ECTS credits ECTS credits: 4.5
ECTS Hours Rules/Memories Student's work ECTS: 74.2 Hours of tutorials: 2.25 Expository Class: 18 Interactive Classroom: 18 Total: 112.45
Use languages Spanish, Galician
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Organic Chemistry
Areas: Organic Chemistry
Center Faculty of Chemistry
Call: First Semester
Teaching: With teaching
Enrolment: Enrollable
At the end of the subject students are expected to be able to demonstrate understanding and knowledge of essential principles and theories related ith bioactive compounds. Furthermore, it must demonstrate the procedures for the synthesis of compounds of biological interest and be capable of aproach to the synthesis of biologically active compounds of intermediate complexity.
Unit 1. Stereoselective synthesis. Concept. General strategies: chiral pool, chiral auxiliaries, chiral reagents and asymmetric catalysis. Protecting groups.
Unit 2. Asymmetric reductions in organic synthesis
Unit 3. Asymmetric oxidations in organic synthesis.
Unit 4. Addiction to nucleophilic carbonyl compounds.
Unit 5. Aldol reaction and similar.
Unit 6. Formation of carbon-carbon bonds by transition metals. Asymmetric Heck reaction. Chiral Suzuki reaction: synthesis of chiral biaryl. Reactions of allylic substitution catalyzed by Pd. Metathesis in organic synthesis. Enantioselective version.
Unit 7. Pericyclic reactions. Classification. Frontier orbitals theory. Electrocyclic reactions. Woodward-Hoffmann Rules. Synthetic applications.
Unit 8. Cycloadditions in organic synthesis. Diels-Alder reaction. Hetero-Diels-Alder Reactions. 1,3-Dipolar cycloaddition reactions.
Unit 9. Sigmatropic reactions. Synthetic applications.
Unit 10. General strategies for the synthesis of complex organic molecules. Classic examples and current trends.
Basic bibliography
ORGANIC CHEMISTRY. J. Clayden, N. Geeves, S. Warren. 2nd Ed. Oxford University Press. 2012.
CATALYSIS IN ASYMMETRIC SYNTHESIS. V. Caprio, J. M. J. Williams. 2nd Ed. Wiley. 2009.
ASYMMETRIC SYNTHESIS. Garry Procter. Oxford Science Publicactions, 1996.
Complementary bibliography
PRINCIPLES AND APPLICATIONS OF ASYMMETRIC SYNTHESIS. Guo-Qiang Lin, Yue-Ming Li, Albert S. C. Chan, WILEY, 2001.
PERICYCLIC REACTIONS: A MECHANISTIC AND PROBLEM SOLVING APPROACH. Kumar, Sunil Kumar, Vinod; Singh, S. P. Elsevier Academic Press, 2016.
TRANSITION METALS IN THE SYNTHESIS OF COMPLEX ORGANIC MOLECULES. L. S. Hegedus, University Science Books, 1994.
Basic and General
CG2 - Being able to gather and interpret data, information and relevant results, draw conclusions and issue reasoned reports on scientific or technological chemical problems.
CG3 - Apply the knowledge and skills acquired as the capacity of analysis and abstraction in the definition and approach to problems and finding solutions in both academic and professional contexts.
CG4 - Ability to communicate, in both writing and orally, knowledge, procedures, results and ideas in chemistry to both specialist and non-specialist audiences.
CG5 - To study and learn independently new knowledge and techniques in any scientific or technological discipline.
Transversal
CT7 - Interdisciplinary team.
CT8 - Working in an international context.
CT9 - Skills in interpersonal relationships.
CT10 - Critical reasoning.
CT11 - Ethical commitment.
Specific
CE4 - Main chemical reactions.
CE11 - Relation between macroscopic properties and properties of individual atoms and molecules, including macromolecules (natural and synthetic), polymers, colloids and other materials.
CE12 - Structure and reactivity of the main classes of biomolecules and the chemistry of the main biological processes.
CE13 - Ability to demonstrate knowledge and understanding of essential facts, concepts, principles and theories related to the areas of chemistry.
CE15 - Recognize and analyze new problems and plan strategies to solve them.
1. Classes (conferences, classes and seminars of problems). The course consists of 4.5 ECTS credits. This workload includes 36 hours (attendance), working in both conferences (14 hours) and seminars (20 hours), there is no practical division between the two. During the seminar, the teacher and the students will solve the problems proposed which will allow the teacher to evaluate the capacities and limitations of each one and to improve the learning.
These classes will be in classroom when we are in scenario 1 described by our university, on scenarios 2 and 3 they will take place on Microsoft Teams platform.
2. Bulletins, online questionnaires and works. Throughout the year, approximately coinciding with the end of each topic will propose a bulletin of problems that the student must convert and deliver for correction as personal work.
Throughout the seminars, students will perform two works:
1. First, it will be the explanation of the complex molecule synthesis to their classmates using digital media present in class (This work will be done as a team, according to the complexity of the synthesis).
2. Second, it will be an individual work where students must demonstrate their knowledge and skill in finding information and problem solving (synthesis, study reaction, chiral auxiliary or chiral catalyst). The completion of this work at home will allow you to acquire the necessary skills for the final exam. Of course, the student can consult and request their help for the teacher at any time.
The bulletins/questionnaires/presentations of the assigned works will be resolved/commented in the classroom when we are in scenario 1 described by our university. On scenarios 2 and 3 they will be developed on the Microsoft Teams platform.
The students will have videos where the bulletins/questionnaires wil be solved after they were solved in class so that they could use them later for subject’s study.
3. Group tutorials (2 hours): Throughout the course will be organized tutorial groups that are used to examine and resolve all the doubts in a group that seek greater participation of the student.
Group tutorials will be in the classroom when we are in scenario 1 described by our university, on scenarios 2 and 3 they will take place on Microsoft Teams platform.
4. Personalized tutorials: They will be used to carry out a close monitoring of the work of each student. These tutorials are an important tool for the teacher and the student since, after correction, allows a close understanding of the strengths and weaknesses in the learning of each student. In the end, the teacher will orient the student's work more adequately.
Personalized tutorials will be carried out on person or virtual according to the scenario in which we find ourselves or due to the preference of the student, otherwise on scenario 3 that it will be "online" through the Microsoft Teams platform.
5. Digital Platform (Moodle): The University of Santiago de Compostela uses a digital platform in which the teacher will provide the necessary information for students (PowerPoint files, topic summaries, problem bulletins, online questionnaires news, announcements, etc.) via Internet. This platform also contains discussion forums and internal mail, which provides excellent communication between teachers and students.
6. Microsoft Teams: Microsoft Teams group videoconferencing platform will be used to give group conferences, seminars, and tutorials in the case of scenarios 2 and 3. Individualized tutorials will preferably be carried out by this means.
In cases of fraudulent performance of exercises or tests, it will be apply normative included on “Normativa de avaliación do rendemento académico dos estudantes e de revisión de cualificacións”.
Likewise, the evaluation system will be continuous based on three points:
• During the course coinciding with the end of each topic, a problem bulletin will be proposed, the student must solve and present it at the seminars for correction. The evaluation of these bulletins will be 15 % of the final mark. It will evaluate all the basic and specific skills that represent respectively 15% and 85% of the value of the note. This material will be delivered using the USC virtual campus platform in all scenarios.
• During the academic year, two academic works will be proposed for the work, which will constitute 15 % of the final grade (7.5 % each one). As already mentioned,
1. first work will be an explanation of the synthesis of a complex molecule to his classmates using the digital media present in the class. On scenario 1 in person or through the Teams platform in case of scenarios 2 and 3. and
2. second work will be an individual student problem work where must demonstrate skill and knowledge in search for information and problem resolution (synthesis, study of a reaction, chiral auxiliary or chiral catalyst). This work will be delivered using the virtual campus platform. On both works all basic, transversal, and specific competences will be evaluated. The percentage of the note will be: basic (CG2, CG3, CG4 and CG5 10% of the rating of this section), transversal (CT7,CT9, CT10 and CT11 20% of the rating of this section) and specific (CE4,CE11, CE12, CE13 and CE15 70% of the rating of this section).
The student will receive a detailed report of his continuous evaluation before the realization of the exam where his note of this section will appear.
• To conclude, a final exam will be done that will include all the contents of the subjects. This exam will be evaluated using theoretical questions and the student's creativity in organic synthesis. The exam grade will be 70 % of the final grade. The exam will be in person in scenarios 1 and 2, in scenario 3 it will be "online" through the virtual campus platform. All specific competences (CE4,CE11, CE12, CE13 and CE15) will be evaluated.
In the case of falling the first opportunity, the student will be evaluated in second opportunity following the same methodology, so it is essential that the students attend classes and seminars and complete the delivery of the requested works during course because this will be the 30% of the qualification.
A student's qualification will not be inferior to the final exam neither the continuous evaluation.
Classload in the classroom:
Lectures: 14
Interactive seminar classes: 20
Interactive tutorial classes: 2
TOTAL HOURS IN THE IN THE CLASSROOM: 36 hours
Personal work:
Individual or group study: 25 hours
Solving exercises and other work: 40 hours
Preparation of oral presentations, preparation of proposed written exercises, or similar activities in the library: 11.5 hours
TOTAL HOURS OF PERSONAL WORK: 76.5 hours
In my opinion, the average student should devote 2-2.5 hours of personal study per hour of classroom.
Attendance to lectures is highly recommended.
It is advisable to keep the study of matter "up to date" to reinforce what the student has studied in class exercises (self-evaluation model).
After the reading of an item in the reference manual, it is useful to summarize the important points, identifying the equations, concepts and basic reactions to be remembered.
The resolution of exercises is essential for learning this subject. For exercises involving concepts of stereochemistry it is advisable to use molecular models.
The main thing is to study day by day.
The languages of this course are spanish and gallician.
Contingency Plan (summary).
Teaching will be carried out in the scenario 1 mode defined in the instruction of the Rector's Office called Contingency Plan for the development of teaching in the 2021/22 academic year and in the complementary regulations established by the Faculty of Chemistry, which entail teaching and exams in a face-to-face format.
If necessary, the modality of scenario 2 will be adapted, also defined by the aforementioned instances, for which two modalities are envisaged: 100% face-to-face, in the case of small groups, and/or the teaching organisation allows it; and a combination of 50% face-to-face and 50% telematic. In the combined modality, the lecture groups will be subdivided and will have alternating face-to-face teaching, i.e. half of the students will be in the classroom and the other half will follow the class via M. Teams. The exams will preferably be taken in classroom mode.
If circumstances so dictate, scenario 3 will be used, with the closure of facilities, also defined in the aforementioned instruction from the Rector's Office, adopting the appropriate teaching and assessment methods for this scenario.
Antonio Rumbo Gómez
Coordinador/a- Department
- Organic Chemistry
- Area
- Organic Chemistry
- antonio.rumbo [at] usc.es
- Category
- Professor: Temporary PhD professor
| Monday | |||
|---|---|---|---|
| 16:00-17:00 | Grupo /CLE_01 | Spanish | Physical Chemistry Classroom (ground floor) |
| Tuesday | |||
| 16:00-17:00 | Grupo /CLE_01 | Spanish | Physical Chemistry Classroom (ground floor) |
| Wednesday | |||
| 11:00-12:00 | Grupo /CLE_01 | Spanish | Mathematics Classroom (3rd floor) |
| 01.19.2022 10:00-14:00 | Grupo /CLE_01 | Biology Classroom (3rd floor) |
| 01.19.2022 10:00-14:00 | Grupo /CLE_01 | Analytical Chemistry Classroom (2nd floor) |
| 07.01.2022 16:00-20:00 | Grupo /CLE_01 | Physical Chemistry Classroom (ground floor) |