ECTS credits ECTS credits: 3
ECTS Hours Rules/Memories Student's work ECTS: 49.5 Hours of tutorials: 1.5 Expository Class: 12 Interactive Classroom: 12 EEES Clinics: 3 Total: 78
Use languages Spanish, Galician
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Biochemistry and Molecular Biology
Areas: Biochemistry and Molecular Biology
Center Faculty of Medicine and Dentistry
Call: Second Semester
Teaching: With teaching
Enrolment: Enrollable
As Clinical Biochemistry is a discipline that applies knowledge of basic biochemistry and analytical chemistry to the medical diagnosis, to the treatment and to the management of patients, it has to provide an objective base to assess the biochemical consequences of a particular pathological process and the response to the therapy, so that the main objectives will be:
1) To know the origin and control of the biological and physiological variability of the biochemical data.
2) To know the use of the results of the clinical biochemistry in the diagnosis and management of the usual medical diseases.
3) To know the biochemical bases and the clinical meaning, of the great part of the tests done in a routine way with serum/plasma and other body fluids at a laboratory of clinical biochemistry.
4) To provide the basic theoretical knowledge and the experimental and interpretative abilities, so that a graduate of medicine can use correctly the clinical analysis.
Several points of interes will be presented during expository-class sections and interactive seminars:
• Causes of variation in the pre-obtaining, obtaining and post-obtaining of biological samples.
• Sources of variation in the urine collection. Collection of samples in children. Criteria for the sample rejection.
• Plasma proteins. Total proteins. Reaction of acute phase.
• Prealbumin and RBP. Albumim. Alpha-1- antitrypsin. Caeruloplasmin. Haptoglobin. Transferrin. Beta-2-microglobulin. C-reactive protein.
• Tumour markers. Classification. Strategies for improving their usefulness. Main tumour markers. Clinical usefulness.
• Laboratory tests in the hepatobiliary diseases
• Laboratory tests in the kidney diseases
• Biochemical exploration of the diseases of the glucose metabolism.
• Tests for the follow-up of the diabetes mellitus. Hypoglycaemia.
• Lipids and lipoproteins. Clinical meaning.
• Heart markers. Clinical applications.
• Metabolism of the iron. Analytical assessment of the iron state. Iron deficiencies. Iron overload.
• Clinical biochemistry of the urine. Collection of the sample. Macroscopic examination. Test strips. Microscopic examination.
Basic Bibliography
* BIOQUIMICA CLINICA Y PATOLOGIA MOLECULAR. Alvaro Gonzalez Hernandez. Elsevier 2010, Excelent book about clinical biochemistry.
* BIOQUÍMICA CLÍNICA.A Gaw, y otros. Ed. Churchill Livingston, 2005. Brief and schematic book .
* BIOQUIMICA CLINICA, González de Buitrago, J. M., y outros, ed. McGraw-Hill Interamericana, Madrid, 1998.
* PATOLOGIA MOLECULAR, González de Buitrago, J. M. y Medina Jiménez, J. M., ED. McGraw-Hill / Interamericana de España, Madrid, 2001.
Complementary Bibliography
* TIETZ TEXTBOOK OF CLINICAL CHEMISTRY, Burtis, A. e Ashwood, E. R., Tietz, N. W.,, 3ª edición, ed. Saunders, Filadelfia, 1999. One of the best book about clinical chemistry.
* BIOQUIMICA, LIBRO DE TEXTO CON APLICACIONES CLINICAS, Devlin, T. M., , 3ª edición, ed. Reverté, Barcelona, 1999. Good book os biochemistry with several clinical topics.
* BIOQUIMICA. CASOS Y TEXTO, Montgomery, R.,, Ed. Harcourt Brace, Madrid, 1999.
The subject has to provide knowledge enough so the future graduate of medicine is able to:
1) To develop a critical appreciation of the role of the biochemical data in the diagnosis and management of the disease.
2) To know the biochemical base of the disease.
3) To assess critically the analytical variations that can affect to the generation of the clinical biochemical data.
4) To interpret the meaning of the biochemical results.
5) To join with reasoned knowledge to the procedures and protocols designed by the clinical laboratory for the obtaining of the most reliable and representative results of the patient’s state.
6) To ask adequately for the most suitable analytical tests in each phase of the diagnosis, treatment and management of the patients.
The USC's Guidelines for the Development of Safe Teaching, in the agreement of the Governing Council on June 19, 2020 supose three alternative scenarios: I) classroom teaching, II) blended teaching and III) virtual teaching.
In scenario I (classroom teaching)
The expository classes will consist of the presentation of the different topics and contents by the teacher who will have the support of the blackboard, presentations, tables and diagrams.
In the interactive seminars, the student will have to give a reasoned answer to the questions, tests or clinical scenarios presented in the classroom and in relation to the contents seen in the expository classes. The sanitary and distancing recomendations will be followed at all times.
The practical sessions will be in very small groups of students and will take place within a visit organized in the CHUS Central Laboratory, to visualize the pre-analytical, analytical and post-analytical phases of the clinical laboratory.
Students who wish it, can do short stays of a week in the facilities of the Special Laboratory of Biochemistry to complement their training and acquire a greater knowledge of Clinical Biochemistry with the possibility of future specialization through MIR.
In scenario 2 (blended teaching)
The teaching will be adapted according to the progress of the course and to that recommended by the Health and Academic Authorities. The contents that cannot be taught in person, described in the previous paragraph, will be addressed with virtual alternatives that are described in scenario 3.
In scenario 3 (virtual teaching).
The training activities described in the first of the scenarios will be adapted to a remote enviroronment as described:
The exhibition classes will adopt the format of videoclasses, available in the Virtual Campus.
The interactive seminars in the classroom will be replaced by a remote and asynchronous activity in which the student will have access to descriptive and analytical data of clinical cases and that will solve and deliver their reasoned answers, preferably in PDF format, on the Moodle platform, hold on the Virtual Campus, up to a deadline to be specified at that time.
The practical sessions are also adapted to virtual format. Here the visit to the CHUS laboratory facilities will be replaced by a virtualized visit with comments and images or video, of the preanalytical, analytical and postanalytical phases.
In scenarios 2 and 3, the development of short stays in the Hospital laboratory facilities is not recommended, so this optional student activity is not offered under such circunstances.
The evaluation of the subject is suported by different training activities of each of the scenarios foreseen for a safe classroom teaching in the academic year 2020-21:
1º) PRACTICES. In any of the scenarios that are forecasted is a mandatory activity, not attending the practical sessions implies a final FAIL grade in the subject. The evaluation of the practical training will be carried out through some questions in the theoretical knowledge test, as well as from the evaluations carried out by the teaching collaborators of the practical classes when the activity will be hold on face to fase format, or through a specific test after the virtual session.
2ª) INTERACTIVE CLASSES. Carrying out these activities is also mandatory. The reasoned answers will be delivered, either in the classroom (scenario I) or in the Virtual Campus (under scenarios II and III), and once reviewed and evaluated they will be taken into account in the general grade, which together with their compliance can modify the marks uot to one point in the final grade.
3º) EXAMINATION OF THEORETICAL KNOWLEDGE. It carries the greatest weight in the percentage of the cualification scheme. This evaluation can be done through any of the following procedures: Test type exam, oral exam or by developing questions on a topic or sections to be developed.
-3.1) TEST TYPE EXAM. It consists of 70 scored questions that must be answered in no more than 70 minutes. The ten most difficult questions will be considered double value in the final score. It can request the reasoned answer to any of the exam questions and, in that case, the grade of the question can reach up to 10 points on the exam, depending on the degree of difficulty. In addition to the allegedly poorly formulated and well-reasoned questions by the student, they will be scored positively.
This exam is designed for a face-to-face realization by the student (under scenario I, or II when a face-to-face is possible), and with small modifications in extension, as it could be adapted to a virtual environment, taking into account that in that case it would be synchronous telematics ( Questionnaires in the Virtual Campus) with a calendar and schedule programmed by the Center under both scenarios II and III.
-3.2) ORAL TYPE EXAM In a teacher-student interview several short questions will be asked about the different topics or sections of the subject. This possibility is only possible in scenario I or II if there are no restrictions for student or staff access and mobility.
-3.3) EXAMINATION QUESTIONS TO BE DEVELOPED. It will consist of asking up to 5 questions on the different topics that must be developed in a limited time. Valid for any of the planned scenarios, either in the classroom (scenario I) or in the virtual environment with a synchronous task, scheduled at a date and time and for a limited time in the Virtual Campus (scenarios II and III ).
The 16th article of the Regulations for the Evaluation of the Academic Performance of Students and the Review of Qualifications of the USC will be applied when a fraudulent exercise or test were completed.
Synchronous virtual hours or in classroom:
* Exhibitions: 27 hours
* Interactive: 7 hours
* Visit to the laboratory / practices: 7 hours
* Tutorials: 1.5 hours
* Evaluation and review hours: 2.5 hours
virtual asynchronous hours of autonomous study:
* Study: 45 hours
Total volume of work: 90 hours
• Attendance to the theoretical classes and to raise doubts and questions in the last 5-10 minutes of class.
• To use the tutorials to clarify concepts.
• To acquire some books from the recommended ones to amplify the knowledge and to see another way of focus the units of the subject.
• To elaborate the units by themselves, from the notes gathered in class and the reference books, do not ever use photocopies of notes taken by other students. The notes, if they are not yours, are a source of mistakes.
Santiago Rodriguez-Segade Villamarin
Coordinador/a- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881814934
- ssegade [at] telefonica.net
- Category
- Professor: University Professor
Maria Dolores Vazquez Illanes
- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881812335
- mdolores.vazquez [at] usc.es
- Category
- Professor: University Lecturer
Javier Rodriguez Garcia
- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- javier.rodriguez.garcia [at] usc.es
- Category
- Professor: LOU (Organic Law for Universities) Associate Professor of Health Sciences
| Monday | |||
|---|---|---|---|
| 10:30-11:30 | Grupo /CLE_01 | Spanish | Aulario-Classroom 1 |
| 11:30-12:30 | Grupo /CLE_02 | Spanish | Aulario-Classroom 2 |
| Tuesday | |||
| 10:30-11:30 | Grupo /CLE_01 | Spanish | Aulario-Classroom 1 |
| 11:30-12:30 | Grupo /CLE_02 | Spanish | Aulario-Classroom 2 |
| Wednesday | |||
| 10:30-11:30 | Grupo /CLE_01 | Spanish | Aulario-Classroom 1 |
| 11:30-12:30 | Grupo /CLE_02 | Spanish | Aulario-Classroom 2 |
| Thursday | |||
| 10:30-11:30 | Grupo /CLE_01 | Spanish | Aulario-Classroom 1 |
| 11:30-12:30 | Grupo /CLE_02 | Spanish | Aulario-Classroom 2 |
| 01.13.2021 11:00-14:00 | Grupo /CLE_01 | Medicine-Central Clinical Hospital Laboratory |
| 05.14.2021 09:00-12:00 | Grupo /CLE_01 | Aula telemática |
| 07.02.2021 16:30-18:30 | Grupo /CLE_01 | Aulario-Classroom 1 |
| 07.02.2021 16:30-18:30 | Grupo /CLE_01 | Aulario-Classroom 2 |
| 07.02.2021 16:30-18:30 | Grupo /CLE_01 | Aulario-Classroom 3 |
| 07.02.2021 16:30-18:30 | Grupo /CLE_01 | Aulario-Classroom 4 |
| 07.02.2021 16:30-18:30 | Grupo /CLE_01 | Aulario-Main Hall |