Mercedes Novo Rodríguez

Full Professor

Tel.: 

+34 982 824 084

Research unit: 

Biographical sketch

  • 1982-1987 Degree in Chemical Sciences (Physical Chemistry) at the USC. Bachelor's thesis.

  • 1991 PhD Thesis "Photoinduced proton transfer processes in 2-pyridylbenzimidazoles", Department of Physical Chemistry, USC, Directors: Profs. Flor Rodríguez Prieto and Manuel Mosquera González.

  • 1988 Predoctoral stay at the Center for Structural Chemistry of the Higher Technical Institute of Lisbon (Portugal), under supervision of Prof. Antonio Maçanita.

  • 1990 Predoctoral stay at the Spectroscopy Department of the Max-Planck-Institut für biophysikalische Chemie in Göttingen (Germany), under supervision of Dr. Bernhard Nickel and Dr. Karl H. Grellmann.

  • 1992 Postdoctoral stay at the Laboratory of Molecular Dynamics and Spectroscopy of the Katholieke Universiteit Leuven (Belgium), under supervision of Prof. Frans C. De Schryver.

  • 1992-1995 Assistant Professor at the USC.

  • 1993-1996 Postdoctoral stays and research-contract in the photobiology group of the Medical Laser Center in Lübeck (Germany), with Dr. Heyke Diddens and Prof. Reginal Birngruber.

  • Since 1996, Associate Professor at the Department of Physical Chemistry of the USC in Lugo (permanent position in 1998).

  • Since 2003, together with Prof. Wajih Al-Soufi, director of the Single Molecule Fluorescence Research Unit of the Group Biophysical Chemistry, Photophysics and Spectroscopy (USC).

  • 2015 National Accreditation as Full Professor (Acreditación National para Catedrático de Universidad), 3th of november, 2015.

  • Since 2013 Founder and Chief Coordinator of the “Teaching Innovation Group XuvenCiencia” http://www.usc.es/xuvenciencia(link is external). “XuvenCiencia”, offers training to school staff, develops educational science kits and organizes one of the biggest annual scientific summer campus for young people in Spain.

  • 2023 Full Professor of Physical Chemistry

I received my training in physical chemistry and especially in photophysics under the direction of Professors Flor Rodríguez Prieto and Manuel Mosquera González and during several stays in laboratories specialized in fluorescence life-time measurements, flash photolysis and phosphorescence techniques applied to systems with photoinduced proton transfer. In postdoctoral stays at the Catholic University of Louvain (Belgium), I worked with Langmuir Blodgett films and the "time of flight" technique, and at the Medical Laser Center in Lübeck (Germany) I conducted studies on the intracellular location of different photosensitizers used for the diagnosis and treatment of cancer in the field of photodynamic therapy (PDT).

In 2003, together with Prof. Dr. Wajih Al-Soufi, I founded the Single Molecule Fluorescence Research Unit for the application of fluorescence microscopy techniques of high spatial and temporal resolution to systems of biological or technological interest such as DNA, proteins, liposomes, micelles or cyclodextrins. Our main interest is the study of the dynamics of the supramolecular association and the processes of biomolecular recognition. For this purpose, we apply fluorescence correlation spectroscopy (FCS), multiparametric fluorescence detection of individual molecules (MFD) and internal reflection fluorescence microscopy (TIRF).

In 2004 we presented for the first time the application of FCS to the dynamics of host-guest-type molecular inclusion processes (JACS 2005, 127, 8775) and to the dynamics of the solubilization in micelles (JPC B, 2007, 3614). We determined the sequence specificity of the binding dynamics of minor groove ligands of DNA (Angew, Chem. Int. Ed., 2012, 51, 7541) and we recently published the first direct determination of the critical aggregation concentration for the formation of early Amyloid-β (1-42) oligomers responsible for Alzheimer’s disease (Scientific Reports 2018, 8.). Since 2004, we have obtained continuous funding in competitive calls and participated in national research networks and EU-COST actions. 

Databases: Web Grupo, USC, ResearchGate, ORCID, Google Scholar, LinkedIn, Scopus

Publications

CRISPR/Cas9 Delivery Systems to Enhance Gene Editing Efficiency

Ana Seijas, Diego Cora, Mercedes Novo, Wajih Al-Soufi, Laura Sánchez, Álvaro J. Arana

Amyloid Capture and Aggregation Inhibition by Human Serum Albumin

Diego Cora, Wajih Al‐Soufi, Mercedes Novo

International Journal of Biological Macromolecules, Volume 301, April 2025, 140367

https://doi.org/10.1016/j.ijbiomac.2025.140367

(Preprint: ChemRxiv, 2024, Version 1, 10.26434/chemrxiv-2024-fr8gt)

Thiazole Orange as fluorescent marker for the detection and quantification of dsDNA

Stella Hernández, Lucas Piñeiro, Wajih Al-Soufi, Mercedes Novo

ChemRxiv, 2024, Version 1, Preprint, 10.26434/chemrxiv-2024-lbxzx

Critical aggregation concentration and reversibility of amyloid-β (1–40) oligomers

Sara Illodo, Wajih Al-Soufi, Mercedes Novo

Archives of Biochemistry and Biophysics2024, 761, 110179, DOI 10.1016/j.abb.2024.110179

Mercedes Novo, Cibrán Pérez-González, Sonia Freire and Wajih Al-Soufi

Methods in Molecular Biology, 2023, 2551, 1–14. DOI: 10.1007/978-1-0716-2597-2_1

Mercedes Novo and Wajih Al-Soufi

Frontiers in Chemistry 2022, 10, 1042658. DOI: 10.3389/fchem.2022.1042658 (Open Access)

Sara Illodo, Cibrán Pérez-González, Ramiro Barcia, Flor Rodríguez-Prieto, Wajih Al-Soufi, Mercedes Novo

International Journal of Molecular Sciences 202223(2), 925. DOI: 10.3390/ijms23020925 (Open Access)

Wajih Al-Soufi, Jorge Carrazana-Garcia, and Mercedes Novo

Journal of Chemical Education 2020, 97, 9, 3090–3096, https://doi.org/10.1021/acs.jchemed.0c00745

Paul A. Dalgarno, José Juan-Colás, Gordon J. Hedley, Lucas Piñeiro, Mercedes Novo, Cibrán Pérez-González, Ifor D. W. Samuel, Mark C. Leake, Steven Johnson, Wajih Al-Soufi, J. Carlos Penedo, Steven D. Quinn

Scientific Reports 2019, 9, Article number: 12897, DOI: 10.1038/s41598-019-49210-0 (Open Access)

Mercedes Novo, Sonia Freire, Wajih Al-Soufi

Scientific Reports 2018, 8, Article number: 1783, DOI: 10.1038/s41598-018-19961-3 (Open Access)

Jorge Bordello, Mateo I. Sánchez, M. Eugenio Vázquez, José L. Mascareñas, Wajih Al-Soufi, and Mercedes Novo

Chemistry - A European Journal 2015, 21,  1609–1619. DOI: 10.1002/chem.201404926

Accepted Author Manuscript

Sonia Freire, Flor Rodríguez-Prieto, M. Carmen Ríos Rodríguez, J. Carlos Penedo, Wajih Al-Soufi, and Mercedes Novo

Chemistry - A European Journal 2015, 21,  3425–3434. DOI: 10.1002/chem.201406110

Accepted Author Manuscript

Lucas Piñeiro, Mercedes Novo, and Wajih Al-Soufi

Advances in Colloid and Interface Science 2015,  215, 1–12. DOI:10.1016/j.cis.2014.10.010

Author post-print and Supplementary Information

Jesús Agulla, David Brea, Bárbara Argibay, Mercedes Novo, Francisco Campos, Tomás Sobrino, Miguel Blanco, José Castillo, Pedro Ramos-Cabrer

Nanomedicine : Nanotechnology, Biology, and Medicine 2014, 10 (4), 851–858, DOI: 10.1016/j.nano.2013.12.004)

Sonia Freire, Marcus H. de Araujo, Wajih Al-Soufi, Mercedes Novo
Lucas Piñeiro, Sonia Freire, Jorge Bordello, Mercedes Novo, and Wajih Al-Soufi

Soft Matter 2013,  9, 10779-10790, DOI: 10.1039/ c3sm52092g (pdf)

Jorge Bordello, Mateo I. Sánchez, M. Eugenio Vázquez, José L. Mascareñas, Wajih Al-Soufi and Mercedes Novo

Angewandte Chemie International Edition 201251, 7541–7544

Wajih Al-Soufi, Mercedes Novo, Manuel Mosquera, and Flor Rodríguez-Prieto

in Reviews in Fluorescence, volume 2009, 2011, 6, 23–45,  ed. Chris D. Geddes, Springer, New York 

Mercedes Novo, Daniel Granadero, Jorge Bordello and Wajih Al-Soufi

Journal of Inclusion Phenomena and Macrocyclic Chemistry 2011, 70, 259-268

Daniel Granadero, Jorge Bordello, María Jesús Pérez-Alvite, Mercedes Novo, and Wajih Al-Soufi

International Journal of Molecular Sciences 2010, 11, 173–188

Jorge Bordello, Mercedes Novo and Wajih Al-Soufi

Journal of Colloid and Interface Science 2010, 345, 369–376

Sonia Freire, Jorge Bordello, Daniel Granadero, Wajih Al Soufi and Mercedes Novo

Photochemical & Photobiological Sciences 2010, 9, 687–696

J. Bordello, B. Reija, W. Al-Soufi, M. Novo

ChemPhysChem 2009, 10, 931–939

W. Al-Soufi, B. Reija, S. Felekyan, C. A. Seidel, M. Novo

ChemPhysChem 20089, 1819–1827

M. Novo, S. Felekyan, C. A. M. Seidel, and W. Al-Soufi

Journal of Physical Chemistry B  2007, 111, 3614-3624

Mercedes Novo, Belén Reija, Wajih Al-Soufi

Journal of Chemical Education 200784, 1673-1675

Wajih Al-Soufi, Belén Reija, Mercedes Novo, Suren Felekyan, Ralf Künemuth, and Claus A. M. Seidel

Journal of the American Chemical Society 2005, 127, 8775-8784

Belén Reija, Wajih Al-Soufi, Mercedes Novo, José Vázquez Tato

Journal of Physical Chemistry B 2005, 109, 1364-1370

Jorge Carrazana, Belén Reija, Pedro Ramos Cabrer, Wajih Al-Soufi, Mercedes Novo, José Vázquez Tato

Supramolecular Chemistry 16, 549-559 (2004)

Minerva Lezcano, Mercedes Novo, Wajih Al-Soufi, Eugenio Rodríguez-Núńez, and José Vázquez Tato

Journal of Agricultural and Food Chemistry 51, 5036-5040 (2003)

Minerva Lezcano, Wajih Al-Soufi, Mercedes Novo, Eugenio Rodríguez-Núńez, and José Vázquez Tato

Journal of Agricultural and Food Chemistry 50, 108-112 (2002)

W. Al-Soufi, M. Novo, and M. Mosquera

Applied Spectroscopy 2001, 55, 630636

Influence of pH on the stability of the inclusion complex of methyl orange and beta-cyclodextrin

Carrazana García, J., Al-Soufi, W., Novo Rodríguez, M., and Vázquez Tato, J.

Proceedings of the 9th International Symposium on Cyclodextrins, 1998, Santiago de Compostela, Spain.
Kluwer Academic Publishers, Dordrecht, 179-182 (1999)

Chemical instability of 5-aminolevulinic acid used in the fluorescence diagnosis of bladder tumors

Mercedes Novo, Gereon Huettmann, and Heyke Diddens

Journal of Photochemistry and Photobiology, B: Biology 34, 143-148 (1996)

M. Novo, M. Mosquera, and F. Rodríguez Prieto

Journal of Physical Chemistry 1995, 99, 14726–14732

Mercedes Novo, Manuel Mosquera, and Flor Rodríguez Prieto

Journal of the Chemical Society, Faraday Transactions 1993, 89, 885889

Photoinduced electron transfer in and electron injection from trichromophoric molecules forming Langmuir Blodgett films

Danny Meerschaut, Mercedes Novo, Mark Van der Auweraer, Wim Dehaen, and Frans C de Schryver

Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals 235, 67-74 (1993)

Anomalous field dependence of the hole mobility in a molecular doped polymer

M. Novo, M. van der Auweraer, F. C. de Schryver, P. Borsenberger, and H. Baessler

Physica Status Solidi B: Basic Research 177, 223-41 (1993)

Tautomerism - to be taken lightly

Flor Rodríguez Prieto, Mercedes Novo, José A. Domínguez Herbón, and Berta Fernández Rodríguez

Education in Chemistry 1992, 29, 139141

Mercedes Novo, Manuel Mosquera, and Flor Rodríguez Prieto

Canadian Journal of Chemistry 1992, 70, 823827

Heike Eisenberger, Bernhard Nickel, A. Andreas Ruth, Wajih Al-Soufi, Karl H. Grellmann, and Mercedes Novo

Journal of Physical Chemistry 95, 10509-10518 (1991)

Flor Rodríguez Prieto, Manuel Mosquera, and Mercedes Novo

Journal of Physical Chemistry 1990, 94, 85368542