom 01. Charles Darwin |
| 01.18.2021 10:00-14:00 | Grupo /CLE_02 | Classroom 01. Charles Darwin |
| 01.18.2021 10:00-14:00 | Grupo /CLE_01 | Classroom 02. Gregor Mendel |
| 01.18.2021 10:00-14:00 | Grupo /CLE_02 | Classroom 02. Gregor Mendel |
| 01.18.2021 10:00-14:00 | Grupo /CLE_01 | Classroom 03. Carl Linnaeus |
| 01.18.2021 10:00-14:00 | Grupo /CLE_02 | Classroom 03. Carl Linnaeus |
| 01.18.2021 10:00-14:00 | Grupo /CLE_01 | Classroom 04: James Watson and Francis Crick |
| 01.18.2021 10:00-14:00 | Grupo /CLE_02 | Classroom 04: James Watson and Francis Crick |
| 06.28.2021 10:00-14:00 | Grupo /CLE_01 | Classroom 04: James Watson and Francis Crick |
| 06.28.2021 10:00-14:00 | Grupo /CLE_02 | Classroom 04: James Watson and Francis Crick |
| 06.28.2021 10:00-14:00 | Grupo /CLE_01 | Main Hall Santiago Ramón y Cajal |
| 06.28.2021 10:00-14:00 | Grupo /CLE_02 | Main Hall Santiago Ramón y Cajal |