Pediatric Basic Life Support and nursery schools.
Authorship
C.A.F.
Bachelor of Medicine
C.A.F.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: To the teachers and educators of the infantile schools to “A Galiña Azul” in Galicia they are not required to have Basic Life Support skills to be able to work in these centers with children of 0-3 years. Basic knowledge of how to act in an emergency situation could save the child’s life and/or minimize the damage that might be caused. In the event of cardiac arrest, performing quality chest compressions is clearly linked to the victim's survival, so performing them correctly is important. Objectives: The main objective is to assess the effectiveness of pediatric chest compressions after participants have received theoretical information and practical training using the low-cost baby. The goal is also to provide teachers with training in pediatric BLS and to verify that the use of the low-cost device is effective for chest compression training. Material and methods: Training and data collection will be carried out in person, using the low-cost baby device for training and a sophisticated mannequin for evaluating the variables to be analyzed. Results and conclusions: participation in the study has been active and, in general terms, the use of the low-cost baby has proven to be a good tool for learning how to perform pediatric chest compressions
Introduction: To the teachers and educators of the infantile schools to “A Galiña Azul” in Galicia they are not required to have Basic Life Support skills to be able to work in these centers with children of 0-3 years. Basic knowledge of how to act in an emergency situation could save the child’s life and/or minimize the damage that might be caused. In the event of cardiac arrest, performing quality chest compressions is clearly linked to the victim's survival, so performing them correctly is important. Objectives: The main objective is to assess the effectiveness of pediatric chest compressions after participants have received theoretical information and practical training using the low-cost baby. The goal is also to provide teachers with training in pediatric BLS and to verify that the use of the low-cost device is effective for chest compression training. Material and methods: Training and data collection will be carried out in person, using the low-cost baby device for training and a sophisticated mannequin for evaluating the variables to be analyzed. Results and conclusions: participation in the study has been active and, in general terms, the use of the low-cost baby has proven to be a good tool for learning how to perform pediatric chest compressions
Direction
Gonzalez Quintela, Arturo (Tutorships)
RODRIGUEZ RUIZ, EMILIO (Co-tutorships)
Gonzalez Quintela, Arturo (Tutorships)
RODRIGUEZ RUIZ, EMILIO (Co-tutorships)
Court
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
Evaluation of photobiomodulation for the treatment of burning mouth syndrome
Authorship
A.B.B.
Grao en Odontología (2ªed)
A.B.B.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Burning Mouth Syndrome is a chronic condition characterized by a burning sensation in the oral cavity without visible lesions or clinical alterations to justify it. Currently, there is no definitive therapy that resolves the syndrome, and many available treatments have limited or poorly tolerated long-term effects. In this context, the main objective of this study is to evaluate the efficacy of low-level laser photobiomodulation in reducing oral pain in patients with Burning Mouth Syndrome. As a secondary objective, the study aims to assess whether this intervention also improves patients’ quality of life during and after treatment. A pilot, randomized, double-blind study was conducted with a sample of 20 patients diagnosed with primary Burning Mouth Syndrome. They were divided into two groups: the treatment group received eight weekly sessions of infrared laser photobiomodulation (808 nm), while the control group received simulated sessions with the laser turned off. Pain was assessed using the Visual Analog Scale, and quality of life was evaluated using the oral health impact profile questionnaire at three points: before treatment, after the last session, and two months later. Statistical analysis was carried out using the independent samples t-test. Results showed a significant improvement in pain perception in the photobiomodulation group: the mean VAS score dropped from 7.6 to 2.7 points (p less than 0.001), reflecting a 64.5% improvement. Regarding quality of life, a sustained improvement was observed, with a 38.7% decrease in oral health impact profile questionnaire scores (from 34.4 to 21.1 points; p less than 0.001). In contrast, the control group showed no relevant changes in any of the variables. These findings align with recent studies showing that photobiomodulation, when applied at the appropriate dose and consistently, can stimulate cellular repair mechanisms, reduce inflammatory mediators, and improve neurosensory function. Furthermore, it is a comfortable therapy, with no significant adverse effects, and is well accepted by patients. We conclude that low-level laser photobiomodulation proved to be an effective and safe alternative for treating Burning Mouth Syndrome. This pilot study supports its clinical use as part of a multidisciplinary and personalized approach. However, further trials with larger sample sizes and extended follow-up are needed to confirm these findings and establish improved clinical protocols.
Burning Mouth Syndrome is a chronic condition characterized by a burning sensation in the oral cavity without visible lesions or clinical alterations to justify it. Currently, there is no definitive therapy that resolves the syndrome, and many available treatments have limited or poorly tolerated long-term effects. In this context, the main objective of this study is to evaluate the efficacy of low-level laser photobiomodulation in reducing oral pain in patients with Burning Mouth Syndrome. As a secondary objective, the study aims to assess whether this intervention also improves patients’ quality of life during and after treatment. A pilot, randomized, double-blind study was conducted with a sample of 20 patients diagnosed with primary Burning Mouth Syndrome. They were divided into two groups: the treatment group received eight weekly sessions of infrared laser photobiomodulation (808 nm), while the control group received simulated sessions with the laser turned off. Pain was assessed using the Visual Analog Scale, and quality of life was evaluated using the oral health impact profile questionnaire at three points: before treatment, after the last session, and two months later. Statistical analysis was carried out using the independent samples t-test. Results showed a significant improvement in pain perception in the photobiomodulation group: the mean VAS score dropped from 7.6 to 2.7 points (p less than 0.001), reflecting a 64.5% improvement. Regarding quality of life, a sustained improvement was observed, with a 38.7% decrease in oral health impact profile questionnaire scores (from 34.4 to 21.1 points; p less than 0.001). In contrast, the control group showed no relevant changes in any of the variables. These findings align with recent studies showing that photobiomodulation, when applied at the appropriate dose and consistently, can stimulate cellular repair mechanisms, reduce inflammatory mediators, and improve neurosensory function. Furthermore, it is a comfortable therapy, with no significant adverse effects, and is well accepted by patients. We conclude that low-level laser photobiomodulation proved to be an effective and safe alternative for treating Burning Mouth Syndrome. This pilot study supports its clinical use as part of a multidisciplinary and personalized approach. However, further trials with larger sample sizes and extended follow-up are needed to confirm these findings and establish improved clinical protocols.
Direction
BLANCO CARRION, ANDRES (Tutorships)
BLANCO CARRION, ANDRES (Tutorships)
Court
GARCIA GARCIA, ABEL (Chairman)
LOPEZ CASTRO, GONZALO (Secretary)
GANDARA VILA, PILAR (Member)
GARCIA GARCIA, ABEL (Chairman)
LOPEZ CASTRO, GONZALO (Secretary)
GANDARA VILA, PILAR (Member)
Effectiveness of Platelet Concentrates versus Conventional Blood Clot as Intracanal Scaffolds in Regenerative Endodontic Procedures for Necrotic Immature Permanent Teeth: A Systematic Review
Authorship
M.R.B.A.
Grao en Odontología (2ªed)
M.R.B.A.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Objectives: To evaluate and compare the effectiveness of autologous platelet concentrates (PRF, PRP) versus blood clot (BC) as intracanal scaffolds in regenerative endodontic procedures (REP) for necrotic immature permanent teeth. Materials and Methods: A systematic review was conducted following the PRISMA 2020 guidelines. The literature search was performed in the PubMed/Medline, Scopus, Cochrane, Web of Science, and CINAHL databases, including articles published in English or Spanish between January 2015 and January 2025. Randomized controlled clinical trials (RCTs) were selected that compared REP using platelet concentrates (PRP or PRF) versus conventional BC in necrotic immature teeth, with a minimum clinical and radiographic follow-up of 12 months. The methodological quality of the included studies was assessed using the Cochrane Risk of Bias 2.0 (RoB 2.0) tool. A qualitative synthesis of the findings was performed. Results: A total of 11 RCTs meeting the inclusion criteria were selected. The analysis of these studies suggests that REP is an effective therapeutic alternative for necrotic immature permanent teeth, achieving high clinical and radiographic success rates regardless of the scaffold used. No statistically significant differences were found among PRP, PRF, and BC groups in clinical outcomes or in radiographic parameters of root development. Regarding study quality, 4 were rated as “low”, 5 as “moderate”, and 2 as “high” quality. Conclusions: The type of scaffold used - whether a platelet concentrate or conventional blood clot - does not appear to significantly influence the success rate of REP. While PRP and PRF are considered promising alternatives, they have not demonstrated consistent clinical advantages over blood clot, which remains a reliable, cost-effective, and easy-to-use scaffold in regenerative endodontics, with highly satisfactory outcomes comparable to those achieved with platelet concentrates.
Objectives: To evaluate and compare the effectiveness of autologous platelet concentrates (PRF, PRP) versus blood clot (BC) as intracanal scaffolds in regenerative endodontic procedures (REP) for necrotic immature permanent teeth. Materials and Methods: A systematic review was conducted following the PRISMA 2020 guidelines. The literature search was performed in the PubMed/Medline, Scopus, Cochrane, Web of Science, and CINAHL databases, including articles published in English or Spanish between January 2015 and January 2025. Randomized controlled clinical trials (RCTs) were selected that compared REP using platelet concentrates (PRP or PRF) versus conventional BC in necrotic immature teeth, with a minimum clinical and radiographic follow-up of 12 months. The methodological quality of the included studies was assessed using the Cochrane Risk of Bias 2.0 (RoB 2.0) tool. A qualitative synthesis of the findings was performed. Results: A total of 11 RCTs meeting the inclusion criteria were selected. The analysis of these studies suggests that REP is an effective therapeutic alternative for necrotic immature permanent teeth, achieving high clinical and radiographic success rates regardless of the scaffold used. No statistically significant differences were found among PRP, PRF, and BC groups in clinical outcomes or in radiographic parameters of root development. Regarding study quality, 4 were rated as “low”, 5 as “moderate”, and 2 as “high” quality. Conclusions: The type of scaffold used - whether a platelet concentrate or conventional blood clot - does not appear to significantly influence the success rate of REP. While PRP and PRF are considered promising alternatives, they have not demonstrated consistent clinical advantages over blood clot, which remains a reliable, cost-effective, and easy-to-use scaffold in regenerative endodontics, with highly satisfactory outcomes comparable to those achieved with platelet concentrates.
Direction
GARCIA VARELA, SANDRA (Tutorships)
Méndez Díaz, Ramón (Co-tutorships)
GARCIA VARELA, SANDRA (Tutorships)
Méndez Díaz, Ramón (Co-tutorships)
Court
GARCIA GARCIA, ABEL (Chairman)
LOPEZ CASTRO, GONZALO (Secretary)
GANDARA VILA, PILAR (Member)
GARCIA GARCIA, ABEL (Chairman)
LOPEZ CASTRO, GONZALO (Secretary)
GANDARA VILA, PILAR (Member)
Use of new molecules for off-label indications in pediatric dermatology.
Authorship
P.C.N.
Bachelor of Medicine
P.C.N.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
INTRODUCTION: An off-label drug is one that is prescribed for an unapproved indication, age group, dosage, or route of administration. In daily clinical practice, the lack of response to first-line therapies or the absence of treatment alternatives often leads to the use of drugs under these conditions. The specific characteristics of the pediatric and adolescent population result in a shortage of clinical trials and a greater use of off-label treatments in this group. OBJETIVE: To describe the new small molecules used for the treatment of dermatological diseases other than those indicated in the official drug label in children and adolescents. Secondarily, to identify the conditions for which they are used and assess their effectiveness and safety profile. METHODOLOGY: Comprehensive review of the literature of articles published in PubMed and Web of Science that included the use of new small molecules under off-label conditions in individuals under 18 years of age. RESULTS: A total of 34 articles were collected, providing information on 57 patients (mean age: 9 years; 52.6% female). The most frequently used small molecule was baricitinib (61.4%), followed by topical ruxolitinib and upadacitinib (14% each). The most common conditions treated with these drugs were dermatomyositis (43.9%) and alopecia areata (21%). In 25% of the patients, remission of the dermatosis was documented, 66.1% showed improvement, and 9% had no response. Five adverse events were reported among 32 patients with individualized data, none of them serious. CONCLUSIONS: The most frequently used small molecule under off-label conditions in the pediatric and adolescent population was baricitinib. Dermatomyositis and alopecia areata were the most commonly treated conditions. The majority of patients achieved remission or improvement of their dermatosis. Adverse events were infrequent and mild in nature.
INTRODUCTION: An off-label drug is one that is prescribed for an unapproved indication, age group, dosage, or route of administration. In daily clinical practice, the lack of response to first-line therapies or the absence of treatment alternatives often leads to the use of drugs under these conditions. The specific characteristics of the pediatric and adolescent population result in a shortage of clinical trials and a greater use of off-label treatments in this group. OBJETIVE: To describe the new small molecules used for the treatment of dermatological diseases other than those indicated in the official drug label in children and adolescents. Secondarily, to identify the conditions for which they are used and assess their effectiveness and safety profile. METHODOLOGY: Comprehensive review of the literature of articles published in PubMed and Web of Science that included the use of new small molecules under off-label conditions in individuals under 18 years of age. RESULTS: A total of 34 articles were collected, providing information on 57 patients (mean age: 9 years; 52.6% female). The most frequently used small molecule was baricitinib (61.4%), followed by topical ruxolitinib and upadacitinib (14% each). The most common conditions treated with these drugs were dermatomyositis (43.9%) and alopecia areata (21%). In 25% of the patients, remission of the dermatosis was documented, 66.1% showed improvement, and 9% had no response. Five adverse events were reported among 32 patients with individualized data, none of them serious. CONCLUSIONS: The most frequently used small molecule under off-label conditions in the pediatric and adolescent population was baricitinib. Dermatomyositis and alopecia areata were the most commonly treated conditions. The majority of patients achieved remission or improvement of their dermatosis. Adverse events were infrequent and mild in nature.
Direction
RODRIGUEZ BLANCO, MARIA ISABEL (Tutorships)
Batalla Cebey, Ana (Co-tutorships)
RODRIGUEZ BLANCO, MARIA ISABEL (Tutorships)
Batalla Cebey, Ana (Co-tutorships)
Court
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
Characteristics of palatine rugae in individuals with Down Syndrome
Authorship
E.M.C.D.
Grao en Odontología (2ªed)
E.M.C.D.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Introduction: Down syndrome (DS) is associated with various craniofacial and oral alterations, including changes in palatal morphology. Palatal rugae are unique anatomical structures, stable over time and useful in clinical and identification contexts. However, there are few studies that describe their characteristics in individuals with DS using three-dimensional digital tools. Objectives: 1) To analyze the morphological characteristics of palatal rugae in individuals with DS; 2) To compare quantitative and qualitative variables with a control group matched by age and sex; 3) To explore their clinical and biometric applicability through intraoral scans and 3D digital models. Material and methods: A total of 40 intraoral scans of the maxillary arch were analyzed, corresponding to 20 individuals with Down syndrome and 20 controls matched by age and sex. Measurements were performed linearly usig Meshmixer software 3.5, once the palatal rugae were delineated. Quantitative variables (number and length) and qualitative variables (shape, thickness, direction, and unification pattern) were assessed. Statistical analysis was conducted using Student’s t-tests and chi-square tests, with the level of significance set at p0,05. Results: No statistically significant differences were found in the quantitative variables. The mean total number of rugae was 10,5+-3,8 in the control group and 9,6+-3,5 in the DS group (p = 0,368). No significant differences were found in the linear length of the rugae either. However, the qualitative variables showed notable differences. In the DS group, a more heterogeneous distribution of shapes (curved, straight, and circular) was observed, whereas the wavy pattern predominated in the control group (p0,001). Thick rugae were more frequent in the DS group, especially among females, while thin rugae were more common in the control group (p0,001). Moreover, the unification pattern showed a higher proportion of unconnected rugae in the DS group compared to the control group (p0,001). Conclusions: Individuals with Down syndrome exhibit morphological differences in palatal rugae compared to subjects without genetic alterations, particularly in terms of shape, thickness, and unification. These findings suggest that palatal rugae could be considered useful anatomical structures for characterizing the palatal phenotype in this population, with potential clinical and research applications. However, the sample size and the inherent limitations of the classification system used highlight the need for future studies employing more advanced methodologies
Introduction: Down syndrome (DS) is associated with various craniofacial and oral alterations, including changes in palatal morphology. Palatal rugae are unique anatomical structures, stable over time and useful in clinical and identification contexts. However, there are few studies that describe their characteristics in individuals with DS using three-dimensional digital tools. Objectives: 1) To analyze the morphological characteristics of palatal rugae in individuals with DS; 2) To compare quantitative and qualitative variables with a control group matched by age and sex; 3) To explore their clinical and biometric applicability through intraoral scans and 3D digital models. Material and methods: A total of 40 intraoral scans of the maxillary arch were analyzed, corresponding to 20 individuals with Down syndrome and 20 controls matched by age and sex. Measurements were performed linearly usig Meshmixer software 3.5, once the palatal rugae were delineated. Quantitative variables (number and length) and qualitative variables (shape, thickness, direction, and unification pattern) were assessed. Statistical analysis was conducted using Student’s t-tests and chi-square tests, with the level of significance set at p0,05. Results: No statistically significant differences were found in the quantitative variables. The mean total number of rugae was 10,5+-3,8 in the control group and 9,6+-3,5 in the DS group (p = 0,368). No significant differences were found in the linear length of the rugae either. However, the qualitative variables showed notable differences. In the DS group, a more heterogeneous distribution of shapes (curved, straight, and circular) was observed, whereas the wavy pattern predominated in the control group (p0,001). Thick rugae were more frequent in the DS group, especially among females, while thin rugae were more common in the control group (p0,001). Moreover, the unification pattern showed a higher proportion of unconnected rugae in the DS group compared to the control group (p0,001). Conclusions: Individuals with Down syndrome exhibit morphological differences in palatal rugae compared to subjects without genetic alterations, particularly in terms of shape, thickness, and unification. These findings suggest that palatal rugae could be considered useful anatomical structures for characterizing the palatal phenotype in this population, with potential clinical and research applications. However, the sample size and the inherent limitations of the classification system used highlight the need for future studies employing more advanced methodologies
Direction
Diniz Freitas, Márcio (Tutorships)
Diniz Freitas, Márcio (Tutorships)
Risk of exocrine pancreatic insufficiency associated with the development of pancreatitis in patients with cystic fibrosis and diseases related to mutations of CFTR. A systematic review.
Authorship
C.C.B.
Bachelor of Medicine
C.C.B.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: Cystic fibrosis (CF) is a common autosomal recessive disease in the Caucasian population. It is caused by mutations in the CFTR gene, whose dysfunction alters chloride and bicarbonate transport in the exocrine glands, causing thick secretions that affect multiple organs. There are more than 2000 variants of the CFTR gene, which are classified into six classes according to their effect on the protein. The most severe mutations are associated with classic CF, while mild mutations can cause CFTR-related disorders (CFTR-RD), such as pancreatitis, bronchiectasis, or infertility. Clinically, CF is a multiorgan disease that primarily affects the respiratory and digestive systems, especially the pancreas. This context justifies the interest in studying the relationship between pancreatitis and EPI in patients with CF and CFTR mutations and exploring whether pancreatitis represents a risk factor for progressing to pancreatic insufficiency in this group of patients. Objectives: To conduct a systematic review of the published literature and assess the risk of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis and diseases associated with CFTR mutations and the development of pancreatitis. Methodology: A search of the PubMed and Web of Science databases was conducted using the PRISMA methodology, selecting studies published since 1998. Results: After initial screening and critical reading, a total of four retrospective observational studies were included, which evaluated the progression to EPI associated with pancreatitis. Conclusions: Pancreatitis is a prevalent complication in patients with cystic fibrosis who retain some exocrine pancreatic function. Available evidence indicates that recurrent pancreatic inflammation may contribute to a more rapid progression to exocrine pancreatic insufficiency (EPI), particularly in patients carrying CFTR gene mutations with lesser functional impact.
Introduction: Cystic fibrosis (CF) is a common autosomal recessive disease in the Caucasian population. It is caused by mutations in the CFTR gene, whose dysfunction alters chloride and bicarbonate transport in the exocrine glands, causing thick secretions that affect multiple organs. There are more than 2000 variants of the CFTR gene, which are classified into six classes according to their effect on the protein. The most severe mutations are associated with classic CF, while mild mutations can cause CFTR-related disorders (CFTR-RD), such as pancreatitis, bronchiectasis, or infertility. Clinically, CF is a multiorgan disease that primarily affects the respiratory and digestive systems, especially the pancreas. This context justifies the interest in studying the relationship between pancreatitis and EPI in patients with CF and CFTR mutations and exploring whether pancreatitis represents a risk factor for progressing to pancreatic insufficiency in this group of patients. Objectives: To conduct a systematic review of the published literature and assess the risk of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis and diseases associated with CFTR mutations and the development of pancreatitis. Methodology: A search of the PubMed and Web of Science databases was conducted using the PRISMA methodology, selecting studies published since 1998. Results: After initial screening and critical reading, a total of four retrospective observational studies were included, which evaluated the progression to EPI associated with pancreatitis. Conclusions: Pancreatitis is a prevalent complication in patients with cystic fibrosis who retain some exocrine pancreatic function. Available evidence indicates that recurrent pancreatic inflammation may contribute to a more rapid progression to exocrine pancreatic insufficiency (EPI), particularly in patients carrying CFTR gene mutations with lesser functional impact.
Direction
DOMINGUEZ MUÑOZ, JUAN ENRIQUE (Tutorships)
DOMINGUEZ MUÑOZ, JUAN ENRIQUE (Tutorships)
Court
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
Anxiety and depression disorders in women with polycystic ovary syndrome.
Authorship
M.C.S.
Bachelor of Medicine
M.C.S.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction and objective: In addition to its reproductive and metabolic manifestations, polycystic ovary syndrome (PCOS) is strongly associated with mood disorders, particularly depression and anxiety. The objective of this study was to review the latest scientific evidence to estimate the prevalence of these symptoms in women with PCOS and analyze their clinical and psychosocial impact. Material and method: A review of the latest scientific evidence was conducted, searching the PubMed and Scopus databases until May 2025. Fourteen studies published in English or Spanish that evaluated symptoms of anxiety and depression in women diagnosed with PCOS were selected. Data on design, population, psychological assessment instruments, and outcomes were extracted. Given the methodological heterogeneity, a narrative synthesis was performed rather than a meta-analysis. Results: Most of the reviewed studies reported a significantly higher prevalence of depression and anxiety in women with PCOS compared to healthy controls. Elevated stress levels and personality disorders were also documented. Obesity, infertility, low educational level, and marital status were found to modulate emotional risk. In adolescents, greater emotional vulnerability was found, related to body image, self-esteem, and social pressure. Conclusions: The present review confirms the association between PCOS and anxiety and depression disorders. The prevalence of depressive symptoms ranges from 16.3% to 75.6%, and that of anxiety symptoms from 10.2% to 67.85%. These psychological disorders remain underrecognized in daily clinical practice. The use of screening instruments such as the Hospital Anxiety and Depression Scale (HADS), the Patient Health Questionnaire (PHQ-9), or the Depression, Anxiety and Stress Scale (DASS-21) is necessary.
Introduction and objective: In addition to its reproductive and metabolic manifestations, polycystic ovary syndrome (PCOS) is strongly associated with mood disorders, particularly depression and anxiety. The objective of this study was to review the latest scientific evidence to estimate the prevalence of these symptoms in women with PCOS and analyze their clinical and psychosocial impact. Material and method: A review of the latest scientific evidence was conducted, searching the PubMed and Scopus databases until May 2025. Fourteen studies published in English or Spanish that evaluated symptoms of anxiety and depression in women diagnosed with PCOS were selected. Data on design, population, psychological assessment instruments, and outcomes were extracted. Given the methodological heterogeneity, a narrative synthesis was performed rather than a meta-analysis. Results: Most of the reviewed studies reported a significantly higher prevalence of depression and anxiety in women with PCOS compared to healthy controls. Elevated stress levels and personality disorders were also documented. Obesity, infertility, low educational level, and marital status were found to modulate emotional risk. In adolescents, greater emotional vulnerability was found, related to body image, self-esteem, and social pressure. Conclusions: The present review confirms the association between PCOS and anxiety and depression disorders. The prevalence of depressive symptoms ranges from 16.3% to 75.6%, and that of anxiety symptoms from 10.2% to 67.85%. These psychological disorders remain underrecognized in daily clinical practice. The use of screening instruments such as the Hospital Anxiety and Depression Scale (HADS), the Patient Health Questionnaire (PHQ-9), or the Depression, Anxiety and Stress Scale (DASS-21) is necessary.
Direction
VICENTE ALBA, FRANCISCO JAVIER (Tutorships)
VICENTE ALBA, FRANCISCO JAVIER (Tutorships)
Court
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
Dental pulp’s histological characterization: toward novel tools for stem cell therapy
Authorship
G.C.L.
Bachelor of Medicine
G.C.L.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Background: Stem cells are characterized by their capacity of self-renewal and differentiation. In recent years the scientific community has shown special interest in their study. Especially to find treatments for mainly chronic diseases, after demonstrating their curative properties through animal studies. These cells are distributed throughout the body, being the dental pulp one of the places where they inhabit. Objectives: This paper involves a bibliographic review about the possible therapeutic options offered by dental pulp stem cells, subsequently clarifying their dental location and describing their main microscopic characteristics. Detailing the advantages, detrimental consequences and challenges that would involve their clinical translation. Methodology: The bibliographic review was carried out in several phases. First, a research was made with textbooks and systematic reviews. The usage of a Boolean operator in various databases allowed to proceed with the main search in order to select the papers that met the inclusion criteria. Results: Dental pulp stem cells are ectomesenchymal cells that hold a great proliferation and differentiation capacity, especially towards the neural lineage. Its experimental testing on animals, such as rats and mice, has proven their effectiveness in treating several diseases; especially the ones involving the nervous system. Likewise, their ease of isolation and culture make them widely used in preclinical research, since there are no standardized methods that ensure their correct medical use. Conclusions: The healing effects of dental pulp stem cells are exerted by their ability to secrete molecules with proliferative, anti-apoptotic and immunomodulatory effect on host cells. Nonetheless, deeper research is required to characterize the molecular mechanisms underlying these effects.
Background: Stem cells are characterized by their capacity of self-renewal and differentiation. In recent years the scientific community has shown special interest in their study. Especially to find treatments for mainly chronic diseases, after demonstrating their curative properties through animal studies. These cells are distributed throughout the body, being the dental pulp one of the places where they inhabit. Objectives: This paper involves a bibliographic review about the possible therapeutic options offered by dental pulp stem cells, subsequently clarifying their dental location and describing their main microscopic characteristics. Detailing the advantages, detrimental consequences and challenges that would involve their clinical translation. Methodology: The bibliographic review was carried out in several phases. First, a research was made with textbooks and systematic reviews. The usage of a Boolean operator in various databases allowed to proceed with the main search in order to select the papers that met the inclusion criteria. Results: Dental pulp stem cells are ectomesenchymal cells that hold a great proliferation and differentiation capacity, especially towards the neural lineage. Its experimental testing on animals, such as rats and mice, has proven their effectiveness in treating several diseases; especially the ones involving the nervous system. Likewise, their ease of isolation and culture make them widely used in preclinical research, since there are no standardized methods that ensure their correct medical use. Conclusions: The healing effects of dental pulp stem cells are exerted by their ability to secrete molecules with proliferative, anti-apoptotic and immunomodulatory effect on host cells. Nonetheless, deeper research is required to characterize the molecular mechanisms underlying these effects.
Direction
GARCIA-CABALLERO PEREZ, LUCIA (Tutorships)
GARCIA-CABALLERO PARADA, TOMAS M. M. (Co-tutorships)
FERREIROS LOPEZ, ALBA (Co-tutorships)
GARCIA-CABALLERO PEREZ, LUCIA (Tutorships)
GARCIA-CABALLERO PARADA, TOMAS M. M. (Co-tutorships)
FERREIROS LOPEZ, ALBA (Co-tutorships)
Court
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
Filicide and gender: a Medico-Legal analysis
Authorship
A.C.P.
Bachelor of Medicine
A.C.P.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
This study on filicide, the killing of a child by one or both parents has been conducted com-prehensively and with a gender-based perspective. Through a systematic literature review, analysis of judicial cases, and child abuse prevention protocols, the main motivations, offender profiles, behavioural patterns, and associated legal consequences are investigated. The fin-dings show clear differences between mothers and fathers: women tend to commit filicide for psychiatric or altruistic reasons and usually employ less violent methods, whereas men are mo-re likely to kill due to revenge or accident, often using more violent means. However, and in contrast with other Western countries, in Spain both sexes tend to receive similar legal penal-ties. The study also highlights the importance of early detection of risk factors within Primary Care, Obstetrics, and Mental Health, especially in contexts involving perinatal depression or suspected child abuse. Finally, it proposes preventive protocols including screening algorithms, mental health evaluations during the perinatal period, and professional awareness strategies. Filicide is a complex phenomenon that demands deeper understanding and further research in order to develop effective and consistent prevention strategies that address the root of the problem
This study on filicide, the killing of a child by one or both parents has been conducted com-prehensively and with a gender-based perspective. Through a systematic literature review, analysis of judicial cases, and child abuse prevention protocols, the main motivations, offender profiles, behavioural patterns, and associated legal consequences are investigated. The fin-dings show clear differences between mothers and fathers: women tend to commit filicide for psychiatric or altruistic reasons and usually employ less violent methods, whereas men are mo-re likely to kill due to revenge or accident, often using more violent means. However, and in contrast with other Western countries, in Spain both sexes tend to receive similar legal penal-ties. The study also highlights the importance of early detection of risk factors within Primary Care, Obstetrics, and Mental Health, especially in contexts involving perinatal depression or suspected child abuse. Finally, it proposes preventive protocols including screening algorithms, mental health evaluations during the perinatal period, and professional awareness strategies. Filicide is a complex phenomenon that demands deeper understanding and further research in order to develop effective and consistent prevention strategies that address the root of the problem
Direction
Rodriguez Calvo, Maria Sol (Tutorships)
Rodriguez Calvo, Maria Sol (Tutorships)
Court
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
Middle Aortic Syndrome in adults. Case report and literature review.
Authorship
S.D.L.
Bachelor of Medicine
S.D.L.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Background: Middle aorta syndrome (MSA) is a rare vascular entity characterized by segmental or diffuse narrowing of the distal or abdominal thoracic aorta, often involving visceral branches (celiac trunk, superior mesenteric artery, renal arteries and inferior mesenteric artery). This is 0.5-2% of aortic coarctations. This condition may be congenital (associated with genetic syndromes or problems in embryogenesis), idiopathic, acquired, and usually clinically manifested in childhood or adolescence with severe arterial hypertension, heart failure, intermittent claudication or symptoms of visceral ischemia. Objective: To present an update on the clinical picture, diagnosis and treatment by collecting and analyzing of the cases studied in adult patients. Method: A bibliographic search was performed in the databases (Pubmed, Cinahl/Medline and Web of Science) based on the PICO format and subsequently analyzed. Results: It is observed that affects more the female sex, the most frequent etiology is the idiopathic, the anatomical zone most affected is at the adrenal level and with involvement of visceral branches, the most frequent complications is refractory arterial hypertension followed by organ damage, the most used diagnostic approach is physical examination and CT-angiography and finally the treatment is usually combined: medical and open surgery (the latter being the most effective and definitive to cure the disease). Conclusion: AMS is a very rare adult disease, which despite existing diagnostic techniques and treatments follows this underdiagnosis, It is necessary for them to continue their research by opening up new early diagnostic fronts and new lines of definitive treatment.
Background: Middle aorta syndrome (MSA) is a rare vascular entity characterized by segmental or diffuse narrowing of the distal or abdominal thoracic aorta, often involving visceral branches (celiac trunk, superior mesenteric artery, renal arteries and inferior mesenteric artery). This is 0.5-2% of aortic coarctations. This condition may be congenital (associated with genetic syndromes or problems in embryogenesis), idiopathic, acquired, and usually clinically manifested in childhood or adolescence with severe arterial hypertension, heart failure, intermittent claudication or symptoms of visceral ischemia. Objective: To present an update on the clinical picture, diagnosis and treatment by collecting and analyzing of the cases studied in adult patients. Method: A bibliographic search was performed in the databases (Pubmed, Cinahl/Medline and Web of Science) based on the PICO format and subsequently analyzed. Results: It is observed that affects more the female sex, the most frequent etiology is the idiopathic, the anatomical zone most affected is at the adrenal level and with involvement of visceral branches, the most frequent complications is refractory arterial hypertension followed by organ damage, the most used diagnostic approach is physical examination and CT-angiography and finally the treatment is usually combined: medical and open surgery (the latter being the most effective and definitive to cure the disease). Conclusion: AMS is a very rare adult disease, which despite existing diagnostic techniques and treatments follows this underdiagnosis, It is necessary for them to continue their research by opening up new early diagnostic fronts and new lines of definitive treatment.
Direction
Fernández González, Angel Luis (Tutorships)
Fernández González, Angel Luis (Tutorships)
Court
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
Gene therapy experience in spinal muscular atrophy (Systematic review)
Authorship
C.E.F.
Bachelor of Medicine
C.E.F.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Spinal Muscular Atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by the progressive degeneration of lower motor neurons, resulting in symmetrical and increasing muscle weakness, associated with high morbidity and mortality in early ages. In recent years, the development of targeted therapies, such as gene therapy, has brought a radical change in the clinical management of the disease, promoting its inclusion in neonatal screening programs. The aim of this work is to conduct a systematic review of the literature published between 2015 and 2024, focusing on the efficacy, efficiency, and tolerability of gene therapy in patients with SMA. The currently available treatments (Nusinersen, Risdiplam, and Onasemnogene Abeparvovec) and their impact on clinical progression were analyzed, with special attention to administration during presymptomatic stages.
Spinal Muscular Atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by the progressive degeneration of lower motor neurons, resulting in symmetrical and increasing muscle weakness, associated with high morbidity and mortality in early ages. In recent years, the development of targeted therapies, such as gene therapy, has brought a radical change in the clinical management of the disease, promoting its inclusion in neonatal screening programs. The aim of this work is to conduct a systematic review of the literature published between 2015 and 2024, focusing on the efficacy, efficiency, and tolerability of gene therapy in patients with SMA. The currently available treatments (Nusinersen, Risdiplam, and Onasemnogene Abeparvovec) and their impact on clinical progression were analyzed, with special attention to administration during presymptomatic stages.
Direction
BLANCO BARCA, MANUEL OSCAR (Tutorships)
Melcón Crespo, Cristina (Co-tutorships)
BLANCO BARCA, MANUEL OSCAR (Tutorships)
Melcón Crespo, Cristina (Co-tutorships)
Court
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
Systematic review on the therapeutic potential of cannabidiol (CBD) in the treatment of psychosis
Authorship
A.E.M.
Bachelor of Medicine
A.E.M.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
The aim of this study is to conduct a systematic review on the therapeutic potential of cannabidiol (CBD) in the management of psychosis, following the PRISMA methodology. Psychosis is a severe psychiatric disorder affecting approximately 1% of the global population, characterized by hallucinations, delusions, and thought disturbances. This review focuses on the analysis of 20 studies published from 2020 to 2024, evaluating the effects of CBD on both positive and negative symptoms of psychosis in comparison to traditional antipsychotic treatments. The reviewed studies suggest that CBD has a favorable safety profile and may reduce the side effects associated with conventional antipsychotic treatments. Furthermore, CBD’s interaction with the endocannabinoid system positions it as a promising alternative for patients who do not adequately respond to current treatments. While preliminary results are encouraging, further research is needed to confirm these findings. In conclusion, CBD presents significant therapeutic potential, and its role in the treatment of psychosis warrants continued investigation.
The aim of this study is to conduct a systematic review on the therapeutic potential of cannabidiol (CBD) in the management of psychosis, following the PRISMA methodology. Psychosis is a severe psychiatric disorder affecting approximately 1% of the global population, characterized by hallucinations, delusions, and thought disturbances. This review focuses on the analysis of 20 studies published from 2020 to 2024, evaluating the effects of CBD on both positive and negative symptoms of psychosis in comparison to traditional antipsychotic treatments. The reviewed studies suggest that CBD has a favorable safety profile and may reduce the side effects associated with conventional antipsychotic treatments. Furthermore, CBD’s interaction with the endocannabinoid system positions it as a promising alternative for patients who do not adequately respond to current treatments. While preliminary results are encouraging, further research is needed to confirm these findings. In conclusion, CBD presents significant therapeutic potential, and its role in the treatment of psychosis warrants continued investigation.
Direction
ARROJO ROMERO, MANUEL (Tutorships)
Veiga Ramos, Iria (Co-tutorships)
ARROJO ROMERO, MANUEL (Tutorships)
Veiga Ramos, Iria (Co-tutorships)
Court
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
P0lycystic ovary syndrome and gynecological cancers. A systematic review.
Authorship
A.F.A.
Bachelor of Medicine
A.F.A.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: Polycystic ovary syndrome is the most common endocrine-metabolic disorder in women of reproductive age. It is characterized by excess androgens, ovulatory dysfunction, and ovaries with a polycystic appearance on ultrasound. Multiple studies have suggested that PCOS may increase the risk of certain gynecological cancers, especially endometrial, ovarian, and breast cancers. However, in some cases, the results are contradictory. Objective: To analyze whether polycystic ovary syndrome is associated with an increased risk of developing gynecological cancers (endometrium, ovaries, breast, cervix, vagina, and vulva). Methodology: A systematic search was conducted in the MEDLINE, Scopus, and Web of Science databases to identify observational cohort and case-control studies investigating the relationship between PCOS and various gynecological cancers published between 2003 and 2025. Results: After the selection period, 9 studies were finally included in the review: 7 cohort studies and 2 case-control studies. Of these, 5 studied the relationship between PCOS and endometrial cancer, 3 focused on ovarian cancer, 5 on breast cancer, and only 1 study investigated the association between the syndrome and cervical cancer. Conclusions: The findings suggest that women with PCOS are at increased risk of developing endometrial cancer, especially premenopausal women. Overall, the association between the syndrome and ovarian and breast cancer is more inconclusive and may be influenced by menopausal status. There is insufficient evidence to study the relationship between PCOS and other gynecological malignancies, probably due to the lack of common causal mechanisms. More prospective studies with adequate follow-up periods and adjustment for confounding factors are needed to draw more solid conclusions.
Introduction: Polycystic ovary syndrome is the most common endocrine-metabolic disorder in women of reproductive age. It is characterized by excess androgens, ovulatory dysfunction, and ovaries with a polycystic appearance on ultrasound. Multiple studies have suggested that PCOS may increase the risk of certain gynecological cancers, especially endometrial, ovarian, and breast cancers. However, in some cases, the results are contradictory. Objective: To analyze whether polycystic ovary syndrome is associated with an increased risk of developing gynecological cancers (endometrium, ovaries, breast, cervix, vagina, and vulva). Methodology: A systematic search was conducted in the MEDLINE, Scopus, and Web of Science databases to identify observational cohort and case-control studies investigating the relationship between PCOS and various gynecological cancers published between 2003 and 2025. Results: After the selection period, 9 studies were finally included in the review: 7 cohort studies and 2 case-control studies. Of these, 5 studied the relationship between PCOS and endometrial cancer, 3 focused on ovarian cancer, 5 on breast cancer, and only 1 study investigated the association between the syndrome and cervical cancer. Conclusions: The findings suggest that women with PCOS are at increased risk of developing endometrial cancer, especially premenopausal women. Overall, the association between the syndrome and ovarian and breast cancer is more inconclusive and may be influenced by menopausal status. There is insufficient evidence to study the relationship between PCOS and other gynecological malignancies, probably due to the lack of common causal mechanisms. More prospective studies with adequate follow-up periods and adjustment for confounding factors are needed to draw more solid conclusions.
Direction
SAMPAYO MONTENEGRO, MARIA VICTORIA (Tutorships)
Turrado Sánchez, Elena María (Co-tutorships)
SAMPAYO MONTENEGRO, MARIA VICTORIA (Tutorships)
Turrado Sánchez, Elena María (Co-tutorships)
Court
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
FRAGA RODRIGUEZ, MAXIMO FRANCISCO (Chairman)
ARROJO ROMERO, MANUEL (Secretary)
SÁNCHEZ SELLERO, INÉS (Member)
Implications of Hepatitis B During Pregnancy and Childbirth.
Authorship
M.D.F.S.
Bachelor of Medicine
M.D.F.S.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: Hepatitis B is a globally prevalent viral infection with a significant risk of vertical transmission during pregnancy and childbirth. Pregnant women infected with the hepatitis B virus (HBV), particularly those with high viral load or HBeAg positivity, are at increased risk of transmitting the infection to their infants. Without preventive measures, up to 90% of infected newborns may develop chronic infection. The combined approach of prenatal screening, maternal antiviral treatment, and neonatal prophylaxis has proven highly effective, although implementation varies across healthcare and social settings. Method: A systematic review of scientific literature was conducted to evaluate the effectiveness of current strategies to prevent mother-to-child transmission of HBV. Searches were performed in PubMed and the Cochrane Library, including studies published between 2018 and 2024. Selected articles included clinical trials, observational studies, and systematic reviews focusing on prenatal screening, third-trimester administration of tenofovir disoproxil fumarate (TDF), and neonatal immunoprophylaxis with vaccine and hepatitis B immunoglobulin. Results: Available evidence strongly supports the efficacy of TDF during the third trimester in women with high viral load, combined with early neonatal immunization, in significantly reducing vertical transmission of HBV. These interventions have been shown to be safe for both mother and infant. However, substantial barriers were identified in access to care, especially among migrant populations or those without adequate prenatal follow-up, which negatively impacts the equitable implementation of these strategies. Conclusions: Combined interventions, prenatal screening, maternal antiviral therapy, and neonatal immunoprophylaxis, are effective and safe measures for preventing perinatal HBV transmission and should be integrated as standard care within maternal and child health programs. Nevertheless, further efforts are needed to ensure equitable access and universal application, particularly in vulnerable populations. Future research should focus on alternative therapies and improving postnatal follow-up models.
Introduction: Hepatitis B is a globally prevalent viral infection with a significant risk of vertical transmission during pregnancy and childbirth. Pregnant women infected with the hepatitis B virus (HBV), particularly those with high viral load or HBeAg positivity, are at increased risk of transmitting the infection to their infants. Without preventive measures, up to 90% of infected newborns may develop chronic infection. The combined approach of prenatal screening, maternal antiviral treatment, and neonatal prophylaxis has proven highly effective, although implementation varies across healthcare and social settings. Method: A systematic review of scientific literature was conducted to evaluate the effectiveness of current strategies to prevent mother-to-child transmission of HBV. Searches were performed in PubMed and the Cochrane Library, including studies published between 2018 and 2024. Selected articles included clinical trials, observational studies, and systematic reviews focusing on prenatal screening, third-trimester administration of tenofovir disoproxil fumarate (TDF), and neonatal immunoprophylaxis with vaccine and hepatitis B immunoglobulin. Results: Available evidence strongly supports the efficacy of TDF during the third trimester in women with high viral load, combined with early neonatal immunization, in significantly reducing vertical transmission of HBV. These interventions have been shown to be safe for both mother and infant. However, substantial barriers were identified in access to care, especially among migrant populations or those without adequate prenatal follow-up, which negatively impacts the equitable implementation of these strategies. Conclusions: Combined interventions, prenatal screening, maternal antiviral therapy, and neonatal immunoprophylaxis, are effective and safe measures for preventing perinatal HBV transmission and should be integrated as standard care within maternal and child health programs. Nevertheless, further efforts are needed to ensure equitable access and universal application, particularly in vulnerable populations. Future research should focus on alternative therapies and improving postnatal follow-up models.
Direction
MORANO AMADO, LUIS ENRIQUE (Tutorships)
González Rodríguez, Laura (Co-tutorships)
MORANO AMADO, LUIS ENRIQUE (Tutorships)
González Rodríguez, Laura (Co-tutorships)
Court
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
Oral hygiene in individuals with Autism Spectrum Disorder: an analysis of potentially determining factors.
Authorship
N.F.R.
Grao en Odontología (2ªed)
N.F.R.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition of unknown aetiology that primarily affects social communication and behavioural flexibility. It has been suggested that individuals with ASD are exposed to numerous risk factors associated with the development of dental caries, yet there is limited solid evidence on the impact of behavioural factors on oral health status. The objective of this study was to analyze whether oral hygiene is compromised in these patients depending on the severity of the disorder. Methods: This study was conducted between 2023 and 2024 at the Santiago de Compostela site of ASPANAES (Association of Parents of Individuals with Autism Spectrum Disorder). For each participant, demographic variables (Age, Sex, Type of Schooling), DSM V variables (level of Social Communication an Behavioural Severity), and Sensory Profile (Registration, Seeking, Sensitivity and Avoiding) were recorded. In addition, dental calculus and plaque accumulation were quantified and the Simplified Oral Hygiene Index (OHIS) was determined. Results: The study group consisted of 68 participants with ASD, 44 males and 24 females, aged between 6 and 55 years. The mean calculus accumulation was 1.86 more less 1.73, mean plaque accumulation was 6.54 more less 2.32, and the mean OHIS was 1.39 more less 0.58. Age was positively correlated with calculus (p less than 0,001), but not with plaque. Sex, Social Communication level, and Behavioural Severity level did not influence either calculus or plaque. Participants with Partial Schooling had lower levels of calculus and plaque than those with Full Schooling (p less than 0.001). None of the Sensory Profile components were significantly correlated with plaque. Conclusion: The level of oral hygiene in individuals with ASD is not related to the severity of the disorder.
Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition of unknown aetiology that primarily affects social communication and behavioural flexibility. It has been suggested that individuals with ASD are exposed to numerous risk factors associated with the development of dental caries, yet there is limited solid evidence on the impact of behavioural factors on oral health status. The objective of this study was to analyze whether oral hygiene is compromised in these patients depending on the severity of the disorder. Methods: This study was conducted between 2023 and 2024 at the Santiago de Compostela site of ASPANAES (Association of Parents of Individuals with Autism Spectrum Disorder). For each participant, demographic variables (Age, Sex, Type of Schooling), DSM V variables (level of Social Communication an Behavioural Severity), and Sensory Profile (Registration, Seeking, Sensitivity and Avoiding) were recorded. In addition, dental calculus and plaque accumulation were quantified and the Simplified Oral Hygiene Index (OHIS) was determined. Results: The study group consisted of 68 participants with ASD, 44 males and 24 females, aged between 6 and 55 years. The mean calculus accumulation was 1.86 more less 1.73, mean plaque accumulation was 6.54 more less 2.32, and the mean OHIS was 1.39 more less 0.58. Age was positively correlated with calculus (p less than 0,001), but not with plaque. Sex, Social Communication level, and Behavioural Severity level did not influence either calculus or plaque. Participants with Partial Schooling had lower levels of calculus and plaque than those with Full Schooling (p less than 0.001). None of the Sensory Profile components were significantly correlated with plaque. Conclusion: The level of oral hygiene in individuals with ASD is not related to the severity of the disorder.
Direction
Limeres Posse, Jacobo (Tutorships)
Limeres Posse, Jacobo (Tutorships)
Court
GARCIA GARCIA, ABEL (Chairman)
LOPEZ CASTRO, GONZALO (Secretary)
GANDARA VILA, PILAR (Member)
GARCIA GARCIA, ABEL (Chairman)
LOPEZ CASTRO, GONZALO (Secretary)
GANDARA VILA, PILAR (Member)
Utility of Point-of-Care Ultrasound in the emergency management of musculoskeletal conditions
Authorship
T.M.G.A.
Bachelor of Medicine
T.M.G.A.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
INTRODUCTION: Point-of-care ultrasound (PoCUS) has gained an increasingly important role in Emergency Medicine, both in hospital (ED) and prehospital settings, establishing itself as an accessible, fast, and versatile diagnostic tool. Its application in the musculoskeletal (MSK) field remains non-standardized, leading to variability between institutions and professionals and limiting its full potential. OBJECTIVES: To critically evaluate the usefulness of PoCUS in the urgent management of musculoskeletal conditions. Secondary objectives include examining the various MSK injuries that lead to ED visits, comparing PoCUS with other imaging modalities (X-ray, CT, MRI) in the acute management of these conditions, and analyzing both the advantages and limitations of this technique, as well as its applicability across different care settings. METHODS: A systematic review of the scientific literature was conducted across three databases to identify and synthesize the available evidence, including articles published within the last 10 years that compared ultrasound performed by emergency physicians with that performed by radiologists and with other imaging techniques. RESULTS: Five publications met the inclusion criteria. PoCUS showed, for suspected fracture diagnosis in general, a sensitivity of 0.91 and specificity of 0.94; for upper limb fractures Sn 0.93 and Sp 0.92; lower limb Sn 0.82 and Sp 0.93; LBFs Sn 0.9 and Sp 0.94. Success rates for long bone fracture reduction reached 100%. Clavicle, distal forearm, metacarpal, and skull fractures showed Sn and Sp greater than 90%. For shoulder dislocation diagnosis, PoCUS achieved Sn 100% and Sp 100%, and for associated fractures Sn 0.97 and Sp 0.99. CONCLUSIONS: The performance of PoCUS in musculoskeletal pathology appears promising, although further evidence is needed to rigorously assess its effectiveness according to anatomical region, methodology used, and operator training.
INTRODUCTION: Point-of-care ultrasound (PoCUS) has gained an increasingly important role in Emergency Medicine, both in hospital (ED) and prehospital settings, establishing itself as an accessible, fast, and versatile diagnostic tool. Its application in the musculoskeletal (MSK) field remains non-standardized, leading to variability between institutions and professionals and limiting its full potential. OBJECTIVES: To critically evaluate the usefulness of PoCUS in the urgent management of musculoskeletal conditions. Secondary objectives include examining the various MSK injuries that lead to ED visits, comparing PoCUS with other imaging modalities (X-ray, CT, MRI) in the acute management of these conditions, and analyzing both the advantages and limitations of this technique, as well as its applicability across different care settings. METHODS: A systematic review of the scientific literature was conducted across three databases to identify and synthesize the available evidence, including articles published within the last 10 years that compared ultrasound performed by emergency physicians with that performed by radiologists and with other imaging techniques. RESULTS: Five publications met the inclusion criteria. PoCUS showed, for suspected fracture diagnosis in general, a sensitivity of 0.91 and specificity of 0.94; for upper limb fractures Sn 0.93 and Sp 0.92; lower limb Sn 0.82 and Sp 0.93; LBFs Sn 0.9 and Sp 0.94. Success rates for long bone fracture reduction reached 100%. Clavicle, distal forearm, metacarpal, and skull fractures showed Sn and Sp greater than 90%. For shoulder dislocation diagnosis, PoCUS achieved Sn 100% and Sp 100%, and for associated fractures Sn 0.97 and Sp 0.99. CONCLUSIONS: The performance of PoCUS in musculoskeletal pathology appears promising, although further evidence is needed to rigorously assess its effectiveness according to anatomical region, methodology used, and operator training.
Direction
SANCHEZ SANTOS, RAQUEL (Tutorships)
Pichel Loureiro, Ángel (Co-tutorships)
Maza Vera, María Teresa (Co-tutorships)
SANCHEZ SANTOS, RAQUEL (Tutorships)
Pichel Loureiro, Ángel (Co-tutorships)
Maza Vera, María Teresa (Co-tutorships)
Court
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
Comparative Efficacy of Biological Versus Conventional Treatments in Severe Pediatric Asthma: A Systematic Review
Authorship
G.G.B.
Bachelor of Medicine
G.G.B.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Severe pediatric asthma represents a major public health challenge due to its impact on the quality of life of affected children and their families. Although conventional treatments, based on inhaled corticosteroids and bronchodilators, have improved asthma control in mild and moderate forms, they show significant limitations in severe cases. The development of biological therapies targeting specific immunological pathways, such as omalizumab, mepolizumab, dupilumab, and tezepelumab, has marked a relevant advancement in the management of severe pediatric asthma. This work presents a systematic review of the literature published between 2019 and 2025, evaluating the efficacy, safety, and role of biomarkers in the selection of biological treatments. Results show that biological therapies significantly reduce exacerbations, improve lung function and quality of life, and decrease systemic corticosteroid use. The need to move towards personalized medicine and improve equitable access to these therapies in clinical practice is emphasized.
Severe pediatric asthma represents a major public health challenge due to its impact on the quality of life of affected children and their families. Although conventional treatments, based on inhaled corticosteroids and bronchodilators, have improved asthma control in mild and moderate forms, they show significant limitations in severe cases. The development of biological therapies targeting specific immunological pathways, such as omalizumab, mepolizumab, dupilumab, and tezepelumab, has marked a relevant advancement in the management of severe pediatric asthma. This work presents a systematic review of the literature published between 2019 and 2025, evaluating the efficacy, safety, and role of biomarkers in the selection of biological treatments. Results show that biological therapies significantly reduce exacerbations, improve lung function and quality of life, and decrease systemic corticosteroid use. The need to move towards personalized medicine and improve equitable access to these therapies in clinical practice is emphasized.
Direction
BLANCO BARCA, MANUEL OSCAR (Tutorships)
Pereiro Fernández, Sara (Co-tutorships)
Arosa Sineiro, Claudia (Co-tutorships)
BLANCO BARCA, MANUEL OSCAR (Tutorships)
Pereiro Fernández, Sara (Co-tutorships)
Arosa Sineiro, Claudia (Co-tutorships)
Court
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
Ocular manifestations in celiac disease.
Authorship
N.G.C.
Bachelor of Medicine
N.G.C.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Context: Celiac disease (CD) is a condition characterized by an immune-mediated intolerance to dietary gluten. It has a worldwide prevalence of approximately 1% and an increasing incidence. Among its extraintestinal manifestations, some of the most disabling are ophthalmological. Objectives: To collect and analyze the evidence on ophthalmological manifestations in celiac disease, as well as to determine the benefits derived from the gluten-free diet (GFD) treatment and the replacement of deficiencies associated with intestinal dysfunction. Methodology: A systematic review of literature published in Spanish and English since 2015 on ocular involvement in celiac disease was conducted, following the PRISMA guidelines, using PubMed, Scopus, and WoS as bibliographic databases. Results: 25 articles were included in this review. The analyzed literature showed that celiac disease can affect all parts of the eye (conjunctiva, uvea, cornea, lens, retina) with manifestations such as keratomalacia induced by vitamin A deficiency, dry eye, uveitis, juxtafoveal telangiectasia, neuropathic corneal pain, cataract, nyctalopia, and retinopathy. Most of these manifestations respond well to a gluten-free diet and supplementation to correct nutritional imbalances associated with digestive involvement in celiac disease. Conclusions: This review confirms ocular involvement as one of the main extraintestinal manifestations in celiac disease and reaffirms the importance of multidisciplinary study and follow-up in systemic diseases, aiming to detect and timely treat ophthalmological manifestations. Dietary treatment and supplementation are key both to prevent the onset of celiac-related ophthalmopathy and to halt its progression.
Context: Celiac disease (CD) is a condition characterized by an immune-mediated intolerance to dietary gluten. It has a worldwide prevalence of approximately 1% and an increasing incidence. Among its extraintestinal manifestations, some of the most disabling are ophthalmological. Objectives: To collect and analyze the evidence on ophthalmological manifestations in celiac disease, as well as to determine the benefits derived from the gluten-free diet (GFD) treatment and the replacement of deficiencies associated with intestinal dysfunction. Methodology: A systematic review of literature published in Spanish and English since 2015 on ocular involvement in celiac disease was conducted, following the PRISMA guidelines, using PubMed, Scopus, and WoS as bibliographic databases. Results: 25 articles were included in this review. The analyzed literature showed that celiac disease can affect all parts of the eye (conjunctiva, uvea, cornea, lens, retina) with manifestations such as keratomalacia induced by vitamin A deficiency, dry eye, uveitis, juxtafoveal telangiectasia, neuropathic corneal pain, cataract, nyctalopia, and retinopathy. Most of these manifestations respond well to a gluten-free diet and supplementation to correct nutritional imbalances associated with digestive involvement in celiac disease. Conclusions: This review confirms ocular involvement as one of the main extraintestinal manifestations in celiac disease and reaffirms the importance of multidisciplinary study and follow-up in systemic diseases, aiming to detect and timely treat ophthalmological manifestations. Dietary treatment and supplementation are key both to prevent the onset of celiac-related ophthalmopathy and to halt its progression.
Direction
FREIRE-GARABAL NUÑEZ, MANUEL (Tutorships)
FREIRE-GARABAL NUÑEZ, MANUEL (Tutorships)
Court
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Clinical consequences on mental health of synthetic catinones’ consumption
Authorship
N.G.S.
Bachelor of Medicine
N.G.S.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: synthetic cathinones are a group of stimulant new psychoactive substances, with similar effects to those of cocaine, methamphetamine or 3,4-methylenedioxymethamphetamine (MDMA). They are sold under the name of “bath salts” in order to avoid their control, presenting themselves as “legal” alternatives to other recreational drugs. Objectives: the aim of this paper is to review the available scientific literature about the clinical effects of CS on mental health. Their mechanism of action, general adverse effects, association with psychosis and suicide, as well as the consumption epidemiology in Spain, are also reviewed. Methodology: following the PRISMA method, a search on the PubMed and Web of Science databases is carried out, including papers published between 2019 and 2024, focused on the CS consumption clinical outcomes, and in particular about the adverse effects on mental health. Results: 15 papers are obtained for this review, which describe the clinical effects of CS in general and of specific substances, as well as their association with suicide and substance-induced psychoses. This review was completed with other documents such as the ones published by UNODC, EUDA and OEDA. Conclusions: the main adverse effects of CS happen on a cardiovascular, neurological, and psychiatric level. The short term psychopathological adverse effects of CS consumption are: agitation, restlessness, anxiety, paranoid ideation, aggressivity, violence and insomnia. On the long term, CS can produce insomnia, depression, anxiety, paranoid ideation, psychosis, dependence and addiction.
Introduction: synthetic cathinones are a group of stimulant new psychoactive substances, with similar effects to those of cocaine, methamphetamine or 3,4-methylenedioxymethamphetamine (MDMA). They are sold under the name of “bath salts” in order to avoid their control, presenting themselves as “legal” alternatives to other recreational drugs. Objectives: the aim of this paper is to review the available scientific literature about the clinical effects of CS on mental health. Their mechanism of action, general adverse effects, association with psychosis and suicide, as well as the consumption epidemiology in Spain, are also reviewed. Methodology: following the PRISMA method, a search on the PubMed and Web of Science databases is carried out, including papers published between 2019 and 2024, focused on the CS consumption clinical outcomes, and in particular about the adverse effects on mental health. Results: 15 papers are obtained for this review, which describe the clinical effects of CS in general and of specific substances, as well as their association with suicide and substance-induced psychoses. This review was completed with other documents such as the ones published by UNODC, EUDA and OEDA. Conclusions: the main adverse effects of CS happen on a cardiovascular, neurological, and psychiatric level. The short term psychopathological adverse effects of CS consumption are: agitation, restlessness, anxiety, paranoid ideation, aggressivity, violence and insomnia. On the long term, CS can produce insomnia, depression, anxiety, paranoid ideation, psychosis, dependence and addiction.
Direction
SÁNCHEZ SELLERO, INÉS (Tutorships)
SÁNCHEZ SELLERO, INÉS (Tutorships)
Court
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
usefulness of surgical staging versus imaging studies of para-aortic lymph nodes in cervical cancer a systematic review
Authorship
N.G.F.
Bachelor of Medicine
N.G.F.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
CERVICAL CANCER IS A HIGHLY PREVALENT GYNECOLOGICAL CANCER THAT REQUIRES A RIGOROUS THERAPEUTIC APPROACH, WITH CHEMORADIOTHERAPY BEING THE STANDARD TREATMENT IN LOCALLY ADVANCED STAGES OR IN THE PRESENCE OF LYMPH NODE METASTASES. PROPER TREATMENT PLANNING LARGELY DEPENDS ON LYMPH NODE STAGING, PARTICULARLY OF THE PARA-AORTIC LYMPH NODES, WHOSE METASTATIC INVOLVEMENT DETERMINES THE LOCALLY ADMINISTERED RADIATION DOSE. THIS SYSTEMATIC REVIEW AIMS TO ASSESS THE AVAILABLE SCIENTIFIC EVIDENCE REGARDING THE COMPARATIVE USEFULNESS OF SURGICAL STAGING VERSUS IMAGING TECHNIQUES IN THE EVALUATION OF PARA-AORTIC LYMPH NODES FOR THE PLANNING OF CHEMORADIOTHERAPY TREATMENT. THE ANALYSIS OF THE REVIEWED STUDIES SHOWS THAT SURGICAL REMOVAL OF LYMPH NODES ALLOWS THE DETECTION OF BETWEEN 8 AND 44 PERCENT OF METASTASES NOT IDENTIFIED BY IMAGING STUDIES. HOWEVER, MOST STUDIES DID NOT FIND SIGNIFICANT DIFFERENCES IN OVERALL SURVIVAL OR DISEASE FREE SURVIVAL BETWEEN PATIENTS STAGED SURGICALLY AND THOSE EVALUATED THROUGH IMAGING TECHNIQUES. THE COMBINED ANALYSIS OF THESE STUDIES HIGHLIGHTS THE NEED FOR SPECIFICALLY DESIGNED RESEARCH TO COMPARE BOTH TECHNIQUES AND TO GUIDE THE SELECTION OF THE MOST APPROPRIATE STAGING METHOD
CERVICAL CANCER IS A HIGHLY PREVALENT GYNECOLOGICAL CANCER THAT REQUIRES A RIGOROUS THERAPEUTIC APPROACH, WITH CHEMORADIOTHERAPY BEING THE STANDARD TREATMENT IN LOCALLY ADVANCED STAGES OR IN THE PRESENCE OF LYMPH NODE METASTASES. PROPER TREATMENT PLANNING LARGELY DEPENDS ON LYMPH NODE STAGING, PARTICULARLY OF THE PARA-AORTIC LYMPH NODES, WHOSE METASTATIC INVOLVEMENT DETERMINES THE LOCALLY ADMINISTERED RADIATION DOSE. THIS SYSTEMATIC REVIEW AIMS TO ASSESS THE AVAILABLE SCIENTIFIC EVIDENCE REGARDING THE COMPARATIVE USEFULNESS OF SURGICAL STAGING VERSUS IMAGING TECHNIQUES IN THE EVALUATION OF PARA-AORTIC LYMPH NODES FOR THE PLANNING OF CHEMORADIOTHERAPY TREATMENT. THE ANALYSIS OF THE REVIEWED STUDIES SHOWS THAT SURGICAL REMOVAL OF LYMPH NODES ALLOWS THE DETECTION OF BETWEEN 8 AND 44 PERCENT OF METASTASES NOT IDENTIFIED BY IMAGING STUDIES. HOWEVER, MOST STUDIES DID NOT FIND SIGNIFICANT DIFFERENCES IN OVERALL SURVIVAL OR DISEASE FREE SURVIVAL BETWEEN PATIENTS STAGED SURGICALLY AND THOSE EVALUATED THROUGH IMAGING TECHNIQUES. THE COMBINED ANALYSIS OF THESE STUDIES HIGHLIGHTS THE NEED FOR SPECIFICALLY DESIGNED RESEARCH TO COMPARE BOTH TECHNIQUES AND TO GUIDE THE SELECTION OF THE MOST APPROPRIATE STAGING METHOD
Direction
ARIAS BALTAR, MARIA EFIGENIA (Tutorships)
Yáñez Madriñán, Sara (Co-tutorships)
ARIAS BALTAR, MARIA EFIGENIA (Tutorships)
Yáñez Madriñán, Sara (Co-tutorships)
Court
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
Long-Term Antiretroviral Treatment: Current Situation and Near Future
Authorship
S.G.O.
Bachelor of Medicine
S.G.O.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Long-acting antiretroviral therapy (LD-ART) is presented as an innovative alternative compared to daily oral treatments in the management of HIV. Spaced administration via injectable or subcutaneous formulations offers clinical and psychosocial advantages, especially in populations with adherence problems. This study examines its effect in terms of virological efficacy, safety, patient satisfaction and health viability. The objectives are to critically examine the recent scientific evidence on LD-ART, assessing its efficacy, safety profile, level of patient acceptance, and its use in both HIV treatment and prophylaxis. Likewise, it seeks to explore its role in therapeutic simplification and health equity.
Long-acting antiretroviral therapy (LD-ART) is presented as an innovative alternative compared to daily oral treatments in the management of HIV. Spaced administration via injectable or subcutaneous formulations offers clinical and psychosocial advantages, especially in populations with adherence problems. This study examines its effect in terms of virological efficacy, safety, patient satisfaction and health viability. The objectives are to critically examine the recent scientific evidence on LD-ART, assessing its efficacy, safety profile, level of patient acceptance, and its use in both HIV treatment and prophylaxis. Likewise, it seeks to explore its role in therapeutic simplification and health equity.
Direction
Antela López, Antonio Rafael (Tutorships)
Antela López, Antonio Rafael (Tutorships)
Court
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
Management of Endo-Periodontal Lesions: A Literature Review.
Authorship
S.D.V.H.F.
Grao en Odontología (2ªed)
S.D.V.H.F.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Introduction: Endo-periodontal lesions (EPL) are combined pathologies that simultaneously affect the pulp and periodontal tissues, which are interconnected through anatomical and, in some cases, pathological pathways. This close relationship complicates both diagnosis and treatment, requiring an interdisciplinary clinical approach. In recent years, various classifications and therapeutic protocols have been proposed, but no clear consensus has been reached regarding optimal management. Objective: to analyze current therapeutic strategies for managing EPL and assess their clinical effectiveness and prognosis. Material and methods: A literature review was conducted using the Pubme dans Scopus databases (2014-2024). A total of 17 articles published in English were included, selected for their clinical relevance and methodological quality. The search strategy combined free-text keywords related to the diagnosis, treatment and prognosis of EPL. Results: Show that both sequential and simultaneous treatments improve clinical parameters. However, initiating therapy with endodontic treatment may offer better control of the initial infection. Regenerative techniques, such as guided tissue regeneration (GTR), have shown added benefits in selected cases. Prognosis depends on factors such as the extent of the lesion, periodontal condition, treatment response and patient compliance. Conclusion: management of EPL requires an accurate diagnosis, individualized therapeutic planning and coordinated care between dental specialists. While several effective approaches are available, further clinical research is needed to standardize treatment protocols and improve long-term outcomes.
Introduction: Endo-periodontal lesions (EPL) are combined pathologies that simultaneously affect the pulp and periodontal tissues, which are interconnected through anatomical and, in some cases, pathological pathways. This close relationship complicates both diagnosis and treatment, requiring an interdisciplinary clinical approach. In recent years, various classifications and therapeutic protocols have been proposed, but no clear consensus has been reached regarding optimal management. Objective: to analyze current therapeutic strategies for managing EPL and assess their clinical effectiveness and prognosis. Material and methods: A literature review was conducted using the Pubme dans Scopus databases (2014-2024). A total of 17 articles published in English were included, selected for their clinical relevance and methodological quality. The search strategy combined free-text keywords related to the diagnosis, treatment and prognosis of EPL. Results: Show that both sequential and simultaneous treatments improve clinical parameters. However, initiating therapy with endodontic treatment may offer better control of the initial infection. Regenerative techniques, such as guided tissue regeneration (GTR), have shown added benefits in selected cases. Prognosis depends on factors such as the extent of the lesion, periodontal condition, treatment response and patient compliance. Conclusion: management of EPL requires an accurate diagnosis, individualized therapeutic planning and coordinated care between dental specialists. While several effective approaches are available, further clinical research is needed to standardize treatment protocols and improve long-term outcomes.
Direction
GARCIA VARELA, SANDRA (Tutorships)
MIGUENS VILA, RAMON (Co-tutorships)
GARCIA VARELA, SANDRA (Tutorships)
MIGUENS VILA, RAMON (Co-tutorships)
Court
SEOANE LESTON, JUAN MANUEL (Chairman)
ABELEIRA PAZOS, MARIA TERESA (Secretary)
Pérez-Sayáns García, Mario (Member)
SEOANE LESTON, JUAN MANUEL (Chairman)
ABELEIRA PAZOS, MARIA TERESA (Secretary)
Pérez-Sayáns García, Mario (Member)
Impact of Multireality in the Dental Clinic.
Authorship
L.H.I.
Grao en Odontología (2ªed)
L.H.I.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Introduction: The integration of emerging technologies such as mixed reality (MR) into the clinical setting is transforming modern dentistry. This paper evaluates the impact of MRI, specifically through the use of the HoloLens 2 headset, on two key phases of the digital dental workflow: intraoral scanning (ARIOS) and the three dimensional visualization of CBCTs, radiographs, and STL models during surgical procedures. Objectives: To evaluate the feasibility, clinical utility, and ergonomic benefits of using MRI in dentistry, combining ARIOS with three dimensional visualization during surgical procedures. It also aimed to identify the current technological advantages and limitations compared to the available scientific evidence. Materials and methods: A systematic literature review was conducted according to the PRISMA criteria, complemented by a pilot clinical experience in a real life dental setting. Two case studies were implemented: one for intraoral scanning with real time holographic visualization of the model, and another for the three-dimensional visualization of CBCT and STL models during implant surgery. Variables such as ergonomics, visual interaction, clinical efficiency, and teaching utility were evaluated. Conclusion: Although current scientific evidence is still limited, the results of this study show significant improvements in ergonomics, visual continuity, and operator experience thanks to holographic projection in the operating room. The implemented connection methodology (without the need for intermediate software or programming) represents an advance compared to previous studies. This work offers promising preliminary data on the feasibility of MRI in clinical and teaching dentistry, proposing a suitable path for future integration.
Introduction: The integration of emerging technologies such as mixed reality (MR) into the clinical setting is transforming modern dentistry. This paper evaluates the impact of MRI, specifically through the use of the HoloLens 2 headset, on two key phases of the digital dental workflow: intraoral scanning (ARIOS) and the three dimensional visualization of CBCTs, radiographs, and STL models during surgical procedures. Objectives: To evaluate the feasibility, clinical utility, and ergonomic benefits of using MRI in dentistry, combining ARIOS with three dimensional visualization during surgical procedures. It also aimed to identify the current technological advantages and limitations compared to the available scientific evidence. Materials and methods: A systematic literature review was conducted according to the PRISMA criteria, complemented by a pilot clinical experience in a real life dental setting. Two case studies were implemented: one for intraoral scanning with real time holographic visualization of the model, and another for the three-dimensional visualization of CBCT and STL models during implant surgery. Variables such as ergonomics, visual interaction, clinical efficiency, and teaching utility were evaluated. Conclusion: Although current scientific evidence is still limited, the results of this study show significant improvements in ergonomics, visual continuity, and operator experience thanks to holographic projection in the operating room. The implemented connection methodology (without the need for intermediate software or programming) represents an advance compared to previous studies. This work offers promising preliminary data on the feasibility of MRI in clinical and teaching dentistry, proposing a suitable path for future integration.
Direction
LOPEZ CASTRO, GONZALO (Tutorships)
LOPEZ CASTRO, GONZALO (Tutorships)
A review of the relationship between adenovirus-based COVID-19 vaccines and the increased risk of positivity for antiphospholipid antibodies.
Authorship
N.E.H.P.
Bachelor of Medicine
N.E.H.P.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Background: COVID19 is a disease with a very heterogeneous clinical presentation, ranging from asymptomatic infections to multi organ failure. It is associated with complications such as arterial and venous thromboembolism, which can be fatal. Vaccines developed against this infection have also been associated with thrombotic events. Antiphospholipid syndrome (APS) is an autoimmune disease that occurs in the presence of one or more antiphospholipid antibodies (anticardiolipin antibodies, lupus anticoagulant, and antibody against beta2 glycoprotein I) and the occurrence of thrombotic events (e.g., pulmonary thromboembolism, stroke) or spontaneous abortions. Several studies have been published attempting to establish an association between antiphospholipid syndrome (APS) and COVID19, based on the similar pathophysiological characteristics of thrombosis in both diseases. VITT (vaccine-induced immune thrombotic thrombocytopenia) is a rare autoimmune response that has been primarily associated with COVID19 replicating adenovirus vaccines. Parallels have often been drawn between VITT, HIT (heparin induced thrombocytopenia), and FAS (fatal acute thrombosis), as these are antibody mediated processes linked to thromboembolic manifestations. Objective: The main objective of our systematic review is to evaluate the possible association between antiphospholipid antibody positivity and COVID-19 vaccination. Material and Methods: A systematic review was conducted to explore the potential relationship between thrombotic phenomena and COVID19 vaccines. The search included the following databases: PubMed and the Cochrane Library, using the combination of the search terms, COVID vaccine and antiphospholipid antibody. The search period covered September 2021 to October 15, 2024. Titles and abstracts were reviewed, selecting articles of interest, and then the full texts were analyzed. Results, conclusions: Although some studies suggest an increase in aPL positivity with viral vector vaccines, it appears to be a transient event; therefore, a cause and effect relationship between COVID19 vaccination and aPL positivity cannot be established.
Background: COVID19 is a disease with a very heterogeneous clinical presentation, ranging from asymptomatic infections to multi organ failure. It is associated with complications such as arterial and venous thromboembolism, which can be fatal. Vaccines developed against this infection have also been associated with thrombotic events. Antiphospholipid syndrome (APS) is an autoimmune disease that occurs in the presence of one or more antiphospholipid antibodies (anticardiolipin antibodies, lupus anticoagulant, and antibody against beta2 glycoprotein I) and the occurrence of thrombotic events (e.g., pulmonary thromboembolism, stroke) or spontaneous abortions. Several studies have been published attempting to establish an association between antiphospholipid syndrome (APS) and COVID19, based on the similar pathophysiological characteristics of thrombosis in both diseases. VITT (vaccine-induced immune thrombotic thrombocytopenia) is a rare autoimmune response that has been primarily associated with COVID19 replicating adenovirus vaccines. Parallels have often been drawn between VITT, HIT (heparin induced thrombocytopenia), and FAS (fatal acute thrombosis), as these are antibody mediated processes linked to thromboembolic manifestations. Objective: The main objective of our systematic review is to evaluate the possible association between antiphospholipid antibody positivity and COVID-19 vaccination. Material and Methods: A systematic review was conducted to explore the potential relationship between thrombotic phenomena and COVID19 vaccines. The search included the following databases: PubMed and the Cochrane Library, using the combination of the search terms, COVID vaccine and antiphospholipid antibody. The search period covered September 2021 to October 15, 2024. Titles and abstracts were reviewed, selecting articles of interest, and then the full texts were analyzed. Results, conclusions: Although some studies suggest an increase in aPL positivity with viral vector vaccines, it appears to be a transient event; therefore, a cause and effect relationship between COVID19 vaccination and aPL positivity cannot be established.
Direction
MERA VARELA, ANTONIO JOSE (Tutorships)
Sueiro Delgado, Diana (Co-tutorships)
MERA VARELA, ANTONIO JOSE (Tutorships)
Sueiro Delgado, Diana (Co-tutorships)
Court
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
Relationship between social networks and self-lytic attempts in teenagers.
Authorship
N.I.F.
Bachelor of Medicine
N.I.F.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: Adolescence is a vulnerable stage in which mental health can be affected by factors such as bullying, violence, and socioeconomic status. Suicide is one of the leading causes of death at this age. There are tools such as the SAD PERSONS scale to assess risk, and early detection is essential. Different behaviors, such as suicidal ideation, non-suicidal self -injury, suicide attempts and completed suicide are distinguished, the first ones lacking lethal intent but still carrying associated risks. Biologically, suicide involves a complex interaction between neurotransmitters, genetic, hormonal, immunological and environmental factors. Justification: Self-injury and suicidal behaviors among adolescents have increased, especially after the pandemic. Social media plays a significant role in this phenomenon, promoting dangerous challenges such as the Superman Challenge. Recent statistics show a worrying rise in cases, underscoring the need for education, prevention, and multidisciplinary care. Objectives: The main objective is to investigate the cause and effect relationship between social media and self-harm attempts in adolescents. Materials and Methods: A systematic review was conducted based on the PRISMA guidelines, using academic databases (PubMed, Scopus, etc.) and specific keywords. Studies from 2015 onward were included, focusing on adolescents aged 10 to 19. The selection process went through several phases (identification, screening, eligibility, and inclusion), excluding non-relevant articles. Results and Discussion: After reviewing 18 medium- and high-quality studies, a significant -though moderate- relationship was found between social media use and self-injurious or suicidal behaviors in adolescents. This risk increases in cases of problematic use, exposure to self-harm content, cyberbullying, and low self-esteem resulting from social comparison. Greater vulnerability was observed in girls and LGBTQ+ adolescents, who show more depressive symptoms and a higher risk of cybervictimization. Content circulating on social media can have both negative (normalization of self-harm, emotional contagion, dangerous challenges) and positive effects (reduction of isolation, access to support and mental health resources). The quality of interactions and the type of content consumed are more determining than total screen time. Conclusions: Although the proposal is not to ban the use of social media, it does emphasize the need to educate, support, and supervise adolescents, as well as improve systems for moderating dangerous content. It is recommended to establish protocols for early detection and create safer digital environments, especially for vulnerable groups. Social media should be considered a significant risk factor, but also a potential support risk factor, but also a potential support tool if used responsibly and in a well-being- oriented manner.
Introduction: Adolescence is a vulnerable stage in which mental health can be affected by factors such as bullying, violence, and socioeconomic status. Suicide is one of the leading causes of death at this age. There are tools such as the SAD PERSONS scale to assess risk, and early detection is essential. Different behaviors, such as suicidal ideation, non-suicidal self -injury, suicide attempts and completed suicide are distinguished, the first ones lacking lethal intent but still carrying associated risks. Biologically, suicide involves a complex interaction between neurotransmitters, genetic, hormonal, immunological and environmental factors. Justification: Self-injury and suicidal behaviors among adolescents have increased, especially after the pandemic. Social media plays a significant role in this phenomenon, promoting dangerous challenges such as the Superman Challenge. Recent statistics show a worrying rise in cases, underscoring the need for education, prevention, and multidisciplinary care. Objectives: The main objective is to investigate the cause and effect relationship between social media and self-harm attempts in adolescents. Materials and Methods: A systematic review was conducted based on the PRISMA guidelines, using academic databases (PubMed, Scopus, etc.) and specific keywords. Studies from 2015 onward were included, focusing on adolescents aged 10 to 19. The selection process went through several phases (identification, screening, eligibility, and inclusion), excluding non-relevant articles. Results and Discussion: After reviewing 18 medium- and high-quality studies, a significant -though moderate- relationship was found between social media use and self-injurious or suicidal behaviors in adolescents. This risk increases in cases of problematic use, exposure to self-harm content, cyberbullying, and low self-esteem resulting from social comparison. Greater vulnerability was observed in girls and LGBTQ+ adolescents, who show more depressive symptoms and a higher risk of cybervictimization. Content circulating on social media can have both negative (normalization of self-harm, emotional contagion, dangerous challenges) and positive effects (reduction of isolation, access to support and mental health resources). The quality of interactions and the type of content consumed are more determining than total screen time. Conclusions: Although the proposal is not to ban the use of social media, it does emphasize the need to educate, support, and supervise adolescents, as well as improve systems for moderating dangerous content. It is recommended to establish protocols for early detection and create safer digital environments, especially for vulnerable groups. Social media should be considered a significant risk factor, but also a potential support risk factor, but also a potential support tool if used responsibly and in a well-being- oriented manner.
Direction
GAGO AGEITOS, ANA MARIA (Tutorships)
GAGO AGEITOS, ANA MARIA (Tutorships)
Court
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
FREIRE-GARABAL NUÑEZ, MANUEL (Chairman)
Barge Caballero, Eduardo (Secretary)
SANTOS PEREZ, SOFIA MARIA SOLEDAD (Member)
Impact of smoking habit and age on the diagnostic prediction of subgingival molecular biomarkers of periodontitis
Authorship
M.I.L.
Grao en Odontología (2ªed)
M.I.L.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Aim: To assess the influence of clinical variables of age and smoking habit on the diagnostic accuracy of subgingival proteins for detecting periodontitis. Material and methods: Gingival crevicular fluid (GCF) samples were collected from 44 periodontally healthy subjects and 40 with periodontitis stages III-IV. Samples were analysed using sequential window acquisition of all theoretical mass spectra (SWATH-MS) proteomic technique. Proteins were identified through the UniProt database, and their diagnostic accuracy was evaluated using the generalised additive models (GAM) package. Individual protein models obtained were calculated unadjusted and adjusted for age and smoking status (years smoking and pack-year index). Three-fold cross-validation was applied to control for overfitting of the predictive models, and the classification parameters were calculated. Results: Eight proteins were evaluated (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], keratin, type II cytoskeletal 6A, zymogen granule protein 16 homolog B [ZG16B], plasma protease inhibitor C1, carbonic anhydrase 1, and haemoglobin subunits [Hbs] alpha, beta, and delta). Unadjusted models showed accuracy (ACC) of 64.3-91.7% (sensitivity/ specificity of 42.5-95.0%/68.2-88.6%). Adjustment for age consistently improved diagnostic performance across all proteins (ACC: 88.1-96.4%; sensitivity/specificity: 87.5-97.5%/81.8-97.7%). According to smoking habit, performance improved for six proteins (ACC: 81.0-92.9%; sensitivity/specificity: 67.5-95.0%/72.7-93.2%), but decreased for GAPDH considering years smoking and pack-year index (ACC: 71.4% and 85.7%; sensitivity/specificity: 72.5% and 87.5%/70.5% and 84.1%) and for Hb beta considering years of smoking (ACC: 72.6%; sensitivity/specificity: 57.5%/86.4%). Conclusions: Age and smoking habit affect the diagnostic accuracy of subgingival proteins biomarkers for periodontitis. Age exerts a more consistent and systematic influence, allowing to achieve exceptional predictive values. The impact of smoking is more variable and biomarker dependent. However, these results must be validated in future research.
Aim: To assess the influence of clinical variables of age and smoking habit on the diagnostic accuracy of subgingival proteins for detecting periodontitis. Material and methods: Gingival crevicular fluid (GCF) samples were collected from 44 periodontally healthy subjects and 40 with periodontitis stages III-IV. Samples were analysed using sequential window acquisition of all theoretical mass spectra (SWATH-MS) proteomic technique. Proteins were identified through the UniProt database, and their diagnostic accuracy was evaluated using the generalised additive models (GAM) package. Individual protein models obtained were calculated unadjusted and adjusted for age and smoking status (years smoking and pack-year index). Three-fold cross-validation was applied to control for overfitting of the predictive models, and the classification parameters were calculated. Results: Eight proteins were evaluated (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], keratin, type II cytoskeletal 6A, zymogen granule protein 16 homolog B [ZG16B], plasma protease inhibitor C1, carbonic anhydrase 1, and haemoglobin subunits [Hbs] alpha, beta, and delta). Unadjusted models showed accuracy (ACC) of 64.3-91.7% (sensitivity/ specificity of 42.5-95.0%/68.2-88.6%). Adjustment for age consistently improved diagnostic performance across all proteins (ACC: 88.1-96.4%; sensitivity/specificity: 87.5-97.5%/81.8-97.7%). According to smoking habit, performance improved for six proteins (ACC: 81.0-92.9%; sensitivity/specificity: 67.5-95.0%/72.7-93.2%), but decreased for GAPDH considering years smoking and pack-year index (ACC: 71.4% and 85.7%; sensitivity/specificity: 72.5% and 87.5%/70.5% and 84.1%) and for Hb beta considering years of smoking (ACC: 72.6%; sensitivity/specificity: 57.5%/86.4%). Conclusions: Age and smoking habit affect the diagnostic accuracy of subgingival proteins biomarkers for periodontitis. Age exerts a more consistent and systematic influence, allowing to achieve exceptional predictive values. The impact of smoking is more variable and biomarker dependent. However, these results must be validated in future research.
Direction
TOMAS CARMONA, INMACULADA (Tutorships)
Blanco Pintos, Triana (Co-tutorships)
TOMAS CARMONA, INMACULADA (Tutorships)
Blanco Pintos, Triana (Co-tutorships)
Court
SEOANE LESTON, JUAN MANUEL (Chairman)
ABELEIRA PAZOS, MARIA TERESA (Secretary)
Pérez-Sayáns García, Mario (Member)
SEOANE LESTON, JUAN MANUEL (Chairman)
ABELEIRA PAZOS, MARIA TERESA (Secretary)
Pérez-Sayáns García, Mario (Member)
Use of Aligners in Individuals with Special Needs: A case series
Authorship
A.J.D.
Grao en Odontología (2ªed)
A.J.D.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
INTRODUCTION: People with Special Care Needs (PSCN) present specific challenges in orthodontic treatment, particularly regarding sensory tolerance, clinical cooperation, and oral hygiene management. Due to their characteristics, clear aligners may represent a more suitable therapeutic alternative than fixed appliances in these cases. OBJECTIVE: To describe and analyze the indications and advantages of using orthodontic aligners in a case series of patients with special needs. METHODOLOGY: Descriptive study of a series of 9 patients with diverse systemic conditions and neurodivergent profiles, treated (or evaluated for treatment) with clear aligners at the Special Care Dentistry Unit of the Faculty of Dentistry, University of Santiago de Compostela. Clinical (medical and dental) characteristics, treatment data, and caregiver and professional assessments through questionnaires were collected. RESULTS: 7 out of 9 patients initiated treatment; 3 completed it, 3 remain in active treatment, and in 1 case it had to be discontinued. The main indications for using aligners were sensory hypersensitivity, the need to improve oral hygiene, and the need to avoid fixed appliances for medical reasons. In most cases, a preliminary desensitization phase was required. No ulcers or mechanical complications were observed. The treatment was generally evaluated positively by both professionals and families. CONCLUSION: Clear aligners represent a viable and safe therapeutic option for patients with special needs, provided that the indication is individualized and the clinical approach is appropriately adapted.
INTRODUCTION: People with Special Care Needs (PSCN) present specific challenges in orthodontic treatment, particularly regarding sensory tolerance, clinical cooperation, and oral hygiene management. Due to their characteristics, clear aligners may represent a more suitable therapeutic alternative than fixed appliances in these cases. OBJECTIVE: To describe and analyze the indications and advantages of using orthodontic aligners in a case series of patients with special needs. METHODOLOGY: Descriptive study of a series of 9 patients with diverse systemic conditions and neurodivergent profiles, treated (or evaluated for treatment) with clear aligners at the Special Care Dentistry Unit of the Faculty of Dentistry, University of Santiago de Compostela. Clinical (medical and dental) characteristics, treatment data, and caregiver and professional assessments through questionnaires were collected. RESULTS: 7 out of 9 patients initiated treatment; 3 completed it, 3 remain in active treatment, and in 1 case it had to be discontinued. The main indications for using aligners were sensory hypersensitivity, the need to improve oral hygiene, and the need to avoid fixed appliances for medical reasons. In most cases, a preliminary desensitization phase was required. No ulcers or mechanical complications were observed. The treatment was generally evaluated positively by both professionals and families. CONCLUSION: Clear aligners represent a viable and safe therapeutic option for patients with special needs, provided that the indication is individualized and the clinical approach is appropriately adapted.
Direction
Limeres Posse, Jacobo (Tutorships)
García Mato, Eliane (Co-tutorships)
Limeres Posse, Jacobo (Tutorships)
García Mato, Eliane (Co-tutorships)
Court
GARCIA GARCIA, ABEL (Chairman)
LOPEZ CASTRO, GONZALO (Secretary)
GANDARA VILA, PILAR (Member)
GARCIA GARCIA, ABEL (Chairman)
LOPEZ CASTRO, GONZALO (Secretary)
GANDARA VILA, PILAR (Member)
Characterization and predictive capacity of the subgingival microbiome associated with peri-implantitis
Authorship
E.L.F.
Grao en Odontología (2ªed)
E.L.F.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
- Objective: To characterize the diversity of the subgingival microbiome in peri-implant health, peri-implantitis, periodontal health, and periodontitis; and to develop predictive models to distinguish between peri-implant health and peri-implantitis. - Materials and Methods: A total of 167 samples were analysed (peri-implant health-Imp H = 36, peri-implantitis-Imp P = 41, periodontal health-Sub H = 45, periodontitis-Sub P = 45). Illumina sequences were processed using mothur, and taxonomy was assigned using an oral-specific database. Statistical analyses were performed in R-Bioconductor. Alpha diversity was assessed using observed ASVs, 95% coverage index, and the Shannon and Pielou indices. Microbial structure was analysed through principal component analysis (PCA) and PERMANOVA. Differences in the abundance of amplicon sequence variants (ASVs) were evaluated using the Mann-Whitney U test. Predictive models were built using sparse partial least squares discriminant analysis and random forest. - Results: More ASVs were observed in peri-implant health than in peri-implantitis (421.00 vs. 288.00; p less than 0.01). Peri-implant richness and diversity were lower than periodontal in both health (coverage= 97.50 vs. 178.00; p less than 0.05) and disease (coverage= 83.00 vs. 132.00; Shannon= 3.59 vs. 4.14; Pielou= 0.62 vs. 0.68; p less than 0.01). The PCA showed clustering of samples according to group to which they belonged (p less than 0.01). The largest differences in abundant ASVs were found between Imp H vs. Imp P (87 ASVs) and Sub H (76); with fewer differences between Imp P and Sub P (29). The Imp H vs. Imp P model included 50 ASVs and achieved an area under the curve (AUC) of 0.87, with an accuracy of 80.95%, sensitivity of 92.06%, and specificity of 69.84%. - Conclusions: Subgingival plaque in peri-implant health is richer than in peri-implantitis. The subgingival peri-implant microbiome is less alpha-diverse than the periodontal microbiome in both health and disease. Additionally, microbiome structure differs significantly across study groups. In terms of abundance, the subgingival microbiome shows marked differences between peri-implant health and peri-implantitis. Differences between peri-implant and periodontal health are greater than those between the respective disease conditions. Finally, our predictive model shows excellent ability to discriminate between peri-implant health and peri-implantitis, supporting the use of the subgingival microbiome as a precision diagnostic tool for peri-implant clinical status.
- Objective: To characterize the diversity of the subgingival microbiome in peri-implant health, peri-implantitis, periodontal health, and periodontitis; and to develop predictive models to distinguish between peri-implant health and peri-implantitis. - Materials and Methods: A total of 167 samples were analysed (peri-implant health-Imp H = 36, peri-implantitis-Imp P = 41, periodontal health-Sub H = 45, periodontitis-Sub P = 45). Illumina sequences were processed using mothur, and taxonomy was assigned using an oral-specific database. Statistical analyses were performed in R-Bioconductor. Alpha diversity was assessed using observed ASVs, 95% coverage index, and the Shannon and Pielou indices. Microbial structure was analysed through principal component analysis (PCA) and PERMANOVA. Differences in the abundance of amplicon sequence variants (ASVs) were evaluated using the Mann-Whitney U test. Predictive models were built using sparse partial least squares discriminant analysis and random forest. - Results: More ASVs were observed in peri-implant health than in peri-implantitis (421.00 vs. 288.00; p less than 0.01). Peri-implant richness and diversity were lower than periodontal in both health (coverage= 97.50 vs. 178.00; p less than 0.05) and disease (coverage= 83.00 vs. 132.00; Shannon= 3.59 vs. 4.14; Pielou= 0.62 vs. 0.68; p less than 0.01). The PCA showed clustering of samples according to group to which they belonged (p less than 0.01). The largest differences in abundant ASVs were found between Imp H vs. Imp P (87 ASVs) and Sub H (76); with fewer differences between Imp P and Sub P (29). The Imp H vs. Imp P model included 50 ASVs and achieved an area under the curve (AUC) of 0.87, with an accuracy of 80.95%, sensitivity of 92.06%, and specificity of 69.84%. - Conclusions: Subgingival plaque in peri-implant health is richer than in peri-implantitis. The subgingival peri-implant microbiome is less alpha-diverse than the periodontal microbiome in both health and disease. Additionally, microbiome structure differs significantly across study groups. In terms of abundance, the subgingival microbiome shows marked differences between peri-implant health and peri-implantitis. Differences between peri-implant and periodontal health are greater than those between the respective disease conditions. Finally, our predictive model shows excellent ability to discriminate between peri-implant health and peri-implantitis, supporting the use of the subgingival microbiome as a precision diagnostic tool for peri-implant clinical status.
Direction
TOMAS CARMONA, INMACULADA (Tutorships)
Regueira Iglesias, Alba (Co-tutorships)
TOMAS CARMONA, INMACULADA (Tutorships)
Regueira Iglesias, Alba (Co-tutorships)
Court
SEOANE LESTON, JUAN MANUEL (Chairman)
ABELEIRA PAZOS, MARIA TERESA (Secretary)
Pérez-Sayáns García, Mario (Member)
SEOANE LESTON, JUAN MANUEL (Chairman)
ABELEIRA PAZOS, MARIA TERESA (Secretary)
Pérez-Sayáns García, Mario (Member)
Training of Medical Residents in the Effective Management of the Pediatric Airway: Expert-Assisted Videolaryngoscope Intubation Using Smartglasses.
Authorship
T.L.G.
Bachelor of Medicine
T.L.G.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Aim: To analyze the efficacy of smartglasses as a didactic tool for guiding and enhancing the learning of orotracheal intubation in medical residents, using a simulated pediatric airway model of a school-aged patient. Methods: A prospective, randomized, blinded, unicenter clinical trial with a crossover design was performed. Participants were randomly assigned in a 1:1 ratio to two groups, performing the same techniques in a different order. In the first measurement (P1), Group 1 performed the intubation without assistance (T1), while Group 2 received real-time assistance from an expert via smartglasses (T2). After a brief rest, the groups exchanged techniques in the second measurement (P2). Efficacy variables (defined by adherence to the steps established in the pediatric airway management protocol and intubation success), time variables and covariates were analyzed. Participants' perception was assessed using Likert and NASA-TLX scales. Results: No statistically significant differences were observed in most of the variables analyzed. However, in the measurement of Technique 1 (intubation without assistance), Group 2, which had previously received assistance, achieved significantly shorter times in three time-related variables (p less than 0.05). Furthermore, this group demonstrated greater adherence to the protocol, fewer attempts, and higher success on the first attempt at intubation, although without statistical significance. Conclusions: The use of smartglasses could reduce pediatric intubation time and enhance learning, suggesting that it could be a promising tool for the training of medical residents. However, further studies with larger sample sizes are needed to draw definitive conclusions and confirm their impact on medical education.
Aim: To analyze the efficacy of smartglasses as a didactic tool for guiding and enhancing the learning of orotracheal intubation in medical residents, using a simulated pediatric airway model of a school-aged patient. Methods: A prospective, randomized, blinded, unicenter clinical trial with a crossover design was performed. Participants were randomly assigned in a 1:1 ratio to two groups, performing the same techniques in a different order. In the first measurement (P1), Group 1 performed the intubation without assistance (T1), while Group 2 received real-time assistance from an expert via smartglasses (T2). After a brief rest, the groups exchanged techniques in the second measurement (P2). Efficacy variables (defined by adherence to the steps established in the pediatric airway management protocol and intubation success), time variables and covariates were analyzed. Participants' perception was assessed using Likert and NASA-TLX scales. Results: No statistically significant differences were observed in most of the variables analyzed. However, in the measurement of Technique 1 (intubation without assistance), Group 2, which had previously received assistance, achieved significantly shorter times in three time-related variables (p less than 0.05). Furthermore, this group demonstrated greater adherence to the protocol, fewer attempts, and higher success on the first attempt at intubation, although without statistical significance. Conclusions: The use of smartglasses could reduce pediatric intubation time and enhance learning, suggesting that it could be a promising tool for the training of medical residents. However, further studies with larger sample sizes are needed to draw definitive conclusions and confirm their impact on medical education.
Direction
Gonzalez Quintela, Arturo (Tutorships)
Gómez Silva, Graciela (Co-tutorships)
RODRIGUEZ RUIZ, EMILIO (Co-tutorships)
Gonzalez Quintela, Arturo (Tutorships)
Gómez Silva, Graciela (Co-tutorships)
RODRIGUEZ RUIZ, EMILIO (Co-tutorships)
Court
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
Impact of Bisphenol A in precocious puberty. A systematic review.
Authorship
M.L.S.
Bachelor of Medicine
M.L.S.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: precocious puberty (PP) is defined as the variation on the onset of growth and development of kids, beggining before 8 yo in girls and 9 yo in boys. Some of the proposed etiologies related to this condition, is the exposure to endocrine disruptors such as Bisphenol A (BPA). Objectives: to evaluate the available evidence about the relationship between chemical compund BPA exposure and PP in kids. Materials and methods: a systematic review has been performed with the avialable literature at the date. Using the Medline and Scopus databases, we tried to answer the PICO question proposed for this work. Results: a total of 10 articles had been included to compare its results. 5 of them, provided a relation between BPA levels in urine/serum and the presence of PP and another 5 did not find that relation. Conclusion: After carrying out this systematic review, it has been concluded that more studies about this topic are necessary, as well as they should have a better methodological quality. A bigger inclusion of men in the studies is also necessary.
Introduction: precocious puberty (PP) is defined as the variation on the onset of growth and development of kids, beggining before 8 yo in girls and 9 yo in boys. Some of the proposed etiologies related to this condition, is the exposure to endocrine disruptors such as Bisphenol A (BPA). Objectives: to evaluate the available evidence about the relationship between chemical compund BPA exposure and PP in kids. Materials and methods: a systematic review has been performed with the avialable literature at the date. Using the Medline and Scopus databases, we tried to answer the PICO question proposed for this work. Results: a total of 10 articles had been included to compare its results. 5 of them, provided a relation between BPA levels in urine/serum and the presence of PP and another 5 did not find that relation. Conclusion: After carrying out this systematic review, it has been concluded that more studies about this topic are necessary, as well as they should have a better methodological quality. A bigger inclusion of men in the studies is also necessary.
Direction
CABANAS RODRIGUEZ, PALOMA (Tutorships)
Vázquez Gómez, Lorena (Co-tutorships)
CABANAS RODRIGUEZ, PALOMA (Tutorships)
Vázquez Gómez, Lorena (Co-tutorships)
Court
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Gastroenteropancreatic Neuroendocrine Tumors. Features and Therapeutic Algorithm. A Bibliographic Review.
Authorship
J.M.R.
Bachelor of Medicine
J.M.R.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a heterogeneous group of tumors with variable clinical behavior. In recent decades, their incidence has increased significantly, partly due to advances in diagnostic techniques and greater clinical awareness. This work provides a comprehensive review of the epidemiology, etiology, diagnosis, and treatment of GEP-NENs, classifying them by anatomical location and differentiation grade. It analyzes the main international clinical guidelines (ENETS and NCCN) and current therapeutic strategies, from surgical resection to targeted therapies. The aim is to offer an updated and practical overview for the clinical management of these neoplasms.
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a heterogeneous group of tumors with variable clinical behavior. In recent decades, their incidence has increased significantly, partly due to advances in diagnostic techniques and greater clinical awareness. This work provides a comprehensive review of the epidemiology, etiology, diagnosis, and treatment of GEP-NENs, classifying them by anatomical location and differentiation grade. It analyzes the main international clinical guidelines (ENETS and NCCN) and current therapeutic strategies, from surgical resection to targeted therapies. The aim is to offer an updated and practical overview for the clinical management of these neoplasms.
Direction
VARELA PONTE, RAFAEL (Tutorships)
Martínez Lago, Nieves Purificación (Co-tutorships)
VARELA PONTE, RAFAEL (Tutorships)
Martínez Lago, Nieves Purificación (Co-tutorships)
Court
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Diagnosis and management of anaphylaxis in the pediatric emergency department. A systematic review.
Authorship
C.M.C.
Bachelor of Medicine
C.M.C.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Anaphylaxis is a severe allergic reaction that develops rapidly and can be fatal. It is usually treated in the emergency department, so the development of protocols and proper evidence-based training for physicians is key. In paediatrics, food is the main cause of this condition. Patients usually present with mucocutaneous manifestations, accompanied by respiratory, digestive or cardiovascular involvement. The diagnosis is based on clinical criteria and can hardly be supported by complementary tests. The initial assessment should follow the ABCDE system and use the Paediatric Assessment Triangle, in addition to the administration of intramuscular adrenaline. Once the symptoms are under control, a period of hospital observation is recommended to monitor for possible biphasic reactions. Upon discharge, all patients should receive instructions on allergen avoidance, be provided with adrenaline auto-injectors and education on their use, and be referred to an allergist for a complete evaluation. Some atypical cases represent a diagnostic challenge, especially in infants, and therefore a high level of suspicion is required. The aim of this study is to conduct a systematic review of the diagnostic criteria and therapeutic management of anaphylaxis in paediatrics.
Anaphylaxis is a severe allergic reaction that develops rapidly and can be fatal. It is usually treated in the emergency department, so the development of protocols and proper evidence-based training for physicians is key. In paediatrics, food is the main cause of this condition. Patients usually present with mucocutaneous manifestations, accompanied by respiratory, digestive or cardiovascular involvement. The diagnosis is based on clinical criteria and can hardly be supported by complementary tests. The initial assessment should follow the ABCDE system and use the Paediatric Assessment Triangle, in addition to the administration of intramuscular adrenaline. Once the symptoms are under control, a period of hospital observation is recommended to monitor for possible biphasic reactions. Upon discharge, all patients should receive instructions on allergen avoidance, be provided with adrenaline auto-injectors and education on their use, and be referred to an allergist for a complete evaluation. Some atypical cases represent a diagnostic challenge, especially in infants, and therefore a high level of suspicion is required. The aim of this study is to conduct a systematic review of the diagnostic criteria and therapeutic management of anaphylaxis in paediatrics.
Direction
Leis Trabazo, María Rosaura (Tutorships)
Presno López, Iván (Co-tutorships)
Leis Trabazo, María Rosaura (Tutorships)
Presno López, Iván (Co-tutorships)
Court
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Chrononutrition and sleep in pediatrics: the influence of the circadian rhythm on hormonal regulation and energy metabolism
Authorship
J.B.M.G.B.
Bachelor of Medicine
J.B.M.G.B.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: Childhood obesity has become a global public health concern, with metabolic repercussions that often persist into adulthood. Alongside traditional factors such as diet and physical activity, recent decades have seen growing recognition of the role of circadian variables, such as sleep, chronotype, and chrononutrition, in hormonal and energy regulation. Chrononutrition, defined as the study of how the timing of food intake interacts with circadian rhythms, represents an emerging approach to preventing excessive weight gain from early stages of development. Objectives: To analyse the influence of circadian rhythm, through factors such as sleep, chronotype, and meal timing, on hormonal regulation and energy metabolism in the paediatric population, by means of a systematic review of recent scientific literature. Material and Methods: A systematic review was conducted following PRISMA methodology. The search was performed in PubMed, Scopus, and Web of Science, and was complemented by manual screening of relevant bibliographic references. Original studies involving humans aged 0 to 18 years were included, provided they examined circadian variables (sleep, chronotype, social jet lag), hormonal markers (melatonin, leptin, ghrelin, insulin, cortisol), and metabolic parameters (BMI, BMI z-score, body fat, glucose, lipids, blood pressure). Specific inclusion and exclusion criteria were defined and applied. Results and discusión: Fifteen studies met the eligibility criteria. The evidence shows that chronic sleep deprivation, evening chronotypes, social jet lag, and late meal timing are associated with increased adiposity, circadian hormonal disruption, and metabolic dysfunction in children and adolescents. In addition, negative impacts were identified from nocturnal exposure to artificial light and breakfast omission on the circadian-metabolic axis. Conclusion: The findings highlight the crucial role of synchrony between circadian rhythms and daily habits in preventing childhood obesity and maintaining hormonal balance. Integrating a chronobiological approach into clinical and educational strategies may serve as an effective, non-invasive, and cost-efficient tool for improving metabolic health from early life.
Introduction: Childhood obesity has become a global public health concern, with metabolic repercussions that often persist into adulthood. Alongside traditional factors such as diet and physical activity, recent decades have seen growing recognition of the role of circadian variables, such as sleep, chronotype, and chrononutrition, in hormonal and energy regulation. Chrononutrition, defined as the study of how the timing of food intake interacts with circadian rhythms, represents an emerging approach to preventing excessive weight gain from early stages of development. Objectives: To analyse the influence of circadian rhythm, through factors such as sleep, chronotype, and meal timing, on hormonal regulation and energy metabolism in the paediatric population, by means of a systematic review of recent scientific literature. Material and Methods: A systematic review was conducted following PRISMA methodology. The search was performed in PubMed, Scopus, and Web of Science, and was complemented by manual screening of relevant bibliographic references. Original studies involving humans aged 0 to 18 years were included, provided they examined circadian variables (sleep, chronotype, social jet lag), hormonal markers (melatonin, leptin, ghrelin, insulin, cortisol), and metabolic parameters (BMI, BMI z-score, body fat, glucose, lipids, blood pressure). Specific inclusion and exclusion criteria were defined and applied. Results and discusión: Fifteen studies met the eligibility criteria. The evidence shows that chronic sleep deprivation, evening chronotypes, social jet lag, and late meal timing are associated with increased adiposity, circadian hormonal disruption, and metabolic dysfunction in children and adolescents. In addition, negative impacts were identified from nocturnal exposure to artificial light and breakfast omission on the circadian-metabolic axis. Conclusion: The findings highlight the crucial role of synchrony between circadian rhythms and daily habits in preventing childhood obesity and maintaining hormonal balance. Integrating a chronobiological approach into clinical and educational strategies may serve as an effective, non-invasive, and cost-efficient tool for improving metabolic health from early life.
Direction
Leis Trabazo, María Rosaura (Tutorships)
Castro Feijoo, Lidia (Co-tutorships)
Leis Trabazo, María Rosaura (Tutorships)
Castro Feijoo, Lidia (Co-tutorships)
Court
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Study of the hormones involved in regulating appetite and satiety, along with their potential clinical use in managing obesity
Authorship
G.M.H.
Bachelor of Medicine
G.M.H.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Obesity is a multifactorial disease and, as such, its treatment may be tackled by many different methods. Among them, control of food intake via regulating appetite and satiety is a highly effective approach which may also avoid invasive procedures such as bariatric surgery. In this work we revised the existing medical literature about the inner workings of the various hormones involved in the mechanisms of satiety, as well as their therapeutic value. It was concluded that endogenous administration of leptin, cholekystokinin and peptide YY offers limited clinical results for a variety of reasons; on the other hand, therapy with GLP1 receptor agonists (particularly, semaglutide), on top of these drugs’ original goal as treatment for type 2 diabetes, proved to regulate patients’ appetite consistently and lead to considerable weight loss both in clinical studies and actual medical practice. Furthermore, the observed adverse effects were within tolerable limits for the large majority of patients. We also established the important role of intestinal microbiota in appetite as well as its frequent interaction with the aforementioned hormones, due to which endeavoring to foster the development of favorable bacterial flora may bring very positive results to the treatment of obesity.
Obesity is a multifactorial disease and, as such, its treatment may be tackled by many different methods. Among them, control of food intake via regulating appetite and satiety is a highly effective approach which may also avoid invasive procedures such as bariatric surgery. In this work we revised the existing medical literature about the inner workings of the various hormones involved in the mechanisms of satiety, as well as their therapeutic value. It was concluded that endogenous administration of leptin, cholekystokinin and peptide YY offers limited clinical results for a variety of reasons; on the other hand, therapy with GLP1 receptor agonists (particularly, semaglutide), on top of these drugs’ original goal as treatment for type 2 diabetes, proved to regulate patients’ appetite consistently and lead to considerable weight loss both in clinical studies and actual medical practice. Furthermore, the observed adverse effects were within tolerable limits for the large majority of patients. We also established the important role of intestinal microbiota in appetite as well as its frequent interaction with the aforementioned hormones, due to which endeavoring to foster the development of favorable bacterial flora may bring very positive results to the treatment of obesity.
Direction
VARELA PONTE, RAFAEL (Tutorships)
Martínez Lago, Nieves Purificación (Co-tutorships)
VARELA PONTE, RAFAEL (Tutorships)
Martínez Lago, Nieves Purificación (Co-tutorships)
Court
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Polishing analysis using profilometry of the roughness of aesthetic and filling composites
Authorship
V.M.S.
Grao en Odontología (2ªed)
V.M.S.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Introduction and objectives: The survival and clinical success of dental restorations can be affected by the characteristics and composition of the restorative material, surface roughness and gloss. Finishing and polishing procedures are essential for the clinical success of restorations, since the surface roughness of composites can facilitate biofilm formation and bacterial adhesion. Objective: The main objective of our work is to compare the final polishability of different types of composites with the most frequently used polishing systems. Material and Methods: A total of 28 samples were analyzed by profilometry (Ra). A total of 7 groups of different types of composites were established. For each group, 4 cube blocks of 0.4 cm diameter were generated using a preformed matrix and polymerization lamp. Seven blocks were used for each polishing system: with discs, polishing cups, acetate matrix and an unpolished control sample. Results: The mean profilometry of all samples was 0.1718482 μm. The lowest profilometry averages were obtained with the SDI Wave HV composite (0.0551200 μm) and with the polishing system with the acetate matrix (0.0154100 μm). Combining the polishing variables and type of composite, the best roughness results were obtained with the SDI Luna 2 composite with acetate matrix (0.00342 μm). The average profilometry obtained was statistically higher in all unpolished samples (p=0.03) compared to samples polished with any of the systems studied. Conclusion: The profilometric results indicate that all of the samples polished with any of the polishing systems had a Ra less than 0.15 μm. No composite material has demonstrated statistically significant better profilometric results after polishing with any of the syst
Introduction and objectives: The survival and clinical success of dental restorations can be affected by the characteristics and composition of the restorative material, surface roughness and gloss. Finishing and polishing procedures are essential for the clinical success of restorations, since the surface roughness of composites can facilitate biofilm formation and bacterial adhesion. Objective: The main objective of our work is to compare the final polishability of different types of composites with the most frequently used polishing systems. Material and Methods: A total of 28 samples were analyzed by profilometry (Ra). A total of 7 groups of different types of composites were established. For each group, 4 cube blocks of 0.4 cm diameter were generated using a preformed matrix and polymerization lamp. Seven blocks were used for each polishing system: with discs, polishing cups, acetate matrix and an unpolished control sample. Results: The mean profilometry of all samples was 0.1718482 μm. The lowest profilometry averages were obtained with the SDI Wave HV composite (0.0551200 μm) and with the polishing system with the acetate matrix (0.0154100 μm). Combining the polishing variables and type of composite, the best roughness results were obtained with the SDI Luna 2 composite with acetate matrix (0.00342 μm). The average profilometry obtained was statistically higher in all unpolished samples (p=0.03) compared to samples polished with any of the systems studied. Conclusion: The profilometric results indicate that all of the samples polished with any of the polishing systems had a Ra less than 0.15 μm. No composite material has demonstrated statistically significant better profilometric results after polishing with any of the syst
Direction
Rivas Mundiña, Berta (Tutorships)
CHAMORRO PETRONACCI, CINTIA MICAELA (Co-tutorships)
Rivas Mundiña, Berta (Tutorships)
CHAMORRO PETRONACCI, CINTIA MICAELA (Co-tutorships)
Court
SEOANE LESTON, JUAN MANUEL (Chairman)
ABELEIRA PAZOS, MARIA TERESA (Secretary)
Pérez-Sayáns García, Mario (Member)
SEOANE LESTON, JUAN MANUEL (Chairman)
ABELEIRA PAZOS, MARIA TERESA (Secretary)
Pérez-Sayáns García, Mario (Member)
Knowledge about oral cancer and precancer in health science students, a scoping review.
Authorship
A.M.L.
Grao en Odontología (2ªed)
A.M.L.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Objectives: The present scoping review aims to identify in the available literature those articles that study knowledge about oral cancer and oral precancer in health sciences students through questionnaires. Material and methods: Two general searches were carried out through three databases; PubMed, Scopus and Web of Science. No filter was applied in terms of year of publication. Articles in spanish and english were included, and articles were discarded if they did not present questionnaires for the assessment of knowledge, or if the questionnaires were incomplete. The review was carried out according to the PRISMA-ScR methodology. Finally, 26 articles were included. Results: The content of the questionnaires selected from the available literature is heterogeneous, although they share a similar thematic structure. Most students identify tobacco and alcohol as risk factors for oral cancer, but do not adequately recognize others such as solar radiation. Most questionnaires only ask about erythroplasia and leukoplakia, leaving aside other precancerous lesions. In addition, all students surveyed consider it necessary to broaden their knowledge about oral cancer and oral precancer. Conclusions: The review performed highlights the need to implement educational programs on the knowledge, prevention and diagnosis of these pathologies in all health science students. We also consider that standardized questionnaires should be further developed and applied to rigorously assess knowledge of oral cancer and potentially malignant lesions.
Objectives: The present scoping review aims to identify in the available literature those articles that study knowledge about oral cancer and oral precancer in health sciences students through questionnaires. Material and methods: Two general searches were carried out through three databases; PubMed, Scopus and Web of Science. No filter was applied in terms of year of publication. Articles in spanish and english were included, and articles were discarded if they did not present questionnaires for the assessment of knowledge, or if the questionnaires were incomplete. The review was carried out according to the PRISMA-ScR methodology. Finally, 26 articles were included. Results: The content of the questionnaires selected from the available literature is heterogeneous, although they share a similar thematic structure. Most students identify tobacco and alcohol as risk factors for oral cancer, but do not adequately recognize others such as solar radiation. Most questionnaires only ask about erythroplasia and leukoplakia, leaving aside other precancerous lesions. In addition, all students surveyed consider it necessary to broaden their knowledge about oral cancer and oral precancer. Conclusions: The review performed highlights the need to implement educational programs on the knowledge, prevention and diagnosis of these pathologies in all health science students. We also consider that standardized questionnaires should be further developed and applied to rigorously assess knowledge of oral cancer and potentially malignant lesions.
Direction
REBOIRAS LOPEZ, MARIA DOLORES (Tutorships)
SEIJAS NAYA, FLAVIO (Co-tutorships)
REBOIRAS LOPEZ, MARIA DOLORES (Tutorships)
SEIJAS NAYA, FLAVIO (Co-tutorships)
Court
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
Morphometric analysis of axial sections of the mandible at the level of the dental canal and its relationship with edentulism
Authorship
S.N.S.
Grao en Odontología (2ªed)
S.N.S.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
All factors that affect the shape of the mandible (ontogenetic, phylogenetic, growth-related, gender-related, edentulousness, and cancellous/cortical bone patterns) also influence the position of the mandibular canal, which is a key consideration in surgical planning. Implant placement and orthognathic surgery require updated morphometric studies to improve our understanding of mandibular bone structure. Common pre-surgical imaging techniques used in these procedures include radiographs and tomographic projections in sagittal, coronal, and axial planes. Although numerous studies have assessed mandibular morphology using these views, there is relatively limited literature focusing on axial evaluations of the mandible using Cone-Beam Computed Tomography (CBCT). This project proposes an axial morphometric study of the mandible at the level of the mandibular canal.
All factors that affect the shape of the mandible (ontogenetic, phylogenetic, growth-related, gender-related, edentulousness, and cancellous/cortical bone patterns) also influence the position of the mandibular canal, which is a key consideration in surgical planning. Implant placement and orthognathic surgery require updated morphometric studies to improve our understanding of mandibular bone structure. Common pre-surgical imaging techniques used in these procedures include radiographs and tomographic projections in sagittal, coronal, and axial planes. Although numerous studies have assessed mandibular morphology using these views, there is relatively limited literature focusing on axial evaluations of the mandible using Cone-Beam Computed Tomography (CBCT). This project proposes an axial morphometric study of the mandible at the level of the mandibular canal.
Direction
SUAREZ QUINTANILLA, JUAN ANTONIO (Tutorships)
SUAREZ QUINTANILLA, JUAN ANTONIO (Tutorships)
Court
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
Forensic applications of single- cell technologies
Authorship
A.S.N.Y.
Bachelor of Medicine
A.S.N.Y.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
This paper examines the forensic applications of single-cell technologies, which enable the isolation and individual analysis of cells within complex biological samples. Techniques such as DEPArray, LCM, FACS, MACS, and micromanipulation are explored in terms of their use, advantages, and limitations in forensic genetics. The integration of these technologies is expected to revolutionize individual identification, enhance the analysis of degraded or mixed samples, and broaden the scope of criminal investigation.
This paper examines the forensic applications of single-cell technologies, which enable the isolation and individual analysis of cells within complex biological samples. Techniques such as DEPArray, LCM, FACS, MACS, and micromanipulation are explored in terms of their use, advantages, and limitations in forensic genetics. The integration of these technologies is expected to revolutionize individual identification, enhance the analysis of degraded or mixed samples, and broaden the scope of criminal investigation.
Direction
PUENTE VILA, MARIA DEL CARMEN DE LA (Tutorships)
PUENTE VILA, MARIA DEL CARMEN DE LA (Tutorships)
Relationship between COVID-19 and irregular uterine bleeding: systematic review
Authorship
A.O.F.
Bachelor of Medicine
A.O.F.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: The COVID-19 pandemic has revealed multiple systemic effects of SARS-CoV-2 and raised concerns about potential adverse effects of vaccines, particularly regarding menstrual health. Numerous women have reported abnormal uterine bleeding after infection or vaccination, prompting research into a possible causal relationship. Objectives: The main objective was to evaluate a possible causal relationship between SARS-CoV-2 infection or COVID-19 vaccination and abnormal uterine bleeding (AUB) in non-pregnant adult women. Secondary objectives included analyzing whether the changes were transient or persistent, and whether they were related to vaccine platform, dose number, or menstrual cycle phase. Methodology: A systematic review was conducted following the PRISMA 2020 guidelines. Included were cohort studies with a non-exposed comparison group, published between 2020 and 2025 in English or Spanish. The databases PubMed, Scopus, and Web of Science were searched. After applying the inclusion criteria, 9 studies were selected: 4 prospective and 5 retrospective cohort studies. Results: The studies show a statistically significant, albeit mild and temporary, association between COVID-19 vaccination and changes in menstrual cycle length, particularly after the second dose of mRNA vaccines. Changes in volume, duration, and regularity of bleeding were also reported, although not shown to be persistent. Evidence regarding SARS-CoV-2 infection was less consistent. Conclusions: There is evidence of an association between COVID-19 vaccination and mild, self-limited, short-term menstrual alterations, mainly in bleeding frequency and volume. No strong evidence supports a persistent causal link or significant clinical consequences. Nevertheless, further research is needed to strengthen public confidence and improve health communication.
Introduction: The COVID-19 pandemic has revealed multiple systemic effects of SARS-CoV-2 and raised concerns about potential adverse effects of vaccines, particularly regarding menstrual health. Numerous women have reported abnormal uterine bleeding after infection or vaccination, prompting research into a possible causal relationship. Objectives: The main objective was to evaluate a possible causal relationship between SARS-CoV-2 infection or COVID-19 vaccination and abnormal uterine bleeding (AUB) in non-pregnant adult women. Secondary objectives included analyzing whether the changes were transient or persistent, and whether they were related to vaccine platform, dose number, or menstrual cycle phase. Methodology: A systematic review was conducted following the PRISMA 2020 guidelines. Included were cohort studies with a non-exposed comparison group, published between 2020 and 2025 in English or Spanish. The databases PubMed, Scopus, and Web of Science were searched. After applying the inclusion criteria, 9 studies were selected: 4 prospective and 5 retrospective cohort studies. Results: The studies show a statistically significant, albeit mild and temporary, association between COVID-19 vaccination and changes in menstrual cycle length, particularly after the second dose of mRNA vaccines. Changes in volume, duration, and regularity of bleeding were also reported, although not shown to be persistent. Evidence regarding SARS-CoV-2 infection was less consistent. Conclusions: There is evidence of an association between COVID-19 vaccination and mild, self-limited, short-term menstrual alterations, mainly in bleeding frequency and volume. No strong evidence supports a persistent causal link or significant clinical consequences. Nevertheless, further research is needed to strengthen public confidence and improve health communication.
Direction
SAMPAYO MONTENEGRO, MARIA VICTORIA (Tutorships)
Gonzalez Cea, Ana Cristina (Co-tutorships)
SAMPAYO MONTENEGRO, MARIA VICTORIA (Tutorships)
Gonzalez Cea, Ana Cristina (Co-tutorships)
Court
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Gonzalez Quintela, Arturo (Chairman)
BRAÑAS GONZALEZ, ANTIA (Secretary)
Sierra Paredes, German (Member)
Purulent Pericarditis as the first manifestation of Esophageal Carcinoma. Case report and literature review.
Authorship
C.M.P.V.V.F.
Bachelor of Medicine
C.M.P.V.V.F.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Advanced esophageal cancer can perforate and fistulize into the airways, mediastinum, or pericardial cavity. More than half of fistulas affect the trachea and main bronchi. Esophagopericardial fistulas are rare. Most purulent pericarditis secondary to perforated esophageal cancer fistulized to the pericardium has been described in patients previously treated with radiotherapy, chemotherapy, or stenting. On the contrary, esophageal-pericardial fistula as the first manifestation of esophageal cancer is exceptional and usually appears in men with advanced squamous cell carcinoma located in the lower third. Symptoms include fever, epigastric pain, and substernal pain. Plugging is usually early. If an esophago-pericardial fistula is suspected, it is recommended to perform a computed tomography scan as it allows identification of the pericardial effusion, the presence of gas outside the esophageal lumen and, sometimes, a frank communication between the esophagus and the pericardial cavity. Purulent pericarditis and tamponade require urgent management by pericardiocentesis or thoracotomy. The microorganisms observed are usually typical of the oral flora. The prognosis of the patients is poor and the majority die within days or weeks as they are advanced tumors. Treatment will be aimed at relieving symptoms, preventing fistula recurrence, improving quality of life and, in selected cases, treating the neoplastic process. The implantation of an endoprosthesis allows closure of the fistula and ensures the patency of the esophageal lumen, although it is not always possible due to the fragility of the tissues. Some cases of long-term survival combining surgery, chemotherapy and radiotherapy have been described. The clinical case of a patient who presented with purulent pericarditis and cardiac tamponade due to an esophago-pericardial fistula caused by an esophageal squamous cell carcinoma is presented.
Advanced esophageal cancer can perforate and fistulize into the airways, mediastinum, or pericardial cavity. More than half of fistulas affect the trachea and main bronchi. Esophagopericardial fistulas are rare. Most purulent pericarditis secondary to perforated esophageal cancer fistulized to the pericardium has been described in patients previously treated with radiotherapy, chemotherapy, or stenting. On the contrary, esophageal-pericardial fistula as the first manifestation of esophageal cancer is exceptional and usually appears in men with advanced squamous cell carcinoma located in the lower third. Symptoms include fever, epigastric pain, and substernal pain. Plugging is usually early. If an esophago-pericardial fistula is suspected, it is recommended to perform a computed tomography scan as it allows identification of the pericardial effusion, the presence of gas outside the esophageal lumen and, sometimes, a frank communication between the esophagus and the pericardial cavity. Purulent pericarditis and tamponade require urgent management by pericardiocentesis or thoracotomy. The microorganisms observed are usually typical of the oral flora. The prognosis of the patients is poor and the majority die within days or weeks as they are advanced tumors. Treatment will be aimed at relieving symptoms, preventing fistula recurrence, improving quality of life and, in selected cases, treating the neoplastic process. The implantation of an endoprosthesis allows closure of the fistula and ensures the patency of the esophageal lumen, although it is not always possible due to the fragility of the tissues. Some cases of long-term survival combining surgery, chemotherapy and radiotherapy have been described. The clinical case of a patient who presented with purulent pericarditis and cardiac tamponade due to an esophago-pericardial fistula caused by an esophageal squamous cell carcinoma is presented.
Direction
Fernández González, Angel Luis (Tutorships)
Fernández González, Angel Luis (Tutorships)
Court
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
Long-acting extended-release injectable antipsychotics: 10-year analysis of efficacy in patients with dual pathology
Authorship
M.P.A.
Bachelor of Medicine
M.P.A.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
A study was conducted on a clinical sample of patients with dual pathology to compare the efficacy and safety of 2 long-acting antipsychotic drugs over a 10-year period. The drugs under study are Aripiprazole and Paliperidone. Methods: We analyzed the history of 210 patients with dual pathology of the Asociación Ciudadana de Lucha contra la Droga de A Coruña, in which we studied the evolution with long-acting antipsychotics. To evaluate the quality of the treatments, we use the CGI scale, the SMARTS criteria, or the number of visits to the emergency room and admissions to hospital services, as well as abstinence from toxic substances and permanence in the program. Results: long-acting antipsychotics show efficacy and safety in patients with dual pathology. We observed a significant improvement in pre and post CGI in both treatments, as well as a reduction in the number of emergency room visits and admissions. In addition, a high rate of permanence in the program with the two APLDs is demonstrated.
A study was conducted on a clinical sample of patients with dual pathology to compare the efficacy and safety of 2 long-acting antipsychotic drugs over a 10-year period. The drugs under study are Aripiprazole and Paliperidone. Methods: We analyzed the history of 210 patients with dual pathology of the Asociación Ciudadana de Lucha contra la Droga de A Coruña, in which we studied the evolution with long-acting antipsychotics. To evaluate the quality of the treatments, we use the CGI scale, the SMARTS criteria, or the number of visits to the emergency room and admissions to hospital services, as well as abstinence from toxic substances and permanence in the program. Results: long-acting antipsychotics show efficacy and safety in patients with dual pathology. We observed a significant improvement in pre and post CGI in both treatments, as well as a reduction in the number of emergency room visits and admissions. In addition, a high rate of permanence in the program with the two APLDs is demonstrated.
Direction
GAGO AGEITOS, ANA MARIA (Tutorships)
GAGO AGEITOS, ANA MARIA (Tutorships)
Integrated Approach to Treatment-Resistant Depression: A Systematic Review.
Authorship
L.E.P.F.
Bachelor of Medicine
L.E.P.F.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: Major depression is a mood disorder characterized by sadness, loss of interest and pleasure, and other symptoms that affect the person's personal, social, and professional functioning. Despite advances in the treatment of this disorder, it is estimated that approximately 40% of patients do not respond adequately to existing medications, presenting with what is known as treatment-resistant depression (TRD). Therefore, the STAR-D study, one of the largest clinical trials in this field, observed the high complexity required to achieve improvement in these cases, highlighting the need for broader and more comprehensive management tailored to the real needs of these patients. Objectives: To explore the management of TRD from five fundamental perspectives: pharmacological, psychological, specialized nursing, nutritional, and exercise, with the aim of providing a more complete view of effective interventions. Materials and methods: Systematic review following the PRISMA model. A bibliographic search was conducted in the PubMed database. Due to the similarity of the results obtained, articles from other databases were not included. Fourteen articles were selected from a total of 13,093. Results and discussion: Regarding pharmacological strategies, it was evident that ECT was more effective in patients with severe to very severe depression, and in hospital settings, esketamine showed a more rapid response, starting from the first week of treatment. Strategies such as rTMS, augmentation with antipsychotics, and atypical antidepressants were evaluated, which improved symptoms more modestly in TRD patients, although they presented fewer cognitive and physical risks and adverse effects than esketamine and ECT. CBT showed slightly greater sustained efficacy than IPT and MBCT, although all three were effective in improving depressive symptoms, remission rates, and improved quality of life when added to pharmacotherapy. Nursing interventions optimized adherence, follow-up, resilience, and community integration. Mediterranean diet-based nutrition and aerobic exercise had complementary benefits in improving mood and cognition that were superior to medication alone. Conclusions: Most studies have methodological limitations due to limited evidence, but overall, the results support a multidimensional, personalized, and sustained approach that combines conventional and integrative therapies to address the clinical complexity of TRD
Introduction: Major depression is a mood disorder characterized by sadness, loss of interest and pleasure, and other symptoms that affect the person's personal, social, and professional functioning. Despite advances in the treatment of this disorder, it is estimated that approximately 40% of patients do not respond adequately to existing medications, presenting with what is known as treatment-resistant depression (TRD). Therefore, the STAR-D study, one of the largest clinical trials in this field, observed the high complexity required to achieve improvement in these cases, highlighting the need for broader and more comprehensive management tailored to the real needs of these patients. Objectives: To explore the management of TRD from five fundamental perspectives: pharmacological, psychological, specialized nursing, nutritional, and exercise, with the aim of providing a more complete view of effective interventions. Materials and methods: Systematic review following the PRISMA model. A bibliographic search was conducted in the PubMed database. Due to the similarity of the results obtained, articles from other databases were not included. Fourteen articles were selected from a total of 13,093. Results and discussion: Regarding pharmacological strategies, it was evident that ECT was more effective in patients with severe to very severe depression, and in hospital settings, esketamine showed a more rapid response, starting from the first week of treatment. Strategies such as rTMS, augmentation with antipsychotics, and atypical antidepressants were evaluated, which improved symptoms more modestly in TRD patients, although they presented fewer cognitive and physical risks and adverse effects than esketamine and ECT. CBT showed slightly greater sustained efficacy than IPT and MBCT, although all three were effective in improving depressive symptoms, remission rates, and improved quality of life when added to pharmacotherapy. Nursing interventions optimized adherence, follow-up, resilience, and community integration. Mediterranean diet-based nutrition and aerobic exercise had complementary benefits in improving mood and cognition that were superior to medication alone. Conclusions: Most studies have methodological limitations due to limited evidence, but overall, the results support a multidimensional, personalized, and sustained approach that combines conventional and integrative therapies to address the clinical complexity of TRD
Direction
TORRES IGLESIAS, ANGELA JUANA (Tutorships)
NUÑEZ ARIAS, DANIEL (Co-tutorships)
TORRES IGLESIAS, ANGELA JUANA (Tutorships)
NUÑEZ ARIAS, DANIEL (Co-tutorships)
Court
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
Impact of preoperative bowel preparation in the context of cytoreductive surgery for the treatment of advanced ovarian cancer: a systematic review
Authorship
L.R.P.P.
Bachelor of Medicine
L.R.P.P.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: ovarian cancer is a highly prevalent gynecological malignancy associated with high mortality due to its often late diagnosis in advanced stages. In these cases, cytoreductive surgery is the cornerstone of treatment, and bowel resection is often necessary. Thus, preoperative bowel preparation has traditionally been used as a preventive measure, but in recent years, several studies have questioned its efficacy and safety. Objectives: to evaluate the degree of implementation and impact of preoperative bowel preparation in the context of cytoreductive surgery for the treatment of advanced ovarian cancer. Material and methods: a systematic review was conducted following the guidelines of the PRISMA declaration. The literature search, limited to articles published since 2016, was conducted in the PubMed, Web of Science, and Scopus databases, using the terms -ovarian cancer surgery- AND -bowel preparation-. Original articles in English or Spanish that addressed bowel preparation in the context of gynecologic oncologic surgery were selected. Reviews, meta-analyses, guidelines, and studies with no available access were excluded. Results and conclusions: thirteen articles (6 surveys and 7 clinical studies) were selected to study the degree of use and impact of preoperative bowel preparation in ovarian cancer cytoreductive surgery, both in the context of ERAS protocol implementation and in other contexts. Their analysis leads to the conclusion that there is significant resistance to abandoning the routine practice of mechanical bowel preparation and low adherence to ERAS recommendations regarding this item, even in centers that had declared the implementation of this type of protocol. Furthermore, the study highlights the heterogeneity and limitations of the available clinical studies, highlighting the need for a large, multicenter, standardized, randomized clinical trial that specifically analyzes the different types of bowel preparation (and the omission of preparation) and sheds light on this controversial practice in the preoperative management of advanced ovarian cancer surgery.
Introduction: ovarian cancer is a highly prevalent gynecological malignancy associated with high mortality due to its often late diagnosis in advanced stages. In these cases, cytoreductive surgery is the cornerstone of treatment, and bowel resection is often necessary. Thus, preoperative bowel preparation has traditionally been used as a preventive measure, but in recent years, several studies have questioned its efficacy and safety. Objectives: to evaluate the degree of implementation and impact of preoperative bowel preparation in the context of cytoreductive surgery for the treatment of advanced ovarian cancer. Material and methods: a systematic review was conducted following the guidelines of the PRISMA declaration. The literature search, limited to articles published since 2016, was conducted in the PubMed, Web of Science, and Scopus databases, using the terms -ovarian cancer surgery- AND -bowel preparation-. Original articles in English or Spanish that addressed bowel preparation in the context of gynecologic oncologic surgery were selected. Reviews, meta-analyses, guidelines, and studies with no available access were excluded. Results and conclusions: thirteen articles (6 surveys and 7 clinical studies) were selected to study the degree of use and impact of preoperative bowel preparation in ovarian cancer cytoreductive surgery, both in the context of ERAS protocol implementation and in other contexts. Their analysis leads to the conclusion that there is significant resistance to abandoning the routine practice of mechanical bowel preparation and low adherence to ERAS recommendations regarding this item, even in centers that had declared the implementation of this type of protocol. Furthermore, the study highlights the heterogeneity and limitations of the available clinical studies, highlighting the need for a large, multicenter, standardized, randomized clinical trial that specifically analyzes the different types of bowel preparation (and the omission of preparation) and sheds light on this controversial practice in the preoperative management of advanced ovarian cancer surgery.
Direction
ARIAS BALTAR, MARIA EFIGENIA (Tutorships)
Correa Orbán, Cándida Rosa (Co-tutorships)
ARIAS BALTAR, MARIA EFIGENIA (Tutorships)
Correa Orbán, Cándida Rosa (Co-tutorships)
Court
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
Use of screens as a risk factor for childhood obesity. A systematic review.
Authorship
E.P.G.
Bachelor of Medicine
E.P.G.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Justification: Screen time interventions, good nutritional education, and physical exercise contribute to good health in children and adolescents, as well as to the prevention of long-term complications. Furthermore, developing these habits from childhood favors their maintenance in adulthood. Objective: To analyze the available evidence to assess whether screen time in children and adolescents may be a risk factor for pediatric obesity. Material and methods: The PubMed search strategy was: (Obesity [Mesh] OR Overnutrition [Mesh] OR Overweight [Mesh] OR Pediatric Obesity [Mesh]) AND (screen time [Mesh] OR Sedentary Behavior [Mesh]). Scopus and the Cochrane Library were also explored. Bias was analyzed using Rob-2 and Robins-E. Results: A total of 237 articles were obtained, of which 11 were included: 3 clinical trials, 6 cohort studies, and 2 observational studies, with a total of 38,888 children between the ages of 1 month and 16 years. Increased screen time, combined with a sedentary lifestyle, is a risk factor for the development of obesity in the short and long term. It can lead to consequences such as reduced sleep quality, unhealthy dietary habits with increased consumption of high-calorie foods and sugary drinks, and impaired hormonal metabolism. Conclusions: Screen time is a risk factor for the development of childhood obesity. Planning prevention strategies should include information and training for children and their families on the appropriate and recommended amount of screen time. The potential role of this variable in the health of children and adolescents should be disseminated to health professionals, schools, and the public.
Justification: Screen time interventions, good nutritional education, and physical exercise contribute to good health in children and adolescents, as well as to the prevention of long-term complications. Furthermore, developing these habits from childhood favors their maintenance in adulthood. Objective: To analyze the available evidence to assess whether screen time in children and adolescents may be a risk factor for pediatric obesity. Material and methods: The PubMed search strategy was: (Obesity [Mesh] OR Overnutrition [Mesh] OR Overweight [Mesh] OR Pediatric Obesity [Mesh]) AND (screen time [Mesh] OR Sedentary Behavior [Mesh]). Scopus and the Cochrane Library were also explored. Bias was analyzed using Rob-2 and Robins-E. Results: A total of 237 articles were obtained, of which 11 were included: 3 clinical trials, 6 cohort studies, and 2 observational studies, with a total of 38,888 children between the ages of 1 month and 16 years. Increased screen time, combined with a sedentary lifestyle, is a risk factor for the development of obesity in the short and long term. It can lead to consequences such as reduced sleep quality, unhealthy dietary habits with increased consumption of high-calorie foods and sugary drinks, and impaired hormonal metabolism. Conclusions: Screen time is a risk factor for the development of childhood obesity. Planning prevention strategies should include information and training for children and their families on the appropriate and recommended amount of screen time. The potential role of this variable in the health of children and adolescents should be disseminated to health professionals, schools, and the public.
Direction
Leis Trabazo, María Rosaura (Tutorships)
García García, Eva María (Co-tutorships)
Leis Trabazo, María Rosaura (Tutorships)
García García, Eva María (Co-tutorships)
Court
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
Relationship between dental malocclusion and orofacial pain in adults: a review of the current scientific evidence
Authorship
A.P.R.
Grao en Odontología (2ªed)
A.P.R.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Objetives: The aim of this study was to conduct a scoping literature review on the relationship between the presence of various types of malocclusions and orofacial pain symptoms in adult population. Design: Scoping literature review. Methods: The PRISMA-ScR guideline was followed. All literature found in the following databases was used: MEDLINE via PUBMED, Cochrane Central Register of Controlled Trials, and Scopus. The exclusion criteria were animal studies, articles considered gray literature and studies without full-text availability. Cross-sectional observational studies published in indexed journals, written in English and investigating the relationship between malocclusions and orofacial pain symptoms in adults were included. The quality assessment is carried out using the Jbi Critical Appraisal Checklist For Analytical Cross Sectional Studies. Outcomes: A total of six observational studies evaluating skeletal and dental malocclusions in adult populations were included. The diagnostic methods employed included standardized clinical criteria such as DC/TMD and RDC/TMD, as well as orthodontic tools like the DAI index, PAR index and cephalometric analysis. Different types of orofacial pain were assessed, including myofascial, articular, periauricular and muscle pain associated with TMD. The results showed that not all studies reported statistically significant associations; however, certain malocclusions- such as skeletal Class II, increased overjet, posterior crossbite and molar asymmetries- had a higher prevalence in individuals with muscle or joint pain. Conclusions: Although direct associations cannot be established, certain types of malocclusions, such as skeletal Class II, may represent predisposing factors for the development of orofacial pain. Based on the results, further comprehensive research including control groups, follow-up periods and larger sample sizes is needed in the future.
Objetives: The aim of this study was to conduct a scoping literature review on the relationship between the presence of various types of malocclusions and orofacial pain symptoms in adult population. Design: Scoping literature review. Methods: The PRISMA-ScR guideline was followed. All literature found in the following databases was used: MEDLINE via PUBMED, Cochrane Central Register of Controlled Trials, and Scopus. The exclusion criteria were animal studies, articles considered gray literature and studies without full-text availability. Cross-sectional observational studies published in indexed journals, written in English and investigating the relationship between malocclusions and orofacial pain symptoms in adults were included. The quality assessment is carried out using the Jbi Critical Appraisal Checklist For Analytical Cross Sectional Studies. Outcomes: A total of six observational studies evaluating skeletal and dental malocclusions in adult populations were included. The diagnostic methods employed included standardized clinical criteria such as DC/TMD and RDC/TMD, as well as orthodontic tools like the DAI index, PAR index and cephalometric analysis. Different types of orofacial pain were assessed, including myofascial, articular, periauricular and muscle pain associated with TMD. The results showed that not all studies reported statistically significant associations; however, certain malocclusions- such as skeletal Class II, increased overjet, posterior crossbite and molar asymmetries- had a higher prevalence in individuals with muscle or joint pain. Conclusions: Although direct associations cannot be established, certain types of malocclusions, such as skeletal Class II, may represent predisposing factors for the development of orofacial pain. Based on the results, further comprehensive research including control groups, follow-up periods and larger sample sizes is needed in the future.
Direction
Santana Mora, Urbano Alejandro (Tutorships)
González Mosquera, Antonio (Co-tutorships)
Santana Mora, Urbano Alejandro (Tutorships)
González Mosquera, Antonio (Co-tutorships)
Court
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
High-Intensity Focused Ultrasound (HIFU): Therapeutic Applications in Oncology and other pathologies. From imaging to treatment: The Therapeutic Use of Radiodiagnostic Modalities.
Authorship
D.P.B.
Bachelor of Medicine
D.P.B.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
High-Intensity Focused Ultrasound (HIFU) is a non-invasive technique that uses ultrasound waves to generate localized heat and precisely destroy pathological tissue while preserving surrounding structures. Its growing application in oncology, particularly in tumors such as prostate, breast, and uterine (fibroids), positions it as an innovative therapeutic alternative. Additionally, its potential use is being investigated in other conditions, such as chronic pain and neurological diseases. However, challenges persist regarding its availability, costs, and clinical standardization. This work aims to describe the physical and technical principles of HIFU as a therapeutic tool and analyze its applications in oncology and other non-oncological conditions, such as chronic pain management or neurological disorders (e.g., essential tremor), evaluating its effectiveness, benefits, and limitations through a literature review.
High-Intensity Focused Ultrasound (HIFU) is a non-invasive technique that uses ultrasound waves to generate localized heat and precisely destroy pathological tissue while preserving surrounding structures. Its growing application in oncology, particularly in tumors such as prostate, breast, and uterine (fibroids), positions it as an innovative therapeutic alternative. Additionally, its potential use is being investigated in other conditions, such as chronic pain and neurological diseases. However, challenges persist regarding its availability, costs, and clinical standardization. This work aims to describe the physical and technical principles of HIFU as a therapeutic tool and analyze its applications in oncology and other non-oncological conditions, such as chronic pain management or neurological disorders (e.g., essential tremor), evaluating its effectiveness, benefits, and limitations through a literature review.
Direction
VARELA PONTE, RAFAEL (Tutorships)
Martínez Lago, Nieves Purificación (Co-tutorships)
VARELA PONTE, RAFAEL (Tutorships)
Martínez Lago, Nieves Purificación (Co-tutorships)
Court
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
Impact of pacifier use on infant health. An analysis of YouTube content
Authorship
R.R.R.
Grao en Odontología (2ªed)
R.R.R.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Introduction: Pacifier use generates controversy; many families turn to YouTube for information. Obxectives: To verify the reliability of pacifier information on YouTube by describing who says what, with what sources, how closely it conforms to guidelines and where it deviates from them, in order to give parents and healthcare providers a clear and up-to-date point of reference. Material and methods: Cross-sectional study of the 50 videos in Spanish ordered by relevance. Information was collected on metadata, benefits, risks, position and references. Results: 64% cited benefits and 68% cited harms. Benefits: calming (44%), prevention of SIDS (26%), otitis (14%). Only 18% cited sources; 36% defended the pacifier, 44% rejected it and 20% were neutral. Conclusion: Most videos lack scientific support. Short, evidence-based videos produced by professional entities are needed to improve parental decision making.
Introduction: Pacifier use generates controversy; many families turn to YouTube for information. Obxectives: To verify the reliability of pacifier information on YouTube by describing who says what, with what sources, how closely it conforms to guidelines and where it deviates from them, in order to give parents and healthcare providers a clear and up-to-date point of reference. Material and methods: Cross-sectional study of the 50 videos in Spanish ordered by relevance. Information was collected on metadata, benefits, risks, position and references. Results: 64% cited benefits and 68% cited harms. Benefits: calming (44%), prevention of SIDS (26%), otitis (14%). Only 18% cited sources; 36% defended the pacifier, 44% rejected it and 20% were neutral. Conclusion: Most videos lack scientific support. Short, evidence-based videos produced by professional entities are needed to improve parental decision making.
Direction
RODRÍGUEZ FERNÁNDEZ, Mª DE LA ALMUDENA (Tutorships)
MULERO DE CASO, MARTA (Co-tutorships)
RODRÍGUEZ FERNÁNDEZ, Mª DE LA ALMUDENA (Tutorships)
MULERO DE CASO, MARTA (Co-tutorships)
Court
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
Integrated care in Parkinson's Disease patients. A pilot study.
Authorship
M.R.F.S.S.
Bachelor of Medicine
M.R.F.S.S.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Parkinson’s Disease (PD) is the second most prevalent neurodegenerative disorder worldwide. This study concludes that integrative care based on neurological follow-up combined with physical exercise and mindfulness-based intervention may contribute to improving the quality of life of people with PD.
Parkinson’s Disease (PD) is the second most prevalent neurodegenerative disorder worldwide. This study concludes that integrative care based on neurological follow-up combined with physical exercise and mindfulness-based intervention may contribute to improving the quality of life of people with PD.
Direction
MARTINON TORRES, FEDERICO (Tutorships)
Sánchez Alonso, Mª Pilar (Co-tutorships)
MARTINON TORRES, FEDERICO (Tutorships)
Sánchez Alonso, Mª Pilar (Co-tutorships)
Court
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
Addressing child abuse in the dental office
Authorship
A.D.P.R.Q.
Grao en Odontología (2ªed)
A.D.P.R.Q.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Child maltreatment is a serious social worldwide problem that negatively impacts the health and well-being of children and adolescents, resulting in devastating physical and emotional consequences. This maltreatment can manifest in various forms, such as physical abuse, psychological abuse, neglect, and sexual abuse, and requires urgent attention and intersectoral efforts for prevention and treatment. Despite surveys conducted, the magnitude of the problem remains difficult to quantify due to a lack of records and reports. Health professionals, particularly dentists, are key in detecting physical abuse, as injuries are common in areas they regularly examine. However, many dentists struggle to identify and report these cases, highlighting the need for training in recognizing signs of abuse. This research focuses on how cases of child maltreatment are handled in dental practice, seeking to identify indicators of maltreatment related to oral health and evaluating the knowledge and attitudes of dentists regarding suspicious injuries, as well as the barriers to reporting. Through a literature review in PubMed, 151 records were found, selecting the most relevant on the topic. It is noted that more than 50% of maltreatment cases present orofacial injuries, and specifically between 58% and 80% of abused children have lesions in the oral region. Although many dentists acknowledge their importance in detecting maltreatment, only a small percentage report suspicious cases, due to legal fears, diagnostic insecurities, and a lack of knowledge about reporting procedures. This underscores the need to improve training and protocols so that dental staff can effectively respond to situations of child maltreatment.
Child maltreatment is a serious social worldwide problem that negatively impacts the health and well-being of children and adolescents, resulting in devastating physical and emotional consequences. This maltreatment can manifest in various forms, such as physical abuse, psychological abuse, neglect, and sexual abuse, and requires urgent attention and intersectoral efforts for prevention and treatment. Despite surveys conducted, the magnitude of the problem remains difficult to quantify due to a lack of records and reports. Health professionals, particularly dentists, are key in detecting physical abuse, as injuries are common in areas they regularly examine. However, many dentists struggle to identify and report these cases, highlighting the need for training in recognizing signs of abuse. This research focuses on how cases of child maltreatment are handled in dental practice, seeking to identify indicators of maltreatment related to oral health and evaluating the knowledge and attitudes of dentists regarding suspicious injuries, as well as the barriers to reporting. Through a literature review in PubMed, 151 records were found, selecting the most relevant on the topic. It is noted that more than 50% of maltreatment cases present orofacial injuries, and specifically between 58% and 80% of abused children have lesions in the oral region. Although many dentists acknowledge their importance in detecting maltreatment, only a small percentage report suspicious cases, due to legal fears, diagnostic insecurities, and a lack of knowledge about reporting procedures. This underscores the need to improve training and protocols so that dental staff can effectively respond to situations of child maltreatment.
Direction
CRUZ LANDEIRA, ANGELINES (Tutorships)
CRUZ LANDEIRA, ANGELINES (Tutorships)
Court
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
MAREQUE BUENO, SANTIAGO (Chairman)
SEOANE ROMERO, JUAN MANUEL (Secretary)
RILO POUSA, BENITO (Member)
Phenotypic characterization of primary failure to anti-TNF in patients with Inflammatory Bowel Disease
Authorship
P.R.B.
Bachelor of Medicine
P.R.B.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
INTRODUCTION. Anti-TNF drugs are monoclonal antibodies directed against tumor necrosis factor (TNF), a cytokine that plays a key role in regulating the inflammatory and immune response. They are used as first-line biological drugs in Inflammatory Bowel Disease is widespread, both in Crohn's disease and ulcerative colitis. However, failure of this treatment is common due to loss of efficacy and adverse effects. AIM. To evaluate the prevalence of non-response to anti-TNF treatment or primary failure in patients with IBD in our setting and the associated clinical factors. METHOD. A cross-sectional, prospective observational study of a cohort of patients with IBD who started treatment with anti-TNF drugs (adalimumab, infliximab and golimumab) at the IBD Unit of the Álvaro Cunqueiro Hospital in Vigo between 2020 and 2023. RESULTS. The sample of patients who participated in the study consisted of 209, with a mean age at the start of treatment of 43.5 (17.1) years. Of these, 127 had Crohn's disease and 82 had ulcerative colitis. During the average follow-up period of 23.3 months, anti-TNF treatment was discontinued in 42.1% of patients, Anti-TNF treatment was discontinued in 42.1% of patients, due to primary failure in 16.3% of the total. Of these, 61.8% were patients with UC and only 38.2% with CD. This shows that, in this cohort, primary failure is significantly more frequent (p = 0.003) in patients with UC. Furthermore, analysis of the clinical factors showed that they were not associated with age, BMI, HLA status, disease duration, previous surgery, or a complex phenotype. No significant relationship was found with clinical severity indexes, neither baseline CRP, CPF, albumin or Hg. In contrast, non-response was associated with greater use of corticosteroids at the start of treatment (76.5% of patients) (p=0.02). CONCLUSIONS. Primary failure is a common reason for discontinuing anti-TNF treatment, and it's more common in patients with ulcerative colitis. Of the different clinical and lab variables we looked at, only using steroids at the start of treatment was linked to a higher chance of primary failure.
INTRODUCTION. Anti-TNF drugs are monoclonal antibodies directed against tumor necrosis factor (TNF), a cytokine that plays a key role in regulating the inflammatory and immune response. They are used as first-line biological drugs in Inflammatory Bowel Disease is widespread, both in Crohn's disease and ulcerative colitis. However, failure of this treatment is common due to loss of efficacy and adverse effects. AIM. To evaluate the prevalence of non-response to anti-TNF treatment or primary failure in patients with IBD in our setting and the associated clinical factors. METHOD. A cross-sectional, prospective observational study of a cohort of patients with IBD who started treatment with anti-TNF drugs (adalimumab, infliximab and golimumab) at the IBD Unit of the Álvaro Cunqueiro Hospital in Vigo between 2020 and 2023. RESULTS. The sample of patients who participated in the study consisted of 209, with a mean age at the start of treatment of 43.5 (17.1) years. Of these, 127 had Crohn's disease and 82 had ulcerative colitis. During the average follow-up period of 23.3 months, anti-TNF treatment was discontinued in 42.1% of patients, Anti-TNF treatment was discontinued in 42.1% of patients, due to primary failure in 16.3% of the total. Of these, 61.8% were patients with UC and only 38.2% with CD. This shows that, in this cohort, primary failure is significantly more frequent (p = 0.003) in patients with UC. Furthermore, analysis of the clinical factors showed that they were not associated with age, BMI, HLA status, disease duration, previous surgery, or a complex phenotype. No significant relationship was found with clinical severity indexes, neither baseline CRP, CPF, albumin or Hg. In contrast, non-response was associated with greater use of corticosteroids at the start of treatment (76.5% of patients) (p=0.02). CONCLUSIONS. Primary failure is a common reason for discontinuing anti-TNF treatment, and it's more common in patients with ulcerative colitis. Of the different clinical and lab variables we looked at, only using steroids at the start of treatment was linked to a higher chance of primary failure.
Direction
DE CASTRO PARGA, MARIA LUISA (Tutorships)
Ucha Abal, Patricia (Co-tutorships)
DE CASTRO PARGA, MARIA LUISA (Tutorships)
Ucha Abal, Patricia (Co-tutorships)
Court
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
Microsurgical free flaps for lower limb reconstructive surgery
Authorship
J.R.L.
Bachelor of Medicine
J.R.L.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Reconstructive surgery has greatly benefited from the development of microsurgery, especially in the treatment of complex injuries such as trauma, severe burns, or chronic infections. This technique allows for the repair of previously irreversible sequelae and improves patients' functionality, aesthetics, and quality of life. In lower limb trauma -often caused by high-energy mechanisms- the variability in severity requires tailored surgical approaches, including coverage of open fractures, avulsions, closed injuries, or amputations. Free microvascular flaps provide effective coverage with well-vascularized tissue, offering the versatility needed for these complex reconstructions. The aim of this study is to assess the effectiveness of microsurgery in reconstructing traumatic lower limb injuries. It includes a review of current literature and a retrospective analysis of 36 patients treated at the Plastic Surgery Department of the University Hospital Complex of A Coruña between January 2015 and January 2025. Clinical variables analyzed include comorbidities, type of flap used, surgical technique, and the occurrence of postoperative complications. Patient demographics, flap types, and anastomosis techniques are described, as well as the main complications observed, such as partial or total flap necrosis and haematomas. Although no statistically significant associations were found between clinical factors (such as smoking or diabetes) and complications, certain clinical trends were observed, which could be relevant in studies with larger sample sizes. The results align with the reviewed literature and support microsurgery as an effective and safe tool for lower limb reconstruction, although outcomes depend on multiple clinical and technical factors that require individualized assessment and specialized surgical expertise.
Reconstructive surgery has greatly benefited from the development of microsurgery, especially in the treatment of complex injuries such as trauma, severe burns, or chronic infections. This technique allows for the repair of previously irreversible sequelae and improves patients' functionality, aesthetics, and quality of life. In lower limb trauma -often caused by high-energy mechanisms- the variability in severity requires tailored surgical approaches, including coverage of open fractures, avulsions, closed injuries, or amputations. Free microvascular flaps provide effective coverage with well-vascularized tissue, offering the versatility needed for these complex reconstructions. The aim of this study is to assess the effectiveness of microsurgery in reconstructing traumatic lower limb injuries. It includes a review of current literature and a retrospective analysis of 36 patients treated at the Plastic Surgery Department of the University Hospital Complex of A Coruña between January 2015 and January 2025. Clinical variables analyzed include comorbidities, type of flap used, surgical technique, and the occurrence of postoperative complications. Patient demographics, flap types, and anastomosis techniques are described, as well as the main complications observed, such as partial or total flap necrosis and haematomas. Although no statistically significant associations were found between clinical factors (such as smoking or diabetes) and complications, certain clinical trends were observed, which could be relevant in studies with larger sample sizes. The results align with the reviewed literature and support microsurgery as an effective and safe tool for lower limb reconstruction, although outcomes depend on multiple clinical and technical factors that require individualized assessment and specialized surgical expertise.
Direction
BREA GARCIA, BEATRIZ (Tutorships)
Mate Martín, Diego (Co-tutorships)
BREA GARCIA, BEATRIZ (Tutorships)
Mate Martín, Diego (Co-tutorships)
Court
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
Psychedelics for the treatment of depression. Psilocybin, a systematic review
Authorship
N.R.C.
Bachelor of Medicine
N.R.C.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Major depressive disorder (MDD) is a prevalent mental illness with significant social and healthcare impact, and current treatments show notable limitations, particularly in treatment-resistant cases. In this context, psilocybin, a classic psychedelic and serotonin 5HT2A receptor agonist, emerges as a promising therapeutic alternative. This systematic review analyzes recent evidence regarding the efficacy, safety, and clinical feasibility of psilocybin in the treatment of MDD, with a specific focus on treatment-resistant depression (TRD). Reviewed studies report a rapid, strong, and sustained therapeutic response following one or two doses, with moderate to large effect sizes and benefits lasting up to 12 months. Psilocybin exhibits a favorable safety profile, with mostly mild and transient adverse effects and no evidence of dependence. Its effectiveness is dose-dependent and significantly influenced by psychological support during treatment, though methodological limitations, such as small sample sizes, heterogeneity, and short follow-up, continue to hinder broader clinical implementation. Neurobiological findings suggest that psilocybin induces neuroplastic changes and functional brain network reorganization, offering potential biomarkers of therapeutic response. In conclusion, while psilocybin shows promising clinical potential for MDD, its widespread therapeutic use will require phase III trials, protocol standardization, cost-effectiveness evaluations, and assessment of real-world healthcare integration.
Major depressive disorder (MDD) is a prevalent mental illness with significant social and healthcare impact, and current treatments show notable limitations, particularly in treatment-resistant cases. In this context, psilocybin, a classic psychedelic and serotonin 5HT2A receptor agonist, emerges as a promising therapeutic alternative. This systematic review analyzes recent evidence regarding the efficacy, safety, and clinical feasibility of psilocybin in the treatment of MDD, with a specific focus on treatment-resistant depression (TRD). Reviewed studies report a rapid, strong, and sustained therapeutic response following one or two doses, with moderate to large effect sizes and benefits lasting up to 12 months. Psilocybin exhibits a favorable safety profile, with mostly mild and transient adverse effects and no evidence of dependence. Its effectiveness is dose-dependent and significantly influenced by psychological support during treatment, though methodological limitations, such as small sample sizes, heterogeneity, and short follow-up, continue to hinder broader clinical implementation. Neurobiological findings suggest that psilocybin induces neuroplastic changes and functional brain network reorganization, offering potential biomarkers of therapeutic response. In conclusion, while psilocybin shows promising clinical potential for MDD, its widespread therapeutic use will require phase III trials, protocol standardization, cost-effectiveness evaluations, and assessment of real-world healthcare integration.
Direction
ARROJO ROMERO, MANUEL (Tutorships)
Núñez Sande, Carmen (Co-tutorships)
ARROJO ROMERO, MANUEL (Tutorships)
Núñez Sande, Carmen (Co-tutorships)
Court
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
Use of vital Lugol staining in the screening of potentially malignant lesions.
Authorship
F.R.
Grao en Odontología (2ªed)
F.R.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Introduction. Currently, there is no diagnostic test that can reliably predict the malignant transformation of potentially malignant lesions. These include leukoplakia (OL), oral lichen planus (OLP), proliferative verrucous leukoplakia (PVL), and oral lichenoid lesions (OLL), each with varying degrees of malignant potential. Moreover, some of these lesions may overlap or start with one clinical appearance and evolve into another over time, making early diagnosis challenging. Vital staining methods are non-invasive, quick, and painless techniques used in oral mucosal examinations. Among them, Lugol’s iodine is a low-cost stain that is easy to apply in daily clinical practice. Objectives. This study aims to evaluate the use of Lugol’s iodine staining as a clinical diagnostic aid for potentially malignant lesions in their early stages, with the goal of preventing malignant transformation of the oral mucosa. Additionally, the study seeks to determine whether it is possible to distinguish between OL, PVL, and OLP lesions based solely on their clinical visual pattern after Lugol staining. Therefore, the clinical pattern after Lugol staining is analyzed to assess whether a consensus can be reached on the visual pattern associated with each type of lesion, comparing it to the biopsy results, which remain the current gold standard. Materials and Methods. A retrospective study was conducted on a sample of 58 patients treated at the Oral Medicine Department of the University of Santiago de Compostela (USC). The sample was divided into a case group (48 patients with biopsy-confirmed potentially malignant lesions) and a control group (10 healthy patients with no oral lesions). A 3% Lugol's iodine solution was used for vital staining to visually assess the lesions, comparing stain uptake between healthy and lesioned tissue. The protocol included mucosal preparation, Lugol application, clinical evaluation of staining patterns, photographic documentation, and comparison with histopathological diagnosis. Finally, sensitivity, specificity, and predictive values of the technique were analyzed to evaluate its effectiveness as a complementary tool for screening potentially malignant oral lesions. Discussion. The results suggest that vital staining with Lugol’s iodine allows identification of specific clinical patterns associated with certain potentially malignant lesions. In particular, the plaque pattern showed high sensitivity for leukoplakia, supporting its utility in screening for these lesions. In oral lichen planus, the combination of reticular patterns, in striae and with plaque showed high specificity, being useful for confirming the diagnosis when present. In proliferative verrucous leukoplakia, the verrucous or mixed pattern with plaque also showed good specificity. These findings support the notion that the appearance of the staining pattern may serve as a relevant clinical indicator, beyond the type of pattern alone. Therefore, Lugol’s iodine vital staining may be a useful complementary tool in the screening and diagnostic approach to suspicious oral lesions. Conclusion. Vital staining with Lugol’s iodine solution is an accessible and effective complementary technique for screening potentially malignant oral lesions. While it shows good sensitivity and specificity, it does not provide a definitive diagnosis, as staining patterns are not exclusively associated with specific lesion types. Its use may aid in early detection in clinical practice but should always be accompanied by histopathological confirmation. Proper training and further studies are recommended to support its application and standardization.
Introduction. Currently, there is no diagnostic test that can reliably predict the malignant transformation of potentially malignant lesions. These include leukoplakia (OL), oral lichen planus (OLP), proliferative verrucous leukoplakia (PVL), and oral lichenoid lesions (OLL), each with varying degrees of malignant potential. Moreover, some of these lesions may overlap or start with one clinical appearance and evolve into another over time, making early diagnosis challenging. Vital staining methods are non-invasive, quick, and painless techniques used in oral mucosal examinations. Among them, Lugol’s iodine is a low-cost stain that is easy to apply in daily clinical practice. Objectives. This study aims to evaluate the use of Lugol’s iodine staining as a clinical diagnostic aid for potentially malignant lesions in their early stages, with the goal of preventing malignant transformation of the oral mucosa. Additionally, the study seeks to determine whether it is possible to distinguish between OL, PVL, and OLP lesions based solely on their clinical visual pattern after Lugol staining. Therefore, the clinical pattern after Lugol staining is analyzed to assess whether a consensus can be reached on the visual pattern associated with each type of lesion, comparing it to the biopsy results, which remain the current gold standard. Materials and Methods. A retrospective study was conducted on a sample of 58 patients treated at the Oral Medicine Department of the University of Santiago de Compostela (USC). The sample was divided into a case group (48 patients with biopsy-confirmed potentially malignant lesions) and a control group (10 healthy patients with no oral lesions). A 3% Lugol's iodine solution was used for vital staining to visually assess the lesions, comparing stain uptake between healthy and lesioned tissue. The protocol included mucosal preparation, Lugol application, clinical evaluation of staining patterns, photographic documentation, and comparison with histopathological diagnosis. Finally, sensitivity, specificity, and predictive values of the technique were analyzed to evaluate its effectiveness as a complementary tool for screening potentially malignant oral lesions. Discussion. The results suggest that vital staining with Lugol’s iodine allows identification of specific clinical patterns associated with certain potentially malignant lesions. In particular, the plaque pattern showed high sensitivity for leukoplakia, supporting its utility in screening for these lesions. In oral lichen planus, the combination of reticular patterns, in striae and with plaque showed high specificity, being useful for confirming the diagnosis when present. In proliferative verrucous leukoplakia, the verrucous or mixed pattern with plaque also showed good specificity. These findings support the notion that the appearance of the staining pattern may serve as a relevant clinical indicator, beyond the type of pattern alone. Therefore, Lugol’s iodine vital staining may be a useful complementary tool in the screening and diagnostic approach to suspicious oral lesions. Conclusion. Vital staining with Lugol’s iodine solution is an accessible and effective complementary technique for screening potentially malignant oral lesions. While it shows good sensitivity and specificity, it does not provide a definitive diagnosis, as staining patterns are not exclusively associated with specific lesion types. Its use may aid in early detection in clinical practice but should always be accompanied by histopathological confirmation. Proper training and further studies are recommended to support its application and standardization.
Direction
GANDARA VILA, PILAR (Tutorships)
Sanmartín Barragáns, Valeria (Co-tutorships)
GANDARA VILA, PILAR (Tutorships)
Sanmartín Barragáns, Valeria (Co-tutorships)
Court
BLANCO CARRION, JUAN (Chairman)
CASTELO BAZ, PABLO (Secretary)
Rivas Mundiña, Berta (Member)
BLANCO CARRION, JUAN (Chairman)
CASTELO BAZ, PABLO (Secretary)
Rivas Mundiña, Berta (Member)
Influence of sleep quality as a determining factor in morbidity, life habits and quality of life
Authorship
A.S.M.
Bachelor of Medicine
A.S.M.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Introduction: Sleep quality is a key determinant of overall health and well-being, with direct implications for quality of life and morbidity in the population. The aim of this study was to analyze the association between sleep quality, quality of life, and prevalence of chronic diseases in adults registered at health centers in Galicia. Materials and methods: A descriptive cross-sectional study was conducted on a random sample of 350 people aged 35 to 74. Sociodemographic, clinical, and lifestyle variables were collected, and sleep quality was assessed using the Pittsburgh test, as well as quality of life using the EQ-5D, VAS, and SF-12 questionnaires. A descriptive and bivariate analysis was performed. Results: 53.4% (95% CI: 48;58.8) of the sample were women, with a median age of 54 years (IQR: 18). Forty percent (95% CI: 34.7; 45.3) reported poor sleep quality, with this percentage being higher in women. Eighteen point eight percent (95% CI: 14.6; 23.1) reported frequent use of sleep medication. The median number of hours of sleep was 6.5 (IQR: 1), with an efficiency of 87.5%. A significant association was observed between poor sleep quality and lower scores on quality of life indices (EQ-5D, VAS, SF-12), as well as a more negative overall perception of health. In addition, poor sleep quality was associated with a higher prevalence of affective disorders 23.4% (17.5; 29.4) and diabetes mellitus 11.5% (6.9; 16), but not with cardiovascular disease or lifestyle habits such as alcohol consumption, physical activity, or adherence to a Mediterranean diet. Conclusions: Poor sleep quality is significantly associated with a poorer quality of life, especially in the physical and mental spheres, and with a higher prevalence of psychological and metabolic morbidity. These findings underscore the need to addresssleep quality in primary care and hospital settings to improve the overall health of the population.
Introduction: Sleep quality is a key determinant of overall health and well-being, with direct implications for quality of life and morbidity in the population. The aim of this study was to analyze the association between sleep quality, quality of life, and prevalence of chronic diseases in adults registered at health centers in Galicia. Materials and methods: A descriptive cross-sectional study was conducted on a random sample of 350 people aged 35 to 74. Sociodemographic, clinical, and lifestyle variables were collected, and sleep quality was assessed using the Pittsburgh test, as well as quality of life using the EQ-5D, VAS, and SF-12 questionnaires. A descriptive and bivariate analysis was performed. Results: 53.4% (95% CI: 48;58.8) of the sample were women, with a median age of 54 years (IQR: 18). Forty percent (95% CI: 34.7; 45.3) reported poor sleep quality, with this percentage being higher in women. Eighteen point eight percent (95% CI: 14.6; 23.1) reported frequent use of sleep medication. The median number of hours of sleep was 6.5 (IQR: 1), with an efficiency of 87.5%. A significant association was observed between poor sleep quality and lower scores on quality of life indices (EQ-5D, VAS, SF-12), as well as a more negative overall perception of health. In addition, poor sleep quality was associated with a higher prevalence of affective disorders 23.4% (17.5; 29.4) and diabetes mellitus 11.5% (6.9; 16), but not with cardiovascular disease or lifestyle habits such as alcohol consumption, physical activity, or adherence to a Mediterranean diet. Conclusions: Poor sleep quality is significantly associated with a poorer quality of life, especially in the physical and mental spheres, and with a higher prevalence of psychological and metabolic morbidity. These findings underscore the need to addresssleep quality in primary care and hospital settings to improve the overall health of the population.
Direction
GUDE SAMPEDRO, FRANCISCO (Tutorships)
FERNANDEZ DOMINGUEZ, MARIA JOSE (Co-tutorships)
GUDE SAMPEDRO, FRANCISCO (Tutorships)
FERNANDEZ DOMINGUEZ, MARIA JOSE (Co-tutorships)
Court
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
SEOANE PRADO, RAFAEL (Chairman)
VIDAL MILLARES, MARIA (Secretary)
FIDALGO PEREZ, MIGUEL ANGEL (Member)
Evidence Based Therapeutics, Clinical Protocol for the Design, Placement, Loading and Biomechanics of Palatal Microimplants Associated with MARPE.
Authorship
P.S.S.
Grao en Odontología (2ªed)
P.S.S.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
The placement of palatal microimplants as stationary skeletal anchorage for maxillary expansion with MARPE Miniscrew-Assisted Rapid Palatal Expansion has become an effective technique for treating maxillary expansion in adults and young adults. Its clinical success depends on adequate primary stability of the miniscrews along with proper planning and insertion. The adoption of this system has enabled the treatment of skeletal maxillary compressions in adults, sparing them from associated comorbidities.
The placement of palatal microimplants as stationary skeletal anchorage for maxillary expansion with MARPE Miniscrew-Assisted Rapid Palatal Expansion has become an effective technique for treating maxillary expansion in adults and young adults. Its clinical success depends on adequate primary stability of the miniscrews along with proper planning and insertion. The adoption of this system has enabled the treatment of skeletal maxillary compressions in adults, sparing them from associated comorbidities.
Direction
OTERO CASAL, MARIA DE LA PAZ (Tutorships)
OTERO CASAL, MARIA DE LA PAZ (Tutorships)
Court
BLANCO CARRION, JUAN (Chairman)
CASTELO BAZ, PABLO (Secretary)
Rivas Mundiña, Berta (Member)
BLANCO CARRION, JUAN (Chairman)
CASTELO BAZ, PABLO (Secretary)
Rivas Mundiña, Berta (Member)
Graphic Medicine applied to the education of patients with type 1 diabetes mellitus: development of educational material aimed at pediatric patients.
Authorship
C.S.V.
Bachelor of Medicine
C.S.V.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Context: Type 1 Diabetes Mellitus (DM1) is one of the most common chronic diseases in childhood and adolescence. International clinical guidelines highlight the importance of therapeutic education as an essential tool to achieve adequate metabolic control and foster self-management and empowerment. This education should be adapted to the patient's age and individual context. In this regard, Graphic Medicine emerges as an innovative strategy to improve the understanding and coping mechanisms for the disease, by using comics as a narrative and pedagogical medium. Objectives: to develop graphic material (game cards and comics) aimed at children and adolescents with DM1, to instruct paediatric patients on the basic concepts of their disease, adapting and taking into account their developmental stage. Materials and Methods: creative project in the format of educational flashcards for preschoolers (3 to 6 years) and two comics aimed at school-aged children (7 to 12 years) and adolescents (from 12 years). This project encompassed everything from theoretical conception (script) to final production. The content was validated through anonymous online questionnaires and written comments via messaging from specialised medical personnel. Results and Conclusion: The use of Graphic Medicine facilitates the understanding of complex medical content, promotes patient engagement, and fosters more empathetic and horizontal healthcare communication. Its application is particularly interesting for T1DM in paediatric patients due to its flexibility and educational potential. The comics and cards developed in this work constitute didactic tools, and their validation was very positive.
Context: Type 1 Diabetes Mellitus (DM1) is one of the most common chronic diseases in childhood and adolescence. International clinical guidelines highlight the importance of therapeutic education as an essential tool to achieve adequate metabolic control and foster self-management and empowerment. This education should be adapted to the patient's age and individual context. In this regard, Graphic Medicine emerges as an innovative strategy to improve the understanding and coping mechanisms for the disease, by using comics as a narrative and pedagogical medium. Objectives: to develop graphic material (game cards and comics) aimed at children and adolescents with DM1, to instruct paediatric patients on the basic concepts of their disease, adapting and taking into account their developmental stage. Materials and Methods: creative project in the format of educational flashcards for preschoolers (3 to 6 years) and two comics aimed at school-aged children (7 to 12 years) and adolescents (from 12 years). This project encompassed everything from theoretical conception (script) to final production. The content was validated through anonymous online questionnaires and written comments via messaging from specialised medical personnel. Results and Conclusion: The use of Graphic Medicine facilitates the understanding of complex medical content, promotes patient engagement, and fosters more empathetic and horizontal healthcare communication. Its application is particularly interesting for T1DM in paediatric patients due to its flexibility and educational potential. The comics and cards developed in this work constitute didactic tools, and their validation was very positive.
Direction
Gonzalez Quintela, Arturo (Tutorships)
López Mato, Pablo (Co-tutorships)
Gonzalez Quintela, Arturo (Tutorships)
López Mato, Pablo (Co-tutorships)
Court
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
Quality management in dental services: current status
Authorship
N.T.N.
Grao en Odontología (2ªed)
N.T.N.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Introduction: Quality in dental services has gained relevance especially from the perspective of patient satisfaction. However, research and implementation of quality improvement initiatives in this aspect is still in its infancy. Objectives: The aim of this study is to systematically review the implementation of quality management by private dental clinics as dental health service companies and to determine the possible selection criteria used by users from their experience of the service provided. Design: Systematic review. Methods: The WoS database was used to identify studies published in English between 2015 and 2025 that evaluated the quality of private dental clinics from the user's perspective. 8 articles were selected that used patient satisfaction as the main mechanism for implementing service quality improvements. Results: The review found complete agreement on the assessment of patient satisfaction as a tool for implementing quality management initiatives. Satisfaction surveys were employed to assess patient opinions/perceptions, and their results resulted in recommendations focused on improving satisfaction and the patient-provider relationship. Conclusions: The relevance of assessing patient satisfaction in dental care setting as an essential factor in improving the quality of the service provided is evident. It is recommended to use clear communication, establish trusting relationships that involve the patient in self-care, develop empathic skills, incorporate organizational technologies and use satisfaction surveys to adapt care to the needs and expectations of the patient.
Introduction: Quality in dental services has gained relevance especially from the perspective of patient satisfaction. However, research and implementation of quality improvement initiatives in this aspect is still in its infancy. Objectives: The aim of this study is to systematically review the implementation of quality management by private dental clinics as dental health service companies and to determine the possible selection criteria used by users from their experience of the service provided. Design: Systematic review. Methods: The WoS database was used to identify studies published in English between 2015 and 2025 that evaluated the quality of private dental clinics from the user's perspective. 8 articles were selected that used patient satisfaction as the main mechanism for implementing service quality improvements. Results: The review found complete agreement on the assessment of patient satisfaction as a tool for implementing quality management initiatives. Satisfaction surveys were employed to assess patient opinions/perceptions, and their results resulted in recommendations focused on improving satisfaction and the patient-provider relationship. Conclusions: The relevance of assessing patient satisfaction in dental care setting as an essential factor in improving the quality of the service provided is evident. It is recommended to use clear communication, establish trusting relationships that involve the patient in self-care, develop empathic skills, incorporate organizational technologies and use satisfaction surveys to adapt care to the needs and expectations of the patient.
Direction
GALLAS TORREIRA, MARIA MERCEDES (Tutorships)
GALLAS TORREIRA, MARIA MERCEDES (Tutorships)
Court
BLANCO CARRION, JUAN (Chairman)
CASTELO BAZ, PABLO (Secretary)
Rivas Mundiña, Berta (Member)
BLANCO CARRION, JUAN (Chairman)
CASTELO BAZ, PABLO (Secretary)
Rivas Mundiña, Berta (Member)
Comparative analysis of the efficiency and outcomes of primary DIEPs versus salvage DIEPs in breast reconstruction
Authorship
A.V.C.
Bachelor of Medicine
A.V.C.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Aims: General objective: 1. The general objective is to estimate the prevalence of complications that occurred in both primary and rescue DIEPs. Specific objectives: 1.To identify risk factors associated with complications. 2.To analyse the number of interventions required depending on the primary reconstruction. 3.To compare the percentage of complications between primary DIEPs vs. salvage DIEPs. Patients and methods: A retrospective analytical study was conducted in 72 patients over 18 years of age who underwent autologous breast reconstruction with DIEP flap after mastectomy for breast cancer, between May 2017 and May 2024, at CHUAC. They were classified into primary or salvage reconstruction, according to reconstructive history. Demographic, clinical, surgical and comorbidity-related variables were analysed. The information was obtained from electronic medical records using the IANUS system, complying with the ethical principles of the Declaration of Helsinki. Results: Seventy-two DIEP flap breast reconstructions were analysed, of which 63.9% were primary and 36.1% salvage. The overall breast complication rate was 37.5%, with no significant difference between the two groups (p=0.899). Fat necrosis was significantly more frequent in the salvage group (15.4% vs. 2.2%; p(menor*)0.05). Flap loss was reported in 11.1% of all patients. Abdominal complications were rare (6.9%) and there were no significant differences between the groups. Conclusion: The results of the present study show that DIEP flap breast reconstruction has a similar overall complication rate in both primary and salvage procedures. However, specific complications, such as fat necrosis, were more significantly frequent in the salvage group. These findings support the efficacy of DIEP in both settings but suggest that its indication as a first option may prevent future complications associated with failed reconstructions.
Aims: General objective: 1. The general objective is to estimate the prevalence of complications that occurred in both primary and rescue DIEPs. Specific objectives: 1.To identify risk factors associated with complications. 2.To analyse the number of interventions required depending on the primary reconstruction. 3.To compare the percentage of complications between primary DIEPs vs. salvage DIEPs. Patients and methods: A retrospective analytical study was conducted in 72 patients over 18 years of age who underwent autologous breast reconstruction with DIEP flap after mastectomy for breast cancer, between May 2017 and May 2024, at CHUAC. They were classified into primary or salvage reconstruction, according to reconstructive history. Demographic, clinical, surgical and comorbidity-related variables were analysed. The information was obtained from electronic medical records using the IANUS system, complying with the ethical principles of the Declaration of Helsinki. Results: Seventy-two DIEP flap breast reconstructions were analysed, of which 63.9% were primary and 36.1% salvage. The overall breast complication rate was 37.5%, with no significant difference between the two groups (p=0.899). Fat necrosis was significantly more frequent in the salvage group (15.4% vs. 2.2%; p(menor*)0.05). Flap loss was reported in 11.1% of all patients. Abdominal complications were rare (6.9%) and there were no significant differences between the groups. Conclusion: The results of the present study show that DIEP flap breast reconstruction has a similar overall complication rate in both primary and salvage procedures. However, specific complications, such as fat necrosis, were more significantly frequent in the salvage group. These findings support the efficacy of DIEP in both settings but suggest that its indication as a first option may prevent future complications associated with failed reconstructions.
Direction
CARREIRA VILLAMOR, JOSE MARTIN (Tutorships)
González Rodríguez, Alba (Co-tutorships)
CARREIRA VILLAMOR, JOSE MARTIN (Tutorships)
González Rodríguez, Alba (Co-tutorships)
Court
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
Rational use of antibiotics in pediatric dentistry. A systematic review.
Authorship
L.V.L.
Grao en Odontología (2ªed)
L.V.L.
Grao en Odontología (2ªed)
Defense date
07.17.2025 09:30
07.17.2025 09:30
Summary
Introduction: antibiotics are an essential tool in modern medicine, but their high and inappropriate use promotes the development of bacterial resistance, which the WHO considers a global health threat. They are the most prescribed medications in pediatric dentistry, which may pose risks to children well-being. For all these reasons, a “One Health” approach is promoted to address antimicrobial resistance in global and interdisciplinary manner. Objectives: to describe the use of antibiotics in pediatric dentistry, to analyse which ones an how many are prescribed, to describe their main indications, to analyse the frequency of prescription, to describe the clinical practice guidelines used and to analyse the data collection methodology in this specialty. Methods: a search was conducted un the PubMed and Scopus databases, including articles published between 2019 and 2025. The PRISMA guidelines were followed to carry out this systematic review. Results: of the 2158 articles found, 8 meeting the inclusion criteria were selected, all cross sectional studies. The studies show inappropriate antibiotic prescribing, although pediatric dentists demonstrate better practices. Amoxicillin is the most commonly used antibiotic. Weekly prescriptions are usually made, and the antibiotics are primarily used in cases of cardiovascular risk, severe infections and surgeries. Lack of adherence to clinical guidelines and the use of imprecise data collection methods make it difficult to assess actual consumption. Conclusions: inappropriate antibiotic prescribing remains common, highlighting the need to update protocols and strengthen training, although pediatric dentists tend to follow better criteria than other professionals. Amoxicillin stands out as the most used antibiotic, with weekly prescriptions in most cases. The limited availability of guidelines and unreliable data collection methods complicate the accurate analysis of antibiotic use.
Introduction: antibiotics are an essential tool in modern medicine, but their high and inappropriate use promotes the development of bacterial resistance, which the WHO considers a global health threat. They are the most prescribed medications in pediatric dentistry, which may pose risks to children well-being. For all these reasons, a “One Health” approach is promoted to address antimicrobial resistance in global and interdisciplinary manner. Objectives: to describe the use of antibiotics in pediatric dentistry, to analyse which ones an how many are prescribed, to describe their main indications, to analyse the frequency of prescription, to describe the clinical practice guidelines used and to analyse the data collection methodology in this specialty. Methods: a search was conducted un the PubMed and Scopus databases, including articles published between 2019 and 2025. The PRISMA guidelines were followed to carry out this systematic review. Results: of the 2158 articles found, 8 meeting the inclusion criteria were selected, all cross sectional studies. The studies show inappropriate antibiotic prescribing, although pediatric dentists demonstrate better practices. Amoxicillin is the most commonly used antibiotic. Weekly prescriptions are usually made, and the antibiotics are primarily used in cases of cardiovascular risk, severe infections and surgeries. Lack of adherence to clinical guidelines and the use of imprecise data collection methods make it difficult to assess actual consumption. Conclusions: inappropriate antibiotic prescribing remains common, highlighting the need to update protocols and strengthen training, although pediatric dentists tend to follow better criteria than other professionals. Amoxicillin stands out as the most used antibiotic, with weekly prescriptions in most cases. The limited availability of guidelines and unreliable data collection methods complicate the accurate analysis of antibiotic use.
Direction
RODRÍGUEZ FERNÁNDEZ, Mª DE LA ALMUDENA (Tutorships)
MULERO DE CASO, MARTA (Co-tutorships)
RODRÍGUEZ FERNÁNDEZ, Mª DE LA ALMUDENA (Tutorships)
MULERO DE CASO, MARTA (Co-tutorships)
Court
BLANCO CARRION, JUAN (Chairman)
CASTELO BAZ, PABLO (Secretary)
Rivas Mundiña, Berta (Member)
BLANCO CARRION, JUAN (Chairman)
CASTELO BAZ, PABLO (Secretary)
Rivas Mundiña, Berta (Member)
Diagnostic and therapeutic advances in POEMS syndrome
Authorship
C.V.N.
Bachelor of Medicine
C.V.N.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
POEMS syndrome is a rare disease, its name being an acronym derived from its most common signs and symptoms: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes. It is an uncommon paraneoplastic disorder associated with plasma cell neoplasms. The condition affects multiple body systems, making early diagnosis and effective treatment challenging. The low prevalence and symptom heterogeneity of this disease contribute to limited awareness, posing a significant clinical and diagnostic challenge. However, the prognosis of POEMS syndrome has improved in recent years due to more accurate diagnostic approaches and the development of targeted therapies, though outcomes still vary depending on the severity of symptoms and timing of diagnosis. The aim of this review is to analyze recent advances in the diagnosis of POEMS syndrome, considering new criteria, laboratory markers, such as the overproduction of vascular endothelial growth factor (VEGF), and imaging techniques that enhance early detection. Therapeutic advances are also discussed, assessing the efficacy and safety of novel treatment options such as immunomodulatory agents, proteasome inhibitors, and alternatives to autologous stem cell transplantation. The findings of this review highlight VEGF as the main biomarker for diagnosis and disease monitoring, as well as for detecting relapses and evaluating treatment response. Although autologous stem cell transplantation remains the treatment with the best-documented outcomes, for patients who are not candidates, lenalidomide with dexamethasone and proteasome inhibitors like ixazomib represent promising therapeutic alternatives. To date, the lack of consistent evidence continues to limit the development of international diagnostic and treatment guidelines.
POEMS syndrome is a rare disease, its name being an acronym derived from its most common signs and symptoms: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes. It is an uncommon paraneoplastic disorder associated with plasma cell neoplasms. The condition affects multiple body systems, making early diagnosis and effective treatment challenging. The low prevalence and symptom heterogeneity of this disease contribute to limited awareness, posing a significant clinical and diagnostic challenge. However, the prognosis of POEMS syndrome has improved in recent years due to more accurate diagnostic approaches and the development of targeted therapies, though outcomes still vary depending on the severity of symptoms and timing of diagnosis. The aim of this review is to analyze recent advances in the diagnosis of POEMS syndrome, considering new criteria, laboratory markers, such as the overproduction of vascular endothelial growth factor (VEGF), and imaging techniques that enhance early detection. Therapeutic advances are also discussed, assessing the efficacy and safety of novel treatment options such as immunomodulatory agents, proteasome inhibitors, and alternatives to autologous stem cell transplantation. The findings of this review highlight VEGF as the main biomarker for diagnosis and disease monitoring, as well as for detecting relapses and evaluating treatment response. Although autologous stem cell transplantation remains the treatment with the best-documented outcomes, for patients who are not candidates, lenalidomide with dexamethasone and proteasome inhibitors like ixazomib represent promising therapeutic alternatives. To date, the lack of consistent evidence continues to limit the development of international diagnostic and treatment guidelines.
Direction
POSE REINO, ANTONIO DOMINGO (Tutorships)
POSE REINO, ANTONIO DOMINGO (Tutorships)
Court
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
Multidrug-resistant bacterial infections in patients with hematologic malignancy: Systematic review
Authorship
Y.Y.A.
Bachelor of Medicine
Y.Y.A.
Bachelor of Medicine
Defense date
07.18.2025 09:00
07.18.2025 09:00
Summary
Objetives: To characterize multidrug-resistant bacterial (MDR) infections in patients with hematologic malignancies (HM), a highly vulnerable population due to immunosuppression related to the disease itself and its treatments. Methods: A systematic review was conducted using the PubMed database, selecting 34 relevant studies published from 1994 onward. Results: Findings showed a high prevalence of MDR infections, particularly in cases of acute myeloid leukemia, severe and prolonged neutropenia or hematopoietic stem cell transplantation (HSCT) recipients. Prior antibiotic use, especially fluoroquinolone prophylaxis, was significantly associated with an increased risk of MDR infections. A high rate of inappropriate empirical antibiotic therapy (IEAT) was also observed, leading to worse clinical outcomes. Other contributing factors included prior colonization with MDR bacteria, the presence of central venous catheters, ICU admissions and prolonged hospitalization. MDR infections were associated with increased mortality, which highlights the importance of early detection and targeted antibiotic therapy. Conclusions: Preventive strategies, early diagnosis, and rational antibiotic use are essential to mitigate the impact of MDR infections in this high-risk population.
Objetives: To characterize multidrug-resistant bacterial (MDR) infections in patients with hematologic malignancies (HM), a highly vulnerable population due to immunosuppression related to the disease itself and its treatments. Methods: A systematic review was conducted using the PubMed database, selecting 34 relevant studies published from 1994 onward. Results: Findings showed a high prevalence of MDR infections, particularly in cases of acute myeloid leukemia, severe and prolonged neutropenia or hematopoietic stem cell transplantation (HSCT) recipients. Prior antibiotic use, especially fluoroquinolone prophylaxis, was significantly associated with an increased risk of MDR infections. A high rate of inappropriate empirical antibiotic therapy (IEAT) was also observed, leading to worse clinical outcomes. Other contributing factors included prior colonization with MDR bacteria, the presence of central venous catheters, ICU admissions and prolonged hospitalization. MDR infections were associated with increased mortality, which highlights the importance of early detection and targeted antibiotic therapy. Conclusions: Preventive strategies, early diagnosis, and rational antibiotic use are essential to mitigate the impact of MDR infections in this high-risk population.
Direction
PERNAS SOUTO, BERTA (Tutorships)
PERNAS SOUTO, BERTA (Tutorships)
Court
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)
SUAREZ QUINTANILLA, JUAN ANTONIO (Chairman)
ABRALDES LOPEZ-VEIGA, MAXIMINO JOSE (Secretary)
GUDE SAMPEDRO, FRANCISCO (Member)