ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Student's work ECTS: 92 Hours of tutorials: 6 Expository Class: 38 Interactive Classroom: 14 Total: 150
Use languages Spanish, Galician
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Biochemistry and Molecular Biology
Areas: Biochemistry and Molecular Biology
Center Faculty of Medicine and Dentistry
Call: First Semester
Teaching: Sin docencia (Extinguida)
Enrolment: No Matriculable | 1st year (Yes)
- To know the behaviour of acid-base equilibrium and buffering systems of the human organism.
- To know the properties and functions of the main biomolecules which compose the human body.
- To know the general metabolism of carbohydrates, lipids, amino acids, nucleotides and nucleic acids.
- To know the metabolism of phosphate and calcium, as well as the processes of hard tissue calcification.
- To know the basic biochemical processes involved in dental health.
INTRODUCTION. Introduction to Biochemistry and Molecular Biology. Dental Biochemistry. Biomolecules: chemical and structural characteristics.
WATER. Structure and properties of water. Water in living organisms. Ionic activity of water. Acids and bases. Buffer solutions or buffers.
CARBOHYDRATES. Carbohydrates: concept and classification. Monosaccharides and derivatives of monosaccharides. Disaccharides. Polysaccharides. Proteoglycans and glycoproteins.
LIPIDS. Lipids: structural features and classification. Fatty acids. Complex lipids. Simple lipids. Lipoproteins.
PROTEIN. Amino acids: properties. Protein structure. Protein folding. Proteins of biological interest.
ENZYMES. Enzymes: characteristics and classification. Catalysis and enzyme kinetics. Regulation and inhibition of enzyme activity.
VITAMINS, MINERALS AND TRACE ELEMENTS. Vitamins: Classification and functions. Fat-soluble vitamins. Water-soluble vitamins. Effects of vitamin deficiencies in oral tissues. Minerals and trace elements.
BIOENERGETICS AND INTERMEDIARY METABOLISM. Thermodynamic relations and high-energy compounds. Tricarboxylic acid cycle. Electron transport chain and oxidative phosphorylation. Electron transport inhibitors and uncoupling agents.
CARBOHYDRATES METABOLISM. Glycolysis and its regulation. Metabolic fates of pyruvate and lactic acid fermentation. Inclusion of other monosaccharides to the glycolytic pathway. Pentose phosphate pathway. Gluconeogenesis and its regulation. Glycogenolysis and glycogenesis. Control of glycogen metabolism.
METABOLISM OF LIPIDS AND LIPOPROTEINS. Fatty acid metabolism and regulation. Complex lipid metabolism and its regulation. Simple lipid metabolism: prostaglandins and thromboxanes. Cholesterol metabolism and its regulation. Lipoprotein metabolism.
AMINO ACID METABOLISM. Protein degradation and protein turnover. Common reactions to the metabolism of amino acids: transamination and oxidative deamination. Ureogenesis and formation of glutamine. Glucogenic and ketogenic amino acids. Metabolism of specific amino acids.
NUCLEOTIDE METABOLISM. Structural features and functions of nucleotides. Nucleotide metabolism: purine and pyrimidine.
DNA REPLICATION. Structure and characteristics of DNA. Replication: DNA synthesis. Mutations and DNA repair mechanisms.
RNA SYNTHESIS: TRANSCRIPTION. Structure and characteristics of RNAs. RNA Synthesis. Post-Transcriptional RNA Processing. Regulation of transcription.
PROTEIN SYNTHESIS: TRANSLATION. The genetic code. Protein synthesis. Post-translational modifications of proteins.
RECOMBINANT DNA TECHNOLOGY. PCR, cloning, sequencing and other techniques.
BASIC ORAL BIOCHEMISTRY . Metabolism of calcium and phosphorus. Structure and chemical composition of the tooth. Biochemistry of saliva. Acquired pellicle and plaque Biochemistry of caries. Biochemistry of fluoride. Minimum requirements of toothpaste.
Basic bibliography:
Electronic version books that are available from the USC Library (Access Medicine; McGraw Hill):
-Trudy McKee, James R. McKee. Bioquímica. Las bases moleculares de la vida, 5e. México, D. F. McGRAW-HILL INTERAMERICANA EDITORES, S.A. de C. V. 2014.
-Victor W. Rodwell, David A. Bender, Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil. Harper Bioquímica ilustrada, TRIGÉSIMA PRIMERA EDICIÓN. Ciudad de México. McGRAW-HILL/INTERAMERICANA EDITORES, S.A. de C.V. 2018.
-Adriana María Salazar Montes, Ana Soledad Sandoval Rodríguez, Juan Socorro Armendáriz Borunda. Biología Molecular. Fundamentos y aplicaciones en las ciencias de la salud, 2e. México, D. F. McGRAW-HILL/INTERAMERICANA EDITORES, S.A. DE C.V. 2016.
Complementary bibliography:
-VOET D., VOET J.Q., PRATT C.W. “Fundamentos de Bioquímica. La vida a nivel molecular”. 4º edición. Editorial Médica Panamericana, 2016.
-Ronner P. “Netter. Bioquímica esencial”. Primera ed. Barcelona: Elsevier; 2019.
-TYMOCZKO J.L., BERG J.M. y STRYER L. "Bioquímica: Curso básico". Editorial Reverté, Barcelona, 2014.
-FEDUCHI E., ROMERO C., YÁÑEZ E., BLASCO I., GARCÍA-HOZ C. "Bioquímica. Conceptos Esenciales". 2º edición. Madrid: Editorial Médica Panamericana; 2015.
-LOZANO J.A., GALINDO J.D., GARCÍA-BORRON J.C., MARTÍNEZ-LIARTE J.H., PEÑAFIEL R., SOLANO F. "Bioquímica y Biología Molecular para Ciencias de la Salud". 3º edición. McGraw-Hill Interamericana, Madrid, 2005.
-BAYNES J.W., DOMINICZAK M.H. "Bioquímica Médica". 5º edición. Barcelona: Elsevier España S.L.U. 2019.
-Meisenberg G, Simmons WH. "Principios de Bioquímica Médica". Cuarta ed. Barcelona: Elsevier; 2018.
-LIEBERMAN M., MARKS A.D., PEET A. “Marks Bioquímica médica básica : un enfoque clínico”. 5º edición. Barcelona. Wolters Kluwer , 2018.
Specific skills
- Know the biochemical foundations of dentistry to ensure proper oral-dental care.
- Have knowledge of basic molecular processes of oral cavity and be familiar with them referring to the rest of the human body.
General skills
- Promote the autonomous learning of new knowledge and skills, and motivation for quality.
- Learn to share information with other health professionals and promote team collaboration.
- Understand the basic biomedical sciences on which dentistry is based to ensure proper oral-dental care.
- Understand and recognize the structure and normal function of the oral cavity at the molecular level in different stages of life.
- Understand the general processes of disease, and the metabolic and genetic disorders.
- Understand, critically evaluate and know how to use biomedical information sources to obtain, organize, interpret and communicate scientific and health information.
- Understand the scientific method and be able to assess the established knowledge and new information.
- Be able to formulate hypotheses, collect and critically evaluate information for problem solving using the scientific method.
Large group lectures.
Large group lectures are designed to enhance independent learning of students. In the lectures the teacher will present and explain the most important aspects of each topic, helping students to achieve the objectives of the subject. In this teaching we will use the blackboard, audiovisual and virtual space of matter (USC virtual), and other means that the teacher considers appropriate to facilitate teaching.
In the scenarios planned for the academic year 2020-2021, this teaching will have the following characteristics:
Scenario 1: classroom teaching
Scenario 2: classroom teaching combined with online teaching, using corporate tools for these purposes (Teams, Virtual Campus, etc.)
Scenario 3: virtual teaching (synchronous or asynchronous), using corporate tools for these purposes (Teams, Virtual Campus, etc.)
Small group interactive classes
Small group interactive classes focus on topics related to the theoretical contents of large group lectures. The teacher will lead and guide the student in the learning process. In this teaching we will use the blackboard, audiovisual and virtual space of matter (USC virtual), and other means that the teacher considers appropriate to facilitate teaching.
In the scenarios planned for the academic year 2020-2021, this teaching will have the following characteristics:
Scenario 1: seminars will be face-to-face.
Scenario 2: seminars will be face-to-face combined with virtual.
Scenario 3: seminars will be virtual (synchronous or asynchronous).
Very small group tutorials
This activity will mainly be used for clarification of doubts about the theory and practice related to the contents of the subject. This activity will make use of media, computers, virtual space (USC virtual) and other matter that the teacher deems appropriate.
In the scenarios planned for the academic year 2020-2021, the tutorials will have the following characteristics:
Scenario 1: face-to-face, without ruling out the convenience of carrying them out virtually, using corporate tools (Teams, Virtual Campus, etc.).
Scenario 2: fundamentally virtual.
Scenario 3: virtual (synchronous or asynchronous.
In the three scenarios, a virtual classroom will be kept at the disposal of the students, also maintaining direct communication channels, for tutorials, forums and virtual sessions.
A final exam representing an 80% of the final grade will be done. The final exam may include multiple choice questions and/or short questions, covering all aspects related to the contents of the subject. The student must demonstrate in the exam an adequate knowledge of each part of the subject. A continuous assessment representing a 20% of the final grade will be also done. This continuous assessment could be done through regular checks of student learning and student participation in scheduled activities.
In addition, students will be able to take, as part of the continuous assessment, a midterm exam that represents 40% of the final grade (if they pass it, the final exam would count 40% of the final grade and would cover the part not included in the midterm exam). Therefore for these students the continuous assessment would reach 60% of the final grade.
Students who do not take the midterm exam. To pass the evaluation the student must obtain:
- a minimum of 3.6 points (out of a maximum of 8.0) in the final exam
- a minimum of 5.0 points (out of a maximum of 10) in the sum of the final exam + the continuous assessment (out of a maximum of 2.0).
The grade corresponding to the continuous assessment will only be valid during the academic year in which it was obtained.
Students who take the midterm exam. To pass the evaluation the student must obtain:
- a minimum of 1.8 points (out of a maximum of 4.0) in the final exam
- a minimum of 5.0 points (out of a maximum of 10) in the sum of the final exam + the continuous assessment (out of a maximum of 6.0).
The grade corresponding to the continuous assessment will only be valid during the academic year in which it was obtained.
In the scenarios planned for the academic year 2020-2021, the evaluations will have the following characteristics:
Scenario 1: as a form of evaluation, a final face-to-face test will be used, combined with a continuous formative evaluation (virtual and face-to-face)
Scenario 2: as a form of evaluation a telematic final test will preferably be used, combined with a continuous formative evaluation of a telematic nature
Scenario 3: as a form of evaluation, a telematic final test will be used, combined with a continuous formative telematic evaluation
In cases in which the fraudulent performance of exercises and assessment tests is detected, the provisions of the “Regulations for the evaluation of student academic performance and review of grades” will be applied.
Student class work: 60 hours
Student personal work: 90 hours
Attendance at all classroom activities relating to the teaching of the subject.
Monitoring and periodic reading of texts and other materials recommended by the teacher.
Use of tutorials to solve any doubts the student may have in relation to the covered contents.
Finally, students will focus their study on the understanding of the concepts given and their possible application in the medical field, not limiting its attention to simply assimilate information.
Antonio Juan Pazos Castelos
Coordinador/a- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881816056
- antonioj.pazos [at] usc.es
- Category
- Professor: University Lecturer
Ramon Soto Otero
- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881812210
- ramon.soto [at] usc.es
- Category
- Professor: University Professor
| Monday | |||
|---|---|---|---|
| 10:30-12:00 | Grupo /CLE_01 | Spanish | Dentistry-Assembly Hall |
| Tuesday | |||
| 11:30-12:30 | Grupo /CLIS_02 | Spanish | Dentistry-Assembly Hall |
| Wednesday | |||
| 10:30-11:30 | Grupo /CLIS_01 | Spanish | Dentistry-Assembly Hall |
| Friday | |||
| 10:00-11:00 | Grupo /CLE_01 | Spanish | Dentistry-Assembly Hall |
| 01.25.2021 09:00-11:00 | Grupo /CLE_01 | Dentistry-A. Suárez Nuñez |
| 01.25.2021 09:00-11:00 | Grupo /CLE_01 | Dentistry-Classroom 3 |
| 01.25.2021 09:00-11:00 | Grupo /CLE_01 | Dentistry-Assembly Hall |
| 07.05.2021 09:00-11:00 | Grupo /CLE_01 | Dentistry-A. Suárez Nuñez |
| 07.05.2021 09:00-11:00 | Grupo /CLE_01 | Dentistry-Classroom 3 |