ECTS credits ECTS credits: 3
ECTS Hours Rules/Memories Student's work ECTS: 46.5 Hours of tutorials: 1.5 Expository Class: 22 Interactive Classroom: 5 Total: 75
Use languages Spanish, Galician
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Biochemistry and Molecular Biology
Areas: Biochemistry and Molecular Biology
Center Faculty of Medicine and Dentistry
Call: First Semester
Teaching: With teaching
Enrolment: Enrollable
To introduce students to the basic knowledge of the functioning of the Human Immune System, which will allow students to understand the defence mechanisms against own and stranger antigens and their pathologies.
MAIN ELEMENTS OF THE SYSTEM IMMUNE
Unit 1. TISSUE, CELLS AND MOLECULES OF THE IMMUNE SYSTEM
Introduction to the study of immunology. Components of the immune system: Tissue, cell and free molecules.
Unit 2. IMMUNOGLOBULINS
Immunoglobulins and structures. Genes, gene expression and origin of the diversity of immunoglobulins. Immunoglobulin properties.
Unit 3. HISTOCOMPATIBILITY ANTIGENS AND COMPLEX
Antigens and their structures. Immunogenicity. Major Histocompatibility Complexes (MHCs) and their structures. Genes, gene expression and origin of the diversity of MHCs. Antigen presentation mechanisms by MHCs. Antigen-presenting cells. CD1 complexes.
Unit 4. RECEPTORS AND SIGNALLING OF IMMUNE CELLS
B lymphocyte receptors (BRCs) and T lymphocytes (TCRs): Structures, genes, gene expression and diversity. Phagocytes receptors, dendritic cells and NK cells. Immune cell signaling by antigen. Cytokines in immune signaling.
Unit 5. COMPLEMENT SYSTEM
Complement in the immune system. The complement system components and their properties. Complement activation pathways and immunogenic properties.
GENERATION OF THE IMMUNE RESPONSE. INNATE AND ADAPTIVE IMMUNITY
Unit 6. INNATE IMMUNITY
Innate immunity and its components. The anatomical and physiological barriers in the Immune response. Activities phagocytes, NK cells and other immune cells in innate immunity. Activities of complement and cytokines in innate immunity.
Unit 7. MATURATION OF T LYMPHOCYTES IMMUNE
Maturation of lymphocytes. Ontogeny and function of lymphocytes T. Thymic maturation of T lymphocytes positive and negative selection and tolerance against self proteins of T (alfa beta) cells. Thymic T(gamma delta) lymphocyte differentiation and NKT cells.
Unit 8. Effector ACTIVATION AND ACTIVITIES OF T LYMPHOCYTES
T lymphocyte circulation postthymic The process of activation of T (alfa beta) lymphocytes by antigens. Differentiation and effector activities of the different populations of T helper and cytolytic lymphocytes. T cell activation by superantigens. Activation and effector activities of T(gamma delta) lymphocytes and NKT cells.
Unit 9. MATURATION AND ACTIVATION OF LYMPHOCYTES B
Ontogeny and immune function of B lymphocytes maturation of B lymphocytes in the bone marrow. Peripheral activation of B cells by antigen. Process B-lymphocyte differentiation and effector memory B cells.
Unit 10. EFFECTOR ACTIVITY OF LYMPHOCYTES AND IMMUNOGLOBULINS IN IMMUNITY HUMORAL.
Antigenic activation of B lymphocytes and effector activities in humoral immunity. Primary and secondary responses humoral immunity. The different isotypes of immunoglobulins and their abilities to eliminate antigens. Polyclonal and monoclonal antibodies.
THE IMMUNE DEFENSE EXERCISE. CLINICAL IMMUNOLOGY
Unit 11. INFECTIOUS PROCESSES. IMMUNE DEFENSE AGAINST VIRAL INFECTION.
Introduction to infectious processes. The main infectious agents. Viruses and viral infection. The presentation of viral antigens in the immune system. The Immune defense against viral infection. Mechanisms of escape and antiviral therapies.
Unit 12. IMMUNE DEFENSE AGAINST BACTERIAL INFECTION.
Bacteria and their antigenic structures. Bacterial toxins. The presentation of bacterial antigens and toxins in the immune system innate and adaptive immunity against extracellular and intracellular bacteria. Immune defense against bacterial toxins. Mechanisms of evasion and antibacterial therapies. Bacterial infection and aggressive production of molecules (inflammatory mediators).
Unit 13. IMMUNE DEFENSE AGAINST OTHER PATHOGENS. IMMUNIZATION AND VACCINE.
Immune Defense against Fungi, Protozoa and Metazoan. Prions, the Activity and Immune Response. Active and passive immunization. Vaccines and their preparation. Immune response induced by vaccines.
Unit 14. INFLAMMATION AND IMMUNE RESPONSE.
Immune defense cell damage and induction of inflammatory processes. Inflammatory pathways and its elements. Mediators of inflammation and their biological activities. Main production routes mediators of inflammation and its local and systemic effects Main routes production of inflammatory mediators and local and systemic effects.. Inflammasome. Inflammation systemic activities. Regulatory activity of the central nervous system. Anti-inflammatory agents.
Unit 15. HYPERSENSITIVITY REACTIONS IN THE IMMUNE RESPONSE.
Immune defence and induction of hypersensitivity reactions. Different types of hypersensitivity reactions. Mechanisms of Immediate hypersensitivity reactions yype I, II, and III. Type IV delayed hypersensitivity. Therapies hypersensitivity processes. Hypersensitivity and induction of inflammation.
Unit 16. AUTOIMMUNITY, TRANSPLANTATION AND IMMUNOLOGY IMMUNODEFICIENCY.
Autoimmunity origin. Autoimmune response and induction of pathologies. Origin and diversity of immunodeficiencies. Functional alterations in congenital immunodeficiencies. The acquired immunodeficiency and AIDS. Transplant immunology: Grafts and immune response.
Unit 17. TUMOR IMMUNOLOGY
Origin cancer molecular transformations. Oncogenes and tumor antigens. Immune response against cancer cells. Inflammation and immune evasion by cancer cells promoted antitumor therapies.
BASIC BIBLIOGRAPHY
ABBAS, A.K.; LICHTMAN, A.H. y PILLAI, S. “Inmunología básica: Funciones y trastornos del sistema inmunitario” Sexta Ed. 2020, Elsevier España.
OWEN, J.A.; PUNT, J.; STRANFORD, S.A. y JONES, P.P. “Kuby. Inmunología” Séptima Ed. 2014, McGraw Hill.
ABBAS, A.K.; LICHTMAN, A.H. y PILLAI, S. "Inmunología celular y molecular” Novena Ed. 2018, Elsevier España
SUPPLEMENTARY BIBLIOGRAPHY
O´HEHIR; R.E.; HOLGATE; S.T. and SHEIKN; A. "Middleton. Alergología esencial" Primera Ed. 2017, Elsevier España
CARBONE, J."Inmunoterapia de enfermedades de base inmunológica" 2018, Elsevier España
MAK, T.W.; SAUNDERS, M.E. and JETT, B.D. "Primer to the Inmune Response” Segunda Ed. 2014, AP Cell – Elsevier
GENERAL SKILLS
Understanding the normal structure and function of the human body at the molecular, cellular, tissue, organ, and system levels and in the different stages of life and in both sexes.
Knowing the basis of normal human behavior and its disorders.
Understanding the effects, mechanisms, and manifestations of the disease on the structure and function of the human body.
Understanding the causative agents and risk factors that determine the health status and development of disease.
Understanding the effects of growth, development, and aging on an individual and his social environment.
Understanding the action, indications, and efficacy of therapeutic interventions based on scientific evidence.
Being able to formulate hypotheses, collect data, and critically evaluate the information for the solving of problems using the scientific method.
Acquiring basic training for research activity.
SPECIFIC SKILLS
Know the morphology, structure and function of the immune system.
Expository teaching
Expository teaching is designed to enhance the autonomous learning of students. In the theoretical classes, the teacher will present and explain the most relevant aspects of each subject, helping students to achieve the objectives of the subject. In this teaching, the blackboard, audiovisual media, virtual space of the subject (USC virtual campus) will be used, as well as other means that the teacher considers appropriate to facilitate teaching.
In the scenarios planned for the 2020-2021 academic year, this teaching will have the following characteristics:
Scenario 1: classroom teaching
Scenario 2: classroom teaching combined with virtual, using corporate tools for these purposes (Teams, Virtual Campus, etc.)
Scenario 3: virtual teaching (synchronous or asynchronous), using corporate tools for these purposes (Teams, Virtual Campus, etc.)
Interactive teaching
Discussion seminars on the different concepts and subjects of the Program, interspersed between the regular classes. Its contents correspond to the review and discussion of the most important facets of the contents of each theme of the program.
In the scenarios planned for the 2020-2021 academic year, this teaching will have the following characteristics:
Scenario 1: the seminars will be face-to-face.
Scenario 2: the seminars will be face-to-face combined with virtual.
Scenario 3: the seminars will be virtual (synchronous or asynchronous).
Tutoring
This activity will be used mainly for the clarification of doubts about aspects related to the contents of the subject. The teacher will guide and guide the student in the learning process.
In the scenarios planned for the 2020-2021 academic year, the tutorials will have the following characteristics:
Scenario 1: face-to-face, without ruling out the convenience of carrying them out virtually, using the latter corporate tools (Teams, Virtual Campus, etc.).
Scenario 2: fundamentally virtual.
Scenario 3: virtual (synchronous or asynchronous).
In the three scenarios, a virtual classroom will be kept at the disposal of the students, also maintaining direct communication channels, for tutorials, forums and virtual sessions.
Final exam (70% of the final grade)
The final exam is used for the evaluation of the acquired knowledge of the subject. The student must demonstrate adequate knowledge of each part of the subject in the exam.
As an evaluation test, an exam with different types of questions (test and / or true-false and / or short question and / or topic question) will be used. In the exam, the mode of qualification of each of the parts will be detailed.
Continuous assessment (30% of the final grade)
For the continuous evaluation, the student is expected to use the virtual campus and the digital media provided by the library of the Faculty of Medicine, to achieve progressive learning of the subject. Learning controls may be carried out and the degree of participation in all the suggested activities will be assessed. Continuous assessment will only be taken into account if the student passes the final exam.
The mark achieved in the continuous evaluation will only be valid in the current call.
In the scenarios planned for the 2020-2021 academic year, the evaluations will have the following characteristics:
Scenario 1: as a form of evaluation, a final face-to-face test will be used, combined with a continuous formative evaluation (face-to-face and telematic)
Scenario 2: as a form of evaluation a telematic final test will preferably be used, combined with a continuous formative evaluation of a telematic nature
Scenario 3: as a form of evaluation, a telematic final test will be used, combined with a continuous formative telematic evaluation
In cases in which the fraudulent performance of exercises and assessment tests is detected, the provisions of the “Regulations for the evaluation of student academic performance and review of grades” will be applied.
The average time of study and work dedicated to each topic of the theoretical program will depend on the activities related to that topic and its complexity.
Assistance to all face-to-face and virtual activities related to teaching the subject.
Monitoring and periodic reading of texts and other materials recommended by the teacher.
Use of the tutorials to solve the doubts that the student has in relation to the content taught.
Finally, the student should focus their study on understanding the concepts taught and their possible application in the medical field, never limiting themselves to simply assimilating the information.
Estefania Maria Salome Mendez Alvarez
Coordinador/a- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881812210
- estefania.mendez [at] usc.es
- Category
- Professor: University Professor
| Monday | |||
|---|---|---|---|
| 10:30-11:30 | Grupo /CLE_03 | Spanish | Medicine-Classroom 3 |
| 17:30-18:30 | Grupo /CLE_01 | Spanish | Medicine-Classroom 3 |
| Tuesday | |||
| 10:30-11:30 | Grupo /CLE_04 | Spanish | Medicine-Classroom 6 |
| 17:30-18:30 | Grupo /CLE_02 | Spanish | Medicine-Classroom 6 |
| Wednesday | |||
| 10:30-11:30 | Grupo /CLE_03 | Spanish | Medicine-Classroom 3 |
| 17:30-18:30 | Grupo /CLE_01 | Spanish | Medicine-Classroom 3 |
| Thursday | |||
| 10:30-11:30 | Grupo /CLE_04 | Spanish | Medicine-Classroom 6 |
| 17:30-18:30 | Grupo /CLE_02 | Spanish | Medicine-Classroom 6 |
| Friday | |||
| 10:30-11:30 | Grupo /CLE_03 | Spanish | Medicine-Classroom 3 |
| 17:30-18:30 | Grupo /CLE_01 | Spanish | Medicine-Classroom 3 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Classroom 1 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Dentistry-Classroom 1 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Classroom 2 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Dentistry-Classroom 2 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Classroom 3 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Classroom 4 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Classroom 5 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Classroom 6 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Classroom 7 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Classroom 8 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Classroom 9 |
| 12.19.2020 09:30-12:00 | Grupo /CLE_01 | Medicine-Castelao Classroom |
| 06.21.2021 12:30-14:30 | Grupo /CLE_01 | Medicine-Classroom 4 |
| 06.21.2021 12:30-14:30 | Grupo /CLE_01 | Medicine-Classroom 5 |
| 06.21.2021 12:30-14:30 | Grupo /CLE_01 | Medicine-Classroom 7 |
| 06.21.2021 12:30-14:30 | Grupo /CLE_01 | Medicine-Classroom 8 |