ECTS credits ECTS credits: 3
ECTS Hours Rules/Memories Hours of tutorials: 1.5 Expository Class: 12 Interactive Classroom: 12 Total: 25.5
Use languages Spanish, Galician
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Zoology, Genetics and Physical Anthropology
Areas: Genetics
Center Faculty of Veterinary Science
Call: Second Semester
Teaching: With teaching
Enrolment: Enrollable
Expansion of basic knowledge of Genetics with special emphasis on Genomics and the methodologies of analysis necessary to develop specific studies and applications of interest in Veterinary Sciences.
Apply through specific modules and case studies of the knowledge acquired in genomic methodologies within specific areas of Veterinary Sciences, such as clinical, production and management of natural resources.
Interactive activities will allow students to solve problems and experimentation in the field of genomics applications to veterinary sciences, as well as discuss their interest and social impact.
Lesson 1. Structure and function of Genomes (3 hours)
Organization of eukaryotic genomes. Genic families. Tandem and dispersed repeats. Transposable elements. The eukaryotic gene. Gene regulation. Regulation in prokaryotes and eukaryotes.
Lesson 2. Recombinant DNA analysis (3 hours)
Restriction enzymes. DNA sequencing. Polymerase chain reaction (PCR). Analysis by blotting. DNA cloning and genetic libraries. Types of genomic libraries. Genetic probes.
Lesson 3. Genomic analysis (3 hours)
Genome sequencing: from Sanger to "Next Generation Sequencing" (NGS). Genotyping by Sequencing (GBS): identification and genotyping of large-scale genetic markers. Physical maps and genetic maps. QTL identification. Whole genomic association analysis (GWAS). Comparative genomics. Functional genomics: transcriptomics and epigenomics.
Lesson 4. Genetic Engineering (2 hours)
Gene transfer in animals and plants. Transgenic and clone organisms. Genomic editing: CRISPR/CAS technology
Lesson 5. Applications to Clinical medicine and forensics (4 hours: 3 t + 1 s)
Inheritance patterns of diseases. Preimplantation diagnosis and prenatal diagnosis. Complex diseases: genetic approaches. Cancer: molecular profiles and therapy. Forensic genetics.
THEORETICAL-PRACTICAL WORKS: Genetic basis of diseases in small and large animals. New prediction and diagnostic technologies.
Lesson 6. Applications for animal genetic enhancement (6 hours: 4 t + 2 s)
Genealogical traceability. High-density genetic maps: genetic mining and candidate genes. Marker-assisted selection. Genomic selection. THEORETICAL-PRACTICAL WORKS: The genetic basis of the productive traits and their application for the improvement of productions.
Lesson 7. Microbiome analysis: applications (4 hours: 3t + 1s)
NGS methodologies for the analysis of microbiome diversity. Metagenome and metatranscriptome. Importance of the microbiome in clinic and production. THEORETICAL-PRACTICAL WORKS: Characterization of the microbiome in relation to characteristics of productive interest.
Lesson 8. Applications to the management and conservation of biodiversity (5 hours: 4t + 1s)
Genetic resources: Diversity, structure and sustainability. Conservation genetics. Sustainable exploitation of natural populations. Management and recovery of threatened species: the problem of small populations. THEORETICAL-PRACTICAL WORKS: Analysis and management of genetic diversity of wild and cultivated populations, breeding and conservation programs.
PRACTICE PROGRAM
Practice 1. IDENTIFICATION OF TRANSGENIC INDIVIDUALS USING PCR AND SEQUENCING IN ZEBRAFISH (3 hours)
Practice 2. PARENTAGE ANALYSIS AND ITS APPLICATION IN A GENETIC BREEDING PLAN (4 hours)
Basic bibliography
- BROOKER R.J. 1999. Genetics. Analysis and Principles. Benjamin Cummings. California.
- BROWN T.A. 1999. Genomes. BIOS Scientific Publishers Ltd, Oxford.
CHARLES, T.C., LILES, M.R. &, SESSITSCH A. 2018. Functional Metagenomics: Tools and Applications. ISBN-13: 978-3319870960
- GRIFFITHS A.J.F., MILLER J.H. SUZUKI D.T., LEWONTIN R.C. & GELBART W.M. 2002. Genética (7ª ed.). McGraw-Hill Interamericana.
- HARTL, D.L. Y JONES, E.W. 2002. "Essential Genetics: A Genomic Perspective". (3ª Ed.). Jones and Bartlett Publishers. Sudbury, Massachusetts.
- IZQUIERDO M. 2014. Ingeniería Genética y Transferencia Génica (2ªEd.) Pirámide, Madrid.
- JÍMENEZ-MONTERO, J. A. 2014. La revolución genómica en la mejora genética animal: su implementación en el vacuno lechero. ISBN-13: 978-8449113994
- KLUG, W.S. Y CUMMINGS, M.R. 2002. Essentials of Genetics (4ª Ed.). Prentice Hall Inc., New Jersey.
- NAGARAJAN, M. 2017. Metagenomics: Perspectives, Methods, and Applications (1st Ed).
- NICHOLL D.S.T. 2002. An Introduction to Genetic Engineering. Cambridge University Press. Cambridge.
- NICHOLAS, F. W. 2009. Introduction to Veterinary Genetics (3ª Ed.). Wiley-Blackwell
- PRIMROSE S.B., TWYMAN R.M. & OLD R.W. 2003. Principles of genome analysis and Genomics. (3ª ed.) Blackwell Science Ltd, Oxford.
- SNYDER, M. 2016. Genomics and Personalized Medicine: What Everyone Needs to Know. Oxford University Press.
- STRACHAN, T. Y READ, A.P. 1999. Genética Molecular Humana. Ediciones Omega. Barcelona.
- TAMARIN R.H. 1996. Principios de Genética. Ed. Reverté. Barcelona.
- THOMPSON J.N., HELLACK J.J., BRAVER G. & DURICA D.S. 1997. Primer of Genetic Analysis: A Problems Approach. (2ª ed.). Cambridge University Press, Cambridge.
Complementary bibliography
- BROWN, T.A. 2008. Genomas. 3ª ed. Buenos Aires: Editorial Médica Panamericana.
- FAO. 2010. Breeding Strategies for Sustainable Management of Animal Genetic Resources (Fao Animal Production and Health Guidelines).
- MCPHERSON, M.J. & MOLLER, S. 2006. PCR. 2nd ed. New York: Taylor & Francis.
- SMITH, J.E. 2009. Biotechnology. 5th ed. Cambridge: Cambridge University Press.
General Competences
GVUSC01. Ability to learn and adapt.
GVUSC02. Capability for analysis and synthesis.
GVUSC03. General knowledge of the working area.
GVUSC04. Planning and work management.
GVUSC05. Capability to put knowledge into practice.
GVUSC06. Capability to work both independently and as part of a team.
GVUSC07. Ability to work in an international context.
GVUSC08. Leadership, initiative and entrepreneurship.
GVUSC09. Capability to communicate in different areas.
GVUSC10. Ethical commitment and undertaking of responsibilities.
Disciplinary specific competences
CEDVUSC 03. Livestock breeding, genetic improvement, management and animal welfare.
CEDVUSC 04. Physical, chemical and molecular bases of the major processes that take place in the animal organism.
CEDVUSC 05. Basic and applied principles of the immune response.
CEDVUSC 07. Knowledge of the changes in the structure and function of the animal organism.
CEDVUSC 10. Knowledge of the techniques applicable to domestic animals, including those with direct influence on animal and human health.
CEDVUSC 11. Knowledge of the functional and optimization bases of plant and animal production systems and its environment impact.
CEDVUSC 12. Principles of Science and Food Technology. Elaborated food quality control and alimentary security.
Specific professional competences
D1VUSC 03. Perform standard laboratory tests, and interpret clinical, biological and chemical results.
D1VUSC 04. Diagnose common diseases using complementary protocols and diagnostic techniques.
D1VUSC 09. Implement basic procedures to ensure proper reproductive activity, and carry on technological processes to solve obstetric problems.
D1VUSC 16. Applying the methods of individual identification of animals.
D1VUSC 17. Perform technical reports specific to veterinary competencies.
Specific academic competences
CEAVUSC 01. Analyze, synthesize and solve problems and make decisions within the scope of the Veterinary profession.
CEAVUSC 02. Be aware of the ethical responsibilities of the veterinary profession in relation to the society.
CEAVUSC 03. Disclose information obtained during the Veterinary professional practice in a easy oral and written way, with other colleagues, authorities and society in general.
CEAVUSC 04. Search and manage information related to veterinary practice.
CEAVUSC 05. Know and apply the scientific method in professional practice, including evidence-based medicine.
CEAVUSC 06. Knowing how to find professional help and advice.
CEAVUSC 07. Have basic knowledge of a foreign language, especially in technical aspects of veterinary science.
CEAVUSC 08. Being aware of the need to keep professional skills and knowledge up-to-date through a process of lifelong learning.
Transversal competences
CTVUSC 01. Capacity for reasoning and argument.
CTVUSC 02. Ability to obtain adequate, diverse and updated information by various means such as literature and Internet information, and critically analyze it.
CTVUSC 03. Ability to develop and present an organized and understandable text.
CTVUSC 04. Ability to make a clear, concise, and consistent public presentation
CTVUSC 05. Skill in the use of ICTs.
CTVUSC 06. Use information in a foreign language.
CTVUSC 07. Ability to solve problems through the Integration and application of knowledge.
All teaching will be face-to-face (Scenario 1: Adapted Normality) following the hygienic-sanitary measures that are mandatory (sanitizing gel, mandatory mask,...) in the schedule approved by the center . For practical classes students must attend with a lab coat. The attendance to all the activities will be mandatory and it will be controlled by attendance lists.
LECTURESHIP
In the whole group, the specific contents of each of the programme topics will be dealt with. The development of the contents will be done with the help of a PowerPoint presentation, specific for each topic, together with transparencies, videos, animations, waxing and any other material that helps and facilitates the understanding of the concepts being studied.
INTERACTIVE TEACHING
Laboratory practices: They have a specific script that the teacher will present at the beginning of the practice to the group of students. The practices will be carried out in groups of 2 people. At the end of each practice the students will complete and hand in a specific questionnaire that the teacher will evaluate.
PRACTICAL SEMINARS
- Solving problem bulletins. Students will have a bulletin of problems of increasing complexity and related to the concepts discussed, some of which will be solved in the seminar classes.
- Elaboration of monographic reports presenting specific applications of genetics and genomics to animal production, veterinary clinics and food technology. The presentation/defense of this work will be in the classroom to the whole group with a duration of 15 minutes.
- Reading, summary and discussion of a book/article related to the applications of Genetics and Genomics to the clinical field.
GROUP TUTORING
Resolution, discussion and presentation of problems and case studies proposed by the teacher.
Like the rest of the subjects of the Degree in Veterinary Medicine, the evaluation system of the subject Genetics and Genomics Applied to Veterinary Science does not intend to determine exclusively the level of knowledge of the specific contents of the discipline that a student has. The evaluation method has also been designed to know if the student has acquired some of the competences that appear in the report of the Degree in Veterinary Medicine which are associated to this subject.
In the case of fraudulent exercises or tests, the provisions of the Regulations on the evaluation of academic performance of students and the review of qualifications will apply.
https://www.usc.gal/export9/sites/webinstitucional/gl/web/descargas/20_…
FIRST-YEAR STUDENT
The evaluation system (Scenario 1: Adapted Normality) combines continuous evaluation (30% of the score) and a final exam or test (remaining 70%). This system will be applied to all qualification opportunities.
The continuous evaluation of each student will be done in a face-to-face way and it will be based equally on the results obtained in the partial controls, the resolution of problems and practical cases that must be answered, their attendance and participation in the expository and interactive classes will also be considered. Moreover, the students will present a monographic work on topics suggested by the teacher that will be exposed to the rest of the students in person and that will be evaluated for the final grade.
The final exam will be held in person.
Note: The students with subject exemption will be evaluated with a exam represent the 100% of the final grade.
REPEAT STUDENT
It also combines continuous evaluation and a final exam.
The continuous assessment will be 30% of the final grade and will correspond to the score of this section that the student obtained in the course in which he or she was first enrolled. The remaining 70% will correspond to the grade of the final test. The methodology used will be the same as that applied to first-time students.
Learning assessment system
- Written exam of the program contents (theory, practices and seminars): 70% of the final score.
- Preparation and presentation of a seminar: 20% of the final score.
- Attendance and participation: 10% of the final score.
Presential hours: 38
Expositive Hours: 25
Seminars: 5
Laboratory practices: 7
Group tutorials: 1
Student work hours: 37
Total workload: 3.0 ECTS credits
It is considered that the student has to devote about 20 hours of individual study, more than 12 hours to solving problems and developing jobs and about 2 hours of literature review. Finally, 2 hours are computed for conducting exams.
In order to improve the effectiveness in the achievement of the subject objectives, the students are recommended to:
Attend classes and perform all laboratory practices.
Use the tutorials.
Consult at least part of the proposed literature.
Solve additional problems from those proposed in the bulletins.
Participate in the classes: questions, formulation of doubts, etc.
CONTINGENCY PLAN
In accordance with the Contingency Plan for the development of teaching for the 2021-22 course approved by Government Council the 30th April 2021, the next contingency plan is proposed:
Teaching methodology
Scenario 2: Distance (partial restrictions to face-to-face attendance)
- Lectures, seminars and tutorials: All of this teaching will become telematic and the institutional tools provided by the USC will be used, both the Virtual Campus and the MS Teams platform. This teaching will keep the same schedule as the face-to-face teaching. The USC Virtual Forum will be used as a tool for communication with students (tutorials, news or queries related to the subject). Exceptionally, institutional e-mail will be used. Attendance will be controlled by student lists.
- Practical classes: The practice to be carried out will be done in a face-to-face way, preparing modules of a maximum of 7 students. Before going to the laboratory, students must see the related tutorial session that will be deposited in the virtual classroom.
Scenario 3: Closing down the facilities
- Lectures, seminars, tutorials and practical classes: The entire teaching will be dealt with telematic way applying the methodology detailed for Scenario 2 and also maintaining the programmed schedule by the center. We have prepared a video for the realization of the practice by telematic way.
Evaluation system
FIRST-YEAR STUDENT
The evaluation system combines continuous evaluation (30% of the grade) and a final exam or test (remaining 70%), for both scenarios:
Scenario 2: Distance (partial restrictions to face-to-face attendance)
Part of the continuous assessment will consider the student's participation in the practice to be carried out. For the rest of the teaching, which will be essentially telematics, participation in the Teams sessions, significant activity in the virtual classroom forums, as well as the resolution and delivery of problem bulletins and case studies will be valued. The students will present a monographic work on topics suggested by the teacher that they will expose to the rest of the students in person or telematics and that will be evaluated for the final grade.
The final test will be in person. If, it is necessary, health regulations do not allow it, the exam will be done telematics through the use of MS Teams.
Scenario 3: Closing down the facilities
Both the continuous assessment, the practice, the student's presentation and the final test will be done by telematics way in the advanced terms for Scenario 2.
REPEAT STUDENT
It also combines continuous evaluation and a final exam.
The continuous assessment will be 30% of the final grade and will correspond to the score of this section that the student obtained in the course in which he or she was first enrolled. The remaining 70% will correspond to the grade of the final test. The methodology used will be the same as that applied to first-time students.
Scenario 2: Distance and Scenario 3: Closure of the facilities
Both the continuous assessment (30%) and the final test (70%) will be carried out under the terms stipulated for first-time students.
In the case of fraudulent exercises or tests, the provisions of the Regulations on the evaluation of academic performance of students and the review of qualifications will apply.
https://www.usc.gal/export9/sites/webinstitucional/gl/web/descargas/20_…
Paulino Martinez Portela
- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- paulino.martinez [at] usc.es
- Category
- Professor: University Professor
María Belén Gómez Pardo
- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- Phone
- 982822428
- belen.gomez [at] usc.es
- Category
- Professor: University Lecturer
Manuel Vera Rodriguez
Coordinador/a- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- Phone
- 982822426
- manuel.vera [at] usc.es
- Category
- Professor: University Lecturer
Paula Rodriguez Villamayor
- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- paularodriguez.villamayor [at] usc.es
- Category
- Xunta Pre-doctoral Contract
Laila Al Soufi Novo
- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- laila.alsoufi.novo [at] usc.es
- Category
- Ministry Pre-doctoral Contract
| Friday | |||
|---|---|---|---|
| 16:00-18:00 | Grupo /CLE_01 | Spanish | Genetic Seminar |
| 05.25.2022 12:00-14:00 | Grupo /CLE_01 | Classroom 8 |
| 06.29.2022 09:00-11:00 | Grupo /CLE_01 | Genetic Seminar |