ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Student's work ECTS: 99 Hours of tutorials: 3 Expository Class: 24 Interactive Classroom: 24 Total: 150
Use languages Spanish, Galician
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Biochemistry and Molecular Biology
Areas: Biochemistry and Molecular Biology
Center Faculty of Biology
Call: Second Semester
Teaching: Sin docencia (Extinguida)
Enrolment: No Matriculable
- Identify the central routes of metabolism and its regulation in different organisms.
- Learn to integrate the different metabolic pathways in the context of the whole of the body.
- Apply knowledge about the metabolism of the genetic information.
- Apply knowledge about the synthesis mechanism of proteins and their post-biosynthesis evolution.
- Identify the relevance of energy and material balances of metabolic pathways.
- Learn design functional modifications of metabolic pathways biotechnological purposes.
• EXPOSITORY CLASSES (THEORY PROGRAM, 27H)
Protein Synthesis*
Lesson 1. Translation of the genetic message and post-biosynthesis evolution of proteins (2.5h).
Aerobic and bioenergetic intermediary metabolism pathways and bioenergetics
Lesson 2. Oxidation of acetyl-CoA: Cycle of citric acid cycle (2 h).
Lesson 3. Electron transport and oxidative phosphorylation (2 h).
Carbohydrate Metabolism
Lesson 4. Catabolism of carbohydrates. Glycolysis (2.5h).
Lesson 5. Gluconeogenesis and the pentose phosphate pathway (2.5h).
Lesson 6. Glycogen metabolism (1.5 h).
Lipid Metabolism
Lesson 7. Catabolism of lipids. Fatty acid oxidation and metabolism of ketone bodies (2.5h).
Lesson 8. Biosynthesis and regulation of fatty acids metabolism (1.5h).
Lesson 9. Biosynthesis of glycerides and sphingolipids (1.5h).
Lesson 10. Terpenes and steroids metabolism (1.5h).
Metabolism of amino acids and nucleotides
Lesson 11. Degradation of proteins and catabolism of amino acids (2h).
Lesson 12. Biosynthesis of amino acids and related metabolites (2h).
Lesson 13. Metabolism of nucleotide (1.5h).
Integration and interrelationships in metabolic pthways
Lesson 14. Integration and coordination of metabolic processes (1.5h).
*Except for the topic dedicated to protein synthesis, and those dedicated to nucleic acids and their metabolism (DNA structures in chromatin and chromosomes, RNAs and gene expression and its regulation, as well as replication processes, transcription, repair, and recombination) will be explained in the subjects of Genetics I and II.
In the subject of Plant Physiology, photosynthesis, photosynthetic electron transport and photophosphorylation and carbohydrate biosynthesis in plant cells are explained. And, in Microbiology I, the subject related to the cycle and nitrogen fixation is explained.
• INTERACTIVE CLASSES (SEMINARS, 15H)
The seminar classes (see teaching methodology and learning evaluation system) will be presented as thematic blocks of approximately 3 hours each, in the thematic sequence proposed in the lectures: translation of the genetic message, intermediate metabolism and
bioenergetics, metabolism of carbohydrates, lipids, and nitrogenous compounds.
• INTERACTIVE CLASSES (LABORATORY, 6H)
In 2-hour sessions, enzymatic purification and analysis and a study of alcoholic fermentation (practice 1 and 2) will be carried out.
• TUTORIAL CLASSES (3H)
Consultation and clarification or resolution of doubts.
Basic Bibliography
- Berg, J.M., Tymoczko, J.L., Gatto, G.J.Jr & Stryer, L. 2019. Biochemistry. Nine ed. New York. W.H. Freeman and
Compnay.
- Garret, R.H. & Grisham, C.M., 2024. Biochemistry. 7th ed. Cengage Learning Inc.
- McKee, T., y McKee, J.R., 2020. Bioquímica. Las bases moleculares de la vida. 7ª ed. México:
McGraw-Hill/Interamericana Editores. Disponible “on line”:
https://accessmedicina-mhmedical-com.ezbusc.usc.gal/book.aspx?bookid=29…
- Mathews, C., Van Holde, K.E., Appling, D.R. & Anthony-Cahill, S.J., 2013. Bioquímica. 4ª ed. Madrid: Pearson.
- Nelson, D.L. & Cox, M.M., 2021. Lehninger Principles of Biochemistry. 8ª ed. New York: Macmillan International.
- Voet, D., Voet, J.G. & Pratt, Ch., 2016. Fundamentos de Bioquímica. 4ª ed. Buenos Aires: Editorial Médica Panamericana.
Complementary Bibliography
- Alberts, B. et al., 2022. Molecular Biology of the Cell. 7th ed. W.W. Norton & Company, Inc, New York.
- Bhagavan, N.V., Chung Eun-Ha. 2015. Essentials of Biochemistry. With Clinical classes. 2nd edition. Academic Press.
Disponible “on line”:
https://www.sciencedirect.com/book/9780124166875/essentials-of-medical-…
- Meissenberg, G., Simmons, W.H. 2018. Principios de Bioquímica Médica. 4ª edición. Elsevier España, S.L.U.
Disponible “on line”: https://www.clinicalkey.com/student/content/toc/3-s2.0-C20170026563
- Rodwell, V.W., Bender, D.A., Botham, K.M., Kennelly, P.J. y Weil, P.A., 2018. Harper Bioquímica ilustrada. 31ª ed.
México: McGraw-Hill/Interamericana. Disponible “on line”:
https://accessmedicina-mhmedical-com.ezbusc.usc.gal/Book.aspx?bookid=27…
The basic and general competences are those that appear in the memory of the degree.
Transversal skills
CT1 - Think in an integrated way and approach problems from different perspectives.
CT2 - Search, process, analyze and synthesize information from various sources.
CT4 - Interpret experimental results and identify consistent elements and
inconsistent.
CT5 -Work as a team.
CT6 - Reason critically
Specific skills
CE2 - Understand and know how to apply the physical-chemical principles of biological processes with application in Biotechnology, as well as the main tools used to investigate them.
CE4 - Have an integrated view of the functioning of cells, including their biomolecules, metabolism, gene expression, relationship between cell compartments, as well as the mechanisms of communication and cell signaling.
• Exhibition classes.
Master classes for the presentation of the contents of the theoretical program of the subject with the use of waxing supported by computer presentations.
• Interactive classes:
(a) Seminars. They will be developed under 2 formats:
- Seminars with the aim of deepening/expanding and reinforcing specific concepts presented in the expository classes (10h). They will be held in the form of a master class.
- Interactive seminars for the approach and resolution of questions/problems related to the subject (5h) and in which the evaluation of the student will be carried out based on the oral and/or written answers that the student can give to questions/exercises/problems formulated in seminar classes (or previously, raised through the virtual classroom) and that are related to each of the lessons or the thematic blocks of the subject.
The evaluable activity may include the elaboration of metabolic routes/maps to be delivered or identified, commented on or explained and described figures/schemes explained in the lecture classes (and which the student will have through files made available to them at the virtual classroom). In addition, it could also involve the realization of individual or group work on topics related to the theoretical content (expository classes) of the subject.
(b) Laboratory practices. The objective of the practices will be to familiarize students with some of the methodologies of a Biochemistry laboratory. The practices will be mandatory.
• Tutorial classes. Clarification and resolution of doubts about the matter.
• Exhibition classes.
Master classes for the presentation of the contents of the theoretical program of the subject with the use of waxing supported by computer presentations.
• Interactive classes:
(a) Seminars. Assessable, not mandatory, and have a double objective: to deepen/broaden and reinforce specific concepts and topics presented in the expository classes and assessable through assignments, presentations, and/or metabolic maps, and aim to enhance student learning and participation in the class (orally or in writing) answering the questions formulated by the teacher, under different formats (see evaluation system).
(b) Laboratory practices. The objective of the practices will be to familiarize students with some of the methodologies of a Biochemistry laboratory. The practices will be compulsory.
• Tutorial classes. Clarification and resolution of doubts about the matter.
LEARNING ASSESSMENT SYSTEM
(A) (Final exam). Compulsory evaluable activity complementary to the continuous evaluation.
The contents of the theoretical program will be assessed through a face-to-face written exam (final exam). The maximum grade obtained in the exam (10 points) is equivalent to 75% of the final grade and as long as a minimum of 85% of the questions have been answered and the exam is compensated in terms of the grade obtained in answers to objective questions (test type...), with respect to that reached in questions whose answer implies relating and/or arguing/reasoning concepts.
(B) Continuous evaluation
(a) Interactiva Seminars. Non-compulsory evaluable activity that will be carried out through the presentation and/or exposition of works, to reinforce knowledge of a specific subject, and/or elaboration of metabolic routes/maps to be delivered and the participation (oral and/or written) of the student in class:
- Identifying/interpreting/describing and explaining images/figures/schemes related to or presented in the contents of the expository classes.
- Responding to issues/questions/exercises posed (by the teacher) in the class itself or previously presented and accessible to students through the virtual classroom and that are related to each of the lessons or thematic blocks of the subject.
This activity will be graded from 0 to 10 points and the maximum achievable assessment (1.5 points) will account for 15% of the final grade for the subject, and as long as more than 4.5 has been achieved in the final exam (see final assessment).
- In the case of repeat students, they will be in the same circumstances as those enrolled for the first time, with respect to this activity.
- For cases of fraudulent completion of exercises or tests, the provisions of the "Regulations for evaluating student academic performance and reviewing grades will apply.
(b) Laboratory practices. Evaluable compulsory activity.
- Attendance at all practical sessions will be compulsory to pass the subject. The work in the laboratory will be valued and will be evaluated by submitting a task or completing an online questionnaire through the virtual classroom (10% of the total grade for the subject). Unexcused absences will qualify as NOT SUITABLE.
- Students must obtain a pass grade (5) in practices to pass the subject.
- The qualification of the practice will be maintained during a course which will mean that the repeating students would not have to repeat the practice the following course.
(C) Final evaluation
The final grade will be obtained as the weighted average of the partial grades obtained in: (A) the (final) content exam of the expositive classes (rated from 0 to 10 points) and which corresponds to 75% of the total grade final and (B) of the continuous evaluation corresponding to the interactive classes (25% of the total), considering the following considerations:
- The grade obtained in the seminars (15%) can only be added to the final exam (A) if a minimum of 4.5 points has been obtained in it, 85% of the questions have been answered and the grade is compensated. obtained in different types of questions/answers, as previously mentioned (assessment, final exam).
- The lack of qualification in the seminars will imply that the student could obtain, at most, 8.5 points in the final grade, if in the exam of the expositive classes and in the laboratory practices he had reached the maximum qualifications (7.5 and 1 point, respectively).
- In the second call, the evaluation depending on the exam will be repeated exclusively and, if it has not been previously carried out, also the exam corresponding to the seminars, which will be voluntary. In any case, the students will only be evaluated in the seminars once per course.
The percentages of each part of the evaluation will be the same as those indicated above.
- The qualification obtained in the practices (10%) can only be added to the final qualification if the corresponding tasks and/or questionnaires have been attended and completed, as well as obtaining a PASS (5) qualification.
- Students who do not pass the subject in the ordinary session may take the opportunity to recover, maintaining the note of the continuous evaluation (the evaluation dependent on the final exam will be repeated exclusively).
- The students who fail the subject and must repeat it, will be able to keep the practical note during the following academic year, if they have done them.
- Repeaters. Repeating students will be exempted from carrying out the practices, but the qualification of the seminars of the previous course will not be kept.
EVALUATION OF THE COMPETENCES
(A) Final exam. The following competences will be evaluated:
- basic CB1, CB2 and CB5
- general CG4 and CG5
- transversal CT1, CT2, and CT6
- specific CE2 y CE4
(B) Continuous evaluation.
(a) Seminars. The competences will be evaluated:
- basic CB1, CB2, CB3 and CB4
- generals CG1, CG2, CG3, CG4 and CG5
- transversal CT1, CT2, CT5 and CT6
- specific CE2 and CE4
(b) Laboratory practices. The competences will be evaluated:
- basic CB2, CB4 and CB5
- generals CG1 and CG3
- transversal CT4, CT5 and CT6
- specific CE2
• For cases of fraudulent completion of exercises or tests, the provisions of the "Regulations for evaluating student academic performance and reviewing grades" will apply.
PRESENTIAL WORK IN AULA
Lectures (expository) 27h
Seminars (interactive) 15h
Laboratory practices (interactive) 6h
Tutorials 3h
3h exam
Total Work in the classroom 54h
PERSONAL WORK
Individual Studio 96h
• Assistance to all teaching activities.
• Use of the recommended bibliography and what is presented in the virtual classroom, where appropriate.
• Active participation in the corresponding classes, answering orally and / or in writing to the questions / questions raised by the teacher, both in the class itself and in those presented in the different lessons of the theoretical program and the specific ones of the seminars.
• Deepen the aspects of the subject indicated and presented by the teacher in the corresponding classes.
• Make summaries / sketches or scripts that synthesize the important contents of each of the lessons of the program, trying to combine and relate different aspects that are explained in each of them.
Elaborate metabolic map (s) that allow to gather the central metabolic routes in different physiological situations that allow to relate, visualize and clarify aspects of the matter explained in separate blocks.
• Self-assessment of content comprehension. The student should try to generate, by himself and using the recommended bibliography, a catalog of questions and answers in an appropriate way to the syllabus.
• Make use of the tutorials for any type of matter related to the subject.
- It is recommended that for a better understanding of the subject of biochemistry II previous knowledge of subjects such as biochemistry I, genetics I / II, cell biology, animal and plant physiology, microbiology, in addition to basic notions of chemistry (organic and inorganic).
- In the theoretical subject explained during the course there could be variations with respect to the program presented in the teaching guide, due to the incorporation of new concepts and more recent updates.
-The virtual campus will be used to leave information related to the subject and that may be useful for the students.
- For cases of fraudulent completion of exercises or tests, the provisions of the "Regulations for evaluating student academic performance and reviewing grades" will apply.
Primitivo Barja Francisco
Coordinador/a- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881816931
- primi.barja [at] usc.es
- Category
- Professor: University Lecturer
Guillermo Covelo Artos
- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881816930
- guillermo.covelo [at] usc.es
- Category
- Professor: Temporary PhD professor
María Crugeiras Ríos
- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- maria.crugeiras.rios [at] usc.es
- Category
- Xunta Pre-doctoral Contract
| Monday | |||
|---|---|---|---|
| 19:00-20:00 | Grupo /CLE_01 | Spanish | Classroom 08. Louis Pasteur |
| Tuesday | |||
| 19:00-20:00 | Grupo /CLE_01 | Spanish | Classroom 08. Louis Pasteur |
| Wednesday | |||
| 19:00-20:00 | Grupo /CLIS_01 | Spanish | Classroom 08. Louis Pasteur |
| 05.21.2024 16:00-20:00 | Grupo /CLE_01 | Classroom 04: James Watson and Francis Crick |
| 07.12.2024 16:00-20:00 | Grupo /CLE_01 | Classroom 03. Carl Linnaeus |