ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Student's work ECTS: 102 Hours of tutorials: 6 Expository Class: 18 Interactive Classroom: 24 Total: 150
Use languages Spanish, Galician
Type: Ordinary subject Master’s Degree RD 1393/2007 - 822/2021
Departments: Pharmacology, Pharmacy and Pharmaceutical Technology, External department linked to the degrees
Areas: Pharmacology, Área externa M.U en Investigación y Desarrollo de Medicamentos
Center Faculty of Pharmacy
Call: First Semester
Teaching: With teaching
Enrolment: Enrollable | 1st year (Yes)
To bring students closer to the current philosophy in the generation of drug discovery programs. To provide students with the theoretical and practical training for the design and execution of preliminary drug screening cascades.
The course is divided into two content modules:
Introductory Module (M1): (3 ECTS credits) is a general view of Pharmacology oriented to researchers with little or no previous training in Pharmacology. This module will comprehensively review the principles of Pharmacology, including the molecular basis of drug action mechanisms, drug-target interactions, the concepts of efficacy and potency, and modern approaches to the design of drug development programs.
The programme of this module includes the following main thematic blocks:
1. Preclinical R&D in the process of drug discovery and development.
2. Basic concepts of Pharmacodynamics. General mechanisms of action of drugs.
Specialized Module (M2): (3 ECTS credits) is of an applied nature to the knowledge of drug screening processes in therapeutic targets and anti-targets.
The program of this module includes the following fundamental thematic blocks:
1. Identification and validation of targets in preliminary drug discovery. Applied proteomics.
2. Design and execution of low (LTS) and high (HTS) throughtput screening drug discovery campaigns.
3. Low and high performance screening methodologies: binding, biochemical, cell-based, siRNA, etc.
The two modules of the course will be offered, also, independently as own research courses of the USC open to researchers who do not perform the Master course. The students of the course will be automatically enrolled in both of them.
Dahlin JL1, English J2, Walters MA3. Mitigating risk in academic preclinical drug discovery. Nat Rev Drug Discov. 2015 Apr;14(4):279-94.
Dugger SA, Platt A, Goldstein DB. Drug development in the era of precision medicine. Nat Rev Drug Discov 2018; 17:183-196
Al Ali H. The evolution of drug discovery: from phenotypes to targets and back. MedChemComm 2016; 5. DOI:10.1039/c6md00129g
Park H, Ha J, Park SB. Label-free target identification in drug discovery via phenotypic screening. Curr Opinion Chem Biol 2019; 50:66-72
- Learning the vocabulary in preliminary Pharmacology.
- Ability to apply the general principles of early drug discovery to real-life situations
- Ability to organize practical work in pharmacological screening.
- Development of a multidisciplinary vision.
The methodology used in the Introductory Module (M1) consists of theoretical classes and seminars.
The methodology used in the Specialized Module (M2) will be carried out in sharing and discussion sessions in which students will prepare and present the works of the selected topics, with new methodologies used in professional environments with the standard formats provided by the teachers in which they will incorporate their own vision after the bibliographic searches.
Students participate in webinars and, as far as possible, visit and learn about the activities in early drug discovery of the ERIC EU-OPENSCREEN Innopharma Platform of the USC
- Continuous evaluation (30% of the final mark). The student's attitude will be taken into account during the course.
- Personal work (70% of the final grade). It consists of the application of learning to the particular situation of the students' work/knowledge environment. The students must participate in the teams that are formed and take responsibility for the adequate performance of the corresponding work, which will be assigned by mutual agreement between them. In addition, they must participate in the presentations.
The course consists of 6 ECTS credits, distributed in 3 ECTS credits per module.
It includes 88 hours of classroom activities and 62 hours of student study and personal work.
It is recommended that students actively participate in the proposed activities and attend conferences by external experts.
Likewise, it is important for the student to employ the recommended bibliography for the subject.
Contingency plan
SCENARIO 2: DISTANCING
Expository and interactive teaching
Teaching can also be carried out either in person or virtually with synchronous and/or asynchronous procedures.
Tutorials
Priority will be given to the programming of tutorials by telematic means
Evaluation
On-site or telematic depending on conditions and number of students
SCENARIO 3: CLOSURE OF THE FACILITIES
Expository and interactive teaching
Teaching would be approached virtually with synchronous and/or asynchronous procedures.
Tutorials
Telematic
Evaluation
Telematic
Maria Isabel Cadavid Torres
- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- Phone
- 881814902
- mariaisabel.cadavid [at] usc.es
- Category
- Professor: LOU (Organic Law for Universities) Emeritus
Maria Isabel Loza Garcia
Coordinador/a- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- Phone
- 881815005
- mabel.loza [at] usc.es
- Category
- Professor: University Professor
Maria De Los Angeles Castro Perez
- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- Phone
- 881815457
- marian.castro [at] usc.es
- Category
- Professor: University Lecturer
Angel Garcia Alonso
- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- Phone
- 881815429
- angel.garcia [at] usc.es
- Category
- Professor: University Lecturer
| Monday | |||
|---|---|---|---|
| 16:30-18:30 | Grupo /CLE_01 | Spanish | 5035 Soil Science Seminar Room |
| 18:30-19:30 | Grupo /CLIL_01 | Spanish | 5035 Soil Science Seminar Room |
| 19:30-20:30 | Grupo /CLIS_01 | Spanish | 5035 Soil Science Seminar Room |
| Tuesday | |||
| 16:30-18:30 | Grupo /CLE_01 | Spanish | 5035 Soil Science Seminar Room |
| 18:30-19:30 | Grupo /CLIL_01 | Spanish | 5035 Soil Science Seminar Room |
| 19:30-20:30 | Grupo /CLIS_01 | Spanish | 5035 Soil Science Seminar Room |
| Wednesday | |||
| 16:30-18:30 | Grupo /CLE_01 | Spanish | 5035 Soil Science Seminar Room |
| 18:30-19:30 | Grupo /CLIL_01 | Spanish | 5035 Soil Science Seminar Room |
| 19:30-20:30 | Grupo /CLIS_01 | Spanish | 5035 Soil Science Seminar Room |
| Thursday | |||
| 16:30-17:30 | Grupo /CLE_01 | Spanish | 5035 Soil Science Seminar Room |
| 17:30-19:30 | Grupo /CLIS_01 | Spanish | 5035 Soil Science Seminar Room |
| Friday | |||
| 16:30-17:30 | Grupo /CLE_01 | Spanish | 5035 Soil Science Seminar Room |
| 17:30-19:30 | Grupo /CLIS_01 | Spanish | 5035 Soil Science Seminar Room |