ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Expository Class: 32 Interactive Classroom: 16 Total: 48
Use languages Spanish, Galician
Type: Ordinary subject Master’s Degree RD 1393/2007 - 822/2021
Departments: Morphological Science, External department linked to the degrees
Areas: Human Anatomy and Embryology, Área externa M.U en Biofabricación
Center Faculty of Pharmacy
Call: First Semester
Teaching: With teaching
Enrolment: Enrollable | 1st year (Yes)
• To apply the fundamental concepts, norms, and ethical principles of research in health sciences.
• To identify, differentiate, and compare various strategies based on cell therapy, advanced therapies, and biomaterials with high regenerative potential aimed at different human pathologies.
Topic 1. Types, sources, and methods of obtaining cells for application in cell therapy. Cell types, characteristics, and collection methods.
Topic 2. Differentiation, transformation, and cellular reprogramming. Concept of cell potential: differentiation and reprogramming.
Topic 3. Cell signaling. Cellular signaling pathways.
Topic 4. Cryopreservation of cells and tissues. Development of techniques and methods for cryopreservation.
Topic 5. Omics analysis in biomedical sciences. Application of genomics, proteomics, and transcriptomics in cell therapy.
Topic 6. Viral and non-viral vectors in gene therapy. Production of viral and non-viral vectors for gene therapy applications.
Topic 7. Introduction to advanced therapies. Immunotherapy, mitochondrial therapy, and CAR-T cells. Methodology for mitochondrial isolation and CAR-T cell generation.
Topic 8. Application of biomaterials in medicine. Properties and types of biomaterials used in biomedicine.
Topic 9. Bioethics and research ethics. Responsible research. Understanding the ethical aspects of biomedical research. Informed consent.
Topic 10. Research involving human beings and human-derived materials. Ethics Committees, biobanks, and human sample collections.
Topic 11. Regulation of Advanced Therapy Medicinal Products (ATMPs) in Spain and the EU. Definition of advanced therapies and current legislation for human application.
Basic Bibliography
• Piñeiro-Ramil M, et al. (2023). Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage: a new tool for cartilage pathophysiology studies. Bone Joint Res; 12:46–57.
• Sanjurjo-Rodríguez C., et al. (2020). Versatility of induced pluripotent stem cells (iPSCs) for improving the knowledge on musculoskeletal diseases. Int J Mol Sci; 21:6124.
• Castro-Viñuelas R., et al. (2020). Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts. Sci Rep; 10:4272.
• Piñeiro-Ramil M., et al. (2019). Usefulness of mesenchymal cell lines for bone and cartilage regeneration research. Int J Mol Sci; 20:6286.
• Castro-Viñuelas R., et al. (2018). Induced Pluripotent Stem Cells for cartilage repair: current status and future perspectives. Eur Cell Mater; 36:96–109.
• Atala, A., Lanza, R., Mikos, A., Nerem, R. (2018). Principles of Regenerative Medicine. 3rd ed. New York: Academic Press-Elsevier. ISBN: 9780128098936.
Supplementary Bibliography
Relevant and updated scientific articles published in high-impact journals will also be used, such as Stem Cells Translational Medicine, Regenerative Medicine, and Journal of Tissue Engineering and Regenerative Medicine, among others.
• A1 HD3 – Ability to evaluate and select appropriate scientific theories and precise methodologies in the field of biofabrication, including ethical and social responsibility considerations.
• A7 CG1 – Mastery of information retrieval and critical analysis techniques to identify relevant scientific theories and methodological approaches for biofabrication design and evaluation.
• A8 CG2 – Ability to apply knowledge to problem-solving and project planning/management in multidisciplinary research and innovation contexts related to biofabrication.
• A9 CG3 – Understanding of social and ethical responsibilities arising from research, development, and innovation in biofabrication.
• A10 CG5 – Knowledge and application of mandatory legal specifications, regulations, and standards in biofabrication for the safe use of biofabrication processes.
• CG7 – Ability for organization and planning in business, institutional, and organizational environments.
• A12 CT1 – Capacity to independently design a research project in multidisciplinary environments and manage R&D&I in biofabrication.
• A13 CT2 – Use of ICT tools to clearly and rigorously communicate knowledge, results, and conclusions in specialized settings.
• A14 CT4 – Understanding and applying gender perspective in academic and professional practice to foster a fairer and more equitable society.
• A15 CT5 – Commitment to sustainability and environmental responsibility. Equitable, responsible, and efficient resource use.
• A20 CON4 – Fundamentals of regenerative medicine. Legislation and bioethics.
• A24 CT3 – Initiative for continuous training and addressing new scientific and technological challenges.
• A36 CON10 – Design and application of clinical models for advanced therapies.
• A41 CE11 – Knowledge of principles, norms, and models for preclinical animal experimentation, and the ability to design and analyze procedures and scientific projects.
• A43 CE13 – Development of an ethical sense in health sciences research.
• A44 HD1 – Advanced knowledge in biofabrication and in-depth understanding of theoretical-practical aspects and working methodologies.
• A45 HD2 – Application and integration of biofabrication knowledge to solve problems in new and multidisciplinary settings, both in research and highly specialized professional contexts.
• A48 CE14 – Knowledge of foundations and procedures for developing and applying advanced therapy systems to treat tissue regeneration disorders in clinical practice.
• Scientific and outreach events: Educational seminars in which students present assigned research topics selected by faculty.
• Field work: Laboratory practice sessions.
• Lectures: Participatory theoretical sessions encouraging discussion, debate, and student interaction.
• Personalized Support: Direct and online individual and group academic mentoring upon request and by appointment.
PERSONALIZED SUPPORT FOR ALL STUDENTS
Personalized guidance is aimed at monitoring each student's academic progress.
Through tutoring sessions (on-campus or online), faculty help resolve doubts and guide study efforts.
An official tutoring schedule is available, either in person or through institutional online platforms.
SUPPORT FOR STUDENTS WITH PART-TIME DEDICATION OR WORK–LIFE BALANCE CHALLENGES
Students who, for justified reasons, face difficulties in balancing academic and family/work life may receive:
• The same support conditions available to all students.
• Additional support upon request via email.
• Class attendance is mandatory.
• Lectures (A9, A10, A12, A13, A14, A15, A43): Final exam with multiple-choice questions (4 options per question, only one correct; no penalty for wrong answers). Passing grade: 60% correct answers. Weight: 80%
• Scientific and outreach events (A1, A7, A8, A24, A44, A45, A48): Systematic observation of student participation. Weight: 10%
• Field work (A20, A36, A41): Systematic observation during laboratory sessions. Weight: 10%
Students are encouraged to keep up with the course content regularly to achieve academic success.
Jannette Rodriguez Pallares
- Department
- Morphological Science
- Area
- Human Anatomy and Embryology
- Phone
- 881815466
- jannette.rodriguez [at] usc.es
- Category
- Professor: University Lecturer
Juan Andres Parga Martin
- Department
- Morphological Science
- Area
- Human Anatomy and Embryology
- juan.parga [at] usc.es
- Category
- Professor: University Lecturer
| Monday | |||
|---|---|---|---|
| 15:00-20:00 | Grupo /CLE_01 | Spanish | 5035 Inorganic Chemistry Seminar Room |
| Tuesday | |||
| 15:00-20:00 | Grupo /CLE_01 | Spanish | 5035 Inorganic Chemistry Seminar Room |
| Wednesday | |||
| 15:00-20:00 | Grupo /CLIS_01 | - | 5035 Inorganic Chemistry Seminar Room |
| Thursday | |||
| 15:00-20:00 | Grupo /CLIS_01 | - | 5035 Inorganic Chemistry Seminar Room |